57 results about "Kitasamycin" patented technology

The invention relates to a feedstuff used for culturing fresh-water crabs. The composition of the feedstuff comprises import fishmeal powder, soybean meal, peanut meal, cotton meal, rapeseed meal, marine yeast, citric acid dregs, flour, soybean phospholipids, cuttle fish grease, bentonitic clay and primary calcium phosphate, and also comprises crabs-using multivitamin, crabs-using multiminerals, compound bacillus subtilis, microzyme, bdellovibrio, biological antibacterial peptide and microcapsule kitasamycin; Additive formulation mainly provides vitamin, mineral ion element, various enzymes, etc., for accelerating the growth of the fresh-water crabs. In addition, the additive formulation do not do harm to the growth of the fresh-water crabs. The additive also comprise antibiotics and various enzymes used for controlling the growth of hazardous enzymes in internal environment of the fresh-water crabs; therefore, after eating the feedstuff containing basic ingredients and the ingredients of the additive, the fresh-water crabs has remarkable growth effect without any side effects.

The invention relates to a liquid artificial milk feed, a production method and a feeding device, and the liquid artificial milk feed is characterized in that the formula comprises the following raw materials by weight percent: 4-6% of soy protein concentrate, 4-7% of beef extract, 1-3% of starch, 9-11% of whey powder, 4-7% of pure milk, 0.4-0.6% of calcium hydrogen phosphate, 0.2-0.4% of calciumcarbonate, 0.1-0.2% of common salt, 0.02-0.04% of compound vitamin, 0.1-0.3% of compound trace element, 0.01-0.03% of colistin, 0.01-0.02% of kitasamycin, 0.04-0.06% of bacillus subtilis and the balance of drinking water. The liquid artificial milk feed has the advantage of retarding a series of inadaptations of piglets in the aspects of emergency and a digestive system caused by direct transition from sow milk to powder material during delectation of the piglets. The product can not only meet the nutritional requirements for physiology, growth and development of the piglets, but also realize the scientific and safe transition from the liquid sow milk to the powder material.

The invention discloses a production method of enteric-coated kitasamycin for feed, which comprises the following process steps: step one, the preparation of drug-loaded pellets; step two, inner layer sustained-release coating of the drug-loaded pellets, which prolongs the release and acting time of kitasamycin; and steps three, outer layer enteric coating of the drug-loaded pellets, which ensures the release in succus entericus and small or no release in gastric juice. The method has the advantages that the kitasamycin is subjected to pellets pelletizing and 99 percent of the prepared granulums can pass through 24 meshes, so the dust is greatly reduced and the fluidity is increased; the coating of the inner layer sustained-release agent (HPMC) prolongs the release and acting time of the kitasamycin, reduces medication times and reduces the medication cost; and a layer of enteric substance, namely acrylic resin-III is sprayed and coated on the outer layer of particles. The substance protects the kitasamycin which is a weakly alkaline antibiotic from being damaged by gastroc acid in stomach, quickly disintegrates after entering enteric canal and releases the kitasamycin; and then the kitasamycin is absorbed by gastrointestinal mucosa into blood drug to play a role of restraining the reproduction of pathogenic microorganism and preventing diarrhea. Insoluble in the stomach, kitasamycin coating formulations have no pessimal stimulation on the stomach, and cannot result in regurgitation and vomiting. In addition, the sustained-release formulation, namely the kitasamycin prolongs the acting time so the medication times is reduced, the medication cost of farmers is reduced, and the economic benefit is improved.

Piglet early-stage care feed is disclosed. Raw materials include corn, puffed corn, soybean meal, fermented soybean meal, bran, puffed soybean, soybean oil, sugar, glucose, fish meal, amino acids, organic trace elements, inorganic trace elements, choline chloride, betaine, sodium chloride, calcium carbonate, calcium hydrophosphate, composite vitamins, composite enzymes, phytase resistant to high temperature, quinocetone, calcium oxytetracycline, 4-6 parts of an acidifying agent and kitasamycin. The acidifying agent is used in the feed to adjust acidity-alkalinity balance in intestinal tracts. Antibiotics are combined to resist intestinal bacteria. The feed can also improve the digestion rate and piglet immunity. An amino acid composition is adopted to improve immunologic balance of piglets. An organic trace element composition and zinc oxide are used to improve body immunity and intestinal health of the piglets. A composition of the white sugar, the glucose, monosodium glutamate, and the like is adopted to improve immunity and palatability. Beneficial effects of the method are that palatability is improved, the feed intake is obviously increased, intestinal tract stress is reduced, the diarrhea rate is reduced by about 20%, and the survival rate is increased by about 30%.

