54results about How to "Appropriate aperture" patented technology

The invention discloses a three-dimensional porous cartilage extracellular matrix sponge scaffold made of natural cartilage, which can compound cells further to construct tissue engineered cartilage, and can be used for clinically repairing cartilage defects. In the invention, conditions which can fully perform cell extraction and form a porous scaffold matrix are provided by processing cartilage into cartilage microfilaments, and then the cell extraction and solidification and / or strengthening treatment are performed to obtain the three-dimensional porous cartilage extracellular matrix sponge scaffold which is completely decellurized. The antigenicity and cell components are removed in the natural cartilage, and an extracellular matrix component of the cartilage is retained to obtain the scaffold with appropriate pore diameter and porosity, suitable degradation rate, good biocompatibility and certain biomechanical strength. The scaffold has the advantages of broad material sources, low cost, simple and feasible preparation technology, and good repetitiveness; and the scaffold can be widely applied in the field of tissue engineering and has good clinical application prospect.

The invention belongs to the technical field of medicines. The invention provides an injectable medicated particle-inlaid porous composite microsphere preparation. The injectable medicated particle-inlaid porous composite microsphere preparation is prepared by the following steps: wrapping polypeptide and protein medicines or chemical medicines by using hydrophilic materials such as chitosan, collagen or albumin to form medicine-loading particles; constructing microspheres with three-dimensional (3D) porous structures by using medicated particles and porous microsphere materials; and inlaying the medicated particles in the porous microspheres. The invention also provides a preparation method of the porous composite microsphere preparation and an application of the porous composite microsphere preparation in preparation of tissue defect repair materials. The porous composite microsphere preparation provided by the invention can realize slow release of the medicines and is favorable for proliferation and differentiation of seed cells.

The present invention relates to a porous scaffold with controllable microstructure, proper degradation rate and good biological compatibility prepared by using natural biological materials of collagen and chitosan as raw material and adopting the processes of freeze-freeze drying, further vacuum drying and heating and cross-linking of aldehyde compound or carbodiimide compound. The biological compatibility of said invented collagen / chitosan scaffold is good, its degradation rate can be controlled, and its raw material source is extensive and its cost is low, and its reproducibility is good. Said scaffold can be extensively used in the field of tissue engineering technology.

The invention discloses a method for preparing a compound hollow fibrous membrane, comprising the following steps: using a solution phase transfer hollow fibre spinning technique to make polrvinyl chloride or copolymer thereof, solvent and pore-forming agent into basal membrane spinning liquid of compound hollow fibrous membrane, making polyvinylidene fluoride or copolymers thereof or mixture of both, solvent and pore-forming agent into compound layer spinning solution, extruding the two spinning fluids through a spinning nozzle of the hollow fibre spinning machine and core liquid in a central pore of spinning head simultaneously, and then entering into outer coagulating bath; and preparing the compound hollow fibrous membrane after the solvents and pore-forming agents in the two prepared spinning fluids enter into condensed liquid phase, and polymer used as the material of a compound layer and a basal membrane is settled into polymer hollow fibrous membrane by phase shift. The invention uses polrvinyl chloride or copolymer thereof as basal membrane materials, and has lower material cost, and higher mechanical strength compared with the prior art; the performances of the basal membrane and compound layer materials are right complementary; besides, polrvinyl chloride or copolymers thereof have various types and are wide for selection.

The invention discloses a microenvironment construction method for three dimensional culture of cells based on a specificity extracellular matrix and an application. A specificity extracellular matrix extraction method, the specificity extracellular matrix and a photocuring material are combined to prepare hydrogel, and the invention relates to an application of the hydrogel to in vitro three dimensional culture and particularly an organ chip technique. According to the technical scheme, in accordance with tissue or organs of different density, surfactants having different decellularization capacity are selected, through combination of the manner that enzyme treatment is selected and an ammonia solution is used as a solvent, particularly-compact tissue or organs are treated, and the preferred combination of the enzyme and surfactants comprises Trypsin and a Triton X-100 solution, and the solvent is a 0.05%-0.5% ammonia solution. The extracellular matrix and a light-initiating colloid-forming material are compounded for preparing the hydrogel so as to construct cell culture microenvironment. The method has the advantages of being high in colloid-forming speed, simple in colloid-forming condition, controllable in hydrogel mechanical property and the like.

