48 results about "Potassium ethoxide" patented technology

The invention discloses a solid basic catalyst, a preparation method of the solid basic catalyst and an application of the solid basic catalyst in ester exchange reaction. The solid basic catalyst catalyzes the ester exchange reaction by the reaction of metal organic compound and hydroxyl on a carrier under the moderate conditions to synthesize dimethyl carbonate. The solid basic catalyst provided by the invention consists of metal organic alkali and the carrier. The metal organic alkali is linked to the carrier in bond-forming manner; the metal organic alkali is one or more of lithium methoxide, lithium ethoxide, lithium isopropoxide, lithium n-butoxide, lithium tert-butoxide, sodium methoxide, sodium ethoxide, sodium isopropoxide, sodium n-butoxide, sodium tert-butoxide, potassium methoxide, potassium ethoxide, potassium isopropoxide, potassium n-butoxide and potassium tert-butoxide; the carrier is one or more of silicon oxide, aluminium oxide, titanium oxide, zirconia, mesoporous silicon oxide synthesized by the template method, mesoporous aluminium oxide synthesized by the template method, mesoporous titanium oxide synthesized by the template method, and mesoporous zirconia synthesized by the template method.

A method of preparing a bis(thio-hydrazide amide) disalt includes the steps of combining a neutral bis(thio-hydrazide amide), an organic solvent and a base to form a bis(thio-hydrazide amide) solution; and combining the solution and methyl tert-butyl ether, thereby precipitating a disalt of the bis(thio-hydrazide amide).In some embodiments, a method of preparing a bis(thio-hydrazide amide) disalt includes the steps of combining a neutral bis(thio-hydrazide amide) and an organic solvent selected from methanol, ethanol, acetone, and methyl ethyl ketone to make a mixture; adding at least two equivalents of a base selected from sodium hydroxide, potassium hydroxide, sodium methoxide, potassium methoxide, sodium ethoxide and potassium ethoxide to the mixture, thereby forming a solution; and combining the solution and methyl tert-butyl ether to precipitate the disalt of the bis(thio-hydrazide amide).The disclosed methods do not require lyophilization and the solvents used in the process can be more readily removed to low levels consistent with pharmaceutically acceptable preparation.

The invention discloses a method for preparing erucic acid sucrose ester, and the method comprises the following steps: a. erucic acid and methyl alcohol are subjected to esterification reaction by using concentrated sulfuric acid as catalyst, reflux reaction is carried out for 6-10 hours, and after the reaction is finished, the reaction solution is post-processed to obtain erucic acid methyl ester; b. the erucic acid methyl ester obtained in step a is added with erucic acid potash soap and sucrose to react for 2-6 hours while stirring in the presence of alkali catalyst at the reaction temperature of 120-150 DEG C and under the vacuum degree of minus 0.09-minus 0.1MPa, thus obtaining crude product of the erucic acid sucrose ester which is then purified to obtain the erucic acid sucrose ester; and the alkali catalyst is potassium carbonate, potassium methoxide, potassium ethoxide, sodium methoxide or potassium hydroxide. The prepared erucic acid sucrose ester has high monoester content and good emulsifying property, and the separation and purification process is simple, thus being suitable for industrial production.

A preparation method of conjugated linoleic acid glycerides comprises the following steps: (1) C1-4 sodium alcoholate / potassium alcoholate is taken as a catalyst, linoleic acid short-chain alcohol ester is prepared to be conjugated linoleic acid short-chain alcohol ester through inversion reaction for 1-8 hours at 90-150 DEG C, and the using amount of the catalyst is 1.5-8.0% of weight of the linoleic acid short-chain alcohol ester; (2) sodium methylate / potassium methylate and sodium ethoxide / potassium ethoxide are taken as catalysts, the conjugated linoleic acid short-chain alcohol ester and acetoglyceride with mole ratio being 3:1-3.5:1 are reacted for 3-10 hours at 100 DEG C and 170 DEG C to prepare the conjugated linoleic acid glycerides, and the using amount of the catalysts is 0.8-10% of the weight of acetoglyceride. According to the preparation method, the natural resources are utilized sufficiently, an organic solvent is not needed in the main reaction; the esterification rate of conjugated oil acid is more than 99%; the reaction time is short, and the postprocessing simple; the triglyceride content of the conjugated linoleic acid glycerides is more than 90%, and the acid value of the conjugated linoleic acid glycerides is under 1.0mgKOH / g; and the conjugated linoleic acid glycerides is free from extraneous odor, good in taste and light in color, and the optimal Gar is less than or equal to 1.0.

The invention relates to a method for preparing triclabendazole serving as a medicine for animal distomiasis. 2,3-dichlorophenol and 3,4-dichloro-5-nitroaniline are used as raw materials and subjected to etherification, reduction reaction, cyclization and methylation to obtain triclabendazole. In the step of etherification, high-alkalinity potassium ethoxide or potassium methoxide is adopted for replacement of potassium hydroxide in the prior art while microwave irradiation heating is performed, and consequently step-by-step preparation of potassium phenoxide is avoided, phase transfer catalysts are not required, 'one-step' etherification is realized, etherification yield is up to 96% or above, product purity reaches 98% or above, and demands of industrial application are met.

