The invention discloses a synthetic method of procarbazine (Pcb). The synthetic method comprises following steps: p-tolualdehyde is taken as an initial
raw material, dibromocyanuric acid and
isopropylamine are added, reaction is carried out at
room temperature so as to obtain p-methyl benzoyl
isopropylamine; p-methyl benzoyl
isopropylamine is dissolved in an organic
reagent, N-bromo-
succinimide and an initiator are added, heating
reflux is carried out, after reaction, the
solvent is removed,
acetonitrile and a
hydrolysis promoter are added, heating
reflux is carried out so as to obtain p-formyl benzoyl isopropylamine; p-formyl benzoyl isopropylamine and
methylhydrazine sulfate are dissolved in an organic
reagent,
triethylamine is added for reaction, and the
solvent is subjected to rotary
drying,
sodium cyanoborohydride is added, an obtained
reaction system is heated to
room temperature, reaction is carried out for more than one night so as to obtain Pcb. According to the synthetic method, bromination is carried out firstly, and then
hydrolysis is carried out, p-methyl benzoyl isopropylamine is converted into p-formyl benzoyl isopropylamine, using of strong
oxidizing agent and strong acid is avoided, the synthetic method is friendly to the environment, the yield is high, and the total yield of the three steps is 52.9%.