A rechargeable non-aqueous lithium-air battery is provided having a multilayered cathode structure which uses a functionized carbon paper base with tubular catalysts. The multilayer cathode has a sufficient pore size to prevent clogging of the cathode by reaction products and further has a hydrophobic coating to repel moisture. The stable electrolyte is made by ionic liquid and additives which have no reaction with discharge products and offers solubility for oxygen and lithium oxide.

The invention belongs to the technical field of medicine, and provides an injectable PLGA porous composite microsphere preparation embedded with BMP-2 containing particles. A drug-carrying particle is formed by wrapping BMP-2 with hydrophilic materials such as chitosan, collagen or albumin; a microsphere with a 3D porous structure is constructed by the drug-carrying particle and a porous microsphere material PLGA; the drug-carrying particle is embedded inside the porous microsphere. The invention also provides a preparation method of the porous composite microsphere preparation, and an application in preparation of a repair material for defects of bone or cartilage tissue. The porous composite microsphere preparation of the invention can not only realize slow release of drugs at an administration site, but also facilitate proliferation and differentiation of porous supports of seed cells.

The invention relates to a preparation method of porous polymer scaffolds used for tissue engineering by means of pore-forming agent bonding and filtering method, comprising two steps: firstly, a mold containing pore-forming agent is positioned in the environment with certain temperature and certain humidity, and the pore-forming agent in the mold then can bond together; secondly, polymer solution is cast into the mold, the pore-forming agent in the mold is filtered out after the solvent volatilizing, and a porous polymer scaffold can be obtained. The invention has the advantages of simple equipment, easy operation, controllable aperture, high porosity, excellent connectivity, and fitness for three-dimension porous cell scaffolds in tissue engineering and other application fields.

The instant disclosure relates to a manufacturing method of a porous composite film. The manufacturing method includes processing a first porous film and a second porous film and includes the following steps: providing a pressing unit, a film-shaping unit, and a cooling unit; intersecting the first and second porous films at an angle; stacking the first and second porous films in forming a half-finished porous composite film; pressing the half-finished porous composite film by the pressing unit at a temperature T1 and under a tension S1; relieving the pressing force against the half-finished porous composite film thermally by the film-shaping unit at a temperature T2; and maintaining the half-finished porous composite film at a pre-determined tension by the cooling unit at a temperature T3.

The preparation process of porous heparinized collagen / chitosan rack with compounded angiogenin includes the following steps: dissolving ox tendon and chitosan separately in acetic acid solution to compound 0.5-5 % concentration solution, mixing chitosan solution in 5-30 % and ox tendon solution, molding and freeze drying to obtain porous collagen / chitosan rack; vacuum treatment, soaking the porous collagen / chitosan rack inside 2-N-morpholynyl ethane sulfonic acid solution of heparin sodium, treating with 1-ethyl-3-3-(dimethylaminopropyl)-carbonized diimine solution and N-hydroxy batanimide solution, washing, re-freezing to dry and to obtain porous heparinized collagen / chitosan rack; and soaking the porous heparinized collagen / chitosan rack inside angiogenin solution to obtain the porous heparinized collagen / chitosan rack with compounded angiogenin. The prepared rack has proper pore size and porosity and is used as the corium substitute in skin tissue engineering.

A 3D porous chitosan-polylactic acid scaffold is prepared through dissolving chitosan in lactic acid, adding sodium (or potassium) chloride, stirring while heating, loading it in mould, drying in oven, heating while vacuum copolymerizing, extracting in methanol or chloroform, drying, washing with deionized water, and freeze drying.

