94 results about "Enteric disease" patented technology

The invention provides novel guanylate cyclase-C agonist peptides and their use in the treatment of human diseases including gastrointestinal disorders, inflammation or cancer (e.g., a gastrointestinal cancer). The peptides can be administered either alone or in combination with an inhibitor of cGMP-dependent phosphodiesterase. The gastrointestinal disorder may be classified as either irritable bowel syndrome, constipation, or excessive acidity etc. The gastrointestinal disease may be classified as either inflammatory bowel disease or other GI condition including Crohn's disease and ulcerative colitis, and cancer.

The invention provides novel guanylate cyclase-C agonist peptides and their use in the treatment of human diseases including gastrointestinal disorders, inflammation or cancer (e.g., a gastrointestinal cancer). The peptides can be administered either alone or in combination with an inhibitor of cGMP-dependent phosphodiesterase. The gastrointestinal disorder may be classified as either irritable bowel syndrome, constipation, or excessive acidity etc. The gastrointestinal disease may be classified as either inflammatory bowel disease or other GI condition including Crohn's disease and ulcerative colitis, and cancer.

This invention relates to glucagon-like peptide 2 (GLP-2) derivatives. In particular this invention relates to GLP-2 peptide derivatives having an extended in vivo half-life, for the treatment or prevention of gastrointestinal disorders or diseases such as inflammatory bowel disease and other gastrointestinal functions, from any segment of the gastrointestinal tract, from the oesophagus to the anus.

Variant of the bacterium Lactobacillus fermentum and its use in treating gastrointestinal disorders, disorders of the mucosal surfaces or disturbances in the immune system or status of a subject.

The present invention relates to the use of an immunogenic composition that comprises a PCV2 antigen for treatment of several clinical manifestations (diseases). Preferably, the clinical manifestations are associated with an enteric infection, even more preferably, with enteric disease. The use relates to a method comprising the steps of administering the composition to an animal in need thereof, preferably prior to disease exposure. Administration of PCV2 antigen, preferably ORF2 of PCV2, lessens the incidence and reduces the severity of the enteric disease.

Bacteria of the sp. Bacillus that produce a lipopeptide are found to be effective in the treatment and prophylaxis of gastro-intestinal disease when administered as a probiotic. In particular, a strain of Bacillus bacteria identified as PB6 is useful for the treatment of Antibiotic Associated Diarrhea (AAD) or the more serious condition Clostridium difficile associated diarrhea (CDAD) when administered as a probiotic. Additionally, these bacteria have been found efficient for the treatment of immunorelated diseases such as Inflammatory Bowel Disease (IBD).

The present invention relates, generally, to oral formulations including one or more recombinantly-produced human milk proteins. The formulations of the present invention may be used to prevent the onset of diarrhea in patients who have been or will be exposed to one or more agents known to cause diarrhea, and to prevent the recurrence of diarrhea in a patient recovering therefrom. The formulations may also be used in the treatment of inflammatory bowel disease, including Crohn's disease and ulcerative colitis. The formulations may also be beneficially administered in accordance with methods for promoting the development of healthy intestinal flora in a human patient.

The present invention provides a new antigenic class of avian reoviruses which are involved in enteric disease conditions in poultry. Moreover, the invention provides a vaccine for use in the protection of poultry against such disease conditions derived from the new type of avian reoviruses.

The invention discloses a method for preparing butyric acid bacteria powder by microencapsulated propagation culture and application, which belong to the technical field of microbial agents. In the invention, an initial strain is clostridium butyricunm JSIM-MCB20040312 with the preservation number of CGMCC (China General Microbiological Culture Collection) No.1647; the butyric acid bacteria powder is prepared by the steps of activation of butyric acid bacteria seeds, microencapsulated embedding of the butyric acid bacteria seeds, viable counting and preparation of butyric acid bacteria powder, wherein the concentration of the obtained bacteria powder is not less than 1.0*1011 / g. The viable organism propagation capacity of the butyric acid bacteria subjected to microencapsulated embedding is enhanced; a strict anaerobic environment created by liquid sealing of nitrogen gas or carbon diode and other inert gases or paraffin is avoided; a high-concentration bacteroid can be obtained without introducing air into a general fermentation tank for culturing; the production cost is low and the requirement for fed microbial additives on viable count can be met; the butyric acid bacteria powder also has the characteristics of heat resistance, acid resistance and favorable entericsolubility and is suitably used as animal intestine probiotics; and intestinal diseases of livestock and poultry farming animals such as chicken, pigs and the like are effectively prevented and the growth of the bred animals is promoted.

