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51results about How to "Has antioxidant effect" patented technology

A health food

Disclosed is a antihypelipidemic and antihyperglycemic health food for preventing diseases including cardiovascular disease, diabetes, adjusting internal secretion, resisting osteoporosis and cancer, and beauty treatment. The raw materials include soybean powder 15-30 parts, pumpkin powder 15-30 parts, soybean isoflavones 0.5-1.5 parts, soybean saponin 2-5 parts, astragalus root 10-20 parts, wolfberry fruit 10-15 parts, kudzuvine root 10-15 parts, Chinese yam 10-15 parts, lotus plumule 6-10 parts, Siberian solomonseal rhizome 6-10 parts, cassia seed 6-10 parts, lily 5-8 parts, mulberry leaf 5-8 parts and ginseng 3-5 parts.
Owner:富天桂

Copper foil electrolysis production equipment with antioxidant effect

The invention relates to the technical field of production equipment for electrolytic copper foil, in particular to copper foil electrolysis production equipment with the antioxidant effect. The copper foil electrolysis production equipment comprises a worktable, a discharging assembly, a first transmission component, an electrolyte component, a first cleaning component, a second cleaning component, a first drying component, an anti-oxidation component, a second drying component, a second transmission component and a shearing component. The second cleaning component is identical to the first cleaning component in structure, and the first transmission component includes a first roller, a second roller and a first motor, and the electrolyte component comprises a copper sulfate solution pooland two lifting devices. According to the copper foil electrolysis production equipment with the antioxidant effect, the first cleaning component and the second cleaning component can thoroughly remove a copper sulfate solution on the surface of copper foil in a cleaning manner, so that the copper foil oxidation time can be prolonged; and the surface of the copper foil is coated with an anti-oxidation metal layer through an electroplating bath of the anti-oxidation component, so that the copper foil has the anti-oxidation effect, and the above technical problems are effectively solved.
Owner:赣州逸豪新材料股份有限公司

Anti-oxidizing preparation method of caviar

The invention relates to an anti-oxidizing preparation method of caviar. The anti-oxidizing preparation method comprises the following steps of stunning by electric shock and blood discharging, cooling by cold water and egg fetching, egg rubbing, screening and inspection, vacuum anti-oxidizing treatment in an emulsifying liquid, vacuum anti-oxidizing treatment in a plant impregnating liquid, pickling, low-temperature sterilizing, packaging and storing. The anti-oxidizing preparation method has the advantages that the fish eggs are treated by the pure natural plant impregnating liquid, and theforeign odor is removed; the certain anti-oxidizing effect is realized; the anti-oxidizing preparation method is suitable for similar fish egg processing technologies of sturgeon caviar, salmon caviar, trout caviar, cod caviar and the like, the standardization degree is high, and the anti-oxidizing preparation method is also suitable for industrialized large-scale production.
Owner:FISHERIES RES INST ANHUI ACAD OF AGRI SCI

Production method and use of natural tremella polysaccharide

The invention discloses a production method of natural tremella polysaccharide, wherein the production method comprises the following steps: selecting dry pest-free and non-toxic tremella, and crushing for standby application; adding distilled water into a container containing the dry tremella, extracting, adjusting the pH to 9.0 or more with an alkali, and extracting for 24-28 h at room temperature; after completion of the extraction, adding cation resin, washing, and adjusting the pH to 7.0 or less; next, intercepting high-molecular-weight impurities with an ultrafiltration film; concentrating the filtrate with a single-effect concentrator to the proportion of 1:3-1:5; carrying out alcohol precipitation of the concentrated liquid with ethyl alcohol, stirring for 1-2 h, and allowing to stand for 12-18 h; then using a plate type filter press, and collecting a white solid, namely the tremella polysaccharide. The invention also discloses an application of the natural tremella polysaccharide in production of cosmetic raw materials. The natural tremella polysaccharide has excellent antioxidant property; compared with ordinary tremella polysaccharide, although the final concentrations of the tremella polysaccharides are the same, the natural tremella polysaccharide has more excellent antioxidant property and has the effect of preventing skin aging.
Owner:BIOLAND BIOCHEM HAIMEN CO LTD

Ginseng leaf extractive manufacturing method and cosmetic composition comprising ginseng leaf extractive serving as effective ingredient

