Clean kitasamycin extraction process

A kitamycin extraction technology, applied in the field of clean extraction technology of kitamycin, can solve the problems of high cost of harmless treatment, difficult treatment, large pH fluctuations, etc., and achieve significant environmental protection and production benefits, and is very practical Sexuality and popularization and application value, and the effect of reducing the proportion of wastewater discharge

Active Publication Date: 2016-12-07
TOPFOND PHARMA CO LTD
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Problems solved by technology

[0003] During the preparation of antibiotics, due to the needs of the production process, a large amount of high-concentration organic wastewater is often produced in the process of antibiotic separation, extraction, refining and purification, and these wastewaters have: high COD content (COD is generally 5000-80000mg/L Between),...

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  • Clean kitasamycin extraction process

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Embodiment

[0031] The clean extraction process of gemitamycin provided by the application specifically includes the following steps:

[0032] (1) Acidify the fermentation broth

[0033] Specifically, adding saturated oxalic acid aqueous solution to the fermented liquid containing gemitamycin obtained after microbial fermentation, and adjusting its pH to 3.5.

[0034] (2) filter

[0035] In this embodiment, the fermented liquid after acidification in step (1) is obtained by suction filtration to obtain the filtrate, that is, the raw liquid to be extracted containing gemitamycin;

[0036] In order to determine better experimental parameters, for the obtained filter residue (filter cake, that is, the insoluble solid substance after filtration of the fermentation broth), clean water and raffinate (that is, heavy liquid, the adopted The heavy liquid is the heavy liquid prepared according to the prior art after adopting the above steps (1) and (2) and is washed three times, and the cleaning ...

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Abstract

The invention belongs to an antibiotic production process and particularly relates to a clean kitasamycin extraction process. The clean kitasamycin extraction process comprises the steps of fermentation broth acidification, filtration, extraction, raffinate recovery and the like. In an existing production process, extracted raffinate is subjected to harmless treatment and then is always and directly discharged. According to the clean kitasamycin extraction process, it is considered that the main component of the raffinate is water based on relevant production technology study, the raffinate can be reused for the production process after being treated properly, the sewage treatment cost can be better reduced while water resources are saved in use, and accordingly production benefits are improved. The process overcomes the technical prejudice on direct discharge of production wastewater to some degree. Compared with existing production processes, the clean kitasamycin extraction process is lower in improvement cost and is simple. Due to the fact that the wastewater discharge proportion can be obviously reduced, the production cost can be reduced and the environmental protection benefits and production benefits are more remarkable, and the antibiotic production process has better practicability and a popularization and application value.

Description

technical field [0001] The method belongs to the production process of antibiotics, and specifically relates to a clean extraction process of kitasamycin. Background technique [0002] In the prior art, the preparation of antibiotics by microbial fermentation is a relatively common and common production process, and its main production process includes: microbial fermentation, filtration, extraction and crystallization, refining, refining and other processes. Among them, solvent extraction is a commonly used method in the extraction process of antibiotics, and it is the most widely used. [0003] During the preparation of antibiotics, due to the needs of the production process, a large amount of high-concentration organic wastewater is often produced in the process of antibiotic separation, extraction, refining and purification, and these wastewaters have: high COD content (COD is generally 5000-80000mg / L Between), high SS concentration (500-25000mg / L), high chroma, large p...

Claims

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Application Information

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IPC IPC(8): C07H17/08C07H1/06
CPCC07H1/06C07H17/08
Inventor 牛金刚周淑梅毛全贵陈忠刚张宏周朱德育朱义彬韩德全邢继红安坤刘守强刘俭国刘玉刘果
Owner TOPFOND PHARMA CO LTD
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