37 results about "Pipemidic acid" patented technology

Novel and optimized classes of pipemidic acid derivative compounds that exhibit effective inhibition of autotaxin enzymes are provided. Such classes of compounds exhibit exhibit reactivity with autotaxin to ultimately reduce the size of the reactive sites thereon to prevent conversion of lysophosphatidyl choline to lysophophatidic acid. Furthermore, such compounds can be incorporated within delivery forms for human ingestion. As such, these compounds accord an excellent manner of potentially reducing generation of certain cancers attributable to the presence of naturally occurring autotaxin within the human body. Methods of inactivating autotaxin to certain degrees therewith such compounds are encompassed within invention as well.

The invention discloses a method for extracting, enriching and quantifying trace pipemidic acid on suspended particulate matters in water. The method comprises the following steps: filtering a target water sample by using a micro-pore fiber membrane; collecting the fiber membrane after filtration; airing the fiber membrane and cutting the fiber membrane into fragments; putting the fragments into a triangular flask; adding an extracting agent and sealing the triangular flask; oscillating and extracting by ultrasonic waves; filtering an extracting liquid by using an organic fiber membrane; meanwhile, transferring the filtered extracting liquid into a K-D concentration bottle; adding a dehydration drying agent into an extracted filtering liquid; after absorbing water, putting the K-D concentration bottle into a rotary evaporator and concentrating; blowing concentrated liquid by nitrogen gas until the volume is smaller than 1mL; making up the concentrated extracted filtering liquid to be 1mL and transferring the concentrated extracted filtering liquid to an Agilent special bottle; detecting the liquid by adopting an internal standard method through a high performance liquid chromatography cascaded three-grade gas chromatograph-mass spectrometer; and analyzing a chromatograph-mass spectrum analysis pattern to finish detection. According to the method, the content of pipemidic acid adsorbed on the suspended particulate matters in a water environment can be supplemented and the blank of the detection of antibiotics can be filled.

This invention relates to extracts rich in N-acids of imino sugars (as opposed to neutral and basic imino sugars) and / or pipecolic acids obtainable from the plant leaves of mulberry (Morus). The extracts have been shown to have enzymatic activities making extracts rich in these compounds, and the compounds isolated from these extracts, to be good candidates for use in the treatment of diseases, particularly, but not exclusively, metabolic disorders, such as, for example, diabetes.

A novel method of producing high-purity hydroxy-L-pipecolic acids in an efficient and inexpensive manner while suppressing the production of hydroxy-L-proline is provided. The method includes allowing an L-pipecolic acid hydroxylase, a microorganism or cell having the ability to produce the enzyme, a processed product of the microorganism or cell, and / or a culture liquid comprising the enzyme and obtained by culturing the microorganism or cell, to act on L-pipecolic acid as a substrate in the presence of 2-oxoglutaric acid and ferrous ion, wherein the L-pipecolic acid hydroxylase has the properties:(1) the enzyme can act on L-pipecolic acid in the presence of 2-oxoglutaric acid and ferrous ion to add a hydroxy group to the carbon atom at positions 3, 4, and / or 5 of L-pipecolic acid; and(2) the enzyme has a catalytic efficiency (kcat / Km) with L-proline that is equal to or less than 7 times the catalytic efficiency (kcat / Km) with L-pipecolic acid.

The present invention provides a kaolin composite adsorption material, which comprises kaolin and chitosan, wherein the chitosan and the kaolin form an intercalation structure, the chitosan loads a core-shell structure photocatalyst, and the core-shell structure photocatalyst comprises a tin dioxide nanometer core and a porous carbon shell coated on the surface of the tin oxide nanometer core. Theinvention further provides the kaolin composite adsorption material prepared through the method, and applications thereof. According to the present invention, the kaolin composite adsorption materialcan be used for treating chloramphenicol, penicillin, erythromycin, streptomycin, vancomycin, pipemidic acid, ibuprofen, diclofenac sodium and other PPCPs contaminants in wastewater, and has good treatment effect. The technology of the present invention is funded by key scientific research projects of universities (15A610008) and PhD research initiation funds (201610009) of North China UniversityOf Water Resources And Electric Power.