The invention relates to a ginseng leaf extractive manufacturing method and a cosmetic composition comprising the ginseng leaf extractive serving as an effective ingredient, and discloses a skin external cosmetic composition and a manufacturing method therefor. Compared with a conventional method which takes a pure ginseng leaf extractive as the ginseng leaf extractive of a conventional processed product, the method further improves the antioxidant effect and the activity inhibition and expression inhibition effect of matrix metalloproteinase through the ginseng leaf extractive (0.001-10.0% by weight) produced through a boiling-on-grain method or a method of stir-baking with vinegar. The composition can inhibit the activity of monophenyl oxidase and further improves the darkening skins or prevents the hyperpigmentation of the skin.
Owner:HANKOOK COSMETICS MFG

Method for separating small molecule peptides from soybeans and for preparing small molecule peptides and cosmetic composition

The invention relates to a method for separating small molecule peptides from soybeans and for preparing small molecule peptides and a cosmetic composition and specifically relates to a cosmetic composition which mainly contains small molecule peptide extractives separated from soybean cakes and therefore the cosmetic composition has antioxidant and anti-aging effects.
Owner:AMOREPACIFIC CORP

Low-roughness coating for automobile surface and preparation method of low-roughness coating

The invention discloses a low-roughness coating for an automobile surface. The low-roughness coating is prepared from the following materials in parts by weight: 26-32 parts of distilled water, 8-14 parts of alkyd resin, 7-11 parts of polyvinyl alcohol, 16-28 parts of a polyacrylate emulsion, 9-15 parts of a chlorosulfonated polyethylene resin emulsion, 16-20 parts of dichloroethylene, 13-15 parts of water-borne wax, 20-24 parts of clay, 6-8 parts of titanium dioxide, 11-15 parts of expanded vermiculite, 6-9 parts of ethyl acetoacetate, 10-12 parts of polysorbate, 4-8 parts of sodium salicylate, 16-20 parts of para aminobenzoic acid, 8-13 parts of nicotinamide and 20-22 parts of aluminite powder. The low-roughness coating for the automobile surface is low in surface roughness after being coated, high in bonding strength and good in antioxidant effect.
Owner:芜湖天鸿汽车零部件有限公司

Preparation method of coatings for waterproof nut granules

The invention relates to a food processing technology, in particular to a preparation method of coatings for waterproof nut granules, and belongs to the technical field of food processing. According to the preparation method disclosed by the invention, an insoluble-in-oil-water principle and a roll coating technique are used, so that surfaces of the granules are sequentially wrapped with hydrophobic substances of syrup, cocoa butter replacer, refined vegetable oil, polisher and the like, and the nut granules have the effects of being waterproof and crispness-keeping. Compared with the prior art, the nut granules wrapped by the coatings made by the method have the important difference that the nut granules can still keep original crisp mouth feel when being added in foods, such as yogurt, milk and milk beverages, being high in moisture content, as well as ice creams, and can achieve the effect of antioxidation, and the shelf life of the nut granules can be prolonged.
Owner:XUZHOU YITONG FOOD IND CO LTD

Easily cleaned automobile coating and preparation method thereof

The invention discloses an easily cleaned automobile coating which is prepared from the following raw materials in parts by weight: 75-80 parts of polytetrafluoroethylene, 32-38 parts of a tetrafluoroethylene-hexafluoropropylene copolymer, 14-16 parts of ethylene glycol monovinyl ether, 7-11 parts of triethanolamine, 6-8 parts of ethylene glycol monomethyl ether, 12-16 parts of epoxy resin, 13-18 parts of polyamide, 5-10 parts of silicon dioxide, 22-24 parts of vinyl acetate, 15-20 parts of isocyanate, 7-12 parts of zinc chromate, 4-8 parts of sodium lauryl sulfate, 12-14 parts of toluene diisocynate, 6-7 parts of methylcellulose, 3-5 parts of tantalum nitride, 1-4 parts of ammonium polyphosphate, 11-15 parts of zinc borate, 13-19 parts of methyl anyl alcohol and 13-16 parts of nano active carbon. The easily cleaned automobile coating disclosed by the invention is small in surface tension, easy to clean, good in high-temperature resistance and good in antioxidant effect.
Owner:芜湖天鸿汽车零部件有限公司

