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Injectable formulations of taxanes for cad treatment

InactiveUS20050272806A1Minimize potential risk of damageReduce frictionBiocideOrganic active ingredientsAntioxidantBlood vessel
Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the formation of blood clots. The drugs, agents, and/or compounds may also be utilized to treat specific diseases, including vulnerable plaque. Therapeutic agents may also be delivered to the region of a disease site. In regional delivery, liquid formulations may be desirable to increase the efficacy and deliverability of the particular drug. Also, the devices may be modified to promote endothelialization. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned. In addition, the devices utilized to deliver the implantable medical devices may be modified to reduce the potential for damaging the implantable medical device during deployment. Medical devices include stents, grafts, anastomotic devices, perivascular wraps, sutures and staples. In addition, various polymer combinations may be utilized to control the elution rates of the therapeutic drugs, agents and/or compounds from the implantable medical devices. Liquid formulations, including solutions and suspensions of the various drugs, agents and/or compounds, may be locally or regionally delivered. In each of these instances, antioxidants are utilized to prolong product integrity.
Owner:CARDINAL HEALTH SWITZERLAND 515 GMBH

Local vascular delivery of cladribine in combination with rapamycin to prevent restenosis following vascular injury

Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the formation of blood clots. Also, the devices may be modified to promote endothelialization. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned. In addition, the devices utilized to deliver the implantable medical devices may be modified to reduce the potential for damaging the implantable medical device during deployment. Medical devices include stents, grafts, anastomotic devices, perivascular wraps, sutures and staples. In addition, various polymer combinations may be utilized to control the elution rates of the therapeutic drugs, agents and/or compounds from the implantable medical devices.
Owner:WYETH LLC

Modular re-configurable profiling core for multiprocessor systems-on-chip

A modular dynamically re-configurable profiling core may be used to provide both operating systems and applications with detailed information about run time performance bottlenecks and may enable them to address these bottlenecks via scheduling or dynamic compilation. As a result, application software may be able to better leverage the intrinsic nature of the multi-core hardware platform, be it homogeneous or heterogeneous. The profiling functionality may be desirably isolated on a discrete, separate and modular profiling core, which may be referred to as a configurable profiler (CP). The modular configurable profiling core may facilitate inclusion of rich profiling functionality into new processors via modular reuse of the inventive CP. The modular configurable profiling core may improve a customer's experience and productivity when used in conjunction with commercial multi-core processors.
Owner:SIMON FRASER UNIVERSITY

Mesoporous nano silicon ball compound targeting drug delivery system as well as preparation method and application thereof

The invention relates to a mesoporous nano silicon ball compound targeting drug delivery system as well as a preparation method and application thereof. The preparation method of the mesoporous nano silicon ball compound targeting drug delivery system comprises the following steps: 1) preparing amino-functionalized drug loading mesoporous silicon dioxide microspheres; 2) preparing hyaluronic acid-hydrosulphonyl polypeptide-adriamycin (HA-RGD-DOX); 3) preparing mesoporous microsphere-hyaluronic acid-hydrosulphonyl polypeptide-adriamycin--paclitaxel (MSNs-HA-RGD-DOX_PTX); and 4) preparing fluorescent marker modified mesoporous microsphere-hyaluronic acid-hydrosulphonyl polypeptide-adriamycin--paclitaxel compound (MSNs-HA-RGD-DOX-PTX). The mesoporous nano silicon ball compound targeting drug delivery system has the beneficial effects that firstly multi-targeting synergistic drug delivery is realized, multiple tumour cells and tissues can be killed, and reversal drug resistance is good; secondly, blood stability is excellent; thirdly, invisibility, drug release degree and controlled release properties are good; fourthly, in vivo tracing function is good; and fifthly, the mesoporous nano silicon ball compound targeting drug delivery system has good general applicability.
Owner:WUHAN UNIV OF TECH

Organic compound, charge-transporting material, composition for charge-transporting material and organic electroluminescent device

An organic compound having excellent heat resistance, an excellent amorphous nature, an excellent ability to transport charges, highly excited singlet and triplet states, and excellent solubility in an organic solvent is an organic compound represented by Formula (I):wherein Ar1 represents an optionally-substituted aromatic hydrocarbon group, an optionally-substituted aromatic heterocyclic group, or an optionally-substituted alkyl group; Ar2 represents an optionally-substituted aromatic hydrocarbon group or an optionally-substituted aromatic heterocyclic group; R1 and R2 each represent a hydrogen atom or a substituent, and R1 and R2 may be bonded to each other to form a ring; and Q is represented by Formula (I-1) or (I-2):wherein Ar3 to Ar5 each represent an optionally-substituted aromatic hydrocarbon group or an optionally-substituted aromatic heterocyclic group, and Ar3 and Ar4 may be bonded to each other to form a ring.
Owner:MITSUBISHI CHEM CORP

