Glucose group-terminated poly(L-lactic acid) (PLLA) diblock copolymer material and preparation method thereof

A diblock copolymer and glucose-based technology, which is applied in the field of poly-L-lactic acid diblock copolymer materials and their preparation, can solve the problems of difficult control of copolymer properties, unstable material properties, and difficult chain structure control.

Inactive Publication Date: 2020-04-21
NANJING FORESTRY UNIV
View PDF1 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] When monosaccharides and polysaccharides are copolymerized to modify polylactic acid, because the sugar molecules contain more hydroxyl groups, it is difficult to control the molecular chain structure of the copolymer, and the properties of the obtained copolymer are also difficult to control, resulting in unstable performance of the material
Among them, glucose contains 5 hydroxyl groups. When copolymerized with PLA, all hydroxyl groups may participate in the reaction. Therefore, it is difficult to control the number of hydroxyl groups of glucose in the copolymer and the number of PLA chain segments, resulting in unstable performance.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Glucose group-terminated poly(L-lactic acid) (PLLA) diblock copolymer material and preparation method thereof
  • Glucose group-terminated poly(L-lactic acid) (PLLA) diblock copolymer material and preparation method thereof
  • Glucose group-terminated poly(L-lactic acid) (PLLA) diblock copolymer material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] use as figure 2 The synthetic route shown prepares a poly-L-lactic acid-isopropylidene glucose diblock copolymer. (1) Preparation of 1,2;5,6-oxo-diisopropylidene glucose (IPG) by hydroxyl protection method. Add 10 g of glucose and 200 ml of acetone into the reactor, stir and add an appropriate amount of zinc chloride and phosphoric acid (the molar ratio of which is 1:0.1) in sequence, and react for 30 h at room temperature and normal pressure. Add 50% NaOH aqueous solution dropwise under rapid stirring to adjust the pH of the reaction system to 8.0, filter with suction, wash with acetone for 2 to 3 times until the filtrate is colorless and transparent, rotary evaporate the filtrate, dissolve the obtained solid in chloroform, wash and extract with water 2 to 3 times, the obtained chloroform solution was rotary evaporated, and the obtained sample was recrystallized 2 to 3 times with ethyl acetate and petroleum ether to obtain white needle-shaped IPG. (2) Preparation of...

Embodiment 2

[0023] The method in Example 1 was used to prepare IPG. The L-lactic acid that takes by weighing 100g is added in the reactor, is heated up to 150 ℃, normal pressure constant temperature reaction 1h, then depressurizes to 200Pa reaction 4h, then adds catalyst stannous octanoate (mass is 0.5wt% of PLLA), heats up to React at 180°C for 10h under reduced pressure to below 10Pa to obtain poly-L-lactic acid, then add IPG to the reaction system, the molar ratio of IPG to PLLA is 8:1, and react for 6h at 10Pa and 200°C. The obtained product was dissolved in chloroform, excess methanol was precipitated, and the precipitate was vacuum-dried to obtain PLLAIPG. The method in Example 1 was used to remove the hydroxyl protecting group of PLLAIPG to obtain PLLAG. use 1 H-NMR spectrum analysis showed that the molecular chain of PLLAG had a double-block structure of PLLA and IPG. The weight-average relative molecular mass of the diblock copolymer is 31600, the melting point is 152°C, the c...

Embodiment 3

[0025] The method in Example 1 was used to prepare IPG. The L-lactic acid that takes by weighing 100g is added in the reactor, is heated up to 150 ℃, normal pressure constant temperature reaction 1h, then depressurizes to 200Pa reaction 4h, then adds catalyst tin protochloride (mass is 0.3wt% of PLLA), heats up to React at 180°C for 6 hours under reduced pressure to below 10Pa to obtain poly-L-lactic acid, then add IPG to the reaction system, the molar ratio of IPG to PLLA is 10:1, and react for 8 hours at 10Pa and 200°C. The obtained product was dissolved in chloroform, excess methanol was precipitated, and the precipitate was vacuum-dried to obtain PLLAIPG. The method in Example 1 was used to remove the hydroxyl protecting group of PLLAIPG to obtain PLLAG. use 1 The molecular chain of diblock copolymer obtained by H-NMR spectrum analysis has PLLA and IPG diblock structure. The weight-average relative molecular weight of the diblock copolymer is 21200, the melting point is...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
crystallinityaaaaaaaaaa
melting pointaaaaaaaaaa
crystallinityaaaaaaaaaa
Login to view more

Abstract

The invention discloses a glucose group-terminated PLLA diblock copolymer material and a preparation method thereof, belonging to the technical field of high polymer materials. The preparation methodcomprises the following steps: firstly, subjecting PLLA and 1,2:5,6-di-O-isopropylidene-D-gulose (IPG) serving as raw materials to a reaction under the conditions that a molar ratio of IPG to PLLA isgreater than 4: 1, a polymerization pressure is 10-300 Pa, and a polymerization temperature is 160-200 DEG C; and carrying out a melt polymerization reaction for 4-12 hours to prepare a poly(L-lacticacid)-isopropylidene glucose diblock copolymer (PLLAIPG), and removing a hydroxyl protection group of the PLLAIPG to obtain the glucose group-terminated PLLA diblock copolymer (PLLAG). The PLLAG material has a melting temperature of about 150 DEG C and a crystallinity of about 50%, which are similar to those of PLLA, but the hydrophilicity of the PLLAG material is superior to the hydrophilicity ofPLLA; and the contact angle of the PLLAG material is about 65 degrees while the contact angle of PLLAG is 88 degrees.

Description

Technical field: [0001] The invention belongs to the technical field of polymer materials, and in particular relates to a glucose group-terminated poly-L-lactic acid diblock copolymer material and a preparation method thereof. Background technique: [0002] Polylactic acid (PLA) is a bio-based green thermoplastic derived from biomass that can eventually decompose into carbon dioxide, water and humus. PLA includes two optical isomers of poly-L-lactic acid (PLLA) and poly-D-lactic acid (PDLA). The specific rotation of PLLA is -160, while the specific rotation of PDLA is +160, and its optical activity has a great influence on the performance of PLA. have a significant impact. PLA has good degradability and mechanical properties, and can be used in biomedicine, packaging, textile fibers and other fields. However, polylactic acid has poor heat resistance and low hydrophilicity, which limit its application. Therefore, PLA needs to be modified to improve its performance. Copoly...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): C08G63/91C08G63/08A61K47/26A61K47/34
CPCA61K47/26A61K47/34C08G63/08C08G63/912
Inventor 高勤卫朱前进祁俐燕刘婷婷常开新曹丹
Owner NANJING FORESTRY UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap