37 results about "Tissue degradation" patented technology

This invention provides methods of treating a patient's lung. One aspect of the invention provides a method of treating a lung including the following steps: inserting a collateral flow blocking agent delivery device into an air passageway of the lung; and delivering a collateral flow blocking agent to reduce airflow between a portion of the lung distal to the delivery device and the exterior of the patient. Another aspect of the invention provides a method of treating a lung including the step of delivering a collateral flow blocking agent to reduce airflow through openings in lung tissue caused by tissue degradation.

Novel modalities are introduced to treat joint and cartilage ischemia and related pathologies to improve outcome in the treatment of arthropathies and spondylopathies. The invention includes compositions, materials or devices which will improve oxygen, substrate and nutrient delivery to joint tissues and modalities to decrease the degradation of joint tissues by inflammatory and other destructive processes.

The present invention provides a synthetic, poorly crystalline apatite (PCA) calcium phosphate containing a biologically active agent and / or cells (preferably tissue-forming or tissue-degrading cells). The compositions provided by the present invention are useful for a variety of in vivo and in vitro applications, including drug delivery (for example, to bony sites, the central nervous system, intramuscular sites, subcutaneous sites, interperitoneal sites, and occular sites) tissue growth (preferably bone or cartilage) osseous augmentation, and methods of diagnosing disease states by assaying tissue forming potential of cells isolated from a host. The invention also provides methods of preparing delivery vehicles, of altering delivery vehicle characteristics, and of delivering biologically active agents to a site. The invention further provides in vitro cell culture systems and cell encapsulation materials. The invention is useful for both medical and veterinary applications.

A compound of formula (I)wherein X is a -CONHOH group and the R groups are defined in the claims. The compounds are inhibitors of matrix metalloproteinases involved in tissue degradation and inhibitors of the release of tumour necrosis factor from cells.

Matrix metalloproteinases are major mediators of tissue destruction in various chronic inflammatory disorders. The present invention demonstrates that over- expression of intracellular isoform of IL-1 receptor antagonist confers to recipient cells resistance to signaling pathways of proinflammatory cytokines (such as tumor necrosis factor alpha and IL-1 beta) that induce matrix metalloproteinase and subsequent tissue degradation. Hence, over-expression of intracellular IL-1 receptor antagonist may inhibit tissue destruction in various inflammatory disorders such as rheumatoid arthritis, other arthritides, degenerative intervertebral disc disease and chronic skin ulcers that occurs in diabetes mellitus and bed-ridden patients.

The invention discloses a strain for promoting germination and seedling formation of a Dendrobium devonianum seed and application thereof. The classification designation of the strain is Tulasnella sp.CY collected to China General Microbiological Culture Collection Center, wherein the collection number is CGMCC NO.9551. The strain can obviously promote germination and seedling formation of the Dendrobium devonianum seed, and has higher specificity. The strain has very import practical meanings for acquiring the symbiotic seed and seedling of Dendrobium devonianum through seed, can be used for nursery seedling raising or outdoor trunk seed direct sowing, has the advantages of low cost, high outdoor survival rate, no tissue degradation and the like as compared with tissue culture, has the application value of acquiring the symbiotic seed and seedling instead of tissue culture, and provides reliable technical guarantees for solving the bottleneck problem of seed and seedling sources in the Dendrobium devonianum culture industry.

The present invention provides, in one embodiment, a method of normalizing the timing of sexual response in a mammal comprising the administration of an amount of a central nervous system sexual response initiator in an amount sufficient to produce genital vasodilation but less than the amount required to produce effective vasocongestive arousal. The method is applicable not only to adjusting or normalizing the timing of sexual response in humans, but in the breeding of valuable commercial animals such as horses, cattle, sheep, swine and the like and domesticated pets such as dogs and cats. In an alternative embodiment, the present invention provides a method for the prophylactic treatment of long-term tissue degradation in the genital organs comprising the administration to a mammal of a central nervous system sexual response initiator in an amount sufficient to produce genital vasodilation but less than the amount required to produce effective vasocongestive arousal. The preferred central nervous system sexual response initiator is apomorphine or a pharmaceutically acceptable acid addition salt thereof.

Formulations and methods for treating joints, such as temporomandibular joint disorders, osteoarthritis of the knee, hip and other types of inflammatory joint diseases. The method involves identifying specific matrix metalloproteinases (MMPs) that may be responsible for degrading the soft tissues of the joint in question, identifying the specific component of the joint the MMP(s) are targeting, and injecting a polymer gel with the component the MMP(s) seek to destroy, thus preserving the joint and allowing time to heal. These formulations typically require a mixture of glycosoaminoglycans and collagen proteins. One formulation in particular includes both hyaluronic acid and at least type I collagen.

