43results about How to "Avoid ingestion" patented technology

The invention discloses a photographing method and a photographing device. The photographing method comprises the steps of acquiring one or more consecutive frames of a preview image of a to-be-photographed scene; detecting whether the one or more consecutive frames have preset features; if yes, controlling a camera to photograph the to-be-photographed scene. Through adoption of the photographing method, the problem caused by the fact that the content displayed by a displayer is easy to photograph in the prior art is solved, so that data shown by the displayer is prevented from being taken and revealed, and the data are better protected.

A process for producing a fat in which a triglyceride formed by the bonding of molecules of one highly unsaturated fatty acid respectively to the three hydroxy groups of glycerol accounts for 20 wt.% or more of all triglycerides, characterized by incubating a microorganism capable of yielding the fat and collecting the fat according to need; and a fat obtained by the process.

The invention belongs to the technical field of medicines, relates to a photosensitizer-chemotherapeutic drug 'photosensitizer-chemotherapeutic integration' micromolecule prodrug, and aims to connecta chemotherapeutic drug with a photosensitizer through ester bonds or mono-thioether bonds to achieve efficient co-carrying and synchronous delivery of the chemotherapeutic drug and the photosensitizer. The photosensitizer-chemotherapeutic drug is prepared from paclitaxel as a chemotherapeutic drug and coked phaeophytin a as a photosensitizer, a self-assembled nano medicine delivery system is alsoprepared, and synergetic medicine release, in-vivo pharmacokinetics and anti-tumor effects of the drug are evaluated. The predrug is simple in preparation process, small and uniform in nanoparticle size, beneficial to enrichment of nanoparticles at tumor parts through an EPR (Enhanced Permeability and Retention) effect, super large in drug loading capacity and easy in surface modification, and reticuloendothelial system uptaking can be effectively avoided, in addition, uptaking of tumor cells upon the nanoparticles can be effectively improved; while photodynamic treatment is carried out, selective release of medicines can be synergistically triggered in tumor cells; by adopting the 'photosensitizer-chemotherapeutic integration' micromolecule prodrug self-assembled nano drug delivery system designed by the invention, the synergetic anti-tumor effects of the photosensitizer and the chemotherapeutic drug can be remarkably improved.

The invention designs and synthesizes a series of paclitaxel-oleic acid small-molecular prodrugs; with the application of a chemical connecting arm which is sensitive to an oxidation-deoxidation environment, the rapid release of the drugs in tumor cells is promoted. On the basis, small-molecular prodrug self-assembled nano-drug delivery systems are prepared. The small-molecular prodrug self-assembled nano-drug delivery systems have the advantages that by virtue of a one-step nano-precipitation method, nano-drug self-assembled nanoparticles are simple in preparation process and easy for industrialization; the nano-drug self-assembled nanoparticles are small and uniform in grain size (to 100nm), and the nano-drug self-assembled nanoparticles are enriched in a tumor part by virtue of an EPR (enhanced permeability and retention) effect; an ultrahigh drug-loading capacity is guaranteed, which is beneficial for reducing adverse reactions caused by auxiliary materials and biological materials; surface modification is easy to implement, and the intake of a reticuloendothelial system can be effectively avoided and the intake of the tumor cells to the nanoparticles can be improved by virtue of PEG (polyethylene glycol) and active targeting modification; and on the basis of the sensitivity of the chemical connecting arm to the oxidation-deoxidation microenvironment of the tumor cells, the specific drug release of paclitaxel in the tumor part is achieved, a curative effect is improved and toxic and side effects are reduced.

The present invention discloses a shooting method and device, wherein the method includes: acquiring one or multiple consecutive frame pictures of a preview image of a scene to be photographed; detecting whether predetermined features are included in the one or multiple continuous frame pictures; If the result is yes, the camera is restricted from shooting the scene to be shot. The present invention solves the problem in the related art that the content displayed on the display is easily photographed, avoids the data displayed on the display from being ingested and leaked, and improves the protection of data.

The present invention relates to weakly basic derivatives of cabazitaxel and preparations thereof, in particular to the synthesis of weakly basic derivatives of cabazitaxel, liposome preparations containing the derivatives and their application in drug delivery systems, belonging to medical technology field. The weakly basic derivative of cabazitaxel is connected with a weakly basic intermediate through an ester bond, and the ester bond can be broken by the action of esterase in the body to release the active drug. Its structural general formula is as follows: wherein, linking group is C 1 -C 4 Alkyl, C 3 -C 6 Cycloalkyl or phenyl; [N] is N-methylpiperazinyl, piperidinyl, 4-(1-piperidinyl) piperidinyl, morpholinyl, tetrahydropyrrolyl or other tertiary amine structures. The weakly basic derivatives of cabazitaxel of the present invention can be prepared into liposome preparations. The liposome preparation has the characteristics of high drug loading, high encapsulation efficiency, good stability and the like. After injection, it can greatly increase the circulation time of the drug in the body, increase the accumulation of the drug in the tumor site, and improve the anti-tumor effect and tolerance dose. .