The invention belongs to the technical field of medicine, and provides a PLGA (poly(lactic-co-glycolic acid)) porous composite microsphere preparation embedded with BMP-2 and TGF-beta1 containing microspheres therein, which not only can bring about benefits for the adhesion and the growth of seed cells by virtue of a 3D porous structure but also can undergo controlled- and sustained-release and can be applied to injection. The invention also provides a preparation method of the porous composite microsphere preparation as well as application of the porous composite microsphere preparation in preparing bone or cartilage tissue defect repairing materials. The porous composite microsphere disclosed by the invention, which can serve as a good carrier for cell adhesion and proliferation and can be directly injected to a target part, can offer a possibility of non-surgical repair to bone and cartilage tissue injuries; and the porous composite microsphere preparation is extensive in clinical application and market prospect.

The invention provides a coal gangue-based porous composite material as well as a preparation method and application thereof. The porous composite material comprises a coal gangue-based porous skeleton, an active carrier and an active component, the active carrier is distributed on the surface of the pore wall of the coal gangue-based porous skeleton; and the active component is loaded in the active carrier. The preparation method comprises the following steps: (1) crushing coal gangue to obtain coal gangue fine powder, carrying out heat treatment, and foaming to obtain the coal gangue-based porous skeleton; and (2) modifying the pore wall surface of the coal gangue-based porous skeleton obtained in the step (1) by using the active carrier and the active component to obtain the coal gangue-based porous composite material. The coal gangue-based porous composite material provided by the invention is low in development cost and simple in process, has excellent solid particle removal capacity and heavy metal ion adsorption capacity for sewage and wastewater, and has a wide application prospect.

The invention discloses a preparation method of a bean dreg-based porous carbon material. The preparation method comprises the following steps: (1) pretreating bean dregs to obtain bean dreg powder; (2) calcining and pyrolyzing the bean dreg powder obtained in the step (1), and carrying out pre-carbonization treatment to obtain pre-carbonized bean dregs; and (3) adding an activating agent into thebean dregs subjected to pre-carbonization treatment in the step (2) for activation to obtain the bean dreg-based porous carbon material. According to the invention, pre-carbonization treatment is carried out on the pretreated bean dregs; in the calcining pyrolysis process, volatilization of moisture and organic matters can form a certain pore structure, and high-temperature carbonization is performed again after the activating agent is added, so that the bean dreg-based porous carbon material has a rich and developed pore structure and proper pore size and pore volume, more active sites are generated, and the adsorption effect is improved. The invention further provides the bean dreg-based porous carbon material which is high in specific surface area, large in pore diameter and pore volume, high in adsorption capacity and large in adsorption capacity. The invention further provides application of the bean dreg-based porous carbon material. The bean dreg-based porous carbon material isused for treating dye wastewater.

The invention discloses a magnesium fluoride catalyst. The magnesium fluoride catalyst has carbon content of less than 10% and a specific surface area of more than 130 m<2> / g. The magnesium fluoride catalyst provided by the invention has high catalytic activity and strong stability in the dehydrohalogenation reaction, fluorine-chlorine exchange reaction, disproportionation reaction or hydrofluorination reaction.

The invention relates to a preparation method of a composite hollow fiber membrane. The preparation method is characterized by comprising the following steps: preparing a casting membrane solution; preparing a core solution and an external gel bath; spinning hollow fibers: injecting the core solution and the casting membrane solution into spinning nozzles together by utilizing dry-wet spinning equipment and extruding the core solution and the casting membrane solution from the spinning nozzles together to prepare hollow fiber membrane silk; and after the hollow fiber membrane silk obtained in the above step passes through a 0-35cm dry spinning path, enabling the hollow fiber membrane silk to enter a first gel bath and a second gel bath to undergo gel phase conversion, thus forming the polymer hollow fiber porous membrane with microchannels. The composite hollow fiber membrane prepared by the method is a hydrophilic hollow membrane material, has higher membrane flux under low pressure, has good pollution resistance and also has better mechanical strength due to the complementarity of the raw materials.