The invention discloses Sebacinales sp. LQ capable of promoting germination of seeds of medicinal Dendrobium officinale andDendrobium flexicauleto form seedlings; and the Sebacinales sp. LQ is preserved in China Center for Type Culture Collection under the preservation number of CCTCC NO: M 2019744. The invention further provides morphological, physiological and biochemical characteristics of theSebacinales sp. LQ. According to the morphological, physiological and biochemical characteristics, as well as nucleotide sequence and phylogenetic analysis results, the Sebacinales sp. LQ. is a fungusstrain pertaining to the Sebacinales sp.. The Sebacinales sp. LQ. can be used for promoting germination of seeds of Dendrobium officinale and seeds of Dendrobium flexicaule to form seedlings; and theSebacinales sp. LQ. has relatively high specificity. Thus, the seeds of the Dendrobium officinale and the seeds of the Dendrobium flexicaule can be separatelyinoculated with the Sebacinales sp. LQ. so as to obtain high-quality symbiotic seedlings, thereby realizing efficient cultivation of seedlings by symbiotic germination; and moreover, symbiosis can be used for seedling raising in nursery or direct seed sowing on trunks in the field. Compared with tissue culture, symbiotic culture has the advantages of being low in cost, high in survival rate in the field, free of the problem of tissue degradation and so on; and thus, the symbiotic culture has application values in obtaining of symbiotic seedlings in replacement of tissue culture.

The inventors sought to provide compositions and methods of prophylaxis to prevent these harmful immune responses in patients and to prevent the related undesirable symptoms biological tissue such as for example inflammation, cell injury, tissue injury, tissue degradation, tenderness, redness, joint stiffness, joint swelling, restricted mobility and reduced strength. The inventors found that prophylactic therapy of an animal comprising administering a pharmaceutical composition comprising a GAG-peptide complex, optionally together with a connective tissue derived polypeptide, prevented the onset of at least one undesirable symptom.

Matrix metalloproteinases are major mediators of tissue destruction in various chronic inflammatory disorders. The present invention demonstrates that over-expression of intracellular isoform of IL-1 receptor antagonist confers to recipient cells resistance to signaling pathways of proinflammatory cytokines (such as tumor necrosis factor alpha and IL-1 beta) that induce matrix metalloproteinase and subsequent tissue degradation. Hence, over-expression of intracellular IL-1 receptor antagonist may inhibit tissue destruction in various inflammatory disorders such as rheumatoid arthritis, other arthritides, degenerative intervertebral disc disease and chronic skin ulcers that occurs in diabetes mellitus and bed-ridden patients.

Matrix metalloproteinases are major mediators of tissue destruction in various chronic inflammatory disorders. The present invention demonstrates that over-expression of intracellular isoform of IL-1 receptor antagonist confers to recipient cells resistance to signaling pathways of proinflammatory cytokines (such as tumor necrosis factor alpha and IL-1 beta) that induce matrix metalloproteinase and subsequent tissue degradation. Hence, over-expression of intracellular IL-1 receptor antagonist may inhibit tissue destruction in various inflammatory disorders such as rheumatoid arthritis, other arthritides, degenerative intervertebral disc disease and chronic skin ulcers that occurs in diabetes mellitus and bed-ridden patients.

The invention provides Sepia pharaonis neuropeptide GnRH and a use thereof. A preparation method of the Sepia pharaonis neuropeptide GnRH comprises 1) pretreatment: taking a living Sepia pharaonis, dissecting to take the brain tissue and storing the brain tissue in a preservation liquid at an ultralow temperature of -70 to -90 DEG C, 2) supernatant collection: taking the brain tissue, adding the equal volume of normal saline into the brain tissue, carrying out homogenization and centrifugation, taking the supernatant A, then adding the equal volume of distilled water into the supernatant A, carrying out centrifugation, taking the supernatant B, and merging the supernatants A and B to obtain a supernatant C, and 3) column chromatography: carrying out column chromatography on the supernatant C, carrying out color development, collecting components and carrying out freeze drying. The preparation method can realize cryopreservation of the tissue, realizes excellent effects, and can effectively prevent the degradation of the Sepia pharaonis brain tissue. The extract can be used in drugs for prevention or treatment on hormone-dependent diseases.

The present invention relates to a method for determining a tissue degradation process by detection on COMP (Cartilage Oligomeric Matrix Protein) neoepitopes, where said COMP neoepitopes appear after cleavage of COMP at one or more site between position 530 and 660 of the amino acid sequence of COMP. Such as between position 550 (N550) And 551 (W551) or between position 625 (N625) and 626 (P626). Furthermore, the invention relates to antibodies against COMP neoepitopes and to fragments and peptides containing COMP neoepitopes for generation of such antibodies, which fragments or peptides comprise in or more COMP neoepitopes with at least partial identity to a selected group of COMP peptides derived from the sequence between amino acids 539-550, 551-562, or 626-637 of human COMP.

