30results about How to "Increase hydrogen bond" patented technology

The invention relates to a super-fine-denier polyester fiber and a manufacturing method thereof. The super-fine-denier polyester fiber is mainly made of polyester through spinneret orifice melt spinning and high-speed coiling by the adoption of a grazing agent. The grazing agent at least comprises fluorine-containing polyether, and the mass of the fluorine-containing polyether is larger than or equal to 45% of the mass of the grazing agent. The fluorine-containing polyether is a random copolymer of ethylene oxide, oxirane,2-[(1,1,2,2-tetrafluoroethoxy)methyl] and epoxypropane. The structural formula of the fluorine-containing polyether is as shown in the specification. The manufacturing method of the super-fine-denier polyester fiber comprises the steps of conducting measuring, extrusion, cooling, grazing, stretching and thermal shaping on the polyester and then conducting high-speed winding, and then the super-fine-denier polyester fiber is manufactured. The super-fine-denier polyester fiber has the advantages of being soft in hand feel, high in flexibility, gentle in gloss, high in water absorbing and oil absorbing performance, density, specific surface area and heat preservation performance and the like. The development of the weaving technology and the printing and dyeing technology enables more potential features of the super-fine-denier polyester fiber to be explored gradually.

The invention uses beta-cyclodextrin to synthesize six kinds of new beta-cyclodextrins derived from alpha-Schiff base and six chiral stationary phases thereof, wherein the invention reacts cyclodextrin aldehyde and six amine compounds to prepare beta-cyclodextrin derived from alpha-Schiff base, the compounds reacted with cyclodextrin aldehyde are L-phenylglycinol, D-phenylglycinol, L-tyrosine, D-tyrosine, L-tryptophan and D-tryptophan. The synthesis route is simple, with high yield, simple operation and easy purification. The invention can be used in chiral separation for the qualitative and quantitative research on optical isomer of amino acid, ferrocene amine compound, drug, sulfur-containing compound, alcohol compound, amino-compound and various chiral compounds. The invention can be used in asymmetry catalysis for recovering and circulating catalyst.

The invention discloses a nucleic acid extraction kit comprising a nucleic acid binding solution and a magnetic adsorbent. The nucleic acid binding solution comprises polyethylene glycol and sodium chloride, and the magnetic adsorbent is magnetic Fe3O4 nano particles with the surfaces covered with polydopamine coatings. The magnetic adsorbent provided by the invention has the superparamagetic nanoparticles, the polydopamine coatings on the surfaces of the nano particles are rich in amino groups and hydroxyl groups, under the salt solution environment provided by the nucleic acid binding solution, nucleic acids can be efficiently adsorbed, the nucleic acid adsorbing efficiency and quality of the existing magnetic nano particles are improved, and the nucleic acids can be extracted efficiently and rapidly; and when the nucleic acid extraction kit is applied to extraction of human whole blood, blood treatment is not needed, and the nucleic acid extraction kit is suitable for gene diagnosis and treatment of clinical diseases. The nucleic acid extraction method provided by the invention uses the nucleic acid extraction kit, the quality and efficiency of extracting of the nucleic acids are improved, and the nucleic acid extraction method is suitable for application and promotion of clinical diagnosis and basic scientific research.

The invention relates to a coarse-denier porous polyester fiber and a preparation method thereof. The coarse-denier porous polyester fiber is mainly prepared by the steps of melt spinning of polyester through multiple spinneret holes, application of an oiling agent, stretching and winding, wherein the oiling agent at least comprises fluorine-containing polyether, the mass of which is more than or equal to 45% of that of the oiling agent, the fluorine-containing polyether is a random copolymer of ethylene oxide, [(1,1,2,2-tetrafluoroethoxy) methyl] oxirane and propylene oxide, and the structural formula of the random copolymer is shown in the specification. The preparation method comprises the steps of metering, extruding, cooling, oiling and high-speed winding of polyester, thereby obtaining the coarse-denier porous polyester fiber. The coarse-denier porous polyester fiber is endowed with soft and elegant silk light sensation. Not only does the porous polyester fiber have excellent optical property, but also a fabric has effect of thick hand feeling and good fluffiness and breathability since a large quantity of fibers cannot be arranged closely and interspaces are correspondingly enlarged.