The invention provides a traditional Chinese medicine capsule (Commodity Name: Weishuning Capsule) used for curing acute and chronic gastric diseases and esophageal enteric diseases, in particular to a traditional Chinese medicine capsule used for treating digestive system diseases; the traditional Chinese medicine capsule can prevent digestive tract cancerization through long-term oral application. The traditional Chinese medicine capsule essentially comprises the components of cuttlebone, concha arcae, ginseng, goldenthread root, common aucklandia root, lilac, semen amomi, amomum cardamomum, rhizoma corydalis, largehead atractylode, spicebush root, bergamot, cinnamon, semen raphani, green tangerine peel, ventriculi galli mucosa, magnolia officinalis, hyacinth bletilla, asarum, areca, agalloch, burreed tuber, zedoary, rhubarb root, calcined concha ostreae, immature orange fruit and liquorice. Coarse powder and a concentrated solution are mixed according to certain proportion, stirred, dried, smashed and sieved to prepare the traditional Chinese medicine capsule; the traditional Chinese medicine capsule has good curative effect for treating varied gastrointestinal diseases including acute and chronic gastritis, gastrointestinal hemorrhage, gastric acid, stomach-ache and duodenal ulcer, superficial, atrophic and vesicant gastritis, colonitis, etc. The traditional Chinese medicine capsule has simple prescription and preparation technique, low cost and is applicable to people in countries and mountainous areas where doctors and medicines are insufficient.

The present invention relates to a combination of an anti-toxin, The present invention relates to a combination of an anti-toxin, an immunomodulator and a component that provides energy to mucosal cells, which may be useful for decreasing effects of Clostridia sp. or coccidia sp based diseases or other enteric diseases or by generally improving gastro intestinal health or function

The present invention relates to methods, compositions, and kits for detecting and quantitating exosomes and exosomal biomarkers and the use of exosomes and exosomal biomarkers in diagnostic and prognostic methods for various diseases and disorders. Disease and disorders of the present invention include neurological disorders, immunological disorders, placental diseases, cancer, hematological disorders, kidney disease, gastrointestinal diseases, liver diseases, and musculoskeletal diseases

The present invention relates to a livestock and poultry feed, and especially to a green livestock and poultry feed containing pine needle powder, and a preparation method thereof. The green livestock and poultry feed is prepared from the following raw materials, by weight, 1500-2000 parts of pine needle, 800-1100 parts of dandelion, 1200-1700 parts of beanstalks, and 4000-4500 parts of water. The green livestock and poultry feed of the present invention has characteristics of rich nutrient, feed saving and cost reducing, and provides significant effects for promotion of livestock and poultry growth and development, increase of disease resistance, and improvement of reproductive function. With the green livestock and poultry feed of the present invention, the disadvantages of low protein content and high digestive ability in the general farm feed and the market premix feed can be overcome, the appetite of the livestock and poultry can be effectively stimulated, the digestion-absorption and the metabolism can be promoted, the feed utilization rate can be increased, the growth and development of the livestock and poultry can be accelerated, the disease resistance can be increased, and the morbidities of the gastrointestinal diseases and the vitamin deficiency can be reduced.

The invention discloses a probiotics Chinese herbal medicine composite biological preparation which comprises Chinese herbal medicine and composite probiotics. The weight ratio of the Chinese herbal medicine to the composite probiotics is 3:1 to 6:1; the Chinese herbal medicine comprises the following components in part by weight: 5 to 20 parts of rhizoma atractylodis, 5 to 20 parts of eucommia ulmoides oliv, 5 to 15 parts of fructus amomi, 10 to 15 parts of Szechuan lovage rhizome, 5 to 15 parts of rehmannia glutinosa, 5 to 20 parts of astragalus and 5 to 15 parts of himalayan teasel root; and the composite probiotics comprises the following components in part by weight: 5 to 20 parts of lactobacillus micro-capsule, 1 to 4 parts of bacillus subtilis and 1 to 4 parts of yeast. The probiotics Chinese herbal medicine composite biological preparation is prepared by mixing 7 types of Chinese herbal medicine and 3 types of probiotics according to a certain proportion, is mainly used for preventing miscarriages of a sow at the late stage of pregnancy, increasing weight of embryos in the uterus of the sow at the time and preventing various enteric diseases, and improves the nutritional level of the sow in the process of preventing miscarriages by utilizing the synergistic effect of the Chinese herbal medicine and the probiotics.

