135 results about "Enterococcus fecalis" patented technology

The invention provides an Enterococcus faecium ANSE228 of which the collection number is CGMCC No.4082. The invention also provides application of the Enterococcus faecium ANSE228 to inhibition of salmonella pullorum and / or Escherichia coli and / or Staphylococcus aureus. The Enterococcus faecium ANSE228 is obtained by processes of repeated separation, purification, rejuvenation and the like, and has high biological activity, obvious probiotic property, high adversity resistance and the like. The invention also provides a microecological agent which contains the Enterococcus faecium ANSE228. When the microecological agent is added into drinking water and / or feeds for breeding animals, the Enterococcus faecium ANSE228 can be quickly activated and reproduced and a dominant beneficial flora can be formed after the Enterococcus faecium ANSE228 is fed into intestinal canals of the animals, and the Enterococcus faecium ANSE228 has the effects of reducing a harmful flora in the intestinal canals, adjusting microecological balance of the intestinal canals, substituting for medicaments such as antibiotic and the like, and improving weight increment of the animals and the utilization rate of the feeds.

The invention discloses microbial feed additive used for pigs, and a preparation process thereof; the prescription is as follows: 1 portion of bacillus licheniformis, 1 portion of bacillus subtilis, 2 portions of bifidobacterium, 2 portions of enterococcus faecalis, 2 portions of enterococcus faecium, 1 portion of boas-oppler bacillus, 1 portion of lactobacillus casei, 1 portion of lactobacillus lactis, 1 portion of plant lactobacillus, 1 portion of candida utilis, 1 portion of saccharomyces cerevisiae, 80kg to 100kg of panela, 3kg to 5kg of salt, 5kg to 8kg of vinegar, 3kg to 5kg of lysine, 1kg to 2kg of methionine, and 1000L of pure water; the weight of each portion of strain is 2g to 5g. The preparation process is as follows: strain preparation, nutrient broth preparation, inoculated fermentation and check. The invention reduces the quantity of the used individual strain, and the strain quality is safe and reliable. The production process is simple and feasible, the effect is obvious; therefore, the invention has promotion value.

The invention provides an Enterococcus faecium ANSE228 of which the collection number is CGMCC No.4082. The invention also provides application of the Enterococcus faecium ANSE228 to inhibition of salmonella pullorum and / or Escherichia coli and / or Staphylococcus aureus. The Enterococcus faecium ANSE228 is obtained by processes of repeated separation, purification, rejuvenation and the like, and has high biological activity, obvious probiotic property, high adversity resistance and the like. The invention also provides a microecological agent which contains the Enterococcus faecium ANSE228. When the microecological agent is added into drinking water and / or feeds for breeding animals, the Enterococcus faecium ANSE228 can be quickly activated and reproduced and a dominant beneficial flora can be formed after the Enterococcus faecium ANSE228 is fed into intestinal canals of the animals, and the Enterococcus faecium ANSE228 has the effects of reducing a harmful flora in the intestinal canals, adjusting microecological balance of the intestinal canals, substituting for medicaments such as antibiotic and the like, and improving weight increment of the animals and the utilization rate of the feeds.

The present invention provides a microbial fermented composite antibiotic-free feed containing natural antibacterial components. The feed comprises a fermented product based on the united segmented fermentation of aerobic-anaerobic composite strains, composite natural antibacterial components, a non-plant source protein / polypeptide compound nutrient supplement agent, and an additive comprising atleast a soybean protein amino acid / polypeptide compound chelate. The composite strains comprises at least lactic acid bacteria, bacillus subtilis, yeast selected from candida utilis or saccharomyces cerevisiae, and enterococcus faecalis. The fermented product based on the united segmented fermentation is prepared by carrying out secondary fermentation on fermentation raw materials through the aerobic-anaerobic composite strains. The combination of the microbial fermented feed and the natural antibacterial components is beneficial to the balance of intestinal flora of animals, and can prevent the dysbacteriosis of digestive tracts, improve the immunity functions of animal organisms, reduce or replace the use of feed antibiotics, and significantly improve the digestion and absorption efficiency of the feed and the meat quality of animals.

