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Ketoprofen transdermal patch and preparation method thereof

A technology of transdermal patch and ketoprofen, which is applied in the directions of anti-inflammatory agents, pharmaceutical formulations, non-central analgesics, etc., can solve the complex preparation process of ketoprofen for injection, the inapplicability of swallowing capsules, and the need for stability. Investigation and other problems, to achieve the effect of no skin irritation and allergic reaction, good transdermal absorption effect, and easy preparation process

Pending Publication Date: 2021-10-26
北京鑫开元医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Oral ketoprofen can easily cause gastrointestinal reactions such as stomach pain, nausea, vomiting, ulcers, bleeding, etc.; ketoprofen for injection has a complicated preparation process, high equipment requirements, and stability to be investigated. Clinically, intramuscular or intravenous injection is required. The side effects of injection medication are relatively large, and there are many problems in the preparation of the drug and the compliance of the body, and the operation is cumbersome, time-consuming and increases the pain of the patient
In addition, if ketoprofen is made into capsules, it is not suitable for swallowing capsules for patients with dysphagia

Method used

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  • Ketoprofen transdermal patch and preparation method thereof
  • Ketoprofen transdermal patch and preparation method thereof
  • Ketoprofen transdermal patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Formula 1 (each component is in wt%)

[0033]

[0034] The preparation method of described ketoprofen transdermal patch is:

[0035] 1. Stir and mix the propylene glycol and glycerin in the formulated amount evenly, add the ketoprofen in the formulated amount in stages, stir to dissolve, heat in a water bath, the heating and dissolving temperature is 40-70°C, add isopropyl myristate and azone and mix Until dissolved, finally add methylparaben and sodium thiosulfate and stir to mix to obtain a mixture.

[0036] 2. Mix zinc oxide, calcium hydroxide and aluminum potassium sulfate evenly, heat and melt together with the hot-melt pressure-sensitive adhesive, and control the temperature above 120°C, so that the obtained colloidal matrix material forms a flowable state.

[0037] 3. Add the mixture into the colloidal matrix material, heat and stir evenly and keep warm to obtain the glue.

[0038] 4. Use a coating machine to carry out coating operations, control the coating...

Embodiment 2

[0041] Formula 2 (each component is in wt%)

[0042]

[0043] The preparation method of described ketoprofen transdermal patch is:

[0044] 1. Stir and mix the propylene glycol and glycerin in the formulated amount evenly, add the ketoprofen in the formulated amount in stages, stir to dissolve, heat in a water bath, the heating and dissolving temperature is 40-70°C, add isopropyl myristate and azone and mix Until dissolved, finally add methylparaben and sodium thiosulfate and stir to mix to obtain a mixture.

[0045] 2. Mix zinc oxide, calcium hydroxide and aluminum potassium sulfate evenly, heat and melt together with the hot-melt pressure-sensitive adhesive, and control the temperature above 120°C, so that the obtained colloidal matrix material forms a flowable state.

[0046] 3. Add the mixture into the colloidal matrix material, heat and stir evenly and keep warm to obtain the glue.

[0047] 4. Use a coating machine to carry out coating operations, control the coating...

Embodiment 3

[0050] Formula 3 (each component is in wt%)

[0051]

[0052]

[0053] The preparation method of described ketoprofen transdermal patch is:

[0054] 1. Stir and mix the propylene glycol and glycerin in the formulated amount evenly, add the ketoprofen in the formulated amount in stages, stir to dissolve, heat in a water bath, the heating and dissolving temperature is 40-70°C, add isopropyl myristate and azone and mix Until dissolved, finally add methylparaben and sodium thiosulfate and stir to mix to obtain a mixture.

[0055]2. Mix zinc oxide, calcium hydroxide and aluminum potassium sulfate evenly, heat and melt together with the hot-melt pressure-sensitive adhesive, and control the temperature above 120°C, so that the obtained colloidal matrix material forms a flowable state.

[0056] 3. Add the mixture into the colloidal matrix material, heat and stir evenly and keep warm to obtain the glue.

[0057] 4. Use a coating machine to carry out coating operations, control ...

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Abstract

The invention relates to a ketoprofen transdermal patch and a preparation method thereof. The ketoprofen transdermal patch comprises a backing layer, a drug-containing colloid layer and an anti-sticking layer, wherein the drug-containing colloid layer comprises ketoprofen, a humectant, an absorption enhancer, a colloid matrix material and an additive. The ketoprofen transdermal patch can improve the local drug concentration of a pain part, can regulate an administration dosage through control of an administration area, can interrupt administration at any time, is convenient in use, and improves the compliance of medication. The ketoprofen transdermal patch has a high drug loading capacity and a good transdermal absorption effect, is small in skin irritation, is free from allergy-prone components, is free from pollution; is good in breathability, is good in skin fitting performance, can be easily peeled off, does not have peculiar smells, does not have skin irritation or anaphylactic reaction, is high in safety, has a simple preparation technology, is easy in implementation, is good in stability, is used for treating rheumatism / rheumatic arthritis and has a good clinical effect.

Description

technical field [0001] The invention relates to a ketoprofen transdermal patch and a preparation method thereof, belonging to the technical field of pharmaceutical preparations. Background technique [0002] Transdermal patch is a transdermal drug delivery system, which is administered on the surface of the skin, and the drug enters the blood circulation of the whole body through the skin through the capillary, reaches an effective blood concentration, and plays a therapeutic or preventive role in various tissues or diseased parts dosage form. Its main feature is that it can avoid the first-pass effect of the liver and prevent the destruction of the gastrointestinal tract, and can maintain a constant blood drug concentration for a relatively long period of time, reducing the number of medications. [0003] Ketoprofen, chemical name a-methyl-3-benzoyl-phenylacetic acid (C 16 h 14 o 3 ), is a non-steroidal antipyretic analgesic anti-inflammatory drug (NSAID), has anti-infl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/192A61K47/10A61K47/14A61K47/22A61P29/00A61P19/02
CPCA61K9/7023A61K31/192A61K47/10A61K47/14A61K47/22A61P29/00A61P19/02
Inventor 马燕辉潘海群侯宇翔齐兵兵戴信敏
Owner 北京鑫开元医药科技有限公司
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