Citric acid half-H2O calcium sulphate bone substitute, its composition and its preparation method and uses

A technology of calcium sulfate hemihydrate and lemon, applied in medical science, prosthesis, etc., can solve the problems of expensive products, calcium sulfate hemihydrate degradation speed is not close to the speed of bone growth and repair, etc., to achieve good biocompatibility, excellent Good bone conduction and biocompatibility

Inactive Publication Date: 2006-12-20
GENERAL HOSPITAL OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the Osteoset series of bone substitutes prepared by the American Wright Company using calcium sulfate hemihydrate is very expensive due to the limitation of the preparation process, and the degradation rate of the prepared calcium sulfate hemihydrate is not close enough to the growth and repair speed of bone.

Method used

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  • Citric acid half-H2O calcium sulphate bone substitute, its composition and its preparation method and uses
  • Citric acid half-H2O calcium sulphate bone substitute, its composition and its preparation method and uses
  • Citric acid half-H2O calcium sulphate bone substitute, its composition and its preparation method and uses

Examples

Experimental program
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Effect test

Embodiment 1

[0111] Citrated calcium sulfate hemihydrate bone graft substitute material and preparation method thereof

[0112] Add 500 grams of analytically pure calcium sulfate dihydrate, add 500ml of 5‰ citric acid, put it in an autoclave, heat it to 127°C, pressurize it to 0.15Mpa, react for 7 hours, take it out immediately, put it in a blast drying oven, Dry at 130°C for 3 hours, grind, and sieve through 180 mesh to obtain citrated calcium sulfate hemihydrate bone graft substitute material.

Embodiment 2

[0114] Citrated calcium sulfate hemihydrate bone graft substitute material and preparation method thereof

[0115] Add 750 grams of analytically pure calcium sulfate dihydrate, add 500ml of 2‰ citric acid, put it in an autoclave, heat to 110°C, pressurize to 0.09Mpa, react for 4 hours, take it out immediately, dry, grind, and sieve through 140 mesh , to obtain citrated calcium sulfate hemihydrate bone graft substitute material.

Embodiment 3

[0117] Citrated calcium sulfate hemihydrate bone graft substitute material and preparation method thereof

[0118] Add 500 grams of analytically pure calcium sulfate dihydrate, add 500 ml of 10‰ citric acid, put it into an autoclave, heat to 140°C, pressurize to 0.3Mpa, react for 8 hours, take it out immediately, dry, grind, and sieve through 200 mesh , to obtain citrated calcium sulfate hemihydrate bone graft substitute material.

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Abstract

The invention relates to a citrate calcium sulfate skeleton replaceable material, relative compound, preparation and application, wherein it comprises: adding citrate into calcium sulphate dehydrate, or still adding metal crystallize agent, to mixed and arranged inside the vaporize kettle, to process high-temperature high-pressure reaction, to be obtained and dried. The invention can be used repair the skeleton, treat the osteoporosis, bone cancer, etc, with simple process, slow degrade speed, high strength, and low cost.

Description

[0001] In this application, the application date is August 30, 2005, the name is "a kind of citrated calcium sulfate calcium sulfate bone graft substitute material, its composition and its preparation method and application", and the application number is 200510093439.4 The invention patent application is the priority right. technical field [0002] The invention relates to a bone graft substitute material, in particular to a citrated calcium sulfate hemihydrate bone graft substitute material, its composition, its preparation method and application. Background technique [0003] The repair and reconstruction of bone defects caused by trauma, infection, surgical tumor resection, and surgical treatment of congenital diseases have always been an important research direction in related disciplines such as orthopedics and plastic surgery. So far, autologous bone grafting is still the main method for bone defect repair, but it needs to use the second surgical area to take bone, wh...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/02A61L27/50
Inventor 陈华张伯勋张巨松王岩梁雨田梁向党王文刚高飞
Owner GENERAL HOSPITAL OF PLA
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