The invention provides a modified maleimide resin composition, which is prepared from epoxy siloxane-modified maleimide prepolymer, thermosetting resin, and inorganic filler; maleimide compound and aromatic amine compound react in advance, so that maleimide-modified aromatic amine compound is prepared, epoxy siloxane is then added into the maleimide-modified aromatic amine compound to react, and thereby the epoxy siloxane-modified maleimide prepolymer is obtained. The invention further provides a prepreg prepared from the modified maleimide resin composition and a laminate prepared by laminating the prepregs. The modified maleimide resin composition and the prepreg and the laminate prepared therefrom which are provided by the invention have the advantages of low thermal expansibility, highbinding property, high heat resistance, excellent reactivity, low moisture absorption rate and high flame-retardant property, can be applied in the field of IC (integrated circuit) packages, such asCSP (Chip Scale Package), PoP and SIP (System in Package), and have a broad application prospect.