30 results about "Palmitoylphosphatidyl choline" patented technology

The invention relates to an ultrasound-sensitive liposome and application thereof, and aims to effectively solve the problems of large toxic and side effects, poor curative effect, low treatment efficiency and high immune toxicity in chemotherapy. According to the technical scheme, the ultrasound-sensitive liposome is prepared by the following steps: weighing 2 to 10mg of cholesterol, 2 to 20mg of 1,2-dipalmitoyl phosphatidylglycerole (DPPG), 5 to 30mg of dipalmitoyl phosphatidylcholine (DPPC) and 0 to 20mg of dioleoyl phosphatidyl ethanolamine (DOPE); dissolving the weighed materials in 5 to 30m of solvent; performing ultrasonic treatment for 5 to 60 minutes till the materials are fully dissolved; performing rotary evaporation at the temperature of 50 DEG C to remove the solvent; performing rotary evaporation under the vacuum condition for 4 hours to remove residual solvent; adding 1 to 10mg of medicinal mannitol containing solution, wherein the mannitol concentration is 0.2 to 1M; quickly blowing the bottom of a bottle with hot air to accelerate hydration; performing ultrasonic treatment for 5 to 10 minutes till the solution becomes uniform and transparent; freezing and unfreezing for 3 to 6 times to obtain the ultrasound-sensitive liposome. Medicaments wrapped in the liposome are released at a fixed point, so that the toxic and side effects of chemical medicaments are lowered, and the curative effect is enhanced; the ultrasound-sensitive liposome can be used as an ultrasonic imaging diagnostic agent, and is an innovation on chemotherapeutic medicaments.

The invention discloses a vitamin D2 and calcium levulinate injection composition and a preparation method thereof. The vitamin D2 and calcium levulinate injection composition comprises vitamin D2, calcium levulinate, dipalmitoyl phosphatidylcholine, cholesterol, distearoyl phosphatidylcholine, polyethylene glycol and water for injection. The preparation method comprises the following steps: (1) weighing the materials for later use according to weight ratio; (2) respectively communicating a three-way selector valve in a constant temperature water supply system with a reaction kettle and a homogenizer; (3) putting the calcium levulinate into the water for injection to dissolve so that a calcium levulinate solution for use is obtained; (4) putting the dipalmitoyl phosphatidylcholine, the distearoyl phosphatidylcholine, the cholesterol and the polyethylene glycol into the reaction kettle to react; (5) putting the materials obtained after the reaction of the step (4) into the homogenizer, and putting the vitamin D2 and the homogenizer into the homogenizer to obtain a semifinished product of the vitamin D2 and a calcium levulinate injection; (6) filtering the semifinished product and potting to obtain the vitamin D2 and calcium levulinate injection. The invention solves the disadvantages of the prior art.