The invention relates to high-ration fiber piglet compound feed. The high-ration fiber piglet compound feed consists of the following ingredients in parts by weight: 250 to 400 parts of corns, 250 to 350 parts of wheat, 80 to 150 parts of extracted soybean meal, 50 to 75 parts of fermented soybean meal, 50 to 100 parts of extruded soybeans, 30 to 100 parts of brown rice, 30 to 60 parts of 65% fish meal, 30 to 70 parts of whey powder, 20 to 80 parts of flour, 10 to 20 parts of soybean oil, 5 to 10 parts of calcium hydrogen phosphate, 5 to 10 parts of stone powder, 4 to 5 parts of piglet micro-mineral premixed material, 5 to 10 parts of citric acid, 3 to 6 parts of 99% lysine, 3 to 5 parts of sodium chloride, 1 to 2 parts of 50% choline chloride, 1 to 2 parts of methionine, 1 to 2 parts of threonine, 4 to 5 parts of self-compounding multi-dimensional premixed material, 0.3 to 0.6 part of tryptophan, 0.3 to 0.5 part of an antioxidant, 0.5 to 0.7 part of origanum oil, 0.05 to 0.1 part of 50% kitasamycin and 0.15 to 0.2 part of colistin sulfate. The ratio of soluble ration fiber to insoluble fiber in the ration is adjusted, so that the weanling stress syndrome of the piglet can be controlled, the intestine health of the piglet can be improved, the diarrhea is reduced, the dependence of the piglet on the antibiotics and the pharmaceutical dose zinc oxide can be alleviated, and the effect is remarkable.

The invention provides an immunocolloidal-gold detection card for kitasamycin and a preparation method thereof, belonging to the technical field of detection of antibiotics. A test strip in the shell of the detection card is composed of a PVC rubber sheet, a sample pad, a colloidal-gold binding pad, a coating film and a water-absorbing pad, wherein a colloidal-gold film is a glass cellulose film containing monoclonal antibody against kitasamycin; the coating film is a cellulose nitrate film which is provided with a T line and C line; the T line is coated with a kitasamycin protein conjugate; and the C line is coated with a goat anti-mounse antibody. The immunocolloidal-gold detection card is used for rapid detection of kitasamycin, is convenient and fast and produces accurate results.

A slow-release kitasamycin microball as a veterinary medicine with high effect to prevent and treat animal' s diseases, and its preparing process with high productivity are disclosed.

The invention relates to a high sensitivity, high accuracy and high accuracy kitasamycin magnetic immunochemiluminescence detection kit. The kit comprises a horse radish peroxidase-labeled kitasamycinhapten label, an enzyme-labeled antigen diluent, a magnetic label antibody, a magnetic label antibody diluent, a series of kitasamycin standard solutions, a concentrated compound solution, a concentrated cleaning solution and solutions A and B of chemiluminescent substrates. A lot of tests screen specific monoclonal antibodies with excellent properties and determine appropriate concentrations ofcomponents in the reaction solution. The kitasamycin magnetic immunochemiluminescence detection kit can fast and accurately detect low content kitasamycin and is suitable for detection of kitasamycinresidue content of pig or poultry animal foods.

The invention belongs to an antibiotic production process and particularly relates to a clean kitasamycin extraction process. The clean kitasamycin extraction process comprises the steps of fermentation broth acidification, filtration, extraction, raffinate recovery and the like. In an existing production process, extracted raffinate is subjected to harmless treatment and then is always and directly discharged. According to the clean kitasamycin extraction process, it is considered that the main component of the raffinate is water based on relevant production technology study, the raffinate can be reused for the production process after being treated properly, the sewage treatment cost can be better reduced while water resources are saved in use, and accordingly production benefits are improved. The process overcomes the technical prejudice on direct discharge of production wastewater to some degree. Compared with existing production processes, the clean kitasamycin extraction process is lower in improvement cost and is simple. Due to the fact that the wastewater discharge proportion can be obviously reduced, the production cost can be reduced and the environmental protection benefits and production benefits are more remarkable, and the antibiotic production process has better practicability and a popularization and application value.

The present invention solves the difficult problem of microlide medicine kitasamycin tartrate in unstable structure, and provides preparation process of kitasamycin tartrate injection. The kitasamycin tartrate injection consists of kitasamycin tartrate or kitasamycin as main medicine component, solvent for injection, pH stabilizer, chemical structure stabilizer, metal ion complexing agent, isosmotic regulator and other auxiliary components. The kitasamycin tartrate injection has high stability, high safety and effectiveness, simplified clinical use and other advantages.

