56 results about "Acute arthropathy" patented technology

Novel modalities are introduced to treat joint and cartilage ischemia and related pathologies to improve outcome in the treatment of arthropathies and spondylopathies. The invention includes compositions, materials or devices which will improve oxygen, substrate and nutrient delivery to joint tissues and modalities to decrease the degradation of joint tissues by inflammatory and other destructive processes.

A glenoid component for treatment of rotator cuff arthropathy includes attachment to the coracoid process by a pin or post imbedded into a hole formed in the coracoid process. The glenoid component preferably also has a keel for extending into the glenoid fossa and protrusions such as ridges cemented to the acromion process. This way, an attachment point is preferably provided in/on the coracoid process, the acromion process, and the glenoid fossa, and at least two of the attachment points include a protrusion extending into a hole/slot drilled or otherwise formed in the bone. A jig is used for guiding/drilling into the bone, wherein the jig has both a glenoid fossa drill guide and a coracoid drill guide. The coracoid drill guide includes structure that abuts against opposing sides of the base of the coracoid process to prevent rotation of the jig relative to the scapula.

A humeral head augment device for use in a modular shoulder prosthesis. The humeral head augment device has an external bearing surface with at least one surface portion that includes a radius of curvature. The radius of curvature is configured to constrain translational movement of the implanted shoulder prosthesis when the humeral head augment device is positioned within the shoulder prosthesis. The humeral head augment device also includes a coupling mechanism designed to lock the humeral head augment device to either the stem or the humeral head, thereby ensuring proper operational positioning of the device within the shoulder prosthesis and allowing the implanted shoulder prosthesis to function in a patient suffering from rotator cuff arthropathy. A shoulder prosthesis using a humeral head augment device, a method for assembling a shoulder prosthesis and method for using a humeral head augment device in a shoulder prosthesis are also disclosed.

The present invention relates to gene therapy delivery and expression systems comprising at least one helper-dependent adenoviral vector containing a nucleic acid sequence encoding for proteoglycan 4 (PRG4) or a biologically active fragment thereof. The invention further relates to a pharmaceutical composition comprising a therapeutically effective amount of at least one helper-dependent adenoviral vector containing said nucleic acid sequence encoding for proteoglycan 4 (PRG4), or a homolog thereof from any other species, or a biologically active fragment thereof. The invention also relates to the use of the novel gene therapy delivery and expression system according to the invention for use in the prevention and/or treatment of camptodactyly-arthropathy-coxa vara-pericarditis (CACP), or a musculoskeletal disorder such as a joint disorder or joint disease.

The invention discloses a traditional Chinese medicinal wine for treating aching waists and legs, which is prepared by the following materials: 60g of zaocys dhumnade, 30g of ground beeltle, 30g of pangolin, 20g of centipede, 90g of eucommia ulmoides, 60g of twotooth achyranthes root, 50g of rheum officinale, 80g of pawpaw, 90g of teasel root, 80g of fructus psoraleae, 40g of hiraute shiny bugleweed herb, 60g of radix angelicae pubescentis, 80g of lumbricus, 90g of parasitic loranthus, 60g of large-leaved gentian, 50g of epimedium herb and 5000ml of wine with the content of alcohol being 70 percent. The traditional Chinese medicinal wine can treat the aching waists and legs caused by protrasion of the lumbar intervertebral disci, arthropathy of lumbar and sacral vertebra, strain of lumbarmuscles and lumbar interspinal muscles, strain of supraspinal ligament, strain of iliolumbar ligament, third lumbar transverse process syndrome, thoracolumbar old fracture and the like, the average healing rate is 76.03%, the average improvement rate is 17.08%, and the average total efficiency is 93.09%. The traditional Chinese medicinal wine has the characteristics of exact curative effect, lessdosage, and convenience in use.

The present invention provides a composition comprising an antibody or fragment thereof against oxidised Collagen II (CII) in which the antibody or fragment thereof is conjugated to a pharmaceutically active moiety. The invention also provides a composition comprising an antibody or fragment thereof against oxidised Collagen II (Gil) and a detectable label. The invention further provides the use of such compositions in medicine, in particular for the treatment of an arthropathy, and in methods of diagnosis.

