54results about How to "Appropriate aperture" patented technology

The invention discloses a three-dimensional porous cartilage extracellular matrix sponge scaffold made of natural cartilage, which can compound cells further to construct tissue engineered cartilage, and can be used for clinically repairing cartilage defects. In the invention, conditions which can fully perform cell extraction and form a porous scaffold matrix are provided by processing cartilage into cartilage microfilaments, and then the cell extraction and solidification and/or strengthening treatment are performed to obtain the three-dimensional porous cartilage extracellular matrix sponge scaffold which is completely decellurized. The antigenicity and cell components are removed in the natural cartilage, and an extracellular matrix component of the cartilage is retained to obtain the scaffold with appropriate pore diameter and porosity, suitable degradation rate, good biocompatibility and certain biomechanical strength. The scaffold has the advantages of broad material sources, low cost, simple and feasible preparation technology, and good repetitiveness; and the scaffold can be widely applied in the field of tissue engineering and has good clinical application prospect.

The invention belongs to the technical field of medicines. The invention provides an injectable medicated particle-inlaid porous composite microsphere preparation. The injectable medicated particle-inlaid porous composite microsphere preparation is prepared by the following steps: wrapping polypeptide and protein medicines or chemical medicines by using hydrophilic materials such as chitosan, collagen or albumin to form medicine-loading particles; constructing microspheres with three-dimensional (3D) porous structures by using medicated particles and porous microsphere materials; and inlaying the medicated particles in the porous microspheres. The invention also provides a preparation method of the porous composite microsphere preparation and an application of the porous composite microsphere preparation in preparation of tissue defect repair materials. The porous composite microsphere preparation provided by the invention can realize slow release of the medicines and is favorable for proliferation and differentiation of seed cells.

The present invention relates to a porous scaffold with controllable microstructure, proper degradation rate and good biological compatibility prepared by using natural biological materials of collagen and chitosan as raw material and adopting the processes of freeze-freeze drying, further vacuum drying and heating and cross-linking of aldehyde compound or carbodiimide compound. The biological compatibility of said invented collagen/chitosan scaffold is good, its degradation rate can be controlled, and its raw material source is extensive and its cost is low, and its reproducibility is good. Said scaffold can be extensively used in the field of tissue engineering technology.

The invention discloses a microenvironment construction method for three dimensional culture of cells based on a specificity extracellular matrix and an application. A specificity extracellular matrix extraction method, the specificity extracellular matrix and a photocuring material are combined to prepare hydrogel, and the invention relates to an application of the hydrogel to in vitro three dimensional culture and particularly an organ chip technique. According to the technical scheme, in accordance with tissue or organs of different density, surfactants having different decellularization capacity are selected, through combination of the manner that enzyme treatment is selected and an ammonia solution is used as a solvent, particularly-compact tissue or organs are treated, and the preferred combination of the enzyme and surfactants comprises Trypsin and a Triton X-100 solution, and the solvent is a 0.05%-0.5% ammonia solution. The extracellular matrix and a light-initiating colloid-forming material are compounded for preparing the hydrogel so as to construct cell culture microenvironment. The method has the advantages of being high in colloid-forming speed, simple in colloid-forming condition, controllable in hydrogel mechanical property and the like.

The invention relates to a preparation method of porous polymer scaffolds used for tissue engineering by means of pore-forming agent bonding and filtering method, comprising two steps: firstly, a mold containing pore-forming agent is positioned in the environment with certain temperature and certain humidity, and the pore-forming agent in the mold then can bond together; secondly, polymer solution is cast into the mold, the pore-forming agent in the mold is filtered out after the solvent volatilizing, and a porous polymer scaffold can be obtained. The invention has the advantages of simple equipment, easy operation, controllable aperture, high porosity, excellent connectivity, and fitness for three-dimension porous cell scaffolds in tissue engineering and other application fields.

