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Organic-inorganic self-solidified composite bone graft formed by hydration bridge formation of multi-trace element organic compound and inorganic compound

A bone graft and compound technology, applied in the field of biomedical materials, can solve the problems of small selectivity, disappearance, single function, etc.

Active Publication Date: 2019-03-29
中鼎凯瑞科技成都有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] (2) It cannot match the corresponding degradation rate with bone tissue reconstruction and regeneration;
[0012] (3) Generally, a self-solidifying composite material with a certain element is formed by mixing other salts. This mixing method is likely to lead to the problem of concentrated release of ions in the early stage and weakened or disappeared functions in the later stage;
[0013] (4) The function is single, either it does not degrade, it only has a supporting function, or it fills or partially degrades, and it acts as a combination of space occupation and interface;
[0014] (5) For patients of different age groups, lesions or injuries in different parts, etc., the material can be changed little and the selectivity is small

Method used

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  • Organic-inorganic self-solidified composite bone graft formed by hydration bridge formation of multi-trace element organic compound and inorganic compound
  • Organic-inorganic self-solidified composite bone graft formed by hydration bridge formation of multi-trace element organic compound and inorganic compound
  • Organic-inorganic self-solidified composite bone graft formed by hydration bridge formation of multi-trace element organic compound and inorganic compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] Experimental steps:

[0065] (1) Add 5000mL of pure water into a 10L glass reactor, stir under the protection of nitrogen, and gradually add 384.28 g of 3-hydroxy-1,3,5-pentanetriic acid. After it is completely dissolved, add in order: 125.42g ZnCO 3 ; After stirring for 20 minutes, add 200.18g CaCO 3 , stir and gradually raise the temperature to 60°C, adjust the pH value to 7.5-8.0 with ammonia water, then maintain for 4 hours, then gradually cool to room temperature naturally, seal the reactor and keep for 48 hours. Then the supernatant was removed by filtration, the precipitate was washed 4 times with 3000ml pure water, and then washed twice with 3000mL absolute ethanol, then dried at 120°C for 12 hours under the protection of nitrogen, and then dried at 100°C for 12 hours in a vacuum oven. Obtain 436.05 g of multi-trace element organic compound of structure shown in formula (I), in this formula (I) structural compound m 1 = 1, M 1 = Zn; m 2 = 2, M 2 = Ca; m 3...

Embodiment 2

[0074] Experimental steps:

[0075] (1) get the product 50g of (I) of anhydrous structure in the above-mentioned embodiment 1 and mix with 50g anhydrous calcium hydrogen phosphate, finely grind 2 hours by ball mill, obtain 96g to have structure (II) multi-trace element organic compound and inorganic Organic-inorganic self-solidifying composite bone graft formed by compound through hydration bridging, wherein M i = Ca, X = HPO 4 2- .

[0076] (2) Take 10g of the above structure (II) multi-trace element organic compound and inorganic compound organic-inorganic self-solidifying composite bone graft, add 5mL of pure water, stir, and after 3 minutes it becomes a dough state, and put it into a φ3×5mm mold , 30 minutes out. Hydration occurs by adding pure water, and the structure (II) is transformed into an organic-inorganic self-solidifying composite bone graft structure (III) formed by hydration bridging of multi-trace element organic compounds and inorganic compounds.

[0077...

Embodiment 3

[0084] Experimental steps:

[0085] (1) Add 5000mL of pure water into a 10L glass reactor, stir under nitrogen protection, and gradually add 384.28 g of 3-hydroxy-1,3,5-pentanetrionic acid. After it is completely dissolved, add 84g of MgCO 3 ; After stirring for 20 minutes, add 200.18g CaCO 3 , stir and gradually raise the temperature to 60°C, adjust the pH value to 7.5-8.0 with ammonia water, then maintain for 4 hours, then gradually cool to room temperature naturally, seal the reactor and keep for 48 hours. Then the supernatant was removed by filtration, the precipitate was washed 4 times with 3000ml pure water, and then washed twice with 3000mL absolute ethanol, then dried at 120°C for 12 hours under the protection of nitrogen, and then dried at 100°C for 12 hours in a vacuum oven. (I) of anhydrous structure was obtained: 420.12 g. m in (I) of the anhydrous structure of the multi-trace element organic compound1 = 1, M 1 = Mg; m 2 = 2, M 2 = Ca; m 3＝ 0, M 3 =0.

[00...

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Abstract

The present invention provides an organic-inorganic self-solidified composite bone graft formed by a hydration bridge formation of a multi-trace element organic compound and an inorganic compound. Themulti-trace element organic compound is prepared by using a solution method, inorganic salts with different metastable-state structures are prepared by a heat treatment, the two materials are mixed and ground to form micro-nano powder, the micro-nano powder is mixed with water-containing solidified liquid to form a bridge structure by diffusion and a hydrated crystalline water structure by self-solidification, and thus a stable bone repair material is formed. The prepared bone graft can be shaped at will and has high strength, can provide various essential elements for bone tissue repair, hasgood biological properties, has a degradation rate consistent with a bone formation cycle, and finally can be completely absorbed by tissues to substitutably form new bones and obtains any desired compressive strengths and degradation cycles according to needs to adjust raw material composition ratios, and can be used as the repair material for bone defects caused by trauma, deformity, bone tumors, osteomyelitis or joint replacement, etc. clinically.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to an organic-inorganic self-solidifying composite bone graft formed by hydration bridging of multi-trace element organic compounds and inorganic compounds and a preparation method thereof. Background technique [0002] Bone tissue is the basic system that supports and maintains the normal physiological functions of the human body. Due to the necrosis, damage and loss of function of bone tissue due to various factors such as diseases, hypoplasia, car accidents and aging, a large number of biomaterials are required for the repair and replacement of bone tissue. In 2015 alone, the domestic consumption of orthopedic materials reached 15.59 billion yuan, an increase of 17% over 2014; in 2016, it reached 18.96 billion yuan, an increase of 22% over 2015. At present, the high-end products of orthopedic medical biomaterials in my country are mainly monopolized by foreign companies such ...

Claims

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Application Information

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IPC IPC(8): A61L27/02A61L27/12A61L27/58C04B28/14C04B28/34
CPCA61L27/025A61L27/12A61L27/58A61L2400/06A61L2430/02C04B28/14C04B28/344C04B2201/50C04B24/06C04B22/10C04B22/06
Inventor 严永刚邓光进戢觅之
Owner 中鼎凯瑞科技成都有限公司
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