The invention provides a hydrogen production catalyst system, a hydrogen production system comprising the same and applications of the hydrogen production catalyst system. The hydrogen production catalyst system comprises a metal nano catalyst and a biomass water solution. The metal nano catalyst catalyzes the biomass water solution to produce hydrogen. The hydrogen production efficiency and hydrogen production capacity of the catalyst system are controlled by the amount of oxygen. The hydrogen production efficiency of the catalyst system is increased, when the pressure or concentration of oxygen in the hydrogen production reaction system increases. For the first time, oxygen molecules are used to control the production speed of hydrogen. Moreover, the hydrogen production method is efficient, clean, and environmentally friendly, and is easy to control; and the equipment is simple. At a low temperature (not lower than 0 DEG C), water hydrolysis and biomass hydrolysis can be realized at the same time, the energy consumption is greatly reduced, an energy-consumption-free reaction condition can be almost realized, and the catalytic method is sustainable and has a wide application prospect. At the same time, the catalyst system can be applied to fields such as hydrogen production, energy and chemical industry, battery, water treatment, paint, functional textile, indoor air purification and formaldehyde removing, petrochemical engineering, carbon-hydrogen bond activation, pharmacy, hydrogen-containing water preparation, and the like.