110 results about "Bone tumours" patented technology

The invention discloses a method for designing and forming a stiffness-controllable bone tumor defect repair implant. The method comprises the following steps of acquiring and preprocessing image data; performing reverse image fusion and registration, and constructing an accurate curve surface materialized repair body model; carrying out parallel finite element analysis and optimization on a porous design scheme by a microscopic porous scheme design; and importing the model into a 3D printing system for printing forming. According to the method, a personalized porous structure, mechanical optimization design and 3D printing forming of a post-bone tumor excision defect area reconstruction repair body are realized in combination with digital modeling, finite element analysis and medical 3D printing technologies according to a symmetric characteristic of a human body structure morphology, so that the reconstruction effect of an individualized anatomic morphology and the design forming efficiency of the repair body are improved, the time and material costs are reduced, the mechanical properties and the bone integration microenvironment after reconstruction are better optimized, and the bone growth repair of a bone defect area is facilitated.

The invention relates to a metal bone graft material with a porous structure, and preparation and application thereof. The metal bone graft material is used as a filling material for transplantation after orthopaedic and oral damage and defects. The metal bone graft material contains the following trace elements in the human body by weight: 70.0 to 98.0 of Mg, 0.1 to 10.0% of Si, 0.1 to 10% of Sr and 0.1 to 10.0% of Ca, wherein the trace elements are uniformly distributed in a substrate and a coating. According to the invention, good ossification capability and matching in-vivo absorption capability are obtained by adjusting the contents of components in an alloy, controlling the shape, quantity and distribution of mesophase in metal, changing processing technology and surface coating protection of the alloy and preparing the porous structure; and the metal bone graft material has good biocompatibility and bone conduction capability, is a medical absorbent metal bone graft material with excellent mechanical properties, and is applicable to bone defects caused by wounds, malformation, bone tumors, osteomyelitis and joint displacement in clinical practice to promote bone restoration and applicable as a drug sustained release system.

An embodiment in accordance with the present invention provides a continuum dexterous manipulator (CDM) with a specially designed flexible tool, to be used as a handheld or robotic steerable device for treatment of hard-tissue-related diseases. The CDM of the present invention works well in treatment of soft and sticky material (similar to a lesion) as well as milling the hard tissues (e.g. sclerotic liner of osteolytic lesions) and bone tumors. The present invention is also directed to flexible drilling tools as well as characterization and evaluation of integrating these tools with the CDM in curved-drilling of hard bone towards treatment of hard tissue related diseases (e.g. osteonecrosis or pelvic fracture). The present invention can also include use of various types of drill geometries, aspiration and irrigation, and endoscope view in curved-drilling and trajectory planning.

The invention discloses a photo-thermal chemotherapy bone repair material and a preparation method of a tissue engineering scaffold. The bone repair material includes an oil-soluble high-molecular material, bio-ceramic powder, an oily solvent, a water-soluble bioactive material, water, an emulsifier, a chemotherapy medicine, and a photo-thermal agent. The preparation method includes: according tothe bone repair material, preparing a W / O emulsion, and sending the W / O emulsion to an ink cartridge of a printer as printing ink; establishing a tissue engineering scaffold three-dimensional model onCAD software, setting printing parameters, regulating the temperature of a shaping chamber in the printer, and printing a tissue engineering scaffold prefabricated member, so that when solvent in theprefabricated member is volatilized naturally, a finish product of the tissue engineering scaffold is formed. The tissue engineering scaffold has good mechanical character, can simulate bone tissue structure, has excellent bone guidance and bone conduction and excellent photo-thermal effect and is toxic-free, and can promote recovery of massive bone defects caused by bone tumor resection.

The invention discloses a 3D printed Ti-PDA-PLGA microsphere bone defect repair stent. A 3D printed Ti stent is prepared by a laser sintering technology. Then, under certain conditions, dopamine is self-polymerized on the fiber surface of the 3D printed Ti stent to form a PDA coating, thereby preparing a 3D printed Ti-PDA stent; then PLGA microspheres carrying VEGF are prepared by a double emulsion-solvent evaporation method, and finally, BMP-2 and PLGA microspheres carrying VEGF are adsorbed and immobilized on the surface of the stent by an adsorption method, and finally the 3D printed Ti-PDA-PLGA microsphere bone defect repair stent is formed. The bone defect repair tissue engineering stent disclosed by the invention has the advantages of reliable mechanical property, high biological activity and safety, convenient implantation, small trauma and low cost, and can be used for the repair treatment of bone defect after bone traumas, bone tumors and bone infection.