Based on the plasma metabolomics research of patients with different molecular subtypes of breast cancer, the present invention finds biomarkers that can be used to distinguish Luminal B type vs HER2 overexpression type, Luminal A type vs Basal-like breast cancer. Compared with the HER2 overexpressing type, the plasma levels of proline, isoleucine, leucine, 2-octenedioic acid and valine in Luminal B patients were significantly up-regulated, and pipecolic acid was significantly down-regulated; Compared with Luminal A type, the content of valine in the plasma of patients with LuminalA type was significantly up-regulated, while pipecolic acid, glycine, glycochenodeoxycholic acid and palmitic acid were significantly down-regulated. The invention can rapidly predict the molecular subtype of breast cancer, and provides an important basis for clinical diagnosis, treatment and prognosis evaluation of breast cancer.

The invention discloses a method for preparing (S)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid and its derivatives, comprising: the compound represented by the formula (I) The racemate or the racemate of the salt of the compound shown in the formula (I) is a substrate, and the R-type isomer of the compound shown in the formula (I) in the substrate is reacted under the catalytic action of oxidative dehydrogenase Generate the imidic acid shown in formula (II); make the imidic acid shown in said formula (II) be converted into said formula (I) in the presence of pipecolic acid reductase and a coenzyme capable of supplying hydride ions The S-type isomer of the indicated compound; the present invention has the characteristics of mild reaction conditions, strong stereoselectivity, high reaction efficiency, and high conversion rate.

The invention relates to gout diagnosis biomarkers and application thereof. The gout diagnosis biomarkers provided by the invention comprise trigonelline, arachidonic acid, betaine, glycocholic acid, pipemidic acid, myristic acid and uracil. The gout diagnosis markers provided by the invention can be detected by adopting a mass spectrum method, and whether a hyperuricemia patient suffers from gout or has a gout suffering risk is determined by using the markers. The invention further comprises a corresponding diagnostic kit.

The invention provides a pipemidic acid pharmaceutical composition which is characterized by being prepared from, by weight, 20-70% of pipemidic acid and 30-80% of pharmaceutic adjuvants. According to the pharmaceutical properties of pipemidic acid, the formula is scientific, the dissolving and absorbing speed of the medicine is increased, the composition is safe and non-toxic, medicine compliance of a patient is good, and the effect is remarkable.

The invention provides a pipemidic acid pharmaceutical composition which is characterized by being prepared from, by weight, 20-70% of pipemidic acid and 30-80% of pharmaceutic adjuvants. According to the pharmaceutical properties of pipemidic acid, the formula is scientific, the dissolving and absorbing speed of the medicine is increased, the composition is safe and non-toxic, medicine compliance of a patient is good, and the effect is remarkable.

The invention discloses an ELISA detection method for pipemidic acid and application thereof. The ELISA detection method is established by using an ELISA detection system consisting of a pipemidic acid antibody and a coating antigen, wherein the coating antigen is a pipemidic acid coating antigen or a quinolones coating antigen; to be specific, the method is a more sensitive and effective ELISA detection method for pipemidic acid, which is established by taking the pipemidic acid antibody and the coating antigen, namely lomefloxacin-OVA as an optimal combination. The ELISA detection method is efficient, convenient, and high in sensitivity and specificity, the linear range (IC20-IC80) of the detection is 0.9-38.5 ng / mL, the half inhibiting concentration (IC50) is 5.99 ng / mL, and the lowest detection limit is 0.31 ng / mL; and besides, the preprocessing method is simple to operate, the requirements for residue detection can be met, and the method can be applied to quick detection of pipemidic acid illegally added into food, and has wide application prospect.

The invention provides a montmorillonite-containing composite adsorbing material. The montmorillonite-containing composite adsorbing material comprises montmorillonite and chitosan forming an intercalated structure with the montmorillonite, wherein the chitosan is loaded with a nanometer titanium dioxide-mesoporous carbon precipitate. The invention provides the montmorillonite-containing compositeadsorbing material prepared by a preparation method and application thereof. The montmorillonite-containing composite adsorbing material can be applied to treatment to PPCP pollutants such as chloramphenicol, penicillin, erythromycin, streptomycin, vancomycin, pipemidic acid, ibuprofen, diclofenac sodium in wastewater and is relatively good in treatment effect. The patented technology is funded by a key research project (15A610008) in a higher education institution and a doctoral research startup fund (201610009) in North China University of Water Resources and Hydropower.