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Eucomman strontium complex and preparation method and application thereof

A technology of eucommia polysaccharides and complexes, which is applied in the field of biomedicine and can solve problems such as toxicity and difficulty in the development of strontium applications

Active Publication Date: 2019-12-24
SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0002] Strontium plays an important role in the formation of bones. Strontium can promote the proliferation of osteoblasts and pluripotent stem cells, improve bone metabolism, etc. However, free strontium ions are toxic in the body, and the application of strontium is difficult to develop

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  • Eucomman strontium complex and preparation method and application thereof
  • Eucomman strontium complex and preparation method and application thereof
  • Eucomman strontium complex and preparation method and application thereof

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preparation example Construction

[0029] Such as figure 1 Shown, the preparation method of the Eucommia polysaccharide strontium complex of one embodiment, comprises the steps:

[0030] Step S110: Under the condition of controlling the pH to 9-11, react Eucommia polysaccharide and water-soluble strontium salt in water to obtain a reaction liquid.

[0031] By controlling the pH to be 9-11, the reaction can be carried out smoothly, and the strontium complex of Eucommia polysaccharide is generated.

[0032] Specifically, the mass molar ratio of the Eucommia polysaccharide to the strontium element in the water-soluble strontium salt is 60g:1mol˜250g:1mol. Too much strontium element will cause a large amount of strontium ions to remain in the complex, which will cause the material to produce harmful effects in the body. If the strontium element is added less, the Eucommia polysaccharide is excessive, and the complexation reaction is insufficient.

[0033] In one embodiment, step S110 includes: respectively disso...

Embodiment 1

[0051] The preparation process of the Eucommia polysaccharide strontium complex of the present embodiment is as follows:

[0052] (1) dissolving Eucommia polysaccharide in deionized water to prepare an aqueous solution of Eucommia polysaccharide with a concentration of 1g / mL; dissolving strontium chloride in deionized water to prepare an aqueous solution of strontium chloride with a concentration of 1.8mol / L; Dissolve sodium hydroxide in deionized water to prepare an aqueous sodium hydroxide solution with a concentration of 1.8 mol / L.

[0053] (2) Under the condition of room temperature, under the condition of continuous stirring and the pH value controlled by the use of aqueous sodium hydroxide solution to be 10, according to the mass molar ratio of eucommia polysaccharide and strontium element being 150g:1mol, add to the aqueous solution of eucommia polysaccharide The aqueous solution of strontium chloride, after the addition of the aqueous solution of strontium chloride is ...

Embodiment 2

[0057] The preparation process of the Eucommia polysaccharide strontium complex of the present embodiment is as follows:

[0058] (1) dissolving Eucommia polysaccharide in deionized water to prepare an aqueous solution of Eucommia polysaccharide with a concentration of 0.5g / mL; dissolving strontium chloride in deionized water to prepare an aqueous solution of strontium chloride with a concentration of 2mol / L; Dissolve sodium hydroxide in deionized water to prepare an aqueous sodium hydroxide solution with a concentration of 1.5 mol / L.

[0059] (2) Under the condition of room temperature, under the condition of continuous stirring and the pH value controlled by the use of aqueous sodium hydroxide solution to be 9, according to the mass molar ratio of eucommia polysaccharide and strontium element is 60g:1mol, add to the aqueous solution of eucommia polysaccharide The aqueous solution of strontium chloride, after the addition of the aqueous solution of strontium chloride is compl...

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Abstract

The invention relates to a eucomman strontium complex and a preparation method and application thereof. The preparation method of the eucomman strontium complex comprises the following steps: under the condition that the pH is controlled to be 9-11, eucomman and a water-soluble strontium salt react in water, and reaction liquid is obtained; and an organic precipitant is added into the reaction liquid, then a still standing reaction is conducted, then through solid-liquid separation, precipitates are collected, and thus the eucomman complex is obtained. The eucomman strontium complex is small in toxicity and has good bone repair and arthropathy prevention and treatment effects.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a strontium complex of Eucommia polysaccharide and its preparation method and application. Background technique [0002] Strontium plays an important role in the formation of bones. Strontium can promote the proliferation of osteoblasts and pluripotent stem cells, improve bone metabolism, etc. However, free strontium ions are toxic in the body, and the application of strontium is difficult to develop. Contents of the invention [0003] Based on this, it is necessary to provide a preparation method of Eucommia polysaccharide strontium complex with less toxicity and better bone repair and joint disease prevention and treatment effects. [0004] In addition, a strontium complex of Eucommia polysaccharide and its application are also provided. [0005] A preparation method of Eucommia polysaccharide strontium complex, comprising the steps of: [0006] Under the condition of controlling...

Claims

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Application Information

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IPC IPC(8): A61K33/24A61K31/715A61P19/08A61P19/02
CPCA61K31/715A61K33/24A61P19/02A61P19/08A61K2300/00
Inventor 唐斌邓雨晴马粉波彭颖贺文琪李思敬
Owner SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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