A clean preparation method of magnesium-aluminum-based layered composite hydroxide. The present invention uses magnesium hydroxide and magnesium oxide, pseudo-boehmite, inorganic strong acid, and functional anion-containing substances as raw materials, uses magnesium chloride or magnesium nitrate as a circulating medium, and utilizes the property that pseudo-boehmite can be peptized under acidic conditions Improve the reactivity of pseudo-boehmite, use magnesium chloride or magnesium nitrate to increase the concentration of magnesium ions in the solution, accelerate the formation rate of layered composite hydroxide and promote the dissolution of magnesium hydroxide and magnesium oxide, shorten the reaction time, overcome the water The preparation of layered composite hydroxide by thermal method has the disadvantages of high reaction temperature and long time consumption, but magnesium-aluminum-based layered composite hydroxide can be rapidly prepared under mild conditions. Magnesium chloride and magnesium nitrate can be recycled, and there is no waste discharge in the preparation process, which is green and environmentally friendly. The method has the advantages of rich source of raw materials, low price, simple preparation process, mild reaction conditions, easy industrial production and the like.