The invention discloses a preparation method for (Z)-3'-hydroxyl-3,4,4',5-tetramethoxyl diphenyl
ethylene. A diphenyl
ethylene framework structure is built by the
Perkin reaction method, and natural aniseed fat-soluble components and
propenyl anisole (
anethole) are taken as raw materials, and oxidized to obtain anisaldehyde; dichlorocarbene
insertion reaction is carried out on the anisaldehyde to obtain p-methoxyl-
mandelic acid which is reduced to obtain methoxyl-
phenylacetic acid, the methoxyl-
phenylacetic acid is brominized to obtain 3-bromo-4-methoxyl-
phenylacetic acid. The compound and the natural 3,4,5-trimethoxybenzaldehyde (nutgall extract derivative) carry out
Perkin reaction to build a cis-form diphenyl
ethylene framework which is further converted and decarboxylated by functional groups to obtain the (Z)-3'-hydroxyl-3,4,4',5-tetramethoxyl diphenyl ethylene. The raw materials of the invention are reproducible natural resources-
anethole which are rich in China and 3,4,5-trimethoxybenzaldehyde, and replace non-renewable
petrochemical materials which are used by the prior art and become less and less so that the method has the advantages of good
sustainable development capability as well as remarkable economic, environmental and ecological benefits.