59 results about "Di block copolymer" patented technology

A medical device or component thereof, and particularly intracorporeal devices for therapeutic or diagnostic uses, formed at least in part of a copolymer having a hard block and a polylactone soft block. In a presently preferred embodiment, the hard block of the copolymer is a polyester, and more specifically, the copolymer comprises a di-block copolymer of poly(ethylene terephthalate) and polycaprolactone. The copolymer is suitable for forming a variety of medical devices or medical device components, and is preferably used to form a catheter balloon, such as a balloon for an angioplasty or stent delivery catheter. However, a variety of medical devices or medical device components can be formed of the copolymer, including stent covers, vascular grafts, and shaft components.

The present invention is directed to controlling aggregation of rare earth particles using block copolymers and rare earth base particles. More particularly, invention is also directed to forming stable complexes of rare earth aggregates by complexing rare earth base particles with oppositely charged-neutral di-block copolymers. Even more particularly, invention is also directed to forming stable complexes of rare earth nanoparticles by complexing rare earth ultrafine particles with oppositely charged-neutral di-block copolymers.

The invention provides a double stimuli responsive type poly amino acid based supermolecular reverse gel used in the technical field of water gel and a method for preparing the same, wherein the method comprises the following steps of: synthesizing a linear poly(L-benzyl-glutaric acid ester)-polyethylene glycol diblock copolymer; preparing a poly(L-glutamic acid)-polyethylene glycol di-block copolymer used for forming the reverse gel; forming the supermolecular reverse micelle in which the alpha-cyclodextrin-polyethylene glycol complex serves an inner core and the poly(L-glutamic acid) servesa shell; and protonating the poly(L-glutamic acid) chain segments in an acid environment, forming crosslinking by using the mutual action of the hydrogen bonds between the poly(L-glutamic acid) chainsegments, and allowing the supermolecular reverse micelles to mutually gather to form the double stimuli responsive type poly amino acid-based supermolecular reverse gel at room temperature. Comparedwith the prior art, the elastic modulus of the gel is further improved, the gel system prepared by the method is damaged when the pH value of the gel system is higher than 8, the reverse gel can be formed again when the pH value of the gel system is adjusted to be 5, so that the pH value reversibility is good.

The invention specifically relates to an additive composition applicable to viscosity reduction of an oil-based drilling fluid and application thereof, and the oil-based drilling fluid and application thereof. The additive composition is a double block copolymer which is composed of a block A and a block B, wherein the block A is composed of a constitutional unit as shown in a formula (1) which is described in the specification and has a number-average molecular weight of 1500 to 10000, and the block B is composed of a constitutional unit as shown in a formula (2) which is described in the specification. The double block copolymer can be used as a viscosity reducer for the oil-based drilling fluid, especially as a viscosity reducer for a high-density clay-free oil-based drilling fluid; and the double block copolymer can greatly reduce the apparent viscosity and plastic viscosity of the oil-based drilling fluid in high-temperature high-pressure strata while guaranteeing proper shearing force, so drilling speed can be conveniently accelerated and difficulty in well drilling can be reduced.

A method and associated structure. A substrate is provided. The substrate has an energetically neutral corrugated surface layer. A film is formed on the corrugated surface layer. The film includes a combination of a di-block copolymer and a stiffening compound. The di-block copolymer includes lamellar microdomains of a first polymer block and lamellar microdomains of a second polymer block. The stiffening compound is dissolved within the first polymer block. At least one lamellar microdomain is removed from the film such that an oriented structure remains on the surface layer.

The invention discloses a degradable copolyester which is a random copolymer or a double-block copolymer composed of polyester fragments which are difficult to hydrolyze and fragments or sites which are easy to hydrolyze, wherein the number-average molecular weight of the copolyester is 30000 g / mol to 500000 g / mol; and the fragments or sites which are easy to hydrolyze are selected from polylactic acid with different chain segment lengths. The copolyester is high in molecular weight, free of environment-unfriendly chain extenders, good in mechanical strength and toughness, resistant to heat and good in processability, and can be independently used as plastic. In various natural environments such as water, soil, compost and the like, the copolyester can be completely degraded in the natural environments to form environment-pollution-free carbon dioxide and water. The invention also discloses a preparation method and application of the degradable copolyester.

The invention discloses a glucose group-terminated PLLA diblock copolymer material and a preparation method thereof, belonging to the technical field of high polymer materials. The preparation methodcomprises the following steps: firstly, subjecting PLLA and 1,2:5,6-di-O-isopropylidene-D-gulose (IPG) serving as raw materials to a reaction under the conditions that a molar ratio of IPG to PLLA isgreater than 4: 1, a polymerization pressure is 10-300 Pa, and a polymerization temperature is 160-200 DEG C; and carrying out a melt polymerization reaction for 4-12 hours to prepare a poly(L-lacticacid)-isopropylidene glucose diblock copolymer (PLLAIPG), and removing a hydroxyl protection group of the PLLAIPG to obtain the glucose group-terminated PLLA diblock copolymer (PLLAG). The PLLAG material has a melting temperature of about 150 DEG C and a crystallinity of about 50%, which are similar to those of PLLA, but the hydrophilicity of the PLLAG material is superior to the hydrophilicity ofPLLA; and the contact angle of the PLLAG material is about 65 degrees while the contact angle of PLLAG is 88 degrees.

The disclosed concept relates to multi-layer dielectric film with nano- or micro-structured block copolymers, such as, but not limited to, di-block copolymers and tri-block copolymers, and, more particularly, to capacitors constructed from the film. More particularly, the disclosed concept provides the ability to tune or control one or more characteristics of the dielectric film and capacitors formed therefrom, by selecting and combining blocks that exhibit different electrical and / or mechanical properties.

A method of controlling both alignment and registration (lateral position) of lamellae formed from self-assembly of block copolymers, the method comprising the steps of obtaining a substrate having an energetically neutral surface layer comprising a first topographic “phase pinning” pattern and a second topographic “guiding” pattern; obtaining a self-assembling di-block copolymer; coating the self-assembling di-block copolymer on the energetically neutral surface to obtain a coated substrate; and annealing the coated substrate to obtain micro-domains of the di-block copolymer.

The invention relates to crizotinib prodrug polymeric micelle co-loaded with a chemotherapeutic drug and a preparation method thereof, belongs to the field of a high molecular material and a new dosage form of a medicinal preparation, and particularly relates to crizotinib prodrug polymeric micelle co-loaded with a chemotherapeutic drug, which has an effect of reinforcing tumor immunogenicity, anda preparation method thereof. The prodrug polymeric micelle is characterized by being formed by firstly polymerizing a hydrophilic POEG block and hydrophobic crizotinib through a Reversible Addition-Fragmentation chain Transfer (RAFT) method to obtain an amphiphilic diblock copolymer and then physically loading the chemotherapeutic drug into the diblock copolymer to carry out self-assembling. According to the invention, a co-delivery mode of adopting conventional predrug polymer physical loading or adopting a polymer predrug to carry out self-assembling and physically loading another drug small molecules is broken through, and by a polymerization method using a drug as a monomer, high-efficiency co-loading of the combined drug and in-vivo accurate co-delivery are effectively implemented.