High-purity hyaluronic acid luster-effect skin-renewing essence

The invention discloses high-purity hyaluronic acid luster-effect skin-renewing essence. The high-purity hyaluronic acid luster-effect and skin-renewing essence is prepared from the following raw materials in parts by weight: 0.1 to 1 part of carbomer, 1 to 10 parts of glycerol, 1 to 10 parts of propylene glycol, 1 to 10 parts of jojoba oil, 0.1 to 1 part of triethanolamine, 0.1 to 5 parts of vitamin E, 0.05 to 1 part of sodium hyaluronate, 0.1 to 1 part of Germaben-II, 0.1 to 3 parts of polydimethylsiloxane, 0.1 to 1 part of allantoin, 1 to 10 parts of an aloe extracting solution, 8 to 15 parts of an earthworm extracting solution, 0.05 to 0.5 part of a flavoring agent and 10 to 100 parts of pure water. The essence disclosed by the invention has remarkable moisture-keeping, nourishing and anti-oxidization effects.
Owner:HUBEI MULAN TONGDA TECH

Method for using fermented soya bean grease as natural anti-oxidant

The invention discloses a method for using fermented soya bean grease as a natural anti-oxidant, comprising the following steps: flattening fermented soya bean and putting the flattened fermented soya bean in a grease extractor; adding an extractant in the grease extractor and conducting pumping filtration to obtain an oil-soluble mixed solution containing the fermented soya bean; carrying out underpressure distillation on the mixed solution to obtain fermented soya bean oil; and adding the fermented soya bean oil in edible oil or plant essential oil to be used as the natual anti-oxidant. According to the invention, by utilizing the method disclosed herein, a method of extracting grease from traditional fermented black curded beans and then using various edible oil or citrus essential oil as a natural anti-oxidant is realized, and the characteristics of simple preparation method, strong antioxidation activity, low cost, natural and health are achieved.
Owner:苏州鲜活饮品股份有限公司

A preparing method for coating color sintered magnesium-aluminum-zirconium refractory bricks

The invention discloses preparing method for coating color sintered magnesium-aluminum-zirconium refractory bricks, the coating color sintered magnesium-aluminum-zirconium refractory bricks are made of a mixture, a binder and a coating agent. The method comprises the steps of 1, preparing the mixture; 2, preparing the mixed slurry; 3,burning brick; 4,Color sintered magnesia alumina zirconia refractory bricks; 5, finishing tiles; 6) coating tiles; 7) coating color sintered magnesium-aluminum-zirconium refractory bricks. The coated color sintered magnesium aluminum-zirconium refractory bricks prepared by the present invention realizes the coloring of the sintered magnesium aluminum-zirconium refractory bricks, which are an important supplement to the achromatic sintered magnesia-alumina refractory bricks and characterized by the durability of anti-oxidation, high temperature, anti-erosion, wear resistance, low thermal conductivity and excellent thermal shock stability and so on.
Owner:CHANGXING MENGYOU REFRACTORIES

Dandelion natural lip balm for improving lip problems and preparation method thereof

PendingCN112402331APoor physical stimulationLighten lip linesCosmetic preparationsToilet preparationsShea butterDry skin
The invention provides a dandelion natural lip balm for improving lip problems, and the dandelion natural lip balm is characterized in that the dandelion natural lip balm comprises the following components: 1.5-3 grams of degreased mixed oil, 0.7-1 gram of white beeswax, 0.1 gram of candelilla wax, 0.1 gram of carnauba wax, 0.4-0.8 gram of shea butter, 0.03-0.08 gram of dandelion powder and 0.05-0.1 milliliter of vitamin E. The dandelion natural lip balm can effectively relieve inflammatory chapped lips, fade lip wrinkles, improve roughness, brighten lip color, diminish inflammation, kill bacteria, heal wounds and save dry skin, and is concentrated in gentle and long-lasting moisturizing, capable of deeply moistening skin, edible and non-toxic and harmless.
Owner:SHANDONG AGRI & ENG UNIV

Composite preservative containing natural essential oil nanoliposomes and application of composite preservative in preservation of sturgeon slices

The invention discloses a composite preservative containing natural essential oil nanoliposomes. The composite preservative comprises 1-2 parts of gallate and 1-2 parts of natural essential oil nanoliposomes (EO-NPs-Lps). The invention also discloses a preparation method of the natural essential oil nano-liposome (EO-NPs-Lps). The invention also discloses application of the preservative formula instorage of the sturgeon meat slices, and the preservative has the effects of preservation, corrosion prevention and oxidation resistance, and can delay the rotting and deterioration speed of food. Meanwhile, the preservative is non-toxic and edible, and the storage life can be effectively prolonged. The processing method is simple, convenient, low in equipment investment, safe and low in production cost.
Owner:ZHEJIANG GONGSHANG UNIVERSITY