The invention discloses a feed fermentation agent and a fermented feed, the feed fermentation agent includes the following components by mass: 20-25% of pichia pastoris, 15-20% of lactobacillus, 10-15% of enterococcus faecalis, 3-10% lactobacillus plantarum, 10-15% of cellobiose lactobacillus and 15%-25% a compound enzyme agent. The fermented feed is a fermented product of soybean meal, corn and wheat bran, mulberry-rich plants and a mixture of mulberry-rich plants and soybean meal by use of the feed fermentation agent, after fermentation of the soybean meal or corn or wheat bran and other traditional feed by use of the feed fermentation agent, harmful materials such as accumulated stool and the like cumulated in pig intestines can be decomposed and removed by cooperation of crude fiber in the traditional feed and microorganism, so that the intestinal absorption efficiency of nutrients can be provided.

A composition and method of treatment for the Staphylococci, Streptococci, and Enterococcus faecalis Family of infections and their associated symptoms using Sangre de Grado (“SDG”). SDG is extracted from the lechleri Croton tree. SDG is formulated and administered to treat the Staphylococci, Streptococci, and Enterococcus faecalis Family of infections and their associated symptoms. SDG is effective against these various bacterial infections including the often deadly MRSA.

The invention discloses a special complex microbial agent for harmless treatment of livestock and poultry excrements. The special complex microbial agent is prepared from the following raw materials in parts by weight: 0.02-0.04 part of bacillus mucilaginosus, 0.01-0.03 part of bacillus licheniformis, 0.01-0.03 part of streptomyces jingyangensis whey powder, 0.01-0.02 part of azotobacter vinelandii, 0.04-0.08 part of aspergillus spore powder, 0.01-0.03 part of streptococcus thermophilus, 0.01-0.02 part of enterococcus faecalis, 0.02-0.04 part of antimicrobial peptide thallus, 80.0-120.0 parts of dried silkworm dropping, 2.0-6.0 parts of peanut cakes, 2.0-3.0 parts of bran, 7.0-8.0 parts of starch, 3.0-3.5 parts of molasses, 2.0-3.0 parts of monocalcium phosphate, and 1.0-1.4 parts of urea. Used for harmless treatment of livestock and poultry excrements, the special complex microbial agent has the advantages that the fermentation time is short, the quality of a fertilizer is high, the active rate of microorganisms in soil can be activated, the temperature permeability of air in soil can be increased, and the special complex microbial agent has an effect of preventing and controlling various fungal diseases and bacterial diseases, as well as effects of increasing the yield and improving the quality while providing complete nutrients for the crop, thus having better economic benefits, social benefits and ecological benefits.

The invention discloses a universal feed starter composed of the following raw materials by weight: 20-30 parts of soybean meal, 20-30 parts of corn, 20-30 parts of straw, 10-20 parts of fish meal, 10-20 parts of bran, 5-10 parts of sugar, 5-10 parts of Omega-3 fatty acid, 100 parts of multidimensional composite enzyme bacteria and 50-100 parts of water; the multidimensional composite enzyme bacteria contains 5-10 parts of bcillus subtilis, 5-1 parts of bacillus licheniformis, 10-20 parts of acetobacter aceti, 10-20 parts of lactobacillus amylovorus, 5-10 parts of candida, 10-20 parts of protease, 5-10 parts of geotrichum candidum, and balance of enterococcus faecalis. The efficient feed starter prepared by fermentation of various raw materials by the multidimensional composite enzyme bacteria can be widely used in breeding of ruminant animals, swine, poultry, aquatics and the like. The efficient feed starter fermentation agent belongs to a micro ecological preparation, does not contain any chemical agents and hormones, and is used in the production of green livestock products and aquatic products beneficial to human health.

The invention provides isolated polypeptide and nucleic acid sequences derived from Enterococcus faecalis that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting from bacterial infection.

