34 results about "O-vanillin" patented technology

The present invention features polymers containing vanillin monomers and / or o-vanillin monomers and the use thereof in darkening the skin.

The invention discloses a new synthesis method of a natural product Salvianolic Acid F. The method comprises the following steps: carrying out hydroxyl group protection on 4-methycatechol used as a raw material, carrying out a methyl radical reaction, and reacting the obtained methyl radical reaction product with triphenyl phosphine to obtain a phosphorus onium salt of formula 7; carrying out hydroxyl group protection, bromination and hydroxyl group deprotection on o-vanillin used as a raw material, carrying out methyl group deprotection on the hydroxyl group, and carrying out hydroxyl group protection to obtain a compound of formula 5; carrying out a Wittig reaction on the compound of formula 5 and the phosphorus onium salt of formula 7, carrying out lithium-halogen exchange under the action of n-butyllithium, and reacting the obtained exchange product with N,N-dimethyl formamide to obtain a compound of formula 3; carrying out an HWE reaction on the compound of formula 3 and phosphate ester of formula 4 to obtain a compound of formula 2; and carrying out hydroxyl deprotection and methyl ester hydrolysis to obtain the Salvianolic Acid F. The synthesis method has the advantages of novel and reasonable route, cheap and easily available raw materials, simple operating technology, mild reaction conditions, few side reactions, high yield and good repeatability.

The invention discloses an o-vanillin bisethylenediamine vanadium complex, a synthesis method and an application thereof. The chemical formula of the o-vanillin bisethylenediamine vanadium complex is: {[VOL·(H 2 O)]·H 2 O} n , the molecular formula is: C 18 h 22 N 2 o 7 V; The ligand of the o-vanillin bisethylenediamine vanadium complex is o-vanillin bisethylenediamine. The present invention uses o-vanillin bisethylenediamine as a ligand, and adopts a hydrothermal method to convert VOSO 4 React with o-vanillin bisethylenediamine to coordinate ligands with metal ions to obtain a new o-vanillin bisethylenediamine vanadium complex. The complex is expected to be applied in the fields of anti-oxidation and anti-cancer. The synthesis method of the invention is simple, convenient and safe, has mild reaction conditions, high yield and high purity, and is beneficial to subsequent tests.

The invention belongs to the field of organic chemistry, and specifically relates to a method for synthesizing 5-halogenated o-veratraldehyde, comprising: using 4-halogenated guaiacol as a raw material to prepare 2-hydroxyl-3-methoxyl-5- Halogenated mandelic acid; further use 2-hydroxy-3-methoxy-5-halogenated mandelic acid to obtain 5-halogenated o-vanillin; further use 5-halogenated o-vanillin to obtain 5-halogenated o-Veratraldehyde. The total yield of the synthesis method of the invention is between 60%-70%, and 4-halogenated guaiacol is used as a raw material, which overcomes the problems of limited source of o-vanillin and low production capacity. Simultaneously, in the synthetic method of 5-halogenated o-veratraldehyde of the present invention, other raw materials used are common and easy-to-obtain raw materials, and through the optimization of the reaction procedure, the reaction conditions are mild, the operation is simple, the chemical yield is high, and the cost is low , very suitable for industrial production.

The invention relates to a method for compounding BNC 105, which uses o-vanillin and 3,4,5- trimethoxy-benzaldehyde as starting materials. The o-vanillin is subjected to hydroxy protection and aldehyde oxidation to be hydrolyzed into phenol, and the phenol is subjected to iodination to generate o-iodophenol intermediates. The 3,4,5-trimethoxy benzaldehyde is subjected to nucleophilic addition and oxidation to generate acetylenic ketone intermediates. The acetylenic ketone intermediates and the o-iodophenol intermediates are processed to obtain the BNC 105 through Michael addition, free-radical ring closing and deprotection. The method for compounding the BNC 105 is low in cost of raw materials, easy to obtain the raw materials, mild in reaction conditions and simple and feasible in operation, and is suitable for commercial process.

The invention provides a fluorescent probe for identifying aluminum ions and its preparation method and application. The molecular formula of the fluorescent probe is C 24 h 25 N 2 o 3 , the preparation method comprises the following steps: adding (1R, 2R)-cyclohexanediamine and dehydrated ethanol successively to a three-neck flask under N2 protection, and then adding o-vanillin to adjust the pH of the solution to pH=4~4 After 5, spin dry under vacuum to obtain a light yellow solid, and dissolve it in 100 mL of distilled water, wash with dichloromethane three times to obtain a yellow aqueous solution, slowly add ammonia water dropwise to pH = 9-10, wash with distilled water three times, and collect Dichloro, vacuum-dried with anhydrous sodium sulfate to obtain yellow semi-body compound A, then add compound A and anhydrous methanol to the three-necked flask in turn, then dissolve 2-hydroxy-1-naphthaldehyde in methanol solution and add to it , continue the reaction at room temperature and then spin dry until a solid is produced. The solid is washed with methanol three times to obtain a fluorescent probe. This method is simple, fast, easy to operate, and has good selectivity and high sensitivity.