Semen plantaginis active part and preparation method thereof

The invention relates to a semen plantaginis active part and a preparation method thereof, and belongs to the technical field of extracts. The technical problems that in the prior art, chemical components of semen plantaginis are different in anti-oxidation effect, the direct oral administration availability is low, and clinical application is restricted are solved. The preparation method of the semen plantaginis active part comprises the following steps of firstly, mixing semen plantaginis with an ethanol solution, carrying out wall-breaking crushing, standing, carrying out heating reflux, and concentrating until the crude drug amount is 2.5-5.0 g / mL, so as to obtain a concentrated solution; and adsorbing the concentrated solution by using macroporous adsorption resin, washing, eluting byusing an ethanol solution with the concentration of 15vol%-70vol%, collecting the eluate, concentrating, and freeze-drying to obtain the active part of the semen plantaginis. According to the preparation method, the active part of the semen plantaginis is separated through a column chromatography technology, wherein the elution part of the ethanol solution with the concentration of 15vol%-70vol%has an anti-oxidation effect, and particularly the elution part of the ethanol solution with the concentration of 50vol% has the optimal effect.
Owner:CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI

Medicament with functions of resisting oxidization and inhibiting hepatic tissue fibrosis and preparation method thereof

The invention provides a medicament with functions of resisting oxidization and inhibiting hepatic tissue fibrosis and a preparation method thereof. The medicament is prepared from the raw powder or extracts of radix codonopsis foetens, herba rhodobryi gigantei par, herba linderniae ruellioides and coconut. When the medicament is prepared from raw powder, the medicament is prepared from the following components in percentage by mass: 30 to 80 percent of radix codonopsis foetens powder, 15 to 40 percent of herba rhodobryi gigantei par powder, 5 to 30 percent of herba linderniae ruellioides rawpowder and the balance of coconut raw powder. When the medicament is prepared from extracts, the medicament is prepared from the following components: 0.02 to 10g / ml of radix codonopsis foetens extract, 0.02 to 10g / ml of herba rhodobryi gigantei par extract, 0.02 to 10g / ml of herba linderniae ruellioides extract and 0.02 to 10g / ml of coconut extract. By adopting the medicament provided by the invention, the MAO (Monoamine Oxidase) in the liver of an AD (Alzheimer disease) model mouse is reduced, the hepatic tissue fibrosis can be inhibited, the MDA (Methylene Dioxyamphetamine) in the serum ofthe AD model mouse can be reduced, and a certain oxidization effect is achieved.
Owner:栾云鹏

Carbon fiber reinforced polyamide composite material and preparation method thereof

The invention discloses a carbon fiber reinforced polyamide composite material comprising the following components in parts by weight: 100 parts of polyamide resin, 100 to 250 parts of carbon fibers,2-18 parts of an ethylene-methacrylic acid copolymer derivative, and 0.1-10 parts of calcium chloride and / or lithium chloride. A specific ethylene-methacrylic acid copolymer derivative is selected, and the crystallinity after impregnation is adjusted through calcium chloride and / or lithium chloride, so that the carbon fiber reinforced polyamide composite material has low porosity in the preparation process, and the mechanical property of the material is improved.
Owner:GUANGZHOU KINGFA CARBON FIBER NEW MATERIALS DEV

Pectin oligosaccharide containing fine dried noodles and preparation method thereof

The invention provides pectin oligosaccharide containing fine dried noodles. The pectin oligosaccharide containing fine dried noodles are prepared from the raw materials: high-gluten flour, edible salt, dietary alkali, pectin oligosaccharides and calcium stearyl lactylate. The invention further provides a preparation method of the pectin oligosaccharide containing fine dried noodles. The method comprises the steps of taking a sweet potato starch processing byproduct, i.e., destarched sweet potatoes as a main raw material, carrying out drying, screening, crushing, fermenting, acid treatment andconcentrating, then, carrying out radiation treatment, then, carrying out precipitating and drying so as to obtain the pectin oligosaccharides with low molecular weight, mixing the pectin oligosaccharides with the high-gluten flour and ingredients, adding water, carrying out dough kneading, and then, carrying out dough proofing, pressing, forming and drying, thereby obtaining the pectin oligosaccharide containing fine dried noodles. According to the pectin oligosaccharide containing fine dried noodles and the preparation method thereof, fine dried noodles, which are deeply loved by customers,serve as a carrier, and the pectin oligosaccharides with a certain nutritional health-care effect are added under the premise of guaranteeing the cooking quality of the noodles, so that the product is endowed with more nutritional health-care effects while the variety of fine dried noodle products is enriched.
Owner:湖北戴氏食品科技股份有限公司