The instant disclosure relates to a manufacturing method of a porous composite film. The manufacturing method includes processing a first porous film and a second porous film and includes the following steps: providing a pressing unit, a film-shaping unit, and a cooling unit; intersecting the first and second porous films at an angle; stacking the first and second porous films in forming a half-finished porous composite film; pressing the half-finished porous composite film by the pressing unit at a temperature T1 and under a tension S1; relieving the pressing force against the half-finished porous composite film thermally by the film-shaping unit at a temperature T2; and maintaining the half-finished porous composite film at a pre-determined tension by the cooling unit at a temperature T3.

The invention belongs to the technical field of medicine, and provides a PLGA (poly(lactic-co-glycolic acid)) porous composite microsphere preparation embedded with BMP-2 and TGF-beta1 containing microspheres therein, which not only can bring about benefits for the adhesion and the growth of seed cells by virtue of a 3D porous structure but also can undergo controlled- and sustained-release and can be applied to injection. The invention also provides a preparation method of the porous composite microsphere preparation as well as application of the porous composite microsphere preparation in preparing bone or cartilage tissue defect repairing materials. The porous composite microsphere disclosed by the invention, which can serve as a good carrier for cell adhesion and proliferation and can be directly injected to a target part, can offer a possibility of non-surgical repair to bone and cartilage tissue injuries; and the porous composite microsphere preparation is extensive in clinical application and market prospect.

The invention discloses a preparation method of a bean dreg-based porous carbon material. The preparation method comprises the following steps: (1) pretreating bean dregs to obtain bean dreg powder; (2) calcining and pyrolyzing the bean dreg powder obtained in the step (1), and carrying out pre-carbonization treatment to obtain pre-carbonized bean dregs; and (3) adding an activating agent into thebean dregs subjected to pre-carbonization treatment in the step (2) for activation to obtain the bean dreg-based porous carbon material. According to the invention, pre-carbonization treatment is carried out on the pretreated bean dregs; in the calcining pyrolysis process, volatilization of moisture and organic matters can form a certain pore structure, and high-temperature carbonization is performed again after the activating agent is added, so that the bean dreg-based porous carbon material has a rich and developed pore structure and proper pore size and pore volume, more active sites are generated, and the adsorption effect is improved. The invention further provides the bean dreg-based porous carbon material which is high in specific surface area, large in pore diameter and pore volume, high in adsorption capacity and large in adsorption capacity. The invention further provides application of the bean dreg-based porous carbon material. The bean dreg-based porous carbon material isused for treating dye wastewater.

The invention relates to a composite hollow fiber membrane. The composite hollow fiber membrane is characterized by comprising the following steps: preparing a membrane casting solution; preparing a core solution and an outer gel bath; utilizing a dry-wet spinning device to inject the core solution and the membrane casting solution into a spinneret together for hollow fiber spinning, and extruding from the spinneret together to prepare a hollow fiber membrane wire; and enabling the hollow fiber membrane wire obtained in the step to pass a dry spinning path of 0-35cm and sequentially enter a first gel bath and a second gel bath for gel phase inversion to form the high polymer hollow fiber porous membrane with a microprous pore canal. The composite hollow fiber membrane prepared by the method disclosed by the invention is a hydrophilic hollow membrane material and has higher membrane flux and good pollution resistance at low pressure; simultaneously, the hollow fiber membrane has better mechanical strength due to the complementary property of the raw materials.

The invention relates to a preparation method of a composite hollow fiber membrane. The preparation method is characterized by comprising the following steps: preparing membrane casting liquid; preparing core liquid and external gel bath; injecting the core liquid and the membrane casting liquid together into a spinning nozzle by utilizing a dry-wet spinning device, and extruding together from the spinning nozzle so as to prepare a hollow fiber membrane filament; carrying out dry spinning on the hollow fiber membrane filament prepared in the previous step in a dry spinning path of 0-35cm, and carrying out gel phase conversion sequentially in first gel bath and second gel bath so as to form a macromolecule hollow fiber porous membrane with a micro duct. The composite hollow fiber membrane prepared by the invention is a hydrophilic hollow membrane material, has relatively high membrane flux at low pressure, is good in pollution resistance, and meanwhile has relatively good mechanical intensity because of complementarity of raw materials.