The invention discloses a clean pulping process for dissociated modified plant fibers. The clean pulping process comprises the following steps: (1) pre-processing raw materials; (2) preparing coarse pulp; (3) pulping; (4) removing sand; (5) screening; and (6) concentrating and extruding pulp. According to the clean pulping process disclosed by the invention, no sodium hydroxide is added, pulp-washing and bleaching processes can be reduced, and the wastewater in the pulping process can be sufficiently reutilized through simple treatment, so that pulping black liquor which is severely polluted is not produced. Meanwhile, plant fibers can be sufficiently dissociated, and the pulping quality is greatly improved.

The invention discloses a preparation method of a cyclodextrin terminated star-shaped polymer. The method includes the steps of: under anhydrous and oxygen-free conditions, using dipentaerythritol asthe initiator, using stannous isooctanate as the catalyst to carry out ring-opening polymerization reaction on epsilon-caprolactone so as to obtain six-armed polycaprolactone, and then carrying out esterification reaction on p-aminobenzoic acid to obtain an arylamine terminated six-armed star-shaped polymer, and then further carrying out addition-dehydration reaction with cyclodextrin monoaldehyde, thus obtaining the imine group chained and cyclodextrin terminated six-armed star-shaped polymer. According to the method, cyclodextrin is disposed at the terminal of the star-shaped polymer, the prepared product not only has the three-dimensional structural characteristics of the star-shaped polymer itself, but also can better retain the advantages of the cyclodextrin chamber and cavity surrounding structure, thus enlarging the application range. The invention expands the types of star-shaped cyclodextrin polymers. The preparation method has the advantages of simple operation, mild reactionconditions, and simple product post-treatment, and is beneficial to realization of industrial production.

The present invention relates to bright warm-keeping lightness type fibers and a preparation method thereof, wherein mainly a polyester is subjected to special-shaped spinning hole melt spinning, oil agent feeding and winding so as to prepare the bright warm-keeping lightness type fibers, wherein the oil agent at least comprises a fluorine-containing polyether, the mass of the fluorine-containing polyether is more than or equal to 45% of the mass of the oil agent, the fluorine-containing polyether is a random copolymer of ethylene oxide, [(1,1,2,2-tetrafluoroethoxy)methyl]ethylene oxide and propylene oxide, and the structure formula is defined in the specification. The preparation method comprises: metering a polyester, extruding, cooling, oiling, stretching, carrying out thermal shaping, and winding so as to prepare the bright warm-keeping lightness type fibers. According to the bright warm-keeping lightness type fibers of the present invention, the fiber cross section shape is changed by the spinning while the fibers have the hollowness, the air permeability and the thermal insulation property are increased, and with the special cross section shape of the fibers, the bright surface light refraction effect is provided so as to make the fabric bright and gorgeous; and the fibers further have characteristics of lightness, light weight, and soft touch feeling.

The invention discloses an agricultural sewage treatment agent and a preparation method thereof. The sewage treatment agent comprises the following raw materials in parts by weight: 30-40 parts of anadsorbent, 15-20 parts of chitosan, 10-20 parts of sodium alginate, 10-20 parts of carbon nanotubes, 10-15 parts of modified beta-cyclodextrin, 10 -15 parts of starch, 10-15 parts of sepiolite, 5-10 parts of cellulose, 5-8 parts of chlorophyll and 3-5 parts of a bactericide. The agricultural sewage treatment agent provided by the invention can effectively remove pesticide residues from sewage, reduces the eutrophication degree of the water quality, and effectively recycles heavy metal pollutants contained in water so as to ensure that after treatment, the water quality meets standards of farmland irrigation and industrial water.