There is provided herein a brachytherapy delivery system for the internal delivery and positioning of therapeutic agent, most particularly, a discrete radiation emitting particulate, within or in proximity to a vertebral or other bony tumor. The system comprises an elongated bone cannula having a proximal and a distal end, the distal end being suitable for disposition within bone. The bone cannula further comprises a bore disposed longitudinally therethrough suitable to axially and slidably receive an elongated and cannulated therapy delivery apparatus through which the therapeutic agent is delivered.

The invention discloses a 3D printed Ti-PDA-PLGA microsphere bone defect repair stent and a preparation method thereof. A 3D printed Ti stent is prepared through a laser sintering technology; then, under a certain condition, dopamine is self-polymerized on the fiber surface of the 3D printed Ti stent to form a PDA coating, so that the 3D printed Ti-PDA stent is prepared; and then VEGF-carrying PLGA microspheres is prepared by a multiple emulsion solvent evaporation method, and finally the BMP2 and the VEGF-carrying PLGA microspheres are absorbed and fixed on the surface of the stent by an adsorption method, finally the 3D printed Ti-PDA-PLGA microsphere bone defect repair stent is prepared. The bone defect repair tissue engineering stent of the invention has the advantages of reliable mechanical property, high biological activity and safety, convenience in implantation, small trauma and low cost, which can be used for repairing treatment of bone trauma, bone tumor and bone defect afterbone infection.

The invention relates to a biological ceramic scaffold with a surface micro-nano structure and a preparation method and application of the biological ceramic scaffold with the surface micro-nano structure. The biological ceramic scaffold with the surface micro-nano structure comprises a Ca7Si2P2O16 biological ceramic scaffold body and a micro-nano structured polydopamine / Ca-P nano layer formed on the surface of the Ca7Si2P2O16 biological ceramic scaffold body. By means of forming the micro-nano structured polydopamine / Ca-P nano layer on the surface of the Ca7Si2P2O16 biological ceramic scaffold body, adhesion, proliferation and differentiation of bone mesenchymal stem cells on the surface of the scaffold can be facilitated to promote in-vivo osteogenesis, and therefore the biological ceramic scaffold (or dopamine-induced biological ceramic scaffold) with the surface micro-nano structure prepared herein can repair bones and treat bone tumors.

A kit for bonding to biological hard tissues, containing a phosphorylated polysaccharide, a polyvalent metal salt other than phosphates, and a solvent. The adhesive composition for biological hard tissues provided by the kit for bonding to biological hard tissues is suitably used in for medical uses, such as cement for bones or dental cement. In addition, since the adhesive composition has excellent bio-absorbability, it is useful as fusion materials for artificial joint prosthesis, fusion materials for spine fracture, fusion materials for extremity fracture, filling materials for bone tumors in the region of orthopedics, filling materials and restorative materials at dental caries-defective sites, luting materials for prosthetic restorative materials such as inlay and crown, pulp-capping and lining materials, implant surface treatment materials, periodontal disease therapeutic materials, hyperesthesia preventive materials, dental pulp capping materials, substrates for DDS, substrates for systems engineering, and tissue bonding materials in the dental region.

The invention discloses a culture method of an osteosarcoma organ and an osteosarcoma culture medium thereof. The invention uses two culture methods, namely a preparation method of a 3D culture modelof an osteosarcoma organ and a preparation method of a gas-liquid culture model of the osteosarcoma organ. The preparation method of the osteosarcoma organ 3D culture model comprises the following steps: (1) tissue cleaning: performing cleaning for 2 to 5 times by using 10ml of ADMEM / F12 containing 1 x Pen-Strep Glutamine; (2) cutting tissues into pieces with a size of 1mm<3>, performing digestionfor 30-60 minutes by using digestive juice, and performing centrifuging for 5 minutes at a temperature of 4 DEG C and a speed of 1200r after the digestion; (3) performing cleaning for three times byusing 10ml of ADMEM / F12 containing 1 x Pen-Strep Glutamine; (4) performing filtering with a 100 [mu]M cell sieve, performing counting and centrifuging, adding Collagen into 1-100 [mu] g / ml laminin, performing re-suspending, and paving a plate; (5) replacing the bone tumor culture medium once every 3-4 days in the culture period; and (6) performing passage on the organoids once every 15-20 days generally, and adding 2-5 times of TrpLE Express into each hole during passage.

The invention relates to a citrate calcium sulfate skeleton replaceable material, relative compound, preparation and application, wherein it comprises: adding citrate into calcium sulphate dehydrate, or still adding metal crystallize agent, to mixed and arranged inside the vaporize kettle, to process high-temperature high-pressure reaction, to be obtained and dried. The invention can be used repair the skeleton, treat the osteoporosis, bone cancer, etc, with simple process, slow degrade speed, high strength, and low cost.

The invention provides composite mesoporous bioglass / graphene oxide bone cement and a preparation method thereof. The composite mesoporous bioglass / graphene oxide bone cement is used for bone defect repair and residual tumor therapy after bone tumor operations and is provided with a photothermal effect. The preparation method of the composite mesoporous bioglass / graphene oxide bone cement includes: (1) preparing graphene oxide; (2) preparing mesoporous bioglass powder; (3) preparing bone cement curing liquid; (4) preparing the composite mesoporous bioglass / graphene oxide bone cement with the photothermal effect. The prepared bone cement has higher mechanical strength as compared with a pure mesoporous bioglass bone cement, is high in biocompatibility and biological activity and capable offacilitating proliferation, differentiation and osteogenesis of bone marrow mesenchymal stem cells, and is expected to provide a new strategy for bone defect reparative therapy after the bone tumor operations clinically.

The invention relates to a bone tumor pathological specimen collection frame. The bone tumor pathological specimen collection frame comprises a fixing clamp board and an adjusting clamp board. The fixing clamp board is L-shaped, the vertical face of the fixing clamp board corresponds to the adjusting clamp board, and the fixing clamp board and the adjusting clamp board are connected through a threaded rod. An adjusting knob is arranged at the outer end of the threaded rod. A guide rail chute is arranged on the bottom of the adjusting clamp board. A guide rail is arranged above the horizontal plane of the fixing clamp board. The guide rail chute on the bottom of the adjusting clamp board is matched with the guide rail in a sliding mode. A pressure sensor is arranged on the surface of one side of the adjusting clamp board. A display screen is embedded in the surface of the other side of the adjusting clamp board. A control device and a storage battery are arranged inside the adjusting clamp board. The pressure sensor, the display screen and the control device are all electrically connected with the storage battery. The control device is electrically connected with the pressure sensor and the display screen. The bone tumor pathological specimen collection frame has the advantages of being reasonable in design, simple in structure, convenient to use, stable in clamping, accurate in positioning an standard in sample collection.

A kit for bonding to biological hard tissues, containing a phosphorylated polysaccharide, a polyvalent metal salt other than phosphates, and a solvent. The adhesive composition for biological hard tissues provided by the kit for bonding to biological hard tissues is suitably used in for medical uses, such as cement for bones or dental cement. In addition, since the adhesive composition has excellent bio-absorbability, it is useful as fusion materials for artificial joint prosthesis, fusion materials for spine fracture, fusion materials for extremity fracture, filling materials for bone tumors in the region of orthopedics, filling materials and restorative materials at dental caries-defective sites, luting materials for prosthetic restorative materials such as inlay and crown, pulp-capping and lining materials, implant surface treatment materials, periodontal disease therapeutic materials, hyperesthesia preventive materials, dental pulp capping materials, substrates for DDS, substrates for systems engineering, and tissue bonding materials in the dental region.

The present invention provides an organic-inorganic self-solidified composite bone graft formed by a hydration bridge formation of a multi-trace element organic compound and an inorganic compound. Themulti-trace element organic compound is prepared by using a solution method, inorganic salts with different metastable-state structures are prepared by a heat treatment, the two materials are mixed and ground to form micro-nano powder, the micro-nano powder is mixed with water-containing solidified liquid to form a bridge structure by diffusion and a hydrated crystalline water structure by self-solidification, and thus a stable bone repair material is formed. The prepared bone graft can be shaped at will and has high strength, can provide various essential elements for bone tissue repair, hasgood biological properties, has a degradation rate consistent with a bone formation cycle, and finally can be completely absorbed by tissues to substitutably form new bones and obtains any desired compressive strengths and degradation cycles according to needs to adjust raw material composition ratios, and can be used as the repair material for bone defects caused by trauma, deformity, bone tumors, osteomyelitis or joint replacement, etc. clinically.

The invention discloses a bone tumor sampling fixing device, which comprises an arc seat. A ring is arranged above the arc seat and in rotational fit with the arc seat, a plurality of column barrels are annularly distributed on the inner periphery of the ring, and inner holes of the column barrels are in slide fit with corresponding steel columns. A slide seat is connected to the lower end of a vertical column which is connected to the lower end of the arc seat, and the slide seat is in slide fit with a slide rail at the lower end of the slide seat. The ring can be connected with the arc seatthrough a pair of first connection mechanisms, the steel columns can be connected with the corresponding column barrels through second connection mechanisms, and the slide seat can be connected with the slide rail through a pair of third connection mechanisms. The bone tumor sampling fixing device has advantages that due to adoption of the structure, reliable connection between the arc seat and the ring, between the column barrels and the steel columns and between the slide seat and the slide rail can be realized, reliable bone fixation is realized, and convenience in sampling is achieved.