The invention discloses an annulus fibrosus and nucleus pulposus integrated composite biphasic scaffold and a construction method thereof, and belongs to the technology of biological tissue engineering. Porcine cancellous bone is used for preparing the outer layer which is a cell-free deminerized bone matrix gelatin ring, pigtail intervertebral disc nucleus gelatinosus tissue is used for preparing the core which is a cell-free nucleus pulposus matrix; and the two materials are frozen and lyophilized, sequentially subjected to ultraviolet irradiation crosslink and chemical reagent EDAC (carbodiimide) and NHS (n-hydroxysuccinimide) crosslink, and compounded. The annulus fibrosus and nucleus pulposus integrated composite biphasic scaffold with the design is good in biocompatibility to avoid immunological rejection reactions, has a composition structure and mechanical performance similar to a human intervertebral disc extracellular matrix, is wide in material source, low in cost and simple in preparation process, can be used for constructing tissue engineering intervertebral disc and repairing intervertebral disc degeneration, and has an excellent clinical application prospect.

The invention relates to a composite hollow fiber membrane. The composite hollow fiber membrane is characterized by comprising the following steps: preparing a membrane casting solution; preparing a core solution and an outer gel bath; utilizing a dry-wet spinning device to inject the core solution and the membrane casting solution into a spinneret together for hollow fiber spinning, and extruding from the spinneret together to prepare a hollow fiber membrane wire; and enabling the hollow fiber membrane wire obtained in the step to pass a dry spinning path of 0-35cm and sequentially enter a first gel bath and a second gel bath for gel phase inversion to form the high polymer hollow fiber porous membrane with a microprous pore canal. The composite hollow fiber membrane prepared by the method disclosed by the invention is a hydrophilic hollow membrane material and has higher membrane flux and good pollution resistance at low pressure; simultaneously, the hollow fiber membrane has better mechanical strength due to the complementary property of the raw materials.

The invention discloses a compound heat insulating and fresh keeping protection film. The compound heat insulating and fresh keeping protection film sequentially comprises a first reflection barrier layer, a first woven cloth layer, an EPE composite layer, a second woven cloth layer and a second reflection barrier layer, the first reflection barrier layer, the first woven cloth layer, the EPE composite layer, the second woven cloth layer and the second reflection barrier layer are respectively bonded through a PE layer, the EPE layer comprises 2-10 EPE layers, the EPE layers are fixed through hot piercing to form the EPE composite layer, the spacing of holes in the EPE composite layer is 1-4cm, and the diameter of the holes in the EPE composite layer is 0.5-1cm. The protection film has good barrier and heat insulation performances, has good flexibility, is suitable for packaging trays with various forms, and can be used to package the trays in 1000km; and the protection film has good barrier and heat insulation performances, so chill cars are not needed, and the transportation cost is saved, thereby products are more economical.

The invention relates to a preparation method of a composite hollow fiber membrane. The preparation method is characterized by comprising the following steps: preparing membrane casting liquid; preparing core liquid and external gel bath; injecting the core liquid and the membrane casting liquid together into a spinning nozzle by utilizing a dry-wet spinning device, and extruding together from the spinning nozzle so as to prepare a hollow fiber membrane filament; carrying out dry spinning on the hollow fiber membrane filament prepared in the previous step in a dry spinning path of 0-35cm, and carrying out gel phase conversion sequentially in first gel bath and second gel bath so as to form a macromolecule hollow fiber porous membrane with a micro duct. The composite hollow fiber membrane prepared by the invention is a hydrophilic hollow membrane material, has relatively high membrane flux at low pressure, is good in pollution resistance, and meanwhile has relatively good mechanical intensity because of complementarity of raw materials.

The invention relates to a preparation method of a composite hollow fiber membrane. The preparation method is characterized by comprising the following steps: preparing a casting membrane solution; preparing a core solution and an external gel bath; spinning hollow fibers: injecting the core solution and the casting membrane solution into spinning nozzles together by utilizing dry-wet spinning equipment and extruding the core solution and the casting membrane solution from the spinning nozzles together to prepare hollow fiber membrane silk; and after the hollow fiber membrane silk obtained in the above step passes through a 0-35cm dry spinning path, enabling the hollow fiber membrane silk to enter a first gel bath and a second gel bath to undergo gel phase conversion, thus forming the polymer hollow fiber porous membrane with microchannels. The composite hollow fiber membrane prepared by the method is a hydrophilic hollow membrane material, has higher membrane flux under low pressure, has good pollution resistance and also has better mechanical strength due to the complementarity of the raw materials.