A dietary and vitamin supplement, in capsule or powder form, for enhancing and maintaining digestive health and colon care, and alleviating gastrointestinal disorders, includes a blend of natural ingredients, including acidophilus, digestive enzymes and antioxidants, and which can be taken on an as-needed basis, in either capsule or liquid form, along with any other medications prescribed for the individual.

The present invention relates generally to therapeutic compositions for the treatment and / or prophylaxis of intestinal disease conditions in animals and birds caused or exacerbated by Lawsonia intracellularis or similar or otherwise related microorganism. In particular, the present invention provides a novel gene derived from Lawsonia intracellularis which encodes an immunogenic OmpH peptide, polypeptide or protein that is particularly useful as an antigen in vaccine preparation for conferring humoral immunity against Lawsonia intracellularis and related pathogens in animal hosts. The present invention is also directed to methods for the treatment and / or prophylaxis of such intestinal disease conditions and to diagnostic agents and procedures for detecting Lawsonia intracellularis or similar or otherwise related microorganisms.

Disclosed herein are compositions containing hydroxylstilbenes or their derivatives or analogues. The compositions are useful to inhibit protein kinease, and for the treatment of inflammatory diseases, including psoriasis, multiple sclerosis, rhumatoid arthritis, restinosis, inflammatory bowel disease, and inflammatory lung disease. They are also useful to treat surgical adhesions and graft rejection. Novel derivatives and analogues are also disclosed.

The invention discloses a direct feeding type biological fermentation feed additive and a preparation method and an application thereof. The feed additive provided by the invention is composed of ingredients, fermentation probiotics, enzymic preparations and saline solution medium. The product can be directly applied to livestock breeding and aquaculture, and has the effects of improving immunity of animals, enhancing premonition, improving food consumption and a feed conversion ratio, treating and preventing enteric diseases of animals, adjusting balance of intestinal microecology of animals and resisting stress. According to the method provided by the invention, the production strains are screened in a combined manner, a purification method is completed, production time of the strains is subjected to strict quality control, and the problem that biological fermentation is instable is solved. The feed additive is directly used after fermentation, the condition that no damage is caused to all bioactivators generated after fermentation is ensured, and meanwhile the problems about transportation and bacterial contamination in storage are also avoided, so that the effect and security of the product are improved, the cultivation cost is greatly reduced, and the feed additive has a positive promotion effect to green cultivation.

The invention discloses a preparation method of feed for fattening a yellow weasel quickly. The feed comprises chicken powder, pork powder, chicken liver powder, grass carp meat, silkworm chrysalis, corn powder, bran, radish powder, chicken wing powder, bone powder, milk powder, cod-liver oil, yeast, vitamins, angelica sinensis powder, liquorice powder, medlar powder and poria cocos powder, and the percentage is a weight percentage. The feed for the yellow weasel prepared by the formula is good in palatability, and can be absorbed easily; the growth speed is high; the disease resistance is high; the yellow weasel fed by the feed grows fast, and is large and healthy; and the preparation method effectively overcomes the defects that the growth and development of the yellow weasel are slow, the motility of young yellow weasels is high, and enteric diseases and constipation are caused easily to result in the death of the yellow weasel, due to the fact that the yellow weasel eats viscera of livestock for a long time, resulting in that the feed is single and is lack of nutrition required by the yellow weasel.

The present invention provides a component having effects in vivo of improving or optimizing the intestinal environment, suppressing intestinal putrefaction, or suppressing alternation of intestinal bacterial growth and / or pathological changes of intestinal bacterial growth in gut microbiota. The invention also provides an active ingredient suitably used for treating intestinal diseases. The invention provides a monoclonal IgA antibody that binds to amino acids 11 to 333 of serine hydroxymethyltransferase.

