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Antibacterial medical drainage polyurethane foam and preparation method thereof

A polyurethane foam and foam stabilizer technology, applied in the field of medical materials, can solve the problems of increasing the burden on patients, multi-drug-resistant bacterial infection of patients, infection risks, etc., achieve good antibacterial and antibacterial performance, and solve the effect of anaerobic bacteria breeding

Inactive Publication Date: 2021-12-07
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since neither polyvinyl alcohol nor polyurethane itself has antibacterial properties, a large amount of antibiotics and anti-inflammatory drugs are still required to treat infections, which will not only increase the physical burden of patients during treatment, but may also lead to the emergence of multi-drug resistant bacteria in patients due to the overuse of antibiotics Infection (MDR), which poses a greater risk of infection

Method used

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  • Antibacterial medical drainage polyurethane foam and preparation method thereof
  • Antibacterial medical drainage polyurethane foam and preparation method thereof
  • Antibacterial medical drainage polyurethane foam and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The preparation method of antibacterial type medical drainage polyurethane foam 1 comprises the following steps:

[0024] 1) Weigh 50 parts of polyether polyols with a hydroxyl value of 55 mg KOH / g and a molecular weight of 4300 according to the ratio of parts by weight, 50 parts of polyether polyols with a hydroxyl value of 103 mg KOH / g and a molecular weight of 3700, and evenly 2.5 parts of foaming agent, 10 parts of dichloromethane, 55 parts of toluene diisocyanate, 0.5 parts of triethylenediamine, 0.5 parts of zinc catalyst, 5 parts of water, for later use;

[0025] 2) Mechanically mix polyether polyol, silicone foam stabilizer, methylene chloride, tannic acid, imidazolidinyl urea, silver sulfadiazine, chitosan and toluene diisocyanate to obtain a white material, which is the pre-mixture. Polymer;

[0026] 3) Pour triethylenediamine, zinc catalyst and water into the prepolymer, mechanically stir and mix evenly, pour into a mold to foam, mature at 80° C. for 24 hour...

Embodiment 2

[0028] The preparation method of antibacterial type medical drainage polyurethane foam 2 comprises the following steps:

[0029] 1) Weigh 50 parts of polyether polyols with a hydroxyl value of 55 mg KOH / g and a molecular weight of 4300 according to the ratio of parts by weight, 50 parts of polyether polyols with a hydroxyl value of 103 mg KOH / g and a molecular weight of 3700, and evenly 2 parts of foaming agent, 8 parts of cyclopentane, 0.5 part of tannic acid, 0.5 part of imidazolidinyl urea, 1 part of silver sulfadiazine, 6 parts of chitosan, 55 parts of toluene diisocyanate, 0.2 part of ethylenediamine, zinc 0.2 parts of catalyst, 4.5 parts of water, set aside;

[0030] 2) Mechanically mix polyether polyol, silicone foam stabilizer, cyclopentane, tannic acid, imidazolidinyl urea, silver sulfadiazine, chitosan and toluene diisocyanate to obtain a white material, which is the prepared Polymer;

[0031] 3) Pour ethylenediamine, zinc catalyst and water into the prepolymer, me...

Embodiment 3

[0033] The preparation method of antibacterial type medical drainage polyurethane foam 3 comprises the following steps:

[0034] 1) Weigh 30 parts of polyether polyols with a hydroxyl value of 55 mg KOH / g and a molecular weight of 4300 according to the ratio of parts by weight, 70 parts of polyether polyols with a hydroxyl value of 103 mg KOH / g and a molecular weight of 3700, and evenly 1.5 parts of foaming agent, 10 parts of cyclopentane, 0.1 part of tannic acid, 0.5 part of imidazolidinyl urea, 2 parts of silver sulfadiazine, 5 parts of chitosan, 45 parts of toluene diisocyanate, 0.3 part of triethylamine, zinc 0.2 parts of catalyst, 5 parts of water, spare;

[0035] 2) Mechanically mix polyether polyol, silicone foam stabilizer, cyclopentane, tannic acid, imidazolidinyl urea, silver sulfadiazine, chitosan and toluene diisocyanate to obtain a white material, which is the prepared Polymer;

[0036] 3) Pour triethylamine, zinc catalyst and water into the prepolymer, mechanic...

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Abstract

The invention discloses antibacterial medical drainage polyurethane foam and a preparation method thereof. The antibacterial medical drainage polyurethane foam is prepared from the following raw materials in parts by weight: 100 parts of polyether polyol, 1.2 to 3.5 parts of an organic silicon foam stabilizer, 1 to 15 parts of a foaming agent, 0.1 to 1 part of tannic acid, 0.1 to 0.6 part of imidazolidinyl urea, 0.5 to 6 parts of sulfadiazine silver, 1 to 10 parts of chitosan, 35 to 65 parts of toluene diisocyanate, 0.1 to 0.5 part of amine catalyst, 0.10 to 0.70 part of a zinc catalyst and 1 to 6 parts of water. According to the antibacterial polyurethane foam disclosed by the invention, various antibacterial agents such as chitosan, tannic acid and sulfadiazine silver are selected, oxygen active sites are provided for the polyurethane foam, so the polyurethane foam has an antibacterial property, meanwhile, the polyurethane foam has excellent biocompatibility, no teratogenic effect, no anaphylactic reaction and excellent anticoagulant performance; a toxicity test result show that the polyurethane foam meets medical requirements; and the te polyurethane foam has the advantages of excellent toughness and elasticity, good processability, various processing modes and the like.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to an antibacterial medical drainage polyurethane foam and a preparation method thereof. Background technique [0002] Vacuum sealing drainage technology (VSD) refers to the use of medical sponge dressings containing drainage tubes to cover or fill the wounds of skin and soft tissue defects, and then seal them with biological semipermeable membranes to make them a closed space. Connecting the drainage tube to a negative pressure source, it is a brand new treatment method to promote wound healing through controllable negative pressure. In traditional wound treatment methods, necrotic tissue around the wound, abscess, wound exudate, infection toxins, and reabsorption of metabolites will form a "second blow" to the patient, causing inflammation, sepsis, and multiple organ dysfunction in the patient's body or signs of exhaustion. The VSD technology, similar to cupping, forms a closed,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G18/48C08J9/14C08L75/08C08L5/08C08K5/3445C08K5/1545C08K5/435A61F13/02C08G101/00
CPCC08G18/4804C08J9/145C08J9/141C08J9/0061C08J9/0023C08J9/0033C08J9/0028C08J2375/08C08J2405/08C08J2203/14C08J2203/142C08G2101/00
Inventor 樊李红谢益思刘爽魏浩杰郭远东
Owner WUHAN UNIV OF TECH
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