Nano-impression test-based test method for determining macroscopic mechanic properties of granite

The invention discloses a nano-impression test-based test method for determining the macroscopic mechanic properties of granite. The method comprises the following steps: carrying out high temperature treatment on a granite sample at a preset temperature, carrying out X-ray diffraction test, analyzing mineral components and the change of the mineral components with the temperature, using a nano-impression tester to measure all mineral mechanical properties and the change of the mechanical properties with the high temperature treatment at different preset temperatures, analyzing the influences of the microscopic mechanic properties of all minerals on the granite, obtaining the macroscopic mechanic properties of the granite by using the measured mineral mechanical properties and equalization method analysis, and compared with the obtained macroscopic mechanic properties with mechanical properties obtained through traditional mechanical test. The method provides a supplement for the macroscopic characteristics of the granite, provides a technical support for engineering practices, makes the macroscopic properties maximally approach practical engineering conditions, and provides reliable data guarantee for the safety of an engineering structure.
Owner:HUBEI UNIV OF TECH

Low-toxicity mannich base compound, prepared acidizing corrosion inhibitor and preparation method thereof

ActiveCN103896877ASafe and easy production operationReduce dosageOrganic chemistryDrilling compositionIonSolvent
The invention relates to a low-toxicity mannich base compound for preparing an acidizing corrosion inhibitor. A molecular formula of the compound is shown in the specification. The invention also relates to a mannich acidizing corrosion inhibitor prepared by using the mannich base compound, and further relates to a mannich synergistic acidification corrosion inhibitor formed by the mannich acidizing corrosion inhibitor and a halide ion synergist in a compounding manner. In addition, the invention relates to a preparation method of the mannich acidizing corrosion inhibitor. A formula of the mannich acidizing corrosion inhibitor is prepared from a main mannich acidizing corrosion inhibitor, an organic solvent, a surfactant, a corrosion additive and a solvent in the compounding manner. The invention further relates to a method for preparing the mannich synergistic acidification corrosion inhibitor by using the method. By adopting the mannich base compound, the acidizing corrosion inhibitor and the preparation method thereof, the problems that the corrosion inhibitor product in the prior art is serious in pollution, high in cost, and unstable in performance are solved.
Owner:BC P INC CHINA NAT PETROLEUM CORP +1

High heat and chlorine resistant polyurethaneurea elastic fiber and preparation of thereof

The present invention relates to a preparation method of polyurethaneurea elastic fiber, particularly a preparation method of high heat-resistant elastic fiber which retains unique physical properties of elastic fiber under the high temperature process. The polyurethaneurea elastic fiber of the present invention is characteristically prepared without using 1 functional mono-alcohol generally usedto regulate the reaction speed and side-reaction during the prepolymer reaction to produce elastic fiber having excellent heat- resistance particularly for the dyeing processing or re-dyeing of polyester but using ethylenediamine alone as a chain extender for the polymerization. To reduce gel formation in polymer after the secondary polymerization and to regulate change of viscosity in the courseof process, the ratio of the chain extender amine to the terminal group of prepolymer of the first polymerization is increased. The present invention relates to the polyurethaneurea elastic fiber andthe preparation method of the same having excellent chlorine resistance, which favors the production of swimsuit by two-way knitting using nylon yarn. The polyurethaneurea elastic fiber prepared by the polymer mixture of the present invention has excellent heat- resistance and chlorine-resistance, so that it is endurable in chlorine -containing water of swimming pool and can be effectively produced as high quality yarn by combined-weaving of nylon or polyester.
Owner:TAEKWANG IND CO LTD

Degradable animal chewing article possessing enhanced safety, durability and mouth-feel

A chewable, biodegradable article for use as a pet toy comprises a matrix made of a natural polymer, a synthetic organic polymer or a mixture thereof, a natural or synthetic fibrous material that comprises fibers and that is bonded chemically or physically with the matrix material, and, optionally, includes one or more microbe inhibiting agents that inhibit the growth of microbes in or on the article. The presence of the fibrous material inhibits formation of sharp edges upon breakage when the article is chewed, thereby rendering the article safer when used by pets. Also disclosed are processes for manufacturing the above article.
Owner:ANIMAL MAJESTY
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