The invention relates to a bis-o-vanillin ethylene diamine schiff base and transitional metal coordination compound and a preparation method thereof, which can solve the problem of the application of a coordination compound prepared by compounding bis-o-vanillin ethylene diamine schiff base serving as a ligand and a transitional metal to a medicament for treating diabetes. The coordination compound is the bis-o-vanillin ethylene diamine schiff base and transitional metal coordination compound prepared by compounding the bis-o-vanillin ethylene diamine schiff base with the transitional metal. The preparation method of the coordination compound comprises the following steps of: dissolving one of 0.02 to 0.03mol of transitional metal vanadium, 0.02 to 0.03mol of cadmium salt or 0.02 to 0.03mol of copper salt and 0.02mol of bis-o-vanillin ethylene diamine schiff base by using 3 to 5mL of methanol or mixed solution of 3 to 5mL of methanol and N,N-dimethyl formamide in the volume ratio of 1:6 respectively; slowly and uniformly mixing; filtering the mixed liquor; diluting the obtained filtrate to 8mL by using methanol; and standing at the temperature of between 18 and 25 DEG C for 5 to 30 days to obtain the coordination compound. The coordination compound has a simple preparation method, can be effectively used for preparing the medicament for treating the diabetes and is an innovation of the medicament for treating the diabetes.

The invention discloses a preparation method for a monomolecular magnet [Co4(hmb)4(mu3-OMe)4(MeOH)4]. The method comprises the following steps of: (1) dissolving 0.3-0.4 g of analytically pure Co(ClO4)2.6H2O and 0.1-0.3 g of analytically pure o-vanillin in 8-12 ml of mixed solution of absolute methanol and analytically pure acetonitrile in volumetric ratio of 1:1; (2) slowly adding analytically pure triethylamine or analytically pure sodium hydroxide into the solution prepared in the step (1), continuously stirring, and adjusting the pH value to be 8-9; and (3) transferring the solution prepared in the step (2) into a reaction kettle of polytetrafluoroethylene, reacting at the temperature of 70-90 DEG C for 60-80 hours, cooling to room temperature, opening the kettle, filtering, and washing with the mixed solution of the absolute methanol and the analytically pure acetonitrile in volumetric ratio of 1:1. The method overcomes the defect of poor repeatability of a solution method, and has the advantages of simple process, low cost, easiness in control over chemical components, superior repeatability, high yield and the like.

The invention belongs to the field of organic chemistry, and relates to a synthetic method of berberine hydrochloride, comprising: S1: N-[2-(3,4-dioxygen phenyl-5-yl)ethyl]-1-(5-halo-2,3-dimethoxybenzyl)methimine; S2: preparation of 2-(3,4-dioxy Phenyl)-N-(5-bromo-2,3-dimethoxybenzyl) ethylamine; S3: 2-(3,4-dioxyphenyl)-N-(5-bromo ‑2,3‑dimethoxybenzyl) ethylamine hydrochloride; S4: preparation of 12‑halogenated berberine derivatives; S5: preparation of berberine. The present invention gets rid of the constraints of using the by-product o-vanillin to synthesize o-veratraldehyde as a raw material, synthesizes 5-substituting o-veratraldehyde and piperonyl ethylamine, and uses the two to prepare berberine hydrochloride, which has the advantages of easy-to-obtain raw materials and mild reaction conditions , easy operation, high chemical yield, low cost and other advantages.

The invention discloses a method for preparing 2,3-dihydroxybenzaldehyde by removing the methyl group of o-vanillin, comprising the following steps: in an organic solvent, in the presence of aluminum trichloride and iodide, O-vanillin undergoes an ether bond cleavage reaction at a temperature of -20°C to reflux to generate 2,3-dihydroxybenzaldehyde. The method has mild conditions, simple operation and high yield.

The invention discloses a preparation method of ion selective electrode capable of measuring trace chromium (III). Schiff base derived from o-vanillin and 4-aminoatipyrine is synthesized by o-vanillin and 4-aminoatipyrine and used as neutral carrier and mixed with carbon powder and liquid paraffin is used as adhesive, therefore the chromium (III) ion selective electrode with Nernst response is prepared. The Nernst response concentration range of the ion electrode to Cr 3+ is 1.00*10-6-1.00*10-2 mol / L at room temperature and gradient is 19.40 mV / dec, the detection lower-limit is 1.58*10-7 mol / L. The response time of electrode is less than 45s, the p H application range is 3.3-5.6, with good stability and long service life. The ion electrode has good selectivity to Cr 3+. The ion electrode is used for measuring the Cr 3+ in industry waste water.