The invention relates to a preparation method of a bioactive glass composite material, and belongs to the technical field of medical materials. The preparation method comprises the following steps: performing reaction on a silk fibroin solution and gelatin, adding bioactive glass dispersing liquid and glutamine transaminase after the reaction, and performing crosslinking reaction under the condition that the glutamine transaminase serves as a catalyst to obtain viscous liquid; and pouring the viscous liquid into a mold, and molding, gelatinizing, ageing and freeze-drying to obtain the bioactive glass composite material. The bioactive glass composite material prepared by the method has high biocompatibility, maintains high mechanical property, has high mineralizing speed, is an ideal tissue material and can be applied to defect regeneration and repair of human bones.

The invention relates to a novel chiral catalyst of an (S)-Alpha, Alpha-fluorine-containing diaryl-2-pyrrolidine methanol derivative and provides a preparation method and applications in an asymmetricreaction thereof. The preparation method comprises the following steps: adopting amino protected N-substitute-2 pyrrolidine methyl formate to react with a grignard reagent, then removing the protecting group; and then reacting with alkyl chlorosilane to prepare the (S)-Alpha, Alpha-fluorine-containing diaryl-2-pyrrolidine methanol derivative. The invention has the following beneficial effects: compared with other chiral catalysts of aryl pyrrolidine methanol derivative, the chiral catalyst of the fluorine-containing aryl pyrrolidine methanol derivative not only enhances the activity on N andimproves catalysis, but also simultaneously increases substrates and hydrogen bonds of catalysts as well as stereoselective reaction of the substrates, and broadens the application scope of the substrates.

The invention discloses a medical composite shaddock peel pectin sponge dressing capable of slowly releasing carried medicines, a preparation method and an application of the dressing. The medical composite shaddock peel pectin sponge dressing is prepared from shaddock peel high-grease pectin solution, chitosan solution and CMC (sodium carboxymethylcellulose)-Na solution according to the volume ratio of (1-3):(2-4):(1-3). The prepared medical composite shaddock peel pectin sponge dressing does not contain cross-linking agents, can stop bleeding and resist bacteria, has good liquid absorption performance and can be used for protection and blooding stop of clinic wounds, a layer-by-layer network structure can be formed, bleeding stopping and resist bacterium resisting medicines such as nano-silver are added, slowly releasing effect of the medicines is improved, medical requirements are further met, and the dressing is simple in preparation process and low in cost.

The invention relates to an ultra-fine denier polyester fiber and a preparation method thereof, and an ultra-fine denier polyester fiber. The ultra-fine denier polyester fiber mainly consists of polyester melt spinning through spinneret holes, oiling agent and high-speed It is prepared by winding; the oil agent of the oiling agent includes at least fluorine-containing polyether, and the mass of the fluorine-containing polyether is greater than or equal to 45% of the mass of the oil agent; the fluorine-containing polyether is ethylene oxide, [(1,1,2,2-tetrafluoroethoxy)methyl]random copolymer of ethylene oxide and propylene oxide, its structural formula is: the preparation method of the present invention is to measure polyester, extrude Extraction, cooling, oiling, drawing, heat setting and high-speed winding to produce ultra-fine denier polyester fibers. The ultra-fine denier polyester fiber of the present invention has excellent characteristics such as soft hand, high flexibility, soft luster, high water and oil absorption, high density, high specific surface area, high thermal insulation performance, etc., and with the development of weaving, printing and dyeing technology, its More potential features are also being discovered day by day.

