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The invention belongs to the field of environmental engineering, which relates to an integrated expanded granular sludge bed-membrane bioreactor whole-course autotrophy denitrification device and a process thereof. The device comprises a reactor main body, an air / liquid separation tank, a three-phase separation device, a membrane assembly, an air pump, an air flow meter, a perforated aeration pipe, a water feeding pump, a reflux pump, a water discharging pump and the like, wherein the reactor main body is divided into two function regions, i.e., a lower whole-course autotrophy denitrification function region and an upper membrane filtration function region, wherein an air aeration mode is adopted by the bottom of the immersion-type membrane assembly in the upper membrane filtration function region; the upper part of the reactor is externally connected with the air / liquid separation tank; the reflux system is used for refluxing heavy-oxygen-enriched water in the tank to a water inlet in the bottom of the reactor so as to provide the necessary dissolved oxygen for the whole-course autotrophy denitrification function region; and the fed sewage is firstly denitrified by the whole-course autotrophy denitrification function region and then filtered by the membrane so as to obtain the clean discharging water. The integrated reactor is small in land occupation. The whole-course autotrophy denitrification process is simple and convenient to operate.