The invention is concerned with a kind of Chinese traditional medicine for external use and its preparetion method to cure spondylopathy and lumbar illness and pain from rheumatism. It relates to 10 g chinese clematis, 10 g prepared dog button, 10 g long-nosed pitviper, 10 g prepared Sichuan aconite root, 10 g prepared wild aconite root, 10 g prepared common monkshood Daughter root, 10 g cassia, 10 g pubescent angelica root, 20 g common flowering quince fruit, 10 g dried argyi leaf, 6 g white mustard seed, 20 g sevenlobed yam rhizome, 10 g hairy birthwort, 10 gherb a lycopodii, 10 g earth worm, 10 g burreed tuber, 10 g zedoary, 10 g prepared eucommia bark, 10 g cloves, 20 g asarum, 10 g bornel , 10 g anisodus acutangucus, 6 g short-pedicel aconite root and 20 g dried ginger. It has perfect effect for neck and vertebra illness, lumbar intervertebral disc protrusion, spondylitis ankylopoietica, hyperosteogeny, pain from rheumatism, lumbar muscle strain and arthropathy.

The present invention relates to a Chinese medicine composition for effectively curing the diseases of prolapse of lumbar intervertebral disk, cervical spondylopathy, spur, hyperosteogeny, hypertrophic arthritis and osteoarthrosis deformans endemica, etc. Said Chinese medicine composition is formed from 17 Chinese medicinal materials of fish glue, Chinese angelica root, cinnamon bark chaenomeles fruit, acanthopanax root bark, cooked rehmannia root, notoginseng and others.

The invention relates to a multifunctional tendon pulling stool and a using method thereof, and belongs to the field of health care instruments. The multifunctional tendon pulling stool is characterized by comprising a stool body, a vertical plate, a slope plate and a fixing belt, wherein a slot is formed in the end of the stool body; one or more vertical plates are inserted into the slot; the fixing belt is arranged on the vertical plate; the slope plate is arranged below the end, provided with the vertical plate in an inserted mode, of the stool body; one end of the slope plate is connected with the stool body; the other end of the slope plate is placed on the ground; and the height of the slope plate from the end connected with the stool body to the end placed on the ground is gradually reduced. By means of the multifunctional tendon pulling stool, a user can conveniently pull tendons, and the good rehabilitation effect on modern people suffering from accumulated fatigue damage such as cervical spondylosis and arthropathy can be achieved. In addition, the user can freely adjust the tendon pulling force and the figure angle in the tendon pulling process. The user can appropriately adjust the multifunctional tendon pulling stool according to needs; the safety performance is good; the universality is high; and the multifunctional tendon pulling stool is suitable for popularization in nowadays society.

The invention discloses a pharmaceutical composition for treating hyperosteogeny and loin and leg pain. The composition includes, by weight ratio, 4-8 parts of prepared frankincense, 4-8 parts of prepared myrrh, 4-8 parts of sangusis draconis, 4-8 parts of malaytea scurfpea fruit, 4-8 parts of prepared common monkshood mother root, 4-8 parts of prepared kusnezoff monkshood root, 4-8 parts of safflower, 4-8 parts of tuberculate speranskia herb, 0.5-1 part of long-nosed pit viper, 0.5-1 part of Chinese azalea fruits, 0.5-1 part of gecko, 0.5-1 part of centipedes, 4.25-8.25 parts of ground beetles, 4.25-8.25 parts of Williams elder twig, 4.25-8.25 parts of Chinese clematis root, 4.25-8.25 parts of stir-fried himalayan teasel roots, 4.25-8.25 parts of fortune's drynaria rhizome, 4.25-8.25 parts of Chinese pyrola herb, 4.25-8.25 parts of rhizoma cibotii, 4.25-8.25 parts of Sichuan lovage rhizome, 2-6 parts of borneol, and 6-10 parts of nux vomica. The composition is scientific and reasonable in traditional Chinese medicine compatibility, so that the mutual cooperation and drug effect co-achieving of medicinal materials can be realized; the composition has effects on activating blood circulation to dissipate blood stasis, expelling wind and removing cold, promoting qi circulation to relieve pain, tonifying liver and kidney, dispersing stasis and dredging collaterals, relieving swelling and pain, warming meridians to dissipate cold and removing obstruction; and the composition can achieve good curative effects on the pain caused by cervical spondylopathy, periarthritis of shoulder, hyperosteogeny, lumbar disc herniation, spur pain, lumbar muscle degeneration, and arthropathy of extremities.

