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Dioxane-coordinated rare-earth coordination compound, and preparation method and application thereof

A technology of rare earth complexes and dioxane, which is applied to compounds containing elements of group 3/13 of the periodic table, pharmaceutical formulations, chemical instruments and methods, etc., can solve the problem of difficulty in finding the second ligand and large steric hindrance And other issues

Inactive Publication Date: 2011-08-17
FUYANG NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Pipemidic acid is a broad-spectrum quinolone antibacterial drug. The molecule has a relatively large conjugated system and a large steric hindrance. Therefore, it is difficult to find a suitable second ligand when it is used as a ligand to synthesize a complex.

Method used

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  • Dioxane-coordinated rare-earth coordination compound, and preparation method and application thereof
  • Dioxane-coordinated rare-earth coordination compound, and preparation method and application thereof
  • Dioxane-coordinated rare-earth coordination compound, and preparation method and application thereof

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Embodiment 1

[0044] Embodiment 1: rare earth complex Eu(PPA) 3 ·nH 2 O and Tb(PPA) 3 ·nH 2 Preparation of O(n is 1~6)

[0045] Under constant stirring, 3 mmol of PPA (0.357 g) and 3 mmol of NaOH (0.12 g) were co-dissolved in 30 ml of absolute ethanol. Then, 1 mmol of EuCl 3 ·6H 2 O was dissolved in 10 mL of absolute ethanol, and this solution was added dropwise to the above solution of PPA and NaOH. Using a rotary evaporator (RE-52AA) under vacuum, the temperature is controlled at 60°C, and the solvent ethanol is evaporated, and the obtained solid powder is Eu(PPA) 3 ·nH 2 O, put it in a desiccator to dry for later use, where n is 1-6, depending on the degree of evaporation and drying, generally n is 6.

[0046] Tb(PPA) 3 ·nH 2 The preparation method of O also adopts similar method, specifically as follows:

[0047] Under constant stirring, 3 mmol of PPA and 3 mmol of NaOH were dissolved in 30 ml of absolute ethanol. Then, 1mmol of TbCl 3 ·6H 2 O was dissolved in 10 mL of abs...

Embodiment 2

[0048] Embodiment 2: rare earth complex Eu(PPA) 3 dioxane and Tb(PPA) 3 Preparation of dioxane

[0049] Preparation method one:

[0050] Under constant stirring, 3 mmol of PPA (0.357 g) and 3 mmol of NaOH (0.12 g) were co-dissolved in 30 mL of absolute ethanol. The temperature is controlled at about 80°C, and the reflux state is maintained. Then, 1mmol of EuCl 3 ·6H 2 O was dissolved in 10 mL of absolute ethanol, and this solution was added dropwise to the above solution of PPA and NaOH. Finally, excess dioxane (10mL) was added to the solution, and a light yellow precipitate Eu(PPA) could be seen 3 dioxane generated. Filter the precipitate and dry it in a desiccator for later use.

[0051] Tb(PPA) 3 The preparation of dioxane also adopts a similar method, as follows:

[0052] Under constant stirring, 3 mmol of PPA and 3 mmol of NaOH were dissolved in 30 mL of absolute ethanol. The temperature is controlled at about 80°C, and the reflux state is maintained. Then, 1m...

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Abstract

The invention provides a rare-earth fluorescent coordination compound synthesized by using dioxane micromolecule as a second ligand and pipemidic acid (PPA) as a first ligand, and a preparation method thereof. Due to the existence of dioxane, the fluorescence of the rare-earth coordination compound is obviously enhanced, and the fluorescence lifetime of the rare-earth coordination compound is greatly influenced when the dioxane is used as the second ligand. The novel rare-earth coordination compound provides a new optional reagent for quinolone broad-spectrum antibacterial drugs, and the fluorescence enhanced phenomenon also provides a new method for detecting existence and content of micromolecule dioxane.

Description

technical field [0001] The invention provides a rare earth complex synthesized by using dioxane small molecule as the second ligand and pipemidic acid (PPA) as the first ligand, and a preparation method thereof. Background technique [0002] In the research and development of rare earth complexes, especially in the process of looking for fluorescent rare earth complexes with excellent performance, it is necessary to find suitable ligands to synthesize rare earth complexes with stable performance, satisfactory luminous intensity and fluorescence lifetime. [0003] 1,4-dioxane, also known as dioxane or dioxane (dioxide), is a colorless flammable liquid with a slight ether-like odor. It is an excellent organic solvent and has a wide range of uses. It can be used as a fiber Solvent for acetates and many resins. It can be used as an extractant in the pharmaceutical industry, as a stabilizer in the production of 1,1,1-trichloroethane, and as a volatile solvent in the production o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F5/00A61K31/519A61P31/00G01N21/64G01N21/75G01N21/25
Inventor 陶栋梁崔玉民徐怡庄
Owner FUYANG NORMAL UNIVERSITY
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