Papaw extract and preparation method and application thereof to cosmetics

The invention discloses a papaw extract. A papaw fruit is dried and then crushed into powder, then papaw powder and an ethyl alcohol or methanol solvent are mixed at the proportion of 1:(10-30), ultrasonic extraction is performed at 60-80 DEG C, liquid is filtered by a microfiltration membrane, the filtrate is collected, vacuum rotary evaporation is performed under the condition that the vacuum degree is controlled to be 0.094-0.096 MPa to obtain a papaw extract concentrated solution, and the concentrated solution is subjected to freeze drying to obtain the papaw extract. The papaw extract can serve as an anti-allergic agent and particularly can be applied to skin cosmetics, the mass ratio of the papaw extract to the skin cosmetics is (0.0002-10):100, and the papaw extract is added into the skin cosmetics. The characteristic of simple and feasible preparation process is achieved, the finally obtained skin cosmetics are natural and safe, and the characteristics of aging resistance and the like are achieved while the antiallergic property is ensured.
Owner:SHANGHAI INST OF TECH

Extraction and separation process of lactic acid bacteria fermentation extract

The invention provides an extraction and separation process of a lactic acid bacteria fermentation extract. The process comprises the following steps of performing fermenting, extracting and separating to obtain the lactic acid bacteria fermentation extract, wherein the temperature and the time are adjusted in a three-stage temperature change mode to effectively improve the extraction rate of the lactic acid bacteria extract. The lactic acid bacteria fermentation extract has the certain anti-oxidation effect and moisturizing effect and can be applied to anti-oxidation daily chemical products.
Owner:绽妍生物科技有限公司

Preparation method of cool sunscreen cream with angelica-dahurica compound plant

The invention discloses a preparation method of cool sunscreen cream with an angelica-dahurica compound plant. The preparation method is characterized by comprising the following steps: adopting angelica-dahurica essential oil, liquorice flavone, green-tea essential oil, mint essential oil and honeysuckle essential oil to prepare compound essential oil; then in a reactor, adding the following components in percent by weight: 0.1-0.2% of carbomer and 25-30% of deionized water, after dissolving, adding 38-45% of compound essential oil, 6-10% of hexadecanol, 2-6% of silk fibroin, 2-4% of glycerinum and 15-20% of EM-90 emulsifier, stirring and mixing uniformly, adding triethanolamine, adjusting pH to be about 7.0, stirring at high speed, mixing together, standing for 24 hours, and thus obtaining the cool sunscreen cream with the angelica-dahurica compound plant and subpackaging into containers. The sunscreen cream emits natural fragrance, has the effects of bacteriostasis, skin moisturizing, whitening and sunscreen, has no side effect to a human body, is convenient in use and realizes average sunscreen effect of more than 90%.
Owner:UNIV OF JINAN

Anti-aging repairing agent and preparation method thereof

The invention belongs to the technical field of cosmetics, and discloses an anti-aging repairing agent and a preparation method thereof.The anti-aging repairing agent is prepared from, by weight, 50-100 parts of beta-nicotinamide mononucleotide, 5-25 parts of fenugreek essential oil, 5-25 parts of camellia oil, 5-12 parts of sodium hyaluronate, 1-15 parts of squalane, 50-100 parts of an anti-inflammatory agent, 20-40 parts of an antioxidant, 5-15 parts of a softening and moistening agent, 1-10 parts of a surfactant and 100-150 parts of water. By adding natural plant components, reducing the use amount of beta-nicotinamide mononucleotide and through the synergistic effect of all the components, the advantages of traditional Chinese medicine / medicinal and edible plants are fully played, skin inflammation caused by light aging is avoided or delayed, meanwhile, damage of free radicals caused by ultraviolet rays to the skin can be avoided and repaired, and the skin care effect is achieved. Therefore, the excellent anti-aging effect of the product is ensured, and the anti-aging effect is effectively realized.
Owner:HUAZHONG AGRI UNIV +1