The invention relates to a pig feed additive with efficacies of protecting intestinal tracts and improving a food calling function. The pig feed additive is characterized by being prepared from the following raw materials in parts by weight: 0.5-0.9 part of glycine zinc, 0.6-1.2 parts of beta-mannase, 0.5-1 part of yeast powder, 0.5-0.8 part of bifidobacterium bifidum probiotic powder, 0.5-0.8 part of enterococcus faecalis powder, 8-12 parts of dry white wine grain stillage and 9-12 parts of a food calling composition, wherein the composition is prepared from the following raw materials in parts by weight in a mixing manner: 10-12 parts of robinia flowers, 9-12 parts of orange peel and 1-3 parts of rapeseeds. The additive is capable of effectively adjusting the balance of intestinal flora, increasing the palatability, improving the growth performance, restraining and sterilizing bacteria, preventing and treating diarrhea and dysentery, obviously improving the animal immunity and the production performance, and reducing the ammonia-nitrogen emission to the environment.

The invention relates to an anti-stress disease-prevention piglet feed comprising the following components in parts by weight: 60-68 parts of corn flour, 5-8 parts of potato four, 3-6 parts of yellow mealworm powder, 2-5 parts of fish meal, 3-5 parts of bone meal, 2-4 parts of enterococcus faecalis, 0.5-1 part of selenium yeast, 5-8 parts of dry sweet potato vine, 8-15 parts of grape skins, 1-3 parts of citric acid, 1-3 parts of anhydrous dextrose and 2-5 parts of Chinese medicinal herb powder. Compared with the prior art, the components and the dosages are reasonably collocated to integrate the synergistic action among the components, improve the palatability of the feed, improve the food intake of piglets and the utilization ratio of the feed, reduce the breeding cost and enhance the immunologic function of the piglets at the same time, so that diseases are reduced, adverse stress responses to the outside of swine herds are reduced, the swine herds are promoted to grow quickly and healthily, the excrement off odor is reduced, and the anti-stress disease-prevention piglet feed is a green piglet feed adaptive to intensive pig production.

The invention relates to a pig-feed additive with a function of improving the immunologic function. The pig-feed additive comprises the following materials with specific proportion: glucose oxidase, alpha-hydracrylic acid, lactobacillus bulgaricus powder, enterococcus faecalis powder, egg yolk immunoglobulin, zinc glycinate, dry-beer vinasse, poplar flowers, orange peel, hawthorn, pine needle powder, ginkgo leaves, folium cortex eucommiae, alfalfa, purple perilla and the like. The pig-feed additive has the effects of invigorating the stomach and promoting digestion, clearing heat and removing toxicity, killing insects and resisting viruses, and improving the immunologic function for pigs, and has strong disease-resisting effect.

The invention discloses a compound micro-ecological preparation for aquaculture, and belongs to the field of micro-ecological preparations for aquaculture technologies. The compound micro-ecological preparation is prepared from compound microorganisms, a complex enzyme system and composite immunity enhancing factors, wherein the compound microorganisms comprise enterococcus faecalis, enterococcusfaecium, bacillus subtilis and saccharomyces cerevisiae, the complex enzyme system comprises protease, cellulase and lipase, and the composite immunity enhancing factors comprise mannan oligosaccharide, beta-glucan, chitosan oligosaccharide and peptidoglycan. The compound micro-ecological preparation has the advantages that the health problems of intestines and stomach in the existing breeding process can be effectively solved, the immunity and the disease-resistant and anti-stress capabilities can be enhanced, and green and healthy breeding can be protected.