The invention relates to a pyrotechnic gas generating agent and a preparation method and belongs to the technical field of gas generating agents. The composition of the pyrotechnic gas generating agent contains 4,5-bitetrozol-1,2,3-triazole, Fe2O3, CuO, oxidizing agents, catalysts, cooling agents and binders. The preparation method includes the steps of sufficiently evenly mixing the oxidizing agents with grain size smaller than or equal to 0.15 mm, 4,5-tetrozol-1,2,3-triazole with the grain size smaller than or equal to 0.15 mm, Fe2O3, CuO and cooling agents, and passing through a 50-mesh sieve to obtain evenly mixed powder; adding an organic solution of the binders into the evenly mixed powder, evenly mixing, passing through a 20-mesh sieve, drying the sieved powder, and passing througha 50-mesh sieve to obtain solid particles; putting the solid particles into an oil press for tabletting to obtain the gas generating agent. The gases generated by the gas generating agent are clean and cause no environment pollution.

This invention relates to a method for synthesizing compounds containing azidotriazine amantadine, whose molecular formulae are shown in formulae I and II. The method comprises: reacting dichlorotriazine amantadine and hydrazine hydrate in a mixture of water and organic solvent by nycleophilic substitution, reacting with sodium nitrite in HCl solution to oxidize hydrazine into azide, extracting the product with ethyl acetate for three times, spin-evaporating to concentrate and obtain white product, dissolving in ethyl acetate, and slowly volatilizing to obtain single crystal of the product. The introduction of amantadine into the synthesized compounds has stable thermodynamic properties, and can release stress energy during thermal decomposition to form intramolecular hydrogen bonds, thus lowering sensitivity and improve thermal stability. The new compounds can be used in high-energy insensitive dynamites, low-signal propellants, gas generators, smoke powder and firecrackers. The method has such advantages as simple process, easy purification, no need for nitrogen protection, and no pollution.

The present invention relates to a kind of ultra-soft and ultra-fine polyester fiber and its preparation method. The super-soft and ultra-fine polyester fiber is mainly prepared by melt-spinning polyester through spinneret holes, oiling agent and high-speed winding; the above The oil agent of the oil agent includes at least fluorine-containing polyether, and the quality of the fluorine-containing polyether ≥ 45% of the quality of the oil agent; the fluorine-containing polyether is ethylene oxide, [(1,1,2,2 ‑Tetrafluoroethoxy) methyl] random copolymer of oxirane and propylene oxide, its structural formula is: the preparation method of the present invention is that polyester is measured, extruded, cooled, oiled, stretched , heat setting and high-speed winding to produce ultra-soft and ultra-fine polyester fibers. The ultra-soft and ultra-fine polyester fiber of the present invention, because its monofilament fineness is very fine, its fabric has the advantages of particularly soft and delicate hand feeling, soft luster, comfortable and breathable, easy to care and good texture of appearance, and has been increasingly obtained. users' favor.

The invention discloses novel environment-friendly degradable PVC artificial leather and a production process thereof. The novel environment-friendly degradable PVC artificial leather comprises hydroxamated polyvinyl chloride, modified talcum powder, decayed apples, citric acid, xanthan gum, copper chloride, a fabric substrate, synthetic resin, a plasticizer, a coupling agent and an anti-wrinkle agent. The hydroxamated polyvinyl chloride contains carbonyl and oximido at the same time, so that the phase compatibility between the components is improved; small molecular carbon compounds formed during degradation can attract bacillus subtilis, so that the degradation of the hydroxamated polyvinyl chloride is promoted; the talcum powder can improve the water contact tolerance of the resin; the citric acid modified talcum powder improves the toughness and tensile strength of the synthetic resin; phytosterol and the citric acid generate phytosterol ester as an artificial leather skin film, and the synthetic artificial leather has waterproof and oilproof effects due to good hydrophobicity and oleophobicity of the phytosterol ester; and the manufacturing process for preparing the artificial leather from the abandoned apples saves resources, protects the environment and increases the additional output value of the abandoned apples.

