91 results about "Pyrylium salt" patented technology

The invention discloses a one and two-photon mitochondrion fluorescence probe. The fluorescence probe is a pyridine salt compound, the structure of which is shown by a general formula (I), wherein R1 in the general formula represents alkyl or hydroxyalkyl, and R2 represents acetyl or hydrogen. The invention also discloses the application of the fluorescence probe of marking or displaying the distribution of the mitochondrion in living cells. Experiments prove that compared with mitochondrion fluorescence probes sold in markets, the mitochondrion fluorescence probe has the characteristics of low price, good two-photon property, low excitation energy, strong developing performance, better biocompatibility, and capability of focusing on fluorescence imaging mitochondrion in the living cells, and has potential application value in the field of exciting fluorescence biomarker with laser.

The invention discloses a polyrotaxane-shaped two-dimensional supermolecule nano-assembly system driven by a photoreaction and a preparation method and application of the system, and belongs to the field of periodic supermolecule nano-assembly systems. The construction unit of the assembly system takes curcubit[8]uril as a host and takes a triphenylamine derivative as a guest. Firstly, triphenylamine modified by alkenyl pyridinium and the curcubit[8]uril form a two-dimensional periodic polyrotaxane-shaped supermolecule assembly system through self-assembly under the host-guest mutual effect; under the visible light irradiation condition, the alkenyl structure in guest molecules can be subjected to a photodimerization reaction, so that the original polyrotaxane-shaped supermolecule assemblysystem is converted into the more stable two-dimensional periodic polyrotaxane-shaped supermolecule assembly system; due to the fact that the obtained polyrotaxane-shaped supermolecule assembly system has good stability and water solubility, the polyrotaxane-shaped supermolecule assembly system can serve as a trapping agent of fullerene (C60), the functional supermolecule composite system is further constructed, a good effect is achieved in the aspect of photodynamics therapy, and the polyrotaxane-shaped two-dimensional supermolecule nano-assembly system has a wide application prospect in theaspect of biological medicine.

The invention provides a circularly polarized light-emitting organic micro-nano crystal material as well as a preparation method and application thereof, belongs to the technical field of organic light-emitting materials, and aims to solve the problems that materials with circularly polarized light-emitting performance in the prior art are generally very complex in molecular structure and relatively long and tedious in preparation process. The circularly polarized light-emitting organic micro-nano crystal is an ionic pyridinium salt compound, and the structural formula is shown as a formula I in the specification; the ionic pyridinium salt compound is composed of positive ions of 2, 2'-bis(2-pyridine)-1, 1'-biphenyl or derivatives thereof and negative ions of camphorsulfonate radicals; and in the formula I, * represents chirality of the camphorsulfonate radicals, the camphorsulfonate radicals are left-handed (L) or right-handed (D), and R groups are H or aromatic substituent groups with different conjugate lengths. According to the method, the high-quality circularly polarized light-emitting two-dimensional micro-nano crystal is prepared in situ through a simple and rapid one-step solution reprecipitation method. The organic micro-nano crystal material can be applied to the fields of optical sensing and the like.

The invention discloses a quinoxaline-based D-A-pi-A type organic photosensitizer as well as a synthesis method and application thereof, and belongs to the field of tumor photodynamic therapy. According to the invention, a series of novel D-A-pi-A structure near-infrared organic photosensitizers are synthesized by taking triphenylamine as an electron donor, diphenyl substituted quinoxaline as an additional receptor and pyridinium as a terminal electron acceptor. The introduction of diphenyl-substituted quinoxaline can effectively red-shift the light absorption and emission spectrum of the photosensitizer, and on the other hand, the existence of benzene rings on triphenylamine and quinoxaline with propeller structures can effectively inhibit the pi-pi accumulation effect between molecules,thereby improving the photodynamic therapy effect of the photosensitizer. By integrating the effects of the two aspects, the organic photosensitizer has a good application prospect in tumor photodynamic therapy.

Pyridinium cationic lipids useful as non-viral gene delivery agents are disclosed. The agents are prepared by reaction of pyrylium salts with primary amines. Also disclosed are methods of trasfectind cells using the pyridinium cationic lipids as gene transfer agents.

A new azo-type quaternary pyridinium salt (Azo-QPS) shows enhanced activity at acidic conditions (e.g., pH = 5); in neutral or basic conditions, this new Azo-QPS shows a much lower level (2-50 times lower) anti-bacterial activity. The use of such a stimulus-enhance antibiotic can response to the proliferation of bacteria directly. It helps reduce or prevent the build-up of potent antibacterial agents in the oral environment. The antibacterial properties of Azo-QPS are activated when the environmental pH becomes acidic; this acidic pH may be indicative of the accumulation of Streptococcus mutans, or the initiation of tooth decay.

The invention discloses a crosslinked polyethylene foam material and a preparation method thereof. The crosslinked polyethylene foam material is prepared by crosslinking polyethylene and alkenyl pyridinium salt. Compared with the prior art, the cross-linked polyethylene foam material disclosed by the invention is better in antibacterial property, and the antibacterial property reaches 95% or above. The cross-linked polyethylene foam material disclosed by the invention is larger in surface tension, longer in surface tension maintaining time, better in product adhesion and wettability, and more beneficial to the gluing performance of the product.