The invention relates to a high-density enterococcus faecalis fermentation culture medium and a fermentation process thereof. The fermentation culture medium is prepared from 20-30 g / L of glycerol, 10-15 g / L of soybean meal, 1-3 g / L of ammonium sulfate, 2-3 g / L of potassium hydrogen phosphate, 3-8 g / L of sodium acetate trihydrate, 2-4 g / L of trisodium citrate dihydrate, 0.3-0.8g / L of magnesium sulfate heptahydrate and 0.1-0.3 g / L of manganese sulfate monohydrate. The fermentation process comprises the steps that high dissolved oxygen (25%) is adopted and combined with glycerin to serve as a fermentation carbon source, the pH value of the constant sodium carbonate fermentation liquid is 5.5, the glycerol concentration is controlled to 10 g / L by adding a supplementary material in the fermentation process in a flowing mode, culture is performed for 16 hours, and then the fermentation is completed when OD (600 nm) is greater than 35, wherein the viable count of the enterococcus faecalis contained in the fermentation liquid can be up to 8*1010 CFU / mL or above. In the fermentation mode that the high dissolved oxygen is combined with the glycerin to serve as the carbon source, the lactic acid concentration in the fermentation liquid is reduced, the enterococcus faecalis contained in the fermentation liquid can be up to 8*1010 CFU / mL or above, the biomass separation cost is reduced, a production cycle is shortened, the production cost is reduced, and the production efficiency is improved.

The invention provides an anti-tumor composition. The anti-tumor composition comprises (A) a triple living bacteria preparation and (B) immune checkpoint inhibitors, such as programmed death-1 (PD-1)inhibitors, programmed cell death-ligand 1 (PD-L1) inhibitors, cytotoxic T-lymphocyte antigen 4 (CTLA-4) inhibitors, etc., wherein the triple living bacteria preparation includes bifidobacterium, lactobacillus acidophilus and enterococcus faecalis.

The invention relates to a method for producing L-lactic acid by simultaneous saccharification and fermentation, which comprises the following steps: by using lignocellulose as a raw material, carrying out simultaneous saccharification and fermentation in the presence of an enterococcus faecalis DLY-FLYC seed solution and cellulase under enzymolysis conditions. The newly separated and screened enterococcus faecalis DLY-LFYC can be used for synchronous saccharification and fermentation at a high temperature, the concentration and optical purity of the L-lactic acid produced by fermentation are high, particularly, cellobiose can be used as a strain, the feedback inhibition effect is small, and the lactic acid fermentation effect is improved.

The invention discloses a loop mediated isothermal amplification detection primer group, a detection method and a kit for enterococcus faecalis. The detection primer group is as follows: an upstream outer primer is F3:5'-GCCATTCCTCATGGAACAG-3'; a downstream outer primer is B 3:5'-CCACGTTATCCATATCACTACA-3'; an upstream inner primer is FIP:5'-CGGTGCCAAAATTAACACCCTTTAGTGAAAAAATCAGGAATCTGTG-3'; a downstream inner primer is BIP:5'-TGCTACCGTATTATTTGGGATTGCAAAGTGCAATTTGTTGGACTA-3'. The detection method has the advantages of high flexibility, strong specificity, high accuracy, short detection time. From sample treatment to report only takes 12 hours, a PCR (polymerase chain reaction) and an electrophoresis apparatus do not need, the operation process is simple, compared with other PCR technology, the detection method has higher specificity, is applicable to self-detection of basic level detection organizations and drinking water processors.

The invention provides a liquid bacterial liquid for fermenting a piglet liquid feed, and a preparation method and application of the piglet liquid fermented feed. The liquid bacterial liquid for fermenting the piglet liquid feed comprises a bacillus liquid and a lactic acid bacteria liquid; the bacillus liquid is a mixed bacteria liquid of bacillus licheniformis and bacillus subtilis; and the lactic acid bacteria liquid is a mixed bacteria liquid of lactobacillus plantarum and enterococcus faecalis. The piglet liquid fermented feed is a feed fermented by adopting the liquid bacterial liquid for fermenting the piglet liquid feed. The liquid bacterial liquid provided by the invention can improve the utilization rate of the feed, improve the flavor of the feed and improve the palatability, and after the feed is fermented, the contents of reducing sugar and lactic acid are obviously increased, the probiotic number is obviously increased, and the feed has acid fragrance. The piglet liquidfermented feed contains a large amount of probiotics, and is mainly used for enhancing the immune function of the piglets, killing pathogenic microorganisms and preventing diseases such as diarrhea ofthe piglets by fermenting to generate lactic acid and secrete some antibacterial substances.