Matrix metalloproteinases are major mediators of tissue destruction in various chronic inflammatory disorders. The present invention demonstrates that over-expression of intracellular isoform of IL-1 receptor antagonist confers to recipient cells resistance to signaling pathways of proinflammatory cytokines (such as tumor necrosis factor alpha and IL-1 beta) that induce matrix metalloproteinase and subsequent tissue degradation. Hence, over-expression of intracellular IL-1 receptor antagonist may inhibit tissue destruction in various inflammatory disorders such as rheumatoid arthritis, other arthritides, degenerative intervertebral disc disease and chronic skin ulcers that occurs in diabetes mellitus and bed-ridden patients.

An anti-jaundice composition for providing coloration to a corpse, comprising a bleaching agent, a coloring agent, and a fixing agent, mixed and stored at room temperature, and administered internally to a corpse for providing uniform, controlled coloration of the skin and tissue and for preventing tissue degradation. The invention is also directed to a method for providing an anti-jaundice composition for providing coloration to a corpse.

A composition for tissue degradation and removal and disinfection is provided for dental and medical applications. It can function as a single intra-canal irrigant that eradicates microorganisms as it facilitates the debridement of a root canal system. It contains one or more hydoxides, a thioglycolate compound, sodium hypochlorite, sodium chloride, sodium chlorate, oxygen, and water, such as lime water and purified water, The thioglycolate compound is capable of degrading a cell by disrupting disulfide bonds in its proteins. The sodium hypochlorite enhances its function. The composition may also incorporate mineral oil, urea, cetearyl alcohol, D&C yellow No. 8, chromium hydroxide, theobroma cocoa seed butter, iron oxides, fragrances, lanolin, and / or ceteareth-20. It is effective against Enterococcus faecalis.

The invention provides nutritional yeast cookie which is natural, healthy and nutritional and is made from beaten egg, butter, powdered sugar, salt, flour and nutritional yeast powder. The nutritional yeast powder is a natural nutrient source and is featured by 'three lows and four excellences', namely low fat, low calorie, low cholesterol, high-quality non-animal protein, high-quality dietary fiber, complete vitamin B family and high-quality mineral, wherein nine of eighteen amino acids are necessary to human bodies. The nutritional yeast cookie has the effects of enhancing immunity, improving physical vitality, promoting brain development, retarding muscular tissue degradation and the like and is the optima selection for vegetarians, persons shaping body for health, night owls and the like.

A single intra-canal substance composition for tissue dissolution, disinfection, tissue degradation, tissue removal and disinfection is provided. The composition includes calcium hydroxide, sodium hydroxide, potassium thioglycolate or calcium thioglycolate, to form an effective single intra-canal substance capable of degrading a cell by disrupting its disulfide bonds. Further, the composition may incorporate mineral oil, urea, cetearyl alcohol, D&C yellow No. 8, chromium hydroxide, theobroma cocoa seed butter, iron oxides, fragrances, water fragrance, lanolin, and ceteareth-20 to enhance its functioning. Furthermore, the composition that is bactericidal against Enterococcus faecalis, Streptococcus mutans and Candida albicans, used in multiple applications in dentistry and medicine. Furthermore, the composition is a single intra-canal irrigant that eradicates microorganisms as it facilitates the chemo-mechanical debridement of the root canal system.

The invention discloses a manufacturing and application method of a bioenzyme-process keratinization mask. The method comprises the following steps: pretreating bioenzyme-process mask raw materials, preparing keratinase, optimizing enzyme action conditions, combining the keratinase with a cotton linter mask, carrying out keratinase low-temperature preservation, and using the mask at room temperature. The keratin degrading bacterium Microbacterium sp. TSMC-99 is fully utilized to ferment and produce the keratinase, and the keratinase adsorbed on the mask catalyzes the degradation of partial keratinized tissues, thereby removing the keratinized scurf on the face, removing dead skin, moisturizing the face, enabling the skin to be clear and bright and performing the function of rejuvenating the skin. The bioenzyme-process keratinization mask is a biological high-tech product which has the advantages of no toxicity, no pollution, no side effect and high safety. The method has the advantages of mild production conditions, environment friendliness and low cost, and is simple to operate and easy for popularization. The technical indexes of the prepared mask satisfy the specifications in Light Industry Standard for masks QB / T 2872-2007.

