The invention relates to a flexible single-electrode friction nano generator which comprises a three-layer structure, wherein the upper layer is a thin silica gel sheet used as a friction layer, the lower layer is a thick silica gel sheet used as a supporting layer, and flexible conductive cloth is arranged between the friction layer and the supporting layer. The flexible single-electrode friction nano generator S-TENG which is simple and easy to popularize is prepared by taking liquid silica gel, flexible conductive cloth, copper foils and copper wires as raw materials, and the prepared S-TENG has good flexibility, stability and a low-frequency mechanical energy collection function. Collected low-frequency mechanical energy can be effectively converted into electric energy, 240 LED lamp beads can be lightened, and an electronic watch and a small calculator can be driven. The nano generator has the advantages of being simple, low in cost, high in electrical output performance, good in stability and easy to produce on a large scale, and the prepared S-TENG sample has important potential application value in the fields of novel electronic devices and biomedicine.