The invention discloses an Enterococcus faecalis strain and its application in bioelectricity production. The strain is characterized in that it is Enterococcus faecalis Z5, which is preserved by China Center for Type Culture Collection (called CCTCC for short) on November 6, 2012 and has a preservation number of CCTCC NO: M2012445. When the strain is inoculated into a microbial fuel cell, it can degrade organic matters and generate electricity simultaneously, but probably does not transmit electrons by secreting its electron transmission intermediates. The Enterococcus faecalis Z5 strain has very strong electrochemical activity, and also can use multiple types of organic matters as the sole carbon source for electricity generation. Based on the above characteristics, the strain has very good application prospects in environmental pollution remediation and bio-energy recovery.

The invention relates to a (6R, 7R)-3-[(acetyloxy) methyl]-7-[alpha-(N, N'-dicyclohexyl amidine thio)-acetylamino]-8-oxo-5-thia-1-azabicyclo [4, 2, 0]-oct-2-ene-2-carboxylic acid, a crystal thereof, and a preparation method and application thereof. Under alkaline conditions, 7-ACA reacts with bromoacetyl bromide to obtain a 7-bromo acetamino-3-[(acetyloxy) methyl]-8-oxo-5-thia-1-azabicyclo [4.2.0] oct-2-ene-2 formic acid intermediate A; and the intermediate A reacts with N, N '- dicyclohexyl thiourea to obtain the compound provided by the invention. The compound is further refined to obtain the crystal with high purity and good stability of the compound provided by the invention. The compound and the crystal thereof have antibacterial effect on Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae and Enterococcus faecalis, and are potential antimicrobial drugs with promising application prospect.

The invention relates to a lamb fourth stomach glycoprotein extraction, separation and purification method and application thereof. The lamb fourth stomach glycoprotein extraction, separation and purification method comprises the following steps that a pretreated fresh lamb fourth stomach is degreased, and ultrasonic-assisted extraction is carried out on a sodium chloride solution; centrifuging is carried out to take a supernatant; vacuum concentration and alcohol precipitation are carried out; free protein is removed with a Sevage reagent; freeze-drying is carried out to obtain crude glycoprotein powder; the glycoprotein is obtained through gel and anion exchange column chromatography separation and purification, the yield is 1.67%, the total sugar content is 70.24%, the protein content is 16.39%, and the uronic acid content is 4.12%; and purifying is carried out by HPLC to obtain the high-purity lamb fourth stomach glycoprotein, and the purity reaches 99.894%. In-vitro probiotic activity experiments prove that the lamb fourth stomach glycoprotein has the effect of promoting the growth of intestinal probiotics of bifidobacterium adolescentis, lactobacillus delbrueckii subspecies bulgaricus and enterococcus faecalis. The lamb fourth stomach glycoprotein extraction, separation and purification method has the advantages of simple process, convenience in operation, high extraction rate, high purity, stable property, no need of using a large amount of toxic solvents, low cost, easiness in popularization and application and the like.

The invention provides a traditional Chinese medicine composition for young poultry, a liquid-state fermented traditional Chinese medicine preparation and a preparation method thereof. The compositionis prepared from 30-38 parts of Astragalus membranaceus, 22-28 parts of rhizoma atractylodis macrocephalae, 20-25 parts of poria cocos, 22-28 parts of hawthorn and 18-25 parts of dandelions. The preparation comprises a composition and probiotics, wherein the probiotics are compound bacteria of clostridium butyricum, bacillus licheniformis and enterococcus faecalis. The preparation method comprises the step that the traditional Chinese medicine composition is prepared through probiotic fermentation. The traditional Chinese medicine preparation not only can increase the number of lactobacillusand bifidobacterium in intestinal tracts of young poultry to reduce the number of escherichia coli in the intestinal tracts and reduce the occurrence rate of diarrhea of the young poultry, but also can avoid the problem of high death and culling rate of the young poultry caused by abuse of antibiotics.