The invention discloses a clean pulping process for dissociated modified plant fibers. The clean pulping process comprises the following steps: (1) pre-processing raw materials; (2) preparing coarse pulp; (3) pulping; (4) removing sand; (5) screening; and (6) concentrating and extruding pulp. According to the clean pulping process disclosed by the invention, no sodium hydroxide is added, pulp-washing and bleaching processes can be reduced, and the wastewater in the pulping process can be sufficiently reutilized through simple treatment, so that pulping black liquor which is severely polluted is not produced. Meanwhile, plant fibers can be sufficiently dissociated, and the pulping quality is greatly improved.

The invention relates to an oil agent and a preparation method thereof. The oil agent at least includes fluorine-containing polyether, and the quality of the fluorine-containing polyether is greater than or equal to 45% of the quality of the oil agent; the fluorine-containing polyether is ethylene oxide, [(1 , 1,2,2-tetrafluoroethoxy) methyl] random copolymer of oxirane and propylene oxide, its structural formula is: preparation method of the present invention: starter and strong base are blended, Then heat up to 105~125°C, then add ethylene oxide, [(1,1,2,2-tetrafluoroethoxy)methyl]oxirane and propylene oxide which are mixed uniformly, under protective atmosphere Polymerization reaction to obtain fluorine-containing polyether; then, mix fluorine-containing polyether, phosphate potassium salt and sodium alkylsulfonate uniformly at room temperature, and then add the mixture to mineral oil to obtain oil agent. The invention increases the hydrogen bond in the system, the increase of the hydrogen bond is beneficial to the improvement of the cloud point, and the quality of the oil agent can be maintained while increasing the concentration of the oil agent.

A kind of nitrogen-rich fused ring compound and its derivatives of the present invention, preparation method thereof, the preparation method of nitrogen-rich condensed ring compound comprises step 1, hydrochloric acid, 1-(2H-tetrazol-5-yl ) Mix the mixed system of guanidine and BrCN uniformly; step 2, react the mixed system at room temperature for 6-48 hours, separate the products in the reaction solution, wash and dry in sequence, and obtain the nitrogen-rich condensed ring compound. Dissolve the nitrogen-rich fused ring compound in fuming nitric acid at -5-5°C for 10-60 minutes, then react at 10-25°C for 30-90 minutes, drop the reaction liquid on ice to precipitate nitrogen-rich fused-ring ammonium nitrate compound. After the compound is dissolved, an organic base and a metal base are added respectively, and the mixed system is reacted at -5-5°C for 5-15 minutes, and finally reacted at room temperature for 5-30 minutes. Organic and inorganic salts of ammonium compounds.

The invention relates to a methylene-bridged nitrogen-rich diheterocyclic compound, a derivative and a preparation method thereof. The preparation method of the methylene-bridged nitrogen-rich diheterocyclic compound comprises the following steps: 1, dissolving 1-acetonitrile-5-amino tetrazole in a NaOH aqueous solution, carrying out a reflux reaction at 100-105 DEG C, and separating out a productto obtain a precipitate; 2, dissolving the precipitate and diaminoguanidine hydrochloride in polyphosphoric acid, and carrying out an addition reaction at 110-130 DEG C; and 3, cooling the reaction solution, adjusting the pH value to 7-9, separating the product, dissloving the methylene-bridged nitrogen-rich diheterocyclic compound in low-temperature fuming nitric acid, reacting at room temperature, dropping the reaction liquid on ice to separate out the compound, respectively adding an organic alkali and a metal alkali after dissloving the compound, reacting the obtained mixed system at -5-5DEG C, reacting at room temperature, filtering the product, and drying to obtain metal salt and non-metal salt of the methylene-bridged nitrogen-rich ammonium nitrate compound.

