The invention provides a formula for non-drug conditioning of obesity with hyperglycemia, hypertension, hyperlipemia and hyperuricemia. The formula comprises the following components: soybean proteinisolate, konjac powder, phosphatide, black soybean powder, red bean powder, oat powder, xylooligosaccharide, nutrient yeast, rhizoma dioscoreae powder, blueberry powder, an edible fungi solid concentrate and mixed nutrient powder. The particular formula is powder prepared by the following components in parts by weight: 20-30 parts of the soybean protein isolate, 5-10 parts of the konjac powder, 0.5-2 parts of the phosphatide, 0.01-0.1 part of the black soybean powder, 0.01-0.1 part of the red bean powder, 0.5-2 parts of the oat powder, 1-3 parts of the xylooligosaccharide, 0.1-1 parts of the nutrient yeast, 0.01-0.1 part of the rhizoma dioscoreae powder, 0.1-1 part of the blueberry powder, 0.1-1 part of the edible fungi solid concentrate and 1-2 parts of the mixed nutrient powder. The components in the formula can be applicable to middle aged and old people with hyperglycemia, hypertension, hyperlipemia and hyperuricemia after reasonable proportioning and can also be edible for other healthy and sub-health groups; and the components can also be applicable to people with cardio-cerebrovascular diseases (hypertension, hyperlipemia, arteriosclerosis and a coronary heart disease), diabetes (hyperglycemia), hyperuricemia, hepatic and renal dysfunction, a fatty liver disease and obesity.