The invention provides a high-temperature molten aluminum filtering and quantitative casting device. The high-temperature molten aluminum filtering and quantitative casting device is accurate in feeding quantity, free of product waste and capable of filtering out and removing large-particle impurities. The high-temperature molten aluminum filtering and quantitative casting device comprises a smelting furnace and a mold conveyor belt. A plurality of molds are equidistantly arranged on the mold conveyor belt. A rotary disk arranged above the conveyor belt through a support. The tail end of a spindle of the rotary disk is connected with a rotary disk power unit. A plurality of casting channels are uniformly distributed on the rotary disk. One end of each casting channel communicates with thesmelting furnace through a molten aluminum channel, and the other end of each casting channel is connected with the corresponding mold. The high-temperature molten aluminum filtering and quantitativecasting device further comprises a PLC device. The molten aluminum channels include the first molten aluminum channel communicating with the smelting furnace, the third molten aluminum channel matchedwith the casting channels and the second molten aluminum channel connecting the first molten aluminum channel with the second molten aluminum channel. Filter devices are arranged between the first molten aluminum channel and the second molten aluminum channel and the between the second molten aluminum channel and the third molten aluminum channel.

The invention discloses antibacterial medical drainage polyurethane foam and a preparation method thereof. The antibacterial medical drainage polyurethane foam is prepared from the following raw materials in parts by weight: 100 parts of polyether polyol, 1.2 to 3.5 parts of an organic silicon foam stabilizer, 1 to 15 parts of a foaming agent, 0.1 to 1 part of tannic acid, 0.1 to 0.6 part of imidazolidinyl urea, 0.5 to 6 parts of sulfadiazine silver, 1 to 10 parts of chitosan, 35 to 65 parts of toluene diisocyanate, 0.1 to 0.5 part of amine catalyst, 0.10 to 0.70 part of a zinc catalyst and 1 to 6 parts of water. According to the antibacterial polyurethane foam disclosed by the invention, various antibacterial agents such as chitosan, tannic acid and sulfadiazine silver are selected, oxygen active sites are provided for the polyurethane foam, so the polyurethane foam has an antibacterial property, meanwhile, the polyurethane foam has excellent biocompatibility, no teratogenic effect, no anaphylactic reaction and excellent anticoagulant performance; a toxicity test result show that the polyurethane foam meets medical requirements; and the te polyurethane foam has the advantages of excellent toughness and elasticity, good processability, various processing modes and the like.

The invention belongs to the technical field of membrane separation, and relates to a separation membrane material and a preparation method and application thereof. Aiming at the problems of poor mechanical properties of a polyvinylidene fluoride membrane and brittleness of a polyvinyl chloride membrane, the invention provides a method for preparing a porous membrane with high pollution resistance and high mechanical strength by blending a polyvinyl chloride material and a polyvinylidene fluoride material and adding water-soluble monoamine. According to the invention, a polyvinyl chloride / polyvinylidene fluoride blended membrane is used as a base membrane, a water phase solution of a conventional interfacial polymerization reaction is coated according to a conventional interfacial polymerization reaction method, then an oil phase solution of the conventional interfacial polymerization reaction is contacted, and a reverse osmosis or nanofiltration composite membrane is prepared; the preparation method comprises the following steps: preparing an intermediate layer of the composite membrane, coating a water-phase solution of a conventional interfacial polymerization reaction according to a conventional interfacial polymerization reaction method, and contacting an oil-phase solution of the conventional interfacial polymerization reaction, thereby preparing the reverse osmosis or nanofiltration composite membrane.