A composition for tissue degradation and removal and disinfection is provided for dental and medical applications. It can function as a single intra-canal irrigant that eradicates microorganisms as it facilitates the debridement of a root canal system. It contains one or more hydoxides, a thioglycolate compound, sodium hypochlorite, sodium chloride, sodium chlorate, oxygen, and water, such as lime water and purified water, The thioglycolate compound is capable of degrading a cell by disrupting disulfide bonds in its proteins. The sodium hypochlorite enhances its function. The composition may also incorporate mineral oil, urea, cetearyl alcohol, D&C yellow No. 8, chromium hydroxide, theobroma cocoa seed butter, iron oxides, fragrances, lanolin, and / or ceteareth-20. It is effective against Enterococcus faecalis.

This invention relates generally to a method, an assay and a kit for determining a tissue degradation process that leads to inflammatory responses opening up for a vicious circle of increased tissue destruction. More specifically the invention relates to kits and methods for an assay that can analyzee human samples, for the presence of a COMP fragment complex that have activated complement exemplified by the complex between COMP and complement factor C3b or natural breakdown fragments of C3b.

Antifibrinolytic agents are administered to a human individual to treat fine lines, wrinkles and overall skin tone of the face and body, as well as inflammation and tissue degradation effects.

The invention discloses a strain for promoting the germination of Dendrobium denticola seeds to form seedlings and an application thereof. The strain is classified as Tulasnella sp.CY, and is preserved in the General Microorganism Center of the China Microorganism Culture Collection Management Committee with the deposit number CGMCC NO.9551. The strain can significantly promote the germination of Dendrobium candidum seeds to form seedlings, and shows strong specificity. It is of great practical significance to solve the problem of obtaining symbiotic seedlings through seeds of Dendrobium dendrobii, which can be used for nursery seedlings or live seeding of trunk seeds in the field. Compared with tissue culture, it has the advantages of low cost, high field survival rate, and no tissue degradation. It has the advantages of replacing Tissue culture obtains the application value of symbiotic seedlings, and provides a reliable technical guarantee for solving the bottleneck problem of seedling sources in Dendrobium candidum cultivation industry.

The present invention provides a compound of formula (I) or pharmaceutically acceptable salts thereof wherein R<1> and R<2> are the same or different and are C1-10alkyl, phenyl, hetero-aryl, or phenyl substituted with C1-4alkyl, OR<3>, NHR<3>, CONHR<3>, NHCOR<3>, or halo; wherein R<3> is H, or C1-4alkyl; and n is 1, 2, 3, 4, 5 or 6. The compounds are inhibitors of matrix metalloproteinases involved in tissue degradation.

Antifibrinolytic agents are administered to a human individual to treat fine lines, wrinkles and overall skin tone of the face and body, as well as inflammation and tissue degradation effects.

A single intra-canal substance composition for tissue dissolution, disinfection, tissue degradation, tissue removal and disinfection is provided. The composition includes calcium hydroxide, sodium hydroxide, potassium thioglycolate or calcium thioglycolate, to form an effective single intra-canal substance capable of degrading a cell by disrupting its disulfide bonds. Further, the composition may incorporate mineral oil, urea, cetearyl alcohol, D&C yellow No. 8, chromium hydroxide, theobroma cocoa seed butter, iron oxides, fragrances, water fragrance, lanolin, and ceteareth-20 to enhance its functioning. Furthermore, the composition that is bactericidal against Enterococcus faecalis, Streptococcus mutans and Candida albicans, used in multiple applications in dentistry and medicine. Furthermore, the composition is a single intra-canal irrigant that eradicates microorganisms as it facilitates the chemo-mechanical debridement of the root canal system.

The present invention provides a compound of formula (I), or pharmaceutical acceptable salts thereof wherein R1 is C4-12 alkyl, C4-12 alkenyl, C4-12 alkynyl, -(CH2)h-C3-8 cycloalkyl, substituted and unsubstituted -(CH2)h-aryl, substituted and unsubstituted-(CH2)h-het, R2 is substituted and unsubstituted C1-12 alkyl, substituted and unsubstituted C2-12 alkenyl, substituted and unsubstituted C2-12 alkynyl, substituted and unsubstituted-(CH2)h-C3-8 cycloakyl, substituted and unsubstituted -(CH2)h-C3-8 cycloalkenyl, substituted and unsubstituted -(CH2)h-aryl, substituted and unsubstituted -(CH2)h-heterocyclic ring, substituted and unsubstituted -(CH2)i-X-R4 (X is -O-, -S(=O)j-, -NR7-, -S(=O)2NR8-, or -C(=O)-), and -(CH2)iCHR5R6. The compounds are inhibitors of matrix metalloproteinases involved in tissue degradation.