The invention discloses multifunctional injectable hydrogel for tumor photo-thermal treatment and bone tissue repair and a preparation method, and belongs to the field of biomedical materials. The preparation method comprises the following steps of firstly, synthesizing micro-nano carbon spheres by adopting a hydrothermal carbonization method; secondly, adding the micro-nano carbon spheres into achitosan solution, and performing uniform stirring to obtain a solution A; thirdly, simultaneously dissolving beta-sodium glycerophosphate and sodium hyaluronate in deionized water, and performing sufficient stirring to obtain a solution B; and finally, in an ice bath environment, adding the solution B into the solution A, uniformly stirring the solutions, and performing sterilizing and disinfection for 24 hours by using an ultraviolet lamp to obtain the injectable composite hydrogel. The injectable hydrogel has good biocompatibility; the injectable hydrogel is in a liquid state at the room temperature, can be directly injected into a bone tumor focus, and can rapidly form gel in situ in an environment with the body temperature of 37 DEG C, so that effective fixation of a photothermal agent and rapid filling of bone defects are realized; and bone tumor cells can be killed through local photo-thermal treatment, meanwhile bone tissue repair can be effectively promoted, and all-dimensional treatment of bone tumors is achieved.

The invention provides a cascade targeted medicine delivery system as well as a preparation method and application thereof. The cascade targeted medicine delivery system comprises first-stage bone target ligand, second tumor targeting ligand and a carrier system, wherein the carrier system is a nano carrier which is made of an amphiphilic polymer with a structure of a hydrophobic core and a hydrophilic shell; the first-stage bone target ligand and the second tumor targeting ligand are connected with the hydrophilic shell of the carrier system. By adopting the cascade targeted medicine deliverysystem prepared by using the preparation method provided by the invention, recognition of specific tumor cells in bone is achieved, the difficulty that a conventional bone tumor medicine cannot be precisely delivered is overcome, and a technical base is made for precise diagnosis and treatment on bone tumor and other bone related diseases.

The invention relates to new use of carbonized cuttlebones, in particular to application of carbonized cuttlebones in preparation of medical materials for treating diseases of bone defect, bone tumor and cyst. The medical materials can be bone tissue engineering scaffold materials or bone grafting substitution materials. The invention has the advantages that: the carbonized cuttlebones have excellent microporous structure and biocompatibility, is beneficial to osteoblast adherence growth and promotes bone differentiation to a certain extent. The microwave carbonized cuttlebones can be used as the bone tissue engineering scaffold materials or bone grafting substitution materials, therefore, the invention is hopeful to be used for clinical treatment and repairing of dead space after the cutting of bone defect, bone tumor and cyst, promotes combination of vertebral column and joints, and can be used as a cell carrier to construct tissue-engineered bones in vitro in a compounding way.

The invention discloses a bone tumor biopsy puncture needle. The bone tumor biopsy puncture needle comprises a bone puncture device, a first electric retractor, an electric rotating device and a splayed base, wherein the bone puncture device is connected to the bottom of the first electric retractor; the upper end of the first electric retractor is fixedly connected to the left side of the bottom of the electric rotating device; the electric rotating device is fixedly connected to the bottom of the base; the right side of the bottom of the electric rotating device is fixedly connected with a second electric retractor, and a second high-definition video camera is arranged at the bottom of a connecting rod; the side edge of the base is connected with a monitoring control device. Through the cooperation of the monitoring control device, the electric retractors and the electric rotating device and the unique structure of the puncture and biopsy acquiring device, a biopsy material can be accurately punctured and accurately grasped, the operation success rate is improved, and the pain of patients is reduced.

The invention belongs to the field of research and development of biological medicines, and particularly relates to a cell-targeted polypeptide for treating bone tumors as well as a preparation method and application of the cell-targeted polypeptide. The polypeptide has a structure as shown in a formula I; the formula I is Dm-X-Rn-C, m is the number of aspartic acid, and m is larger than or equal to 6 and smaller than or equal to 10; n is the number of arginine, and n is larger than or equal to 6 and smaller than or equal to 10; X is a polypeptide fragment which can be recognized and sheared by MMP. The polypeptide-modified polydopamine nanoparticles taking the metal organic framework as the core are loaded with an anti-tumor drug adriamycin, so that the targeting effect can be obviously enhanced, and the toxic and side effects of the drug can be reduced.