The present invention relates to bright warm-keeping lightness type fibers and a preparation method thereof, wherein mainly a polyester is subjected to special-shaped spinning hole melt spinning, oil agent feeding and winding so as to prepare the bright warm-keeping lightness type fibers, wherein the oil agent at least comprises a fluorine-containing polyether, the mass of the fluorine-containing polyether is more than or equal to 45% of the mass of the oil agent, the fluorine-containing polyether is a random copolymer of ethylene oxide, [(1,1,2,2-tetrafluoroethoxy)methyl]ethylene oxide and propylene oxide, and the structure formula is defined in the specification. The preparation method comprises: metering a polyester, extruding, cooling, oiling, stretching, carrying out thermal shaping, and winding so as to prepare the bright warm-keeping lightness type fibers. According to the bright warm-keeping lightness type fibers of the present invention, the fiber cross section shape is changed by the spinning while the fibers have the hollowness, the air permeability and the thermal insulation property are increased, and with the special cross section shape of the fibers, the bright surface light refraction effect is provided so as to make the fabric bright and gorgeous; and the fibers further have characteristics of lightness, light weight, and soft touch feeling.

The invention relates to the technical field of research and development and processing of fishing tools, in particular to a preparation method of modified chitosan-based bionic fish baits. The preparation method of the modified chitosan-based bionic fish baits, provided by the invention, has the benefits that the modified chitosan-based bionic fish baits are prepared by taking a modified chitosanacetic acid solution as a base material, taking modified corn starch and glass fibers as modifying agents and supplementing with stannous octoate, allicin and the like; firstly the modified chitosanacetic acid solution is prepared by taking shrimp shells as a raw material, then glass fibers are added in the base material, and the base material transfers stress among the glass fibers, so that thestrengths of the bionic fish baits are improved; the corn starch is simply treated with ammonium persulfate and acrylic acid, so that the enhancement in the dependence between the modified corn starch and the base material in a whole system is promoted; the corn starch is modified by utilizing a homemade dihydrosalicylate crystal; a benzene ring is introduced in a corn starch main chain after modification, the mechanical properties of the corn starch are improved; and in addition, the corn starch has excellent biodegradability, has no pollution to an environment and has a wide application prospect.

The invention discloses a method for improving mechanical properties of paper by using a glycosyl transferase promoter to drive GA20ox. The glycosyl transferase 8D1 promoter specifically expressed by xylem is used for driving gibberellin oxidase GA20ox gene overexpression to change the characteristics of poplar wood nanocellulose; the method comprises the following steps: obtaining a recombinant vector which is over-expressed by a GA20ox gene driven by a promoter 8D1P which is specifically expressed in the xylem of a poplar stalk, and applying the recombinant vector to genetic transformation of the poplar to obtain an 8D1P: GA20ox transgenic poplar, and achieving the purpose of improving the characteristics of the wood nanocellulose; the wood nano-cellulose characteristic improvement of the transgenic poplar is embodied in that the diameter of the nano-cellulose is increased, the nano-cellulose is used as an additive to increase hydrogen bonds among fibers by increasing the specific surface area, and the binding capacity of the fibers is improved, so that the mechanical property of the paper is better enhanced. The diameter of the transgenic material nanocellulose is larger, the mechanical strength of paper fibers can be remarkably improved, and the change of the characteristics can be more beneficial to application of pulping and papermaking.

The invention relates to a method for improving the indigo dyeing wet rubbing color fastness of cellulosic fibers. The objective of the invention is to overcome the problem of low wet rubbing color fastness of cowboy wear in the prior art. The method comprises the following steps: 1, rapid concentrated-alkali treatment of cellulosic fibers; 2, rapid formylation of the surfaces of cellulosic fibers; and 3, rapid graft modification of the formylated cellulosic fibers with an aqueous solution of taurine. According to the invention, the sulfonic acid group-modified cellulosic fibers have wet rubbing color fastness of grade 4, meeting the requirement that the grade wet rubbing color fastness should be no less than 3 as prescribed in national standards in China. The method of the invention is applied to the field of cellulosic fiber dyeing.

