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Pharmaceutical compound preparation for treating acute gastritis

A technology for compound preparations and acute gastritis, applied in the field of drug compound preparations, can solve serious complications and other problems, achieve less sequelae, significant therapeutic effect, and reduce complications

Inactive Publication Date: 2018-01-16
CHENGDU LINGXI SHANGPIN TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The existing treatment methods are all through the injection of antibacterial drugs, and then observe the patient's condition, and do further treatment according to the patient's condition. Generally, they are accompanied by relatively serious complications. At present, there is no better way to treat this condition

Method used

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  • Pharmaceutical compound preparation for treating acute gastritis
  • Pharmaceutical compound preparation for treating acute gastritis
  • Pharmaceutical compound preparation for treating acute gastritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The compound oral preparation of this embodiment is prepared by a method known in the pharmaceutical industry, and the specific dosage of each component is shown in Table 1:

[0028] Table 1 The specific dosage of each component

[0029]

[0030] The treatment effect of taking two oral drugs of profenacine and pipemidic acid at the same time shows that the effect of using profenacine and pipemidic acid is better than that of a single drug, which is a reasonable combination for the development of two drugs. The compound preparation used has laid the foundation.

Embodiment 2

[0032] Validation of therapeutic effect in rat model:

[0033] Objective: To observe the effect of different ratios of compound preparations of Probenzine combined with pipemidic acid on rats with DOCA (deoxycorticosterone acetate) suffering from acute gastritis, so as to explore the therapeutic effect of different doses of the compound.

[0034] Methods: 1200 SD rats, ♂, body weight 180-190g. After resecting the right kidney under aseptic conditions, DOCA 5mg / cattle was administered twice a week, sc, and fed with 1% sodium chloride solution; they were randomly divided into 12 groups, 8 in each group, and the specific grouping and treatment were shown in the table two.

[0035] Table 2 Animal grouping and drug formulation, administration method

[0036] model group

normal saline

Probenzine group

Probenzine 400mg

pipemidic acid high group

Pipemidic acid 40 mg

compound group

Probenzine 20 mg, pipemidic acid 2 mg

Compound two...

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Abstract

The invention discloses a pharmaceutical compound preparation for treating acute gastritis. The compound preparation comprises the following components in parts by weight: 10 to 300 parts of propantheline bromide, 10 to 120 parts of pipemidic acid, and 10 to 1600 parts of drug carrier. Propantheline bromide and pipemidic acid are taken as the pharmaceutical components and mixed with the drug carrier to prepare the compound preparation. The compound preparation is convenient to take, is very safe, has a prominent effect, can greatly reduce complications, generates few sequelae, barely causes adverse reactions, and promotes the healing.

Description

technical field [0001] The invention relates to the field of drug compound preparations, in particular to a drug compound preparation for treating acute gastritis. Background technique [0002] The stomach is the main digestive organ of the human body. Acute gastritis is a common disease, mainly manifested as epigastric pain, discomfort, loss of appetite, nausea and vomiting, sometimes accompanied by diarrhea, severe acute gastritis can also cause hematemesis, blood in the stool and other symptoms. Acute gastritis includes four types, and what is often encountered in daily life is acute simple gastritis. [0003] The general causes of acute gastritis are: (1) physical and chemical factors: food and beverages that are too cold or too hot, strong tea, coffee, spirits, irritating condiments, too rough food, drugs (especially non-steroidal anti-inflammatory Lin, indomethacin, etc.), can stimulate the gastric mucosa and destroy the mucosal barrier. Drugs such as aspirin can al...

Claims

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Application Information

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IPC IPC(8): A61K31/4985A61K31/352A61P1/04
Inventor 姜迪蛟
Owner CHENGDU LINGXI SHANGPIN TECH CO LTD
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