Composition containing camellia sinensis extract

The present invention relates to a composition containing an extract of Camellia sinensis, preferably an extract of a novel variety of Camellia sinensis (Jangwon number 3), and more particularly, to acomposition containing, as an active ingredient, an extract of Camellia sinensis having a high content of epigallocatechin-3-O-(3-O-methyl) gallate (EGCG3'Me; 3'-O-Me-EGCG). A composition according to the present invention containing, as an active ingredient, an extract of Camellia sinensis having a high content of epigallocatechin-3-O-(3-O-methyl) gallate has an antioxidant effect due to the elimination and suppression of free radicals, has an anti-aging effect on the skin due to having an excellent ability to inhibit the formation of collagenase, has an anti-inflammatory effect due to inhibiting the expression and secretion of inflammatory factors, such as prostaglandin and IL-8 and the like, in skin cells, and has an excellent anticancer effect with respect to cancer cell lines derivedfrom various tissues.
Owner:AMOREPACIFIC CORP

Skin external preparation composition containing lotus seed extract

The invention relates to a skin external use composition using lotus seed extract as effective constituents and specifically relates to a skin external use composition which uses sprout lotus seed extract as effective constituents and which is capable of providing substantial skin moisture preservation improving effects.
Owner:AMOREPACIFIC CORP

Allium macrostemon extract and application thereof to antioxidation efficacy cosmetics

The invention provides an allium macrostemon extract and application thereof to antioxidation efficacy cosmetics. The allium macrostemon extract is characterized in that a preparation method comprisesthe steps of cleaning allium macrostemon; performing freeze drying and crushing; soaking obtained allium macrostemon powder by an ethanol water solution with the mass percent concentration being 60 to 80 percent; under the ultrasonic conditions that the temperature is 45 to 55 DEG C, the power is 140 to 160W and the frequency is 35 to 45KHz, ultrasonic treatment is performed for 25 to 35min; then, performing filtering by a microfiltration membrane with the hole diameter being 0.4 to 0.5mum; collecting filtering liquid; concentrating the obtained filtering liquid; performing freeze drying to obtain the allium macrostemon extract. The allium macrostemon extract has an antioxidation effect, so that when the allium macrostemon extract is used as an antioxidant to be applied to skin cosmetics,the antioxidation efficacy is achieved.
Owner:SHANGHAI INST OF TECH

Plant preservative composition suitable for cosmetics and preparation method of plant preservative composition

The invention relates to the technical field of cosmetics, in particular to a plant preservative composition suitable for cosmetics and a preparation method of the plant preservative composition. Theplant preservative composition suitable for cosmetics is prepared from ampelopsis grossedentata, cortex magnoliae officinalis and phellodendron bark. According to the plant preservative composition suitable for cosmetics, the ampelopsis grossedentata, the cortex magnoliae officinalis and the phellodendron bark are selected as a compound, the synergistic effect of active ingredients in the three plants is utilized, the inhibiting effect on microorganisms is achieved, and the high free radical scavenging effect is achieved, so that the defects in the prior art are overcome, the plant preservative composition has the advantages of being natural, free of irritation and good in corrosion resistance, and has the antioxidant effect; and according to the preparation method, the ampelopsis grossedentata, the cortex magnoliae officinalis and the phellodendron bark are subjected to a series of extraction operations of primary extraction and secondary extraction to prepare the plant preservative composition, and the preparation method has the characteristics of simple process, low production cost and suitability for large-scale production.
Owner:东晟源研究院(广州)有限公司

Clindamycin phosphate injection preparation and preparation method thereof

ActiveCN113143856ASolve the problem of "gluteal muscle contracture" caused by injectionHas antioxidant effectAntibacterial agentsOrganic active ingredientsPhosphoric Acid EstersPenicillin
The invention relates to the field of medicine invention, in particular to a clindamycin phosphate injection preparation and a preparation method thereof. According to the clindamycin phosphate injection preparation and the preparation method thereof, the clindamycin phosphate injection preparation is prepared from 130-170 g of clindamycin phosphate, 0.3-0.8 g of thioglycerol and 8-16 g of sodium hydroxide, and water for injection is added to fix the volume to 1000ml. The thioglycerol has the effect of a bacteriostatic agent and can replace benzyl alcohol in the prescription of an original developed preparation; meanwhile, thioglycerol has the effect of an antioxidant and can replace nitrogen charging in the production process, the problem that nitrogen charging is difficult due to the fact that the headspace of an injection penicillin bottle is too small is solved, and therefore the product stability is improved; and the clindamycin phosphate and the sodium hydroxide are added multiple times, the liquid preparation efficiency is very low, the thioglycerol has a pH buffering effect, the clindamycin phosphate and the sodium hydroxide can be quantitatively added multiple times and can be controlled within a target pH value range, the solution stability is improved, the dissolution time in the liquid preparation process is greatly shortened, and the production cost is reduced.
Owner:广东金城金素制药有限公司
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