The invention relates to a coarse-denier porous polyester fiber and a preparation method thereof. The coarse-denier porous polyester fiber is mainly prepared by melt-spinning, oiling, stretching and winding of polyester through a number of spinneret holes; The oil agent of the oiling agent includes at least fluorine-containing polyether, and the quality of the fluorine-containing polyether ≥ 45% of the quality of the oil agent; the fluorine-containing polyether is ethylene oxide, [(1,1, 2,2-tetrafluoroethoxy) methyl] random copolymer of oxirane and propylene oxide, its structural formula is: the preparation method of the present invention is that polyester is measured, extruded, cooled, oiled And high-speed winding, made coarse denier porous polyester fiber. The coarse denier porous polyester fiber of the present invention endows the polyester fiber with a soft and elegant silk light feeling, not only has excellent optical properties, but due to the large number of fibers, the arrangement between the fibers cannot be tight, and the gaps increase accordingly, thereby The fabric feels thicker, with better fluffiness and air permeability.

The invention discloses a snow-melting agent. The snow-melting agent comprises following components by weight: 30-60% of low-molecular organic polyol, 0.8-1.2% of triethanolamine, 0.1-1% of a metal ion chelate or salts thereof, 0.2-0.4% of sodium metasilicate, 0.1-1% of benzotriazole, 0.2-0.5% of sodium dihydrogen phosphate, and 30-70% of water. The snow-melting agent adopts a formula combining an organic phase and an inorganic phase, and comprises a mixture of two or three compounds selected from glycol, propylene glycol and ethanol, and a composite corrosion inhibitor including the water, the triethanolamine, the metal ion chelate or the salts thereof, the sodium metasilicate, the benzotriazole and the sodium dihydrogen phosphate. The freezing point of the snow-melting agent is below -40 DEG C, and the snow-melting agent has significant ice and snow melting effects.

The invention relates to a methylene-bridged nitrogen-rich heterocyclic compound and derivatives thereof, and preparation methods thereof. The preparation method of the compound comprises the following steps: adding a hydroxylamine solution into an acetonitrile solution of 1-acetonitrile-5-aminotetrazole at low temperature, reacting at room temperature, separating the product to obtain a precipitate, dispersing the precipitate, sodium bicarbonate and cyanogen bromide into ethanol, reacting at room temperature for 10-14 hours, and separating and drying the product to obtain the methylene-bridged nitrogen-rich heterocyclic compound. The preparation method of the derivatives comprises the following steps: dissolving the methylene-bridged nitrogen-rich heterocyclic compound in fuming nitric acid at -5-5 DEG C at room temperature, reacting at room temperature to obtain a reaction solution, dripping the reaction solution on ice, and separating out a methylene-bridged nitrogen-rich ammonium nitrate compound on the ice; and dissolving a methylene-bridged nitrogen-rich ammonium nitrate compound, respectively adding organic alkali or metal alkali, reacting the obtained system at -5-5 DEG C for 10-30 minutes, finally reacting at room temperature for 30-60 minutes, filtering the product, and drying to obtain the non-metal salt and metal salt of the methylene-bridged nitrogen-rich ammoniumnitrate compound.

The invention relates to a novel chiral catalyst of an (S)-Alpha, Alpha-fluorine-containing diaryl-2-pyrrolidine methanol derivative and provides a preparation method and applications in an asymmetric reaction thereof. The preparation method comprises the following steps: adopting amino protected N-substitute-2 pyrrolidine methyl formate to react with a grignard reagent, then removing the protecting group; and then reacting with alkyl chlorosilane to prepare the (S)-Alpha, Alpha-fluorine-containing diaryl-2-pyrrolidine methanol derivative. The invention has the following beneficial effects: compared with other chiral catalysts of aryl pyrrolidine methanol derivative, the chiral catalyst of the fluorine-containing aryl pyrrolidine methanol derivative not only enhances the activity on N andimproves catalysis, but also simultaneously increases substrates and hydrogen bonds of catalysts as well as stereoselective reaction of the substrates, and broadens the application scope of the substrates.