The invention provides a fermented traditional Chinese medicine microecological preparation for preventing and treating piglet diarrhea, and relates to the field of fermented traditional Chinese medicine preparations. The fermented traditional Chinese medicine microecological preparation is prepared by fermenting a traditional Chinese medicine composition and compound microorganisms by a modern fermentation technology. The traditional Chinese medicine composition is prepared from six traditional Chinese medicinal materials including radix astragali, liquorice roots, radix rubiae, purslane herb, fructus alpiniae oxyphyllae and poplar flowers, and the compound microorganisms comprise clostridium butyricum, bacillus subtilis, lactobacillus acidophilus, bacillus licheniformis and enterococcusfaecalis. Different microorganisms are reasonably proportioned, the number of beneficial microorganisms in intestinal tracts of piglets can be increased, intestinal mucosa repair is facilitated, meanwhile, traditional Chinese medicinal materials are fermented through compound microorganisms, effective components and active substances of the traditional Chinese medicinal materials can be extractedand utilized to the maximum extent, and the absorption rate of the piglets is increased. The fermented traditional Chinese medicine microecological preparation can effectively prevent and treat pigletdiarrhea and significantly reduce mortality, has a positive effect on weight gain of the piglets, and promotes growth and development of the piglets.

The invention designs a feed additive for improving quality of eggshells in later laying period and a preparation method thereof and belongs to the field of feed additives. The feed additive is used for solving the problems of quality of eggshells in later laying period and production performance and contains the following raw materials: 15-20 parts of fructo-oligosaccharide, 20-30 parts of fermented folium cortex eucommiae, 15-20 parts of bacillus subtilis, 4-5 parts of enterococcus faecalis, 8-10 parts of sodium bicarbonate, 2-2.5 parts of vitamin C, 1.5-2 parts of zinc, 0.1-0.3 part of copper, 1-1.5 parts of manganese and 10-15 parts of zeolite powder. The invention adopts a compound nutrition technology for comprehensively increasing health level of laying hens and use ratio of calcium, phosphate and the like, promoting anti-stress capacity of the laying hens in later laying period, increasing eggshell thickness and eggshell strength, reducing loss cost of eggshells, relieving thedecreasing of laying rate, increasing egg weight and promoting production performance of laying hens.

The invention relates to application of a substitutive 2,3-didetonindoline compound in preparing bacterial infection preventing and / or treating medicines. Bacteria can be gram-positive bacteria, specifically, enterococcus faecalis and / or staphylococcus aureus. Pharmacodynamic tests show that the substitutive 2,3-didetonindoline compound has an obvious inhibiting function on virulence factors of the gram-positive bacteria, also has a regulating function on innate immune systems of caenorhabditis elegans, and can become a quite excellent candidate medicine for preventing and / or treating bacterial infection.

The invention provides a LAMP (Loop-Mediated Isothermal Amplification) primer group, a micro-fluidic chip and a kit for detecting reproductive tract pathogenic microorganisms, and belongs to the technical field of reproductive tract infection detection. The LAMP primer group comprises a streptococcus agalactiae detection primer group, an enterococcus faecalis primer group, a gardnerella vaginosisprimer group, a Candida albicans primer group and a Chlamydia trachomatis primer group. The above LAMP primer group is fixed on the micro-fluidic chip. The LAMP primer group, the micro-fluidic chip and the kit can quickly, sensitively and accurately detect streptococcus agalactiae, enterococcus faecalis, gardnerella vaginosis, Candida albicans and Chlamydia trachomatis by high repeatability.