The invention discloses a method for raising n-propanol tolerance of kitasamycin producing strain. The method comprises the following steps: using the kitasamycin producing strain as an original strain, adding 1.5% of n-propanol into a spore suspension, performing microwave mutagenesis, and performing preliminary screening and secondary screening to obtain a strain with strong n-propanol tolerance. The method has advantages of simple equipment, convenience in operation and slight radiation damage. The method is safe and can be adopted to stably raise the level of fermentation production.

Provided is a ureaplasma urealyticum/mycoplasma hominis combined rapid culture and drug sensitivity detection kit. The kit can complete detection in 8-24 h, and meanwhile, drug-resistant detection of various antibiotics can be performed. The combined rapid culture kit is mainly composed of pork stomach digestive juice or lung digestive juice, a beef extracting solution or a beef heart extracting solution, cattle serum or horse serum or other animal serum, sodium chloride, peptone, yeast powder, urea, L-arginine, phenol red indicator or cresol red indicator, and penicillin or other antibiotics. The drug detection kit can detect doxycycline hyclate, roxithromycin, acetylspiramycin, gatifloxacin, clarithromycin, azithromycin, clindamycin, erythromycin, kitasamycin, ofloxacin, levofloxacin hydrochloride, sparfloxacin, ciprofloxacin, doxycycline, erythromycin cydocarbonate and various other antibiotics. By means of the detection kit, not only is the mycoplasma detection time shortened, but also drug-resistant detection can be performed at the same time so that clinical medication can be guided. The detection kit has the beneficial effects of being high in sensitivity, high in specificity, high in detection rate, easy and convenient to operate and the like.

A kitasamycin antimicrobial nanoemulsion drug and a preparation method thereof. The kitasamycin antimicrobial nanoemulsion drug is a composition having a particle size range of between 1nm to 100nm and comprising 0.1%-5% by weight of kitasamycin, 0.1%-8% by weight of an oil phase, 25%-40% by weight of a surfactant, and 4%-25% by weight of a cosurfactant, and the balance water. Combining the composition with the preparation method, the kitasamycin antimicrobial nanoemulsion drug with high bioavailability, low toxic and side effects, good stability, and good palatability is obtained.

The invention discloses a preparation method of kitasamycin microcapsules. The method includes the steps of firstly, evenly stirring and mixing liquid grease and an oleophylic emulsifier to obtain first mixed liquid, adding a kitasamycin solution into the first mixed liquid, and evenly stirring and mixing to obtain a primary emulsion; secondly, evenly stirring and mixing a sodium alginate solutionand a hydrophilic emulsifier to obtain second mixed liquid, adding the primary emulsion into the second mixed liquid, and evenly stirring and mixing to obtain a compound emulsion; thirdly, dropwise adding the compound emulsion into a calcium chloride solution to perform calcification, and filtering to obtain the kitasamycin microcapsules. The method has the advantages that a water-oil-water emulsification method is used to wrap kitasamycin inside sodium alginate, calcium alginate is formed through the calcification reaction to tightly wrap the emulsification system inside, the kitasamycin ishigh in encapsulation rate, and good stability is achieved; the kitasamycin microcapsules can increase the bioavailability of the kitasamycin, and the kitasamycin is not released in the stomach, doesnot irritate the stomach and is only released and absorbed in the intestinal tract.

The invention discloses a feed for benefiting the spleen, removing dampness and promoting growth of a growing-finishing pig. The feed comprises the following raw materials in percentage by weight: 8%-15% of coix seed bran and 85%-92% of a general feed. The feed is prepared by the following steps: performing superfine grinding on the coix seed bran through a 100-mesh sieve, heating to 90 DEG C, curing at the high temperature, adding the general feed according to the proportion, and uniformly mixing. According to the feed, the coix seed byproduct is added into the general feed, so that the effects of benefiting the spleen, removing dampness and promoting growth of the growing-finishing pig are improved and the disease resistance of the growing-finishing pig can be enhanced; the coix seed bran is used for replacing healthcare drugs and antibiotics in the pig feed, and the effect of the coix seed bran is remarkably superior to that of the antibiotics such as kitasamycin and enramycin; wastes are turned into wealth, the resources are saved, the cost is reduced, and great economic benefits are brought to regions abounding in coix seeds.