48 results about "Potassium ethoxide" patented technology

A method of preparing a bis(thio-hydrazide amide) disalt includes the steps of combining a neutral bis(thio-hydrazide amide), an organic solvent and a base to form a bis(thio-hydrazide amide) solution; and combining the solution and methyl tert-butyl ether, thereby precipitating a disalt of the bis(thio-hydrazide amide).In some embodiments, a method of preparing a bis(thio-hydrazide amide) disalt includes the steps of combining a neutral bis(thio-hydrazide amide) and an organic solvent selected from methanol, ethanol, acetone, and methyl ethyl ketone to make a mixture; adding at least two equivalents of a base selected from sodium hydroxide, potassium hydroxide, sodium methoxide, potassium methoxide, sodium ethoxide and potassium ethoxide to the mixture, thereby forming a solution; and combining the solution and methyl tert-butyl ether to precipitate the disalt of the bis(thio-hydrazide amide).The disclosed methods do not require lyophilization and the solvents used in the process can be more readily removed to low levels consistent with pharmaceutically acceptable preparation.

A preparation method of conjugated linoleic acid glycerides comprises the following steps: (1) C1-4 sodium alcoholate / potassium alcoholate is taken as a catalyst, linoleic acid short-chain alcohol ester is prepared to be conjugated linoleic acid short-chain alcohol ester through inversion reaction for 1-8 hours at 90-150 DEG C, and the using amount of the catalyst is 1.5-8.0% of weight of the linoleic acid short-chain alcohol ester; (2) sodium methylate / potassium methylate and sodium ethoxide / potassium ethoxide are taken as catalysts, the conjugated linoleic acid short-chain alcohol ester and acetoglyceride with mole ratio being 3:1-3.5:1 are reacted for 3-10 hours at 100 DEG C and 170 DEG C to prepare the conjugated linoleic acid glycerides, and the using amount of the catalysts is 0.8-10% of the weight of acetoglyceride. According to the preparation method, the natural resources are utilized sufficiently, an organic solvent is not needed in the main reaction; the esterification rate of conjugated oil acid is more than 99%; the reaction time is short, and the postprocessing simple; the triglyceride content of the conjugated linoleic acid glycerides is more than 90%, and the acid value of the conjugated linoleic acid glycerides is under 1.0mgKOH / g; and the conjugated linoleic acid glycerides is free from extraneous odor, good in taste and light in color, and the optimal Gar is less than or equal to 1.0.

A method of synthesizing soluble polyphosphides by activating red phosphorous using organic solvents is presented. A reaction between an alkali metal alkoxy compound or alkali metal alkyl thiolate compound, such as potassium ethoxide, and shelf stable red phosphorus generated soluble polyphosphides in a variety of organic solvents with the 31P NMR spectrum being used to detect the species of polyphosphides produced.

The invention provides a swainsonine derivative and a preparation method of a research reagent of the swainsonine derivative. The swainsonine is prepared through the following synthesis steps: a, adding chloroacetic acid and potassium hydroxide by taking swainsonine as a raw material and taking water as a solvent; b, feeding hematoporphyrin into thionyl chloride, and then adding cordycepin; and c, pouring the product obtained in the step a into the product obtained in the step b, and dropwise adding newly prepared potassium ethoxide into the obtained mixture, so that a swainsonine derivative solution is obtained. The swainsonine derivative disclosed by the invention is a product derived on the basis of a swainsonine structure, and by comparing, the difference is as follows: an enriched heterocyclic ring is connected, so that the swainsonine derivative disclosed by the invention has a function of enriching cancer cells, and can allow drugs to tend to parts with tumors but allow the drug concentration of other parts to be little.