The present invention relates to a parvovirus for the treatment of mesenchymal tumors, preferably malignant bone tumors such as localized and metastasized bone tumors, in particular osteosarcoma and Ewing's sarcoma. A preferred parvovirus includes a replication competent parvovirus H-1PV.

The invention discloses a bionic repair method for bone tumors, and belongs to the computer-aided biomedical engineering, and the method comprises the steps: carrying out segmentation with semantic characteristics on tumor image data of a patient, accurately segmenting and extracting an area corresponding to a target bone tissue, and realizing accurate reconstruction of a segmentation result basedon an envelope and approximation bone surface model three-dimensional reconstruction algorithm; constructing a bionic constraint set and a recovery framework for bone loss caused by bone tumors according to biomedical characteristics of a bone system, realizing accurate recovery of a bone loss form, and designing a constrained free form internal fixation prosthesis based on a bone loss form recovery result; designing an internal bionic porous scaffold structure with good mechanical property and machinability according to the information characteristics of the classified bone area and in combination with a skeleton kinematic mechanical analysis result; and finally, generating an integrated implant prosthesis through fusion, so that a personalized and accurate bone tumor repair system is realized.

The invention relates to a bone tumor prosthesis for firmly connecting a tendon and a making method thereof. The bone tumor prosthesis for firmly connecting a tendon belongs to the technical field of medical apparatus and instruments in the department of orthopaedics and is used for firmly connecting a tendon after the excision of a bone tumor. The technical scheme of the bone tumor prosthesis for firmly connecting a tendon is that: the tendon connecting position of the prosthesis is provided with a plug-in unit slot, the plug-in unit is a cuboid, the cuboid shape of the plug-in unit matches with the plug-in unit slot of the prosthesis, the plug-in unit is provided with micro holes in which tendons can grow, multiple micro holes are distributed uniformly along the surface of the plug-in unit, the plug-in unit is fixed in the plug-in unit slot of the prosthesis by a bolt, the plug-in unit is internally provided with a U-shaped pinhole for fixing the tendon, and two U-shaped ends of the pinhole are provided with openings in the surface of the plug-in unit. The prosthesis and the plug-in unit are respectively made by a 3D printing technology which realizes multiple micro hole structures that are difficult to be completed by a conventional technology. The bone tumor prosthesis is invented for the first time in the department of orthopaedics, the tendon fibers can grow into the micro holes in the plug-in unit to form a firm connection, the stability of a prosthesis joint and the strength of joint motion are improved obviously, the limb salvage success rate is enhanced, and a new way is opened up for the development of prosthesis treatment in the department of orthopaedics.

The invention provides a preparation method for a composite photothermal material. The method comprises the following steps: adding potassium hexachloroplatinate solution to G4.5-COONa solution (pH=2), regulating a pH value to be 9.16, after reacting for 12 h in a dark place, adding sodium borohydride solution, after the reaction, dialyzing in a dialysis bag of which a cut-off molecular weight is3500 Da, to obtain the composite photothermal material (DEPt-COOH). A polyamide-amine tree-form macromolecule of which an end group is a carboxyl is used as a carrier, and metal nano photothermal particles are coated in the interior to synthesize a novel compound (DEPt-COOH) which is used for a therapy research of bone tumor. In the multi-functional compound, a poly carboxyl terminal is efficiently chelated with the surface of a corrosion bone so as to realize efficient targeted delivery of the composite material in a bone tumor focal area. Efficient killing to the bone tumor is realized through photothermal therapy, and side effects to a normal tissue are greatly reduced.

The invention relates to the technical field of medical apparatus and instruments, and provides a bone tumor windowing biopsy device. The device comprises a sampling mechanism used for conducting windowing sampling on a bone tumor; a sampling mechanism which is used for windowing sampling, wherein the limiting mechanism is used for guiding and limiting the sampling mechanism, the limiting mechanism is connected with the sampling mechanism, the limiting mechanism comprises a fixing assembly and a limiting assembly, the fixing assembly is used for positioning windowing sampling, the limiting assembly is used for guiding the sampling mechanism, and the fixing assembly is connected with the limiting assembly. Through arrangement of the sampling mechanism, the fixing assembly and the limiting assembly, the sampling mechanism is limited by the fixing assembly and the limiting assembly during windowing sampling, the sampling mechanism cannot deviate during sampling, and the opening position is accurate.

The present invention relates to a parvovirus for the treatment of mesenchymal tumors, preferably malignant bone tumors such as localized and metastasized bone tumors, in particular osteosarcoma and Ewing's sarcoma. A preferred parvovirus includes a replication competent parvovirus H-1PV.