The invention discloses a bone-imitated hydroxyapatite-collagen composite scaffold and a preparation method thereof. The bone-imitated hydroxyapatite-collagen composite scaffold comprises hydroxyapatite and collagen molecules, and the weight ratio of the hydroxyapatite to the collagen molecules is 1.7-2.3; the hydroxyapatite is of an ultrathin sheet structure, the length is 25-50 nm, the width is 10-30 nm, the thickness is 2-6 nm, and the maximum exposed crystal face is a (100) crystal face; and the 2theta value of the XRD spectrum is 30-35 degrees, the XRD spectrum shows a large envelope peak, and the Ca / P molar ratio of the XRD spectrum is 1.5-1.6. The collagen of the composite scaffold is of a triple helix structure and has biological activity; and the water absorption rate is 17.4-19.3 times of the self weight, the pore size is 50-300 [mu]m, the void ratio is as high as 98%-98.7%, and the compression modulus is as high as 0.84-0.9 MPa.

The invention relates to a preparation method of a composite hollow fiber membrane. The preparation method is characterized by comprising the following steps: preparing a membrane casting solution; preparing a core solution and an outer gel bath; utilizing a dry-wet spinning device to inject the core solution and the membrane casting solution into a spinneret together for hollow fiber spinning, and extruding from the spinneret together to prepare a hollow fiber membrane wire; and enabling the hollow fiber membrane wire obtained in the step to pass a dry spinning path of 0-35cm and sequentially enter a first gel bath and a second gel bath for gel phase inversion to form the high polymer hollow fiber porous membrane with a microprous pore canal. The composite hollow fiber membrane prepared by the method disclosed by the invention is a hydrophilic hollow membrane material and has higher membrane flux and good pollution resistance at low pressure; simultaneously, the hollow fiber membrane has better mechanical strength due to the complementary property of the raw materials.

The invention discloses an LED lamp aluminum alloy shell high in heat dissipation performance. The LED lamp aluminum alloy shell comprises an aluminum alloy substrate and a heat-dissipation coating, wherein the surface of the aluminum alloy substrate is coated with the heat-dissipation coating. The heat-dissipation coating comprises, by weight part, 60-100 parts of main ingredients, 20-40 parts ofa sepiolite compound, 0.1-0.18 part of tetrabutyl titanate, 1-1.9 parts of epoxy end-capping polyether amine, 0.4-1 part of phthalic anhydride, 1-1.8 parts of alpha-sulpho fatty acid methyl ester, 0.5-1 part of 1, 5-naphthalene disulfonic acid, 0.6-1.4 parts of fatty alcohol-polyoxyethylene ether sodium sulfate, 1-2 parts of glycerinum, 1-2 parts of calcium stearate, 1-1.8 parts of pigment, 0.4-1part of a dispersing agent and 0.4-1 part of a flatting agent. The invention discloses an LED lamp excellent in heat dissipation performance. The LED lamp excellent in heat dissipation performance comprises the LED lamp aluminum alloy shell high in heat dissipation performance and an LED chip, wherein the LED chip is encapsulated onto the LED lamp aluminum alloy shell high in heat dissipation performance.

The invention belongs to the field of heterogeneous catalysis, and discloses a preparation method of hollow mesoporous inorganic oxide nanosphere solid alkali, which comprises the following steps: adding nano colloidal carbon spheres into an inorganic metal salt solution / inorganic metal salt mixed solution, stirring, adsorbing, filtering, and washing to obtain a hollow mesoporous inorganic oxide carbon sphere precursor; drying the hollow mesoporous inorganic oxide carbon sphere precursor, grinding the dried hollow mesoporous inorganic oxide carbon sphere precursor into powder, and carrying outgradient heating calcination on the powder to obtain hollow mesoporous inorganic oxide nanosphere solid alkali. The invention also discloses an application of the hollow mesoporous inorganic oxide nanosphere solid base prepared by the preparation method. The hollow mesoporous inorganic oxide nanosphere solid base is used for catalyzing selective O-alkylation reaction of phenolic compounds. The hollow mesoporous inorganic oxide nanosphere solid alkali prepared by the method is uniform in particle size, proper in pore diameter and rich in porous structure, can be easily separated from a productafter catalyzing the selective O-alkylation reaction of phenolic compounds, and is convenient to recycle.