The invention belongs to the biologically technical field and relates to Enterococcus faecalis and applications and a feed additive and a leavening agent thereof. The Enterococcus faecalis has a good stress resistance function and a good function of benefiting life, can be dried at high temperature under the protection of a protective agent, is also capable of tolerating pelleting temperature of 90 DEG C, has a stronger inhibitory action on escherichia coli k88 and k99 and Staphylococcus aureus, has very high capacity of producing acids and cellulase and is capable of reducing pH values and decomposing certain celluloses. The biological feed additive prepared by using the Enterococcus faecalis is capable of replacing part of antibiotics in livestock breeding and aquaculture, thereby, the use of the antibiotics is reduced, the immunity of animals is improved, the conversion rate of the feed is increased, and the culture benefits are increased. The Enterococcus faecalis also can be used for leavening bean meals, cottonseed meals, green grass and the like, and is capable of effectively preventing feeds from mildewing and increasing the use ratio of nutrients in the feeds.

A composition for tissue degradation and removal and disinfection is provided for dental and medical applications. It can function as a single intra-canal irrigant that eradicates microorganisms as it facilitates the debridement of a root canal system. It contains one or more hydoxides, a thioglycolate compound, sodium hypochlorite, sodium chloride, sodium chlorate, oxygen, and water, such as lime water and purified water, The thioglycolate compound is capable of degrading a cell by disrupting disulfide bonds in its proteins. The sodium hypochlorite enhances its function. The composition may also incorporate mineral oil, urea, cetearyl alcohol, D&C yellow No. 8, chromium hydroxide, theobroma cocoa seed butter, iron oxides, fragrances, lanolin, and / or ceteareth-20. It is effective against Enterococcus faecalis.

The invention provides a fermented traditional Chinese medicine microecological preparation for preventing and treating piglet diarrhea, and relates to the field of fermented traditional Chinese medicine preparations, and the fermented traditional Chinese medicine microecological preparation is prepared by fermenting a traditional Chinese medicine composition and compound microorganisms by utilizing a modern fermentation technology. The traditional Chinese medicine composition is prepared from six traditional Chinese medicinal materials including the root of membranous milk vetch, the licorice root, radix rubiae, herba portulacae, fructus alpiniae oxyphyllae and flower of poplar, and the compound microorganisms comprise clostridium butyricum, bacillus subtilis, lactobacillus acidophilus, geobacillus and enterococcus faecalis. Different microorganisms are reasonably matched, the number of beneficial microorganisms in intestinal tracts of piglets can be increased, and repairing of intestinal mucosa is facilitated; meanwhile, the traditional Chinese medicinal materials are fermented through compound microorganisms, effective components and active substances of the traditional Chinese medicinal materials can be extracted and utilized to the maximum extent, and the absorption rate of the piglets is increased. The traditional Chinese medicine composition can effectively prevent and treat piglet diarrhea, obviously reduce the death rate, play a positive role in weight gain of piglets and promote growth and development of the piglets.

The invention belongs to the novel technical field of medicaments, and relates to a novel dosage form of amoxicillin used for treating: 1, upper respiratory tract infections, such as tympanitis, nasosinusitis, pharyngitis and tonsillitis resulted from streptococcus hemolyticus, streptococcus pneumoniae, staphylococcus or haemophilus influenzae; 2, genitourinary tract infections resulted from escherichia coli,proteus mirabilis or enterococcus faecalis; 3, skin and soft tissue infection resulted from streptococcus hemolyticus, staphylococcus bacteria or escherichia coli; 4, lower respiratory tract infections, such as acute bronchitis and pneumonia, resulted from streptococcus hemolyticus, streptococcus pneumoniae, staphylococcus bacteria or haemophilus influenzae; 5, acute simple gonorrhea; and 6, typhoid, typhoid bacteria-carrier, leptospirosis and the like. The novel dosage form is characterized in that the stomach floating tablet is hydrated into gel on the surface to expand the volume thereof after contacting with the gastric juice at the body temperature because of a plurality of hydrophilic macromolecular materials contained. Meanwhile, the weight of the tablet is less than the buoyant force of the gastric juice to float the tablet on the gastric juice and prolong the retention time in the stomach.