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Vitamin D2 and calcium levulinate injection composition and preparation method thereof

A technology of calcium fructonate and vitamins, which is applied in the field of medicine, can solve the problems of inability to guarantee sterile injection and high risk of use, and achieve the effects of excellent stability, increased safety, and guaranteed product quality

Active Publication Date: 2014-08-27
JIANGXI GANNAN HAIXIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology allows certain chemicals called phytophthora-derived lipids (PLT) inside tiny particles made up mostly by fat cells or other organisms without losing their effectiveness over time when stored below 0 degrees Celsius due to its stable nature even if it becomes decomposed quickly under normal conditions. These small particles can be used safely throughout this range from medical applications where they are needed most often such as treating arterial disease symptoms through blood flow improvement therapy.

Problems solved by technology

This patented technical problem addressed in this patents relates to finding ways to improve the quality control (QC) value of certain drugs during their manufacture without containing any harmful ingredients like saturation agents. Current methods involve adding these chemical compounds separately from each others until they meet specific conditions required for effective administration. These techniques result in increased risk due to potential contamination issues associated with unstable compositions.

Method used

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  • Vitamin D2 and calcium levulinate injection composition and preparation method thereof
  • Vitamin D2 and calcium levulinate injection composition and preparation method thereof
  • Vitamin D2 and calcium levulinate injection composition and preparation method thereof

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preparation example Construction

[0026] one of the vitamin D 2 and the preparation method of calcium fructonate injection composition, the steps are as follows:

[0027] ①According to vitamin D 2 The weight ratio to calcium fructonate is 1:23-32, vitamin D 2 The weight ratio with dipalmitoylphosphatidylcholine is 1:40-80, vitamin D 2 The weight ratio with cholesterol is 1:24-40, Vitamin D 2 The weight ratio with distearoylphosphatidylcholine is 1:24-48, Vitamin D 2 1:64-120 by weight with polyethylene glycol, vitamin D 2 The weight-to-volume ratio of water for injection is 1 mg: 8-12 ml, and the material is taken for later use;

[0028] ②Connect the first water outlet of the three-way reversing valve in the constant temperature water supply system to the reactor, and the second water outlet of the three-way reversing valve to the homogenizer;

[0029] ③ Take calcium fructonate according to the ratio of step ① and put it into water for injection to dissolve. The amount of water for injection is 10% of th...

Embodiment 1

[0040] Embodiment 1, vitamin D 2 And the composition of calcium fructonate injection composition is:

[0041] Vitamin D 2 0.125g, 3.82g of calcium fructonate, 8g of dipalmitoylphosphatidylcholine, 5g of distearoylphosphatidylcholine, 3g of cholesterol, 12g of polyethylene glycol, pH value 7, dilute to 1000ml with water for injection.

Embodiment 2

[0042] Embodiment 2, vitamin D 2 And the composition of calcium fructonate injection composition is:

[0043] Vitamin D 2 0.125g, calcium fructonate 2.87g, dipalmitoylphosphatidylcholine 5g, distearoylphosphatidylcholine 6g, cholesterol 4g, polyethylene glycol 12g, pH value 7.1, dilute to 1000ml with water for injection.

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Abstract

The invention discloses a vitamin D2 and calcium levulinate injection composition and a preparation method thereof. The vitamin D2 and calcium levulinate injection composition comprises vitamin D2, calcium levulinate, dipalmitoyl phosphatidylcholine, cholesterol, distearoyl phosphatidylcholine, polyethylene glycol and water for injection. The preparation method comprises the following steps: (1) weighing the materials for later use according to weight ratio; (2) respectively communicating a three-way selector valve in a constant temperature water supply system with a reaction kettle and a homogenizer; (3) putting the calcium levulinate into the water for injection to dissolve so that a calcium levulinate solution for use is obtained; (4) putting the dipalmitoyl phosphatidylcholine, the distearoyl phosphatidylcholine, the cholesterol and the polyethylene glycol into the reaction kettle to react; (5) putting the materials obtained after the reaction of the step (4) into the homogenizer, and putting the vitamin D2 and the homogenizer into the homogenizer to obtain a semifinished product of the vitamin D2 and a calcium levulinate injection; (6) filtering the semifinished product and potting to obtain the vitamin D2 and calcium levulinate injection. The invention solves the disadvantages of the prior art.

Description

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Claims

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Application Information

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Owner JIANGXI GANNAN HAIXIN PHARMA
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