The invention provides a high-temperature molten aluminum filtering and quantitative casting device. The high-temperature molten aluminum filtering and quantitative casting device is accurate in feeding quantity, free of product waste and capable of filtering out and removing large-particle impurities. The high-temperature molten aluminum filtering and quantitative casting device comprises a smelting furnace and a mold conveyor belt. A plurality of molds are equidistantly arranged on the mold conveyor belt. A rotary disk arranged above the conveyor belt through a support. The tail end of a spindle of the rotary disk is connected with a rotary disk power unit. A plurality of casting channels are uniformly distributed on the rotary disk. One end of each casting channel communicates with thesmelting furnace through a molten aluminum channel, and the other end of each casting channel is connected with the corresponding mold. The high-temperature molten aluminum filtering and quantitativecasting device further comprises a PLC device. The molten aluminum channels include the first molten aluminum channel communicating with the smelting furnace, the third molten aluminum channel matchedwith the casting channels and the second molten aluminum channel connecting the first molten aluminum channel with the second molten aluminum channel. Filter devices are arranged between the first molten aluminum channel and the second molten aluminum channel and the between the second molten aluminum channel and the third molten aluminum channel.

The invention discloses an LED lamp aluminum alloy shell high in heat dissipation performance. The LED lamp aluminum alloy shell comprises an aluminum alloy substrate and a heat-dissipation coating, wherein the surface of the aluminum alloy substrate is coated with the heat-dissipation coating. The heat-dissipation coating comprises, by weight part, 60-100 parts of main ingredients, 20-40 parts ofa sepiolite compound, 0.1-0.18 part of tetrabutyl titanate, 1-1.9 parts of epoxy end-capping polyether amine, 0.4-1 part of phthalic anhydride, 1-1.8 parts of alpha-sulpho fatty acid methyl ester, 0.5-1 part of 1, 5-naphthalene disulfonic acid, 0.6-1.4 parts of fatty alcohol-polyoxyethylene ether sodium sulfate, 1-2 parts of glycerinum, 1-2 parts of calcium stearate, 1-1.8 parts of pigment, 0.4-1part of a dispersing agent and 0.4-1 part of a flatting agent. The invention discloses an LED lamp excellent in heat dissipation performance. The LED lamp excellent in heat dissipation performance comprises the LED lamp aluminum alloy shell high in heat dissipation performance and an LED chip, wherein the LED chip is encapsulated onto the LED lamp aluminum alloy shell high in heat dissipation performance.

The invention belongs to the field of heterogeneous catalysis, and discloses a preparation method of hollow mesoporous inorganic oxide nanosphere solid alkali, which comprises the following steps: adding nano colloidal carbon spheres into an inorganic metal salt solution/inorganic metal salt mixed solution, stirring, adsorbing, filtering, and washing to obtain a hollow mesoporous inorganic oxide carbon sphere precursor; drying the hollow mesoporous inorganic oxide carbon sphere precursor, grinding the dried hollow mesoporous inorganic oxide carbon sphere precursor into powder, and carrying outgradient heating calcination on the powder to obtain hollow mesoporous inorganic oxide nanosphere solid alkali. The invention also discloses an application of the hollow mesoporous inorganic oxide nanosphere solid base prepared by the preparation method. The hollow mesoporous inorganic oxide nanosphere solid base is used for catalyzing selective O-alkylation reaction of phenolic compounds. The hollow mesoporous inorganic oxide nanosphere solid alkali prepared by the method is uniform in particle size, proper in pore diameter and rich in porous structure, can be easily separated from a productafter catalyzing the selective O-alkylation reaction of phenolic compounds, and is convenient to recycle.