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Material with antibacterial and osteogenesis promoting performance and preparation method thereof

A technology that promotes bone and performance. It is used in medical science, prosthesis, tissue regeneration, etc. to achieve high safety, promote bone repair, and improve osteogenic activity.

Active Publication Date: 2022-04-15
HENAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the antibacterial properties of gallium can be best exerted under acidic conditions, while many bone graft materials based on the basic elements of bone are neutral or alkaline, which is not conducive to their antibacterial properties.

Method used

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  • Material with antibacterial and osteogenesis promoting performance and preparation method thereof
  • Material with antibacterial and osteogenesis promoting performance and preparation method thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0033] A method for preparing a material with antibacterial and bone-promoting properties, comprising the following steps:

[0034] S1, load gallium β-calcium phosphate (gallium accounts for 2-5 mol% of the total metal ions in molar weight) and Ca(H 2 PO 4 ) 2 ·H 2 O powder is ground separately, and is standby after sieving;

[0035] S2. Weigh the loaded gallium β-calcium phosphate and Ca(H 2 PO 4 ) 2·H 2 The O powder is mixed and ground to obtain a mixed powder for subsequent use;

[0036] S3, adding calcium alginate microspheres loaded with acidic fiber growth factor to S2, grinding and mixing evenly;

[0037] S4, preparation concentration is the chitosan solution of 0.8~1.2wt% as bone cement liquid phase, stand-by;

[0038] S5. Add the solution prepared by S4 to the mixed powder prepared in S3 at a ratio of 2.2 to 3 g / mL, and stir to obtain a uniform slurry, and put it into a mold;

[0039] S6. After the material is solidified and demolded, the product is obtain...

Embodiment example 1

[0056] S1. Preparation of gallium-loaded β-TCP

[0057] S11. Prepare 3 L (Ga / (Ga +Ca)= 2 mol%) of Ca(NO 3 ) 2 and Ga(NO 3 ) 3 Mixed solution, Ca in the solution 2+ and Ga 3+ The concentration is 0.1 mol / L.

[0058] S12, in the solution of S11, dropwise add 2 L concentration be the (NH 4 ) 2 HPO 4 solution. During the 4 h reaction, stirring was continued, and NH 3 ·H 2 O, keep the pH around 7-8.

[0059] S13. Precipitate the mixed suspension of S12 at 40°C for 24 h, suction filter the precipitate obtained from the reaction, put the filter cake into a glass dish, and dry it in a drying oven at 110°C for 24 h.

[0060] S14. Calcining the dried semi-finished material of S13 at 1100° C. for 2 h, pulverizing the sintered powder, and sieving with 200 mesh.

[0061] S2. Preparation of calcium alginate microspheres loaded with acidic fibroblast growth factor

[0062] S21. Prepare 1wt% sodium alginate solution A1 and store it at 4°C for later use;

[0063] S22. Weighing ...

Embodiment example 2

[0074] S1. Preparation of gallium-loaded β-TCP

[0075] S11. Prepare 3 L (Ga / (Ga +Ca)= 3mol%) of Ca(NO 3 ) 2 and Ga(NO 3 ) 3 Mixed solution, Ca in the solution 2+ and Ga 3+ The concentration is 0.1 mol / L.

[0076] S12, in the solution of S11, dropwise add 2 L concentration be the (NH 4 ) 2 HPO 4 solution. During the 4 h reaction, stirring was continued, and NH 3 ·H 2 O, keep the pH around 7-8.

[0077] S13. Precipitate the mixed suspension of S12 at 40°C for 24 h, suction filter the precipitate obtained from the reaction, put the filter cake into a glass dish, and dry it in a drying oven at 110°C for 24 h.

[0078] S14. Calcining the dried semi-finished material of S13 at 1100° C. for 2 h, pulverizing the sintered powder, and sieving with 200 mesh.

[0079] S2. Preparation of calcium alginate microspheres loaded with acidic fibroblast growth factor

[0080] S21. Prepare 1wt% sodium alginate solution A1 and store it at 4°C for later use;

[0081] S22. Weighing 0...

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Abstract

The invention discloses a material with antibacterial and osteogenesis promoting properties and a preparation method thereof. The preparation method comprises the following steps: S1, respectively grinding gallium-loaded beta-calcium phosphate and Ca (H2PO4) 2. H2O powder; s2, weighing gallium-loaded beta-calcium phosphate and Ca (H2PO4) 2. H2O powder according to a molar ratio of 1: (0.9-1.1), mixing and grinding to obtain mixed powder; s3, adding calcium alginate microspheres loaded with acidic fibroblast growth factors into the mixture obtained in S2, grinding and uniformly mixing; s4, preparing a chitosan solution as a bone cement liquid phase; s5, stirring the mixed powder prepared in the step S3 and the solution prepared in the step S4 to obtain uniform slurry, and filling the uniform slurry into a mold; s6, after the material is solidified and demoulded, a product is obtained.The prepared material has the growth stimulating effect on osteoblasts, osteogenesis is facilitated, and the obvious inhibiting effect on growth of high-concentration bacteria can be achieved.

Description

technical field [0001] The invention relates to the technical field of biomedical material processing, in particular to a material with antibacterial and osteogenic properties and a preparation method thereof. Background technique [0002] In recent years, the incidence of infectious bone defects in my country has shown an upward trend. On the one hand, with the development of my country's economy, the incidence of open fractures caused by high-energy trauma such as traffic accidents has increased year by year, and open fractures can easily induce severe infectious bone defects. On the other hand, my country's adult diabetic patients rank first in the world. According to the 2019 Chinese Guidelines for the Prevention and Treatment of Diabetic Foot, the incidence of diabetic foot in my country is as high as 8.1% among diabetic patients over 50 years old, and 27%-60% of them are complicated with severe bone infection, which is very easy to form infectious bone defect. my cou...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/20A61L27/50A61L27/54
CPCA61L27/12A61L27/20A61L27/50A61L27/54A61L2300/414A61L2430/02A61L2300/102A61L2300/404C08L5/08
Inventor 赵三团李光大李晓芳蔺利峰张子林蔡变云李景华
Owner HENAN UNIV OF SCI & TECH
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