The invention provides a natural feed additive with functions of relieving diarrhea, resisting bacteria and eliminating inflammation. The natural feed additive is formed by main drugs and optional auxiliary materials, wherein the main drugs comprise the components in parts by weight: 5-40 parts of geranium wilfordii, 5-40 parts of houttuynia cordata, 2-15 parts of garden burnet, 2-35 parts of gallnut, 2-20 parts of radix berberidis or golden cypress and 1-20 parts of liquorice, and 0.5-10 parts of radix scutellariae, 1-8 parts of perfoliote knotweed herb, 5-10 parts of pileostegia viburnoides, 2-30 parts of purslane and 2-18 parts of cortex acanthopanacis (root, stem and / or leaf) can be added to the main drugs. The feed additive can be used for preventing or treating the respiratory diseases or enteric diseases of the domestic animals, especially the pneumonia or dysentery.

The invention discloses a thallus compound with an animal intestine repairing function and a production method of the compound. The compound mainly comprises three or any two of bacillus coagulans, clostridium butyricum and bacillus licheniformis. The production method of the thallus complex comprises the following steps of: selecting thallus, buffering and mixing materials, detecting viable bacteria, and packaging and storing. The thallus compound with a protecting and repairing function for the animal intestine can be used for shortening the repairing or recovering time of the injured intestine, reducing the occurrence of intestine diseases and improving the animal production efficiency.

A Chinese medicine for treating and curing the enteropathy of domestic animals and fowls is prepared from 9 Chinese-medicinal materials including pulsatilla root, phelldendron bark, houttuynia, isatis root, etc.

The present invention provides a method of treatment or prophylaxis of enteric disease caused by Gram negative bacteria. The method includes the step of administering a vaccine or a hyperimmune material raised against said vaccine to an individual. The vaccine comprises one or more cell wall antigens reactive in a manner characteristic of O group serotypes, or reactive in a manner characteristic of lipopolysaccharide associated antigens, and at least some of said antigens are separated from bacterial cell walls or wall fragments. The invention also provides composition containing hyperimmune material as well as uses of the composition and vaccine.

The invention relates to a microorganism multienzyme additive for promoting the growth and development of pets, which is characterized in that beneficial strains that are fixedly planted in healthy animal intestinal tract are filtered by microwave and radial-induced technology by adopting co-induction; methods of liquid complex culture and solid amplification culture are adopted, and special enzyme inducer and protein source are added, thereby causing the beneficial strains to amount to 3 billion / g and contain large quantity of physiological metabolites, such as organized eozymes, small peptides, antioxidants, free amino acid, vitamin, etc. The microorganism multienzyme additive of the invention facilitates the pets to be more glossy, massively built, more immune competent and protected from enteric diseases, such as diarrhea, constipation, acute and chronic enteritis, etc., rickets, osteoporosis, etc. Meanwhile, the pollution caused by the excrement of livestock and poultry is relieved; as being free of antibiotic or steroid hormone, the microorganism multienzyme additive is an environmental friendly, safe and novel product of breed technology.

The invention discloses a strain Anaerostipes sp B2131. The strain Anaerostipes sp B2131 has a collection number of CGMCC No. 1. 5295. The invention further simultaneously discloses application of thestrain Anaerostipes sp B2131 in preparation of drugs for preventing and / or treating inflammatory intestinal diseases. The enteric canal separated bacterium disclosed by the invention can be applied to products such as pharmaceutical compositions, foods, healthcare products and food additives as a probiotics preparation and is used for regulating a stable state of enteric canal florae and preventing and treating occurrence of enteric canal diseases such as the inflammatory intestinal diseases.

The invention provides a preparation method of a wild duck feed, which is composed of the following components in percentage by weight: pork liver powder, miscellaneous fish meal, worm powder, blood worm powder, silkworm powder, bone meal, soybean cake meal, corn flour, licorice powder, bamboo leaf powder, immature bitter orange powder, Chinese eaglewood powder, pumpkin seed powder, peucedanum root powder, tabasheer powder, clam shell powder and malt powder; the feed has the advantages of low production cost, easily-fetched materials, simple formula and preparation method and good raising effects; the raised wild ducks have bright feather color and low morbidity and are big and strong; according to the wild duck feed, the following defects that the feather color of the wild duck is dark and has no luster, the growth and development of the wild duck are slow, the stature is small and the weight is light, feathers of the whole body are loosened and the wild duck is not favor of moving, and the wild duck is easy to infect influenza, cough, rhinorrhea, vomiting, body fluid deprivation and diarrhea and enteric diseases, which are caused by nutritional deficiency which is caused by unreasonable feeding matching of some raising households and some raising fields are effectively overcome.