The invention discloses a gradient material for promoting cartilage calcification layer repair and a preparation method. The gradient material is composed of a superfine fiber microporous membrane, an organic fiber microporous membrane and an organic-inorganic composite fiber microporous membrane, wherein the upper surface and the lower surface of the superfine fiber microporous membrane are covered with the organic fiber microporous membrane and the organic-inorganic composite fiber microporous membrane respectively. The upper layermembrane contains components that promote cartilage healing, an inorganic component in the lower layer membrane is composed of multifunctional inorganic particles which can inhibit inflammation, prevent and control infection and promote regeneration and repair of a cartilage calcification layer, and the gradient material is prepared through a three-step electrostatic spinning technology. The method is convenient to operate, and the gradient material has a remarkable promoting effect on various articular cartilage injury problems, especially on regeneration, repair and reconstruction of a calcified layer, can also promote healing of subchondral bones and cartilage tissues, is adjustable in degradation rate of gradient materials, and has a good regulating effect on various joint lesion inflammations.

The invention discloses a medicine for treating the rheumatism and rheumatoid disease, belongs to the technical field of traditional Chinese medicine, and particularly relates to a medicine for arthralgia of the rheumatism and rheumatoid disease and the rheumatism and rheumatoid disease caused by wind, coldness and dampness. The rheumatism and rheumatoid disease is a common frequently-occurring disease and belongs to arthralgia according to the traditional Chinese medicine; particularly, according to the rheumatoid arthropathy, sclerotin looseness is remarkable, general osteoporosis is caused, the structure of bone is fine, the bone cortex is thin, and the density is almost equal to those of medullary spaces and surrounding tissue. Soft tissue at joints swells and fades away, muscle atrophy is caused, joint dislocation is generated, and joints are shaped like chicken feet when the disease is serious. Joint gaps are narrowed and even disappear. Fiber or bony ankylosis is caused, and labor and self-care capacity is lost. Joint redness and swelling, heat pain, dysfunction and joint deformation are clinically shown, and joint disablement is caused when the disease is serious. At present, the number of types of medicine for treating the rheumatism and rheumatoid disease is large. The pure traditional Chinese medicine preparation is manufactured with various types of pure natural plants, mineral and animals as raw materials.

A method of treating and/or preventing blood-associated disorders is provided. Also provided is a method of treating and/or preventing hemophilic arthropathy and/or hemochromatosis arthropathy in a subject.

The invention relates to an oral traditional Chinese medical preparation for treating rheumatism and rheumatoid diseases. Limb pain or numb caused by wind, coldness and wetness is called as a Bi syndrome in traditional Chinese medical science and mainly caused by the sudden attacks of the wind, the coldness and the wetness which flow through meridians and joints and block qi and blood, and the rheumatoid disease is a synovitis-based arthropathy caused by an autoimmune response because of infectious diseases. The oral traditional Chinese medical preparation for treating rheumatism and rheumatoid diseases is prepared from the following components in parts by weight: 15-25 parts of astragalus, 5-15 parts of ephedra, 5-15 parts of papaya, 5-15 parts of loranthaceae, 5-15 parts of lycopodium calvatum, 5-15 parts of henry magnoliavine stems, 5-15 parts of homalomena occulta, 5-15 parts of couchgrass root, 5-15 parts of angelica, 5-15 parts of achyranthes, 1-5 parts of dried immature fruit of citron orange, 5-15 parts of orientavine, 15-25 parts of clematis chinensis, 5-15 parts of cassia twig, 5-15 parts of garden balsam stem and 1-10 parts of dipsacus asperoides. The invention is applied to treat rheumatism and rheumatoid diseases.

The invention belongs to the technical field of medicine, discloses a drug for treating vasculogenesis mediated diseases and application and provides the drug for treating the vasculogenesis mediateddiseases prepared by using arsenic trioxide. A method for evaluating a treatment effect of the drug for treating the vasculogenesis mediated diseases comprises the steps: evaluating an inhibiting effect on a blood vessel multiplication functional module of arthropathy synoviocyte TSP-1-TGF-beta-CTGF-VEGF caused by arsenic trioxide; evaluating an inhibiting effect on multiplication of capillary endotheliocyte of pathological joints caused by arsenic trioxide through inhibiting the blood vessel multiplication functional module of the TSP-1-TGF-beta-CTGF-VEGF. According to the drug and the application, the arsenic trioxide can be used for inhibiting blood vessel multiplication through inhibiting the functional module of the TSP-1-TGF-beta-CTGF-VEGF, thereby playing a role in treating blood vessel multiplication diseases.

Soluble pharmaceutical composition for the treatment of articular pathologies comprising an effective amount of a least one linear or cyclic polymetaphosphate or a soluble and pharmaceutically acceptable salt thereof, and appropriate diluents.