A method of generating soluble polyphosphides using solution chemistry is presented. A reaction between potassium ethoxide and shelf stable red phosphorus generated soluble polyphosphides in a variety of organic solvents with the 31P NMR spectrum being used to detect the species of polyphosphides produced.

A method of synthesizing soluble polyphosphides by activating red phosphorous using organic solvents is presented. A reaction between an alkali metal alkoxy compound or alkali metal alkyl thiolate compound, such as potassium ethoxide, and shelf stable red phosphorus generated soluble polyphosphides in a variety of organic solvents with the 31P NMR spectrum being used to detect the species of polyphosphides produced.

The invention provides a swainsonine derivative and a preparation method of a research reagent of the swainsonine derivative. The swainsonine is prepared through the following synthesis steps: a, adding chloroacetic acid and potassium hydroxide by taking swainsonine as a raw material and taking water as a solvent; b, feeding hematoporphyrin into thionyl chloride, and then adding cordycepin; and c, pouring the product obtained in the step a into the product obtained in the step b, and dropwise adding newly prepared potassium ethoxide into the obtained mixture, so that a swainsonine derivative solution is obtained. The swainsonine derivative disclosed by the invention is a product derived on the basis of a swainsonine structure, and by comparing, the difference is as follows: an enriched heterocyclic ring is connected, so that the swainsonine derivative disclosed by the invention has a function of enriching cancer cells, and can allow drugs to tend to parts with tumors but allow the drug concentration of other parts to be little.

A method of using alkali metal compounds and organic solvents to activate red phosphorous for synthesizing soluble polyphosphides is presented. A reaction between an alkali metal alkoxy compound or alkali metal alkyl thiolate compound, such as potassium ethoxide, and shelf stable red phosphorus generated soluble polyphosphides in a variety of organic solvents with the 31P NIVIR spectrum being used to detect the species of polyphosphides produced.

The invention discloses a pipeline dredging deodorant which is prepared from the following raw materials in parts by weight: 6 to 9 parts of sodium persulfate, 4 to 7 parts of potassium citrate, 10 to14 parts of potassium carbonate, 3 to 5 parts of sodium silicate, 8 to 10 parts of potassium ethoxide, 2 to 5 parts of stearyl alcohol sodium sulfovinate, 3 to 5 parts of polypropylene glycol, 2 to 4parts of oleyl alcohol sodium sulfovinate, 6 to 9 parts of ethyoxyl sodium acetate, 3 to 6 parts of alkylphenol polyoxyethylene ether, 2 to 5 parts of di-lauroyl tartaric acid ester, 6 to 9 parts ofpolyethylene glycol, 10 to 15 parts of potassium carboxylate, 3 to 6 parts of sodium n-alkyl sulfate and 5 to 8 parts of hydroxy-butanedioic acid. The dredging deodorant disclosed by the invention caneliminate odor of a sewer line in several minutes in the kitchen and bathroom and catering industries, completely clear obstructions in the sewer line within ten minutes, fulfills the aims of havingno toxicity or odor and rapidly removing odor and dredging the sewer line, and is poisonless and harmless for an operator and the kitchen and bathroom environment. The invention further discloses a preparation method of the pipeline dredging deodorant.

The invention relates to a method for producing safe and environment-friendly carbonic ester series mixed solvents. Raw materials of dimethyl carbonate and an initiator in the presence of a catalyst are subjected to a transesterification. The initiator comprises a first initiator, which is at least one selected from the group containing ethanol, isopropyl alcohol, isobutyl alcohol, n-butyl alcohol, glycol, diglycol and glycerol, and a second initiator, which is least one selected from the group consisting of ethyl acetate, isopropyl acetate, SEC-butyl acetate and isobutyl acetate. The catalyst comprises a first catalyst, which is at least one selected from the group consisting of sodium methoxide, sodium ethoxide, potassium methoxide, potassium ethoxide, triethanolamine and polyethylene glycol, and a second catalyst, which is at least one selected from the group consisting of dibutyltin oxide, tetrabutyl titanate, rare earth salt and rare earth oxide. The through selection of catalyst and initiator, the invention uses an ester exchange method to obtain carbonic ester series solvents with different boiling points, which can be used as green and environment-friendly coating solvents.

The present invention provides a new topiroxostat synthesis intermediate 4-(2-(imino(pyridine-4-yl)methyl)hydrazinocarbonyl)pyridine N-oxide (compound VI) and a preparation method thereof, wherein isoniazid N-oxide IV and 4-cyanopyridine V are subjected to a reaction in a suitable solvent under an alcohol alkali condition to obtain the product, the alcohol alkali is selected from sodium methoxide, sodium ethoxide, potassium ethoxide or potassium t-butoxide, and the reaction formula is defined in the specification. According to the present invention, through the compound VI, the gout treating drug topiroxostat can be prepared under the mild and easy industrial control reaction conditions.