A compound represented by formula (I) or formula (II):

The invention belongs to the technical field of chemical engineering. The invention provides a preparation method of carboxymethyl inulin. According to the invention, inulin, pyridinium salt and a solvent are mixed, gelatinization of the inulin is avoided in the alkalization reaction, and the whole reaction process can be carried out at room temperature; due to the solubilizing effect of the pyridinium salt on reactants, molecules of the reactants are in effective contact, alkalization and etherification reactions are promoted, the reaction time is shortened, and the substitution degree of the carboxymethyl inulin is increased; and meanwhile, sodium hydroxide is added in batches, so that degradation of inulin under a strong alkali condition and reaction of organic chloride and alkali are avoided. Therefore, the preparation method provided by the invention is mild in reaction condition and high in reaction speed, and the prepared carboxymethyl inulin is excellent in appearance.

The invention provides a synthesis method of multi-substituted chiral furanose 3 and intermediate compound. The method comprises the following steps: using compound 12 beta-hydroxyl methyl myristate as raw material to prepare compound 13 by reducing and removing hydroxyl; performing diazotization addition reaction, [3,3] Claisen rearrangement reaction and [1,2] allyl transfer reaction on the compound 13 to obtain compound 14; cutting off double bonds of the compound 14 by using ozone, performing condensation with methanol under the catalyst of pyridinium p-toluenesulfonate to obtain the multi-substituted chiral furanose 3. The process has 9 steps in all and the total yield is 14%. The multi-substituted chiral furanose 3 is a key intermediate used for synthesizing K252a and CEP-701 which have anti-cancer bioactivity, the reaction adopts the compound 12 which is cheap and accessible and can be prepared through industrial production as the raw material, the raw material cost and the manufacturing cost are lower, the chemical yield of the key reaction and the diastereoselectivity are high, the protective group is easy to control, and the operation is simple.

The invention discloses a rate hydrogen sulfide chemical dosimeter and a preparation method and application thereof. The rate hydrogen sulfide chemical dosimeter is iodized 1-methyl-2-(4-nitro)styryl pyridinium with the structural formula shown in the description. The preparation method of the rate hydrogen sulfide chemical dosimeter comprises the steps that iodized 1,2-dimethyl pyridinium and 4-nitrobenzaldehyde are added into a normal butanol solution according to the certain proportion, then, piperazine is added, a reaction is performed on the reflux condition to obtain the rate hydrogen sulfide chemical dosimeter. The rate hydrogen sulfide chemical dosimeter has the good rate chemical dosimeter characteristics, hydrogen sulfide can be rapidly and accurately detected on the physiological conditions, the selectivity of hydrogen sulfide is high, and the antijamming capability of other biological active small molecules is high. The rate hydrogen sulfide chemical dosimeter is simple in synthesis method, high in yield and suitable for industrial production.

The invention discloses an indolizine derivative and a preparation method thereof. The indolizine derivative is prepared from pyridinium bromide and allenic acid ester through [3+2] cycloaddition reaction in a reaction solvent under the action of an inorganic base catalyst and a Lewis base promoter in a nitrogen atmosphere. The reaction substrate of the preparation method is simple, easy to synthesize and low in price; wherein the [3+2] cycloaddition reaction has the advantages of mild reaction conditions, high reaction efficiency, high indolizine derivative yield and high atom economy. Therefore, the indolizine derivative has the advantages of no catalyst residue, high purity and high application value.

The invention discloses a polarity-sensitive triphenyl pyridinium salt fluorescent probe and preparation and application thereof. The structural general formula of the fluorescent probe is shown in the specification, and R1 is H, a halogen atom or a methoxy group; and R2 is alkyl or substituted alkyl. The pyridinium salt part in the fluorescent probe with the structure is used as an electron acceptor (Acceptor, A) and has very strong electron withdrawing capability, and meanwhile, the three benzene ring parts in the fluorescent probe are used as an electron donor (Donor, D) and can provide proper electron donating capability; the fluorescent probe with a D-A structure formed in this way has certain fluorescence capability and atypical AIE properties; the solid fluorescence quantum yield is20% or above; in a certain polarity range, along with the enhancement of the solvent polarity, the luminescence red shift in the solvent is realized, the fluorescence intensity is weakened, and the quantum yield is reduced.

The invention discloses a purification method of 5-bromine-2-(2-methyl-2H-tetrazol-5-yl) pyridine. The purification method comprises the following steps: (1) dissolving 5-bromo-2-(2-methyl-2H-tetrazol-5-yl) pyridine in a solvent, dropwise adding an acidic ethanol solution, stirring and heating, keeping, then cooling to separate out crystals, filtering, washing the crystals with ethanol, and dryingto obtain 5-bromo-2-(2-methyl-2H-tetrazol-5-yl) pyridine acid salt; and 2) adding the 5-bromine-2-(2-methyl-2H-tetrazol-5-yl) pyridine salt into water for dissolving, adding a solvent, dropwise adding liquid caustic soda, stirring, heating, keeping, cooling to separate out crystals, filtering, washing the crystals with ethanol, and drying to obtain the 5-bromine-2-(2-methyl-2H-tetrazol-5-yl) pyridine. The purification method disclosed by the invention has the characteristics of mild purification conditions, safety, simplicity and convenience in operation, high purity, high yield and the like,reduces the production cost, and overcomes the problems of low product purity and need of repeated recrystallization due to the use of a large amount of isopropyl acetate in the existing process.