The invention discloses a preparation method of a green degradable rice hull fast food oil absorption film. The preparation method comprises the following steps: carrying out cleaning, acid treatmentand steam explosion on rice hulls; preparing a colloidal solution containing chitosan, polylactic acid, isopropyl titanate triisostearate, and the like; compounding the rice husks and the colloidal solution to prepare a film; carrying out phase inversion on the prepared film; and performing lipophilic treatment on the prepared thin film. The preparation method of the oil absorption film provided by the invention is simple and easy to operate; the raw materials are cheap, easy to obtain, safe, non-toxic and low in cost, the prepared fast food oil absorption film has the advantages of being safe, environmentally friendly, attractive, degradable and the like, excessive oily substances overflowing from upper-layer food can be effectively adsorbed when the fast food oil absorption film is placed at the bottom of a fast food box, and the fast food oil absorption film is particularly suitable for staple food fast food mixed with cooked rice such as cooked rice.

The invention discloses an miRNA-supported composite nanoparticle. The miRNA-supported composite nanoparticle is prepared from a cation targeted membrane material, an acid sensitivity membrane material and at least one miRNA, wherein the cation targeted membrane material is selected from a galactose-polylysine-polycysteine polymer; the acid sensitivity membrane material is selected from a polyethylene glycol-polylysine polymer of which a side chain is modified by 3,4,5,6-tetrahydrophthalic anhydride ligand; and the miRNA is selected from miRNA for inducing differentiation from tumor-associatedmacrophage to M1 type macrophage. According to the miRNA-supported composite nanoparticle disclosed by the invention, accurate delivery of the tumor-associated macrophage is realized by pH value targeting and active targeting, and the function of promoting the differentiation from the tumor-associated macrophage to the M1 type macrophage is realized.

The present invention relates to an antitumor drug or a drug carrier comprising a glutamine-modified cyclodextrin, and its application in the preparation of an antitumor drug, wherein the glutamine-modified β-cyclodextrin can form an inclusion complex with a chemotherapeutic drug Drugs that transport chemotherapy drugs into tumor cells by targeting the abnormally high-expressed glutamine transporter ASCT2 in tumors, glutamine-modified cyclodextrin or glutamine-modified β-cyclodextrin combined with doxorubicin or paclitaxel The formed clathrate can target the glutamine transporter ASCT2, and be recognized by the transporter, transported into the tumor cells, and then kill the tumor cells; in the tumor-bearing body, the tumor is the largest glutamine uptake organ, while the liver, Kidneys, lungs, and muscles are all glutamine-secreting organs, so targeting glutamine transporters can reduce the toxic and side effects of chemotherapy drugs on liver, kidney, lungs and other major organs.

The invention belongs to the field of biotechnology, and relates to a tumor active targeting nano drug delivery system controlled by slightly acidic environment, and a preparation method thereof. The tumor active targeting nano drug delivery system controlled by slightly acidic environment is prepared by self-assembly of a targeting peptide modified dendrimer encapsulated gene, wherein connection of the targeting peptide is realized via pH sensitive bonds using shielding molecules, and the surface of the dendrimer is rich of amino groups. According to the nano drug delivery system, because modification effect of the shielding molecules in the system, the active targeting nano drug delivery system is improved; targeting and curing efficiency are high; the preparation method is simple and convenient; and tumor cell drugs, which are derived from human or animal, and is used for targeted therapy, can be prepared.

The invention relates to a toxin-removed animal liver food which includes a complete and fresh toxin-removed animal liver, seasonings and spices. A complete and fresh liver is rapidly taken out of an animal body, the gall bladder is cut off, the first porta hepatis of the liver is rapidly dissected, a disinfected medical catheter is inserted into the portal vein, biliary tract and hepatic artery blood vessel; perfusate is filled, macrophages and other immune cells containing a large amount of toxins, blood, harmful substances and bile of the liver are constantly discharged out; when the fresh liver changes from blood red to white, liver processing is completed. The toxin-removed animal liver is made into the food, nutrient substances in the liver are supplemented, meanwhile toxic substance ingestion is avoided, and the liver food is safer and healthy. In addition, the animal liver subjected to toxin removal processing has not poor smell and dry and hard taste existing in the common liver. Compared with common liver foods, the product has a more elastic, softer and unique taste and is more delicious.