The invention belongs to the field of vacuum thermal-insulation plates, and particularly relates to a vacuum thermal-insulation plate core material for building. In the prior art, the existing core material does not have excellent pressure-resistant stability and excellent thermal-insulation stability, and has disadvantages of high heat thermal conductivity, high cost and difficult processing, and the heat inertness and the thermal insulation do not meet the stringent requirements. A purpose of the present invention is to solve the problems in the prior art. The technical scheme of the present invention is that the raw materials comprise, by weight, 20-25 parts of stone wool fibers, 18-22 parts of glass fibers, 23-26 parts of mineral wool, 22-26 parts of silicon dioxide, 14-18 parts of calcium chloride hexahydrate, 8-12 parts of quicklime, 6-9 parts of acrylic acid, 7-11 parts of polyvinyl alcohol, 4-8 parts of potassium bisulfite, 13-16 parts of bentonite, 11-14 parts of quartz sand, 9-13 parts of magnesium oxide, 5-8 parts of zinc oxide, and 30-35 parts of deionized water. The preparation method comprises: S1, adding acrylic acid and deionized water to a reaction kettle. According to the present invention, the vacuum thermal-insulation plate core material has advantages of excellent pressure-resistant stability, excellent thermal-insulation stability, low thermal conductivity, high hardness, excellent heat inertness, excellent heat insulation effect, low production cost, and convenient processing.