Patents
Literature
Hiro is an intelligent assistant for R&D personnel, combined with Patent DNA, to facilitate innovative research.
Hiro

59 results about "WATER SOLUBLE BASE" patented technology

In water, by altering the autoionization equilibrium, bases yield solutions in which the hydrogen ion activity is lower than it is in pure water, i.e., the water has a pH higher than 7.0 at standard conditions. A soluble base is called an alkali if it contains and releases OH− ions quantitatively.

Subing (quick effect heart rescue) spraying agent and its preparation method

InactiveCN102370673AAvoid Volatile DefectsPlay suitable forHydroxy compound active ingredientsAerosol deliveryNasal cavityAngina
The invention provides a novel traditional Chinese medicinal compound Subing (quick effect heart rescue) spraying agent and its preparation method and belongs to the field of biomedicine, wherein the Subing (quick effect heart rescue) spraying agent has a good curative effect of resisting coronary angina pectoris. The problem of dissolving borneol with levant storax oil is solved by a new technology and a new method. The prescription is composed of styrax, borneol, a solubiliser, an absorption enhancer and a solvent. By the simple new technology of dissolution, homogenization and the like, borneol which is completely insoluble in water and levant storax oil which is not miscible with water phase are dissolved together in an oral water-soluble base so as to obtain an oral solution which is uniform and transparent without layers and suspension. The spraying agent or aerosol prepared in the invention can be quantitatively and directly sprayed into mouth or sprayed under tongue or directly sprayed into nasal cavity. In comparison with a solid preparation, the spraying agent prepared by styrax and borneol for oral administration has advantages of fast absorption and rapid effect, can perform a curative effect better and faster, is applicable to be taken by patients with angina pectoris during the acute phase. By the adoption of the preparation method provided by the invention, the effect onset time is greatly shortened within 60 seconds. The preparation method provides a good therapeutic novel medicine for currently high frequency and high occurrence of heart disease in our country.
Owner:王登之

Pesticide effervescence combination and preparation method thereof

The invention relates to a agricultural chemicals branch of technology, specifically to an agriculture chemicals effervescence composition and a preparation method thereof.The invention discloses an agricultural chemicals effervescence composition comprising effervescence components, active compounds of agricultural chemicals, and the invention is characterized in that, taking the total weight as the basic reference, the agricultural chemicals effervescence composition also comprises the following components that water soluble base with a percentage by weight of 5-45% and water-soluble high molecular polymer with percentage by weight of 3-30% which form a united vector, and the active ingredients of agricultural chemicals are coated by the carrier to form a solid highly dispersed system.Every type of matters in the agricultural chemicals effervescence composition of the present invention has a better water-soluble performance, active compounds of agricultural chemicals can be highly dispersed into particles with a size of 0.001-0.1micrometre, the particle size of the active compounds of agricultural chemicals is much smaller than that of water-dispersion granulas, water dispersible powder and the like, the composition does not include any water-insoluble matters such as waterproofing agents, thinning agent and the like that are used by conventional effervescing agents, and once in water, the obtained effervescence composition is disintegrated instantly and rapidly and can be diffuse easily.Therefore, suspending particulate matters will never appear in the obtained solution, and if the prescription is reasonable, the solution will be clear and transparent; therefore, the composition can not only be used for expelling agriculture disease, but also be extensively used in the filed of expelling sanitation disease.
Owner:NAVY MEDICINE RES INST OF PLA

A method for preparing oil-soluble iron ferric oxide nanoparticles by oil-water interface method

The invention relates to a method for preparing oil-soluble ferroferric oxide nanoparticles by virtue of an oil-water interface, and the method comprises the following steps: synthesizing oil-soluble iron stearate from a water-soluble iron salt and a fatty acid salt and dispersing the oil-soluble iron stearate in a non-polar solvent to prepare an oil-phase reaction solution; mixing an aqueous phase, namely a water-soluble ferrous salt solution) with the oil phase, adding an oil-soluble surfactant, adding a water-soluble base solution into the oil-water system, stirring at a high speed, and reacting while condensing and refluxing; and after the reaction is finished, standing for layering, and collecting the upper-layer oil phase to finally prepare the ultra-fine oil-soluble ferroferric oxide nanoparticles. The method provided by the invention has the advantages of simplicity and convenience in operation, low production cost, short production period and good repeatability; and the prepared ferroferric oxide nanoparticles are monodisperse and have the advantages of excellent particle uniformity and dispersion property, very small particle size, high purity, no settlement when being dispersed in the oil phase for a long time, easiness in storage and the like.
Owner:DONGHUA UNIV

Depolymerization process

The present invention relates to a method for decomposing polymers into monomers or oligomers by hydrolysis using subcritical water or supercritical water. The method of the present invention is characterized in that at least a part of the polymer is a polymer containing structural units derived from organic acids in the molecular structure, and the polymer is mixed with subcritical water or supercritical water in the presence of a water-insoluble alkali. touch.
Owner:MATSUSHITA ELECTRIC WORKS LTD

Base for external preparations for the skin and cosmetic containing the same

A base for a skin external composition comprises, as a main ingredient, an alkylene oxide derivative represented by the following formula (I): R1O—[(AO)m(EO)n]—R2  (I) wherein AO is an oxyalkylene group having a carbon number of 3 to 4; EO is an oxyethylene group; and R1 and R2 may be the same or different, and are a hydrocarbon group having a carbon number of 1 to 4, or a hydrogen atom. The base is a water-soluble base that can exert both of the smooth feeling and the moist feeling.
Owner:SHISEIDO CO LTD +1

Anti-shrinking lace containing highly-water-soluble base fabric

The invention discloses an anti-shrinking lace containing a highly-water-soluble base fabric. The lace comprises a water-soluble base fabric layer, an embroidered structural layer is arranged on the water-soluble base fabric layer, the embroidered structural layer is formed by computer design and machine embroidery, and the water-soluble base fabric layer is made through mixing polyvinyl alcohol and vinylon fibers; a product obtained after the machine embroidery is finished is placed in a cleaning device at a water temperature of 80-85 DEG C for 4-5 min to dissolve the water-soluble base fabric layer in order to obtain a hollow-out water-soluble embroidery; the embroidered structural layer is made by boiling viscose filaments at 120-135 DEG C for 30-45 min, air-drying the boiled viscose filaments, and embroidering the boiled viscose filaments on the water-soluble base fabric layer; and a mixing ratio of the polyvinyl alcohol to the vinylon fibers in the water-soluble base fabric layeris 1:1.
Owner:JIANGSU WEIMIAO TEXTILE TECH CO LTD

Process for the production of cilostazol

InactiveUS20070105898A1Mass productionExcellent starting materialBiocideOrganic chemistryOrganic solventHalogen
A process for the preparation of cilostazol of formula I from 6-hydroxy-3,4-dihydroquinolinone of formula II and 1-cyclohexyl-5-(4-halobutyl)-tetrazole of formula III, wherein X is a halogen atom such as Cl, Br, and I, that includes combining compounds II, III, a water-miscible organic solvent, a water-soluble base and water. The cilostazol can then be separated from the reaction mixture and dissolved in a solvent A. The resulting cilostazol solution is mixed with a solvent B to precipitate cilostazol particles of defined particle size range, milling the precipitate if desired, and filtering and drying the product.
Owner:APOTEX PHARMACHEN INC

No-clean type gel film eye masks and preparation method thereof

The invention discloses no-clean type gel film eye masks and a preparation method thereof. The preparation method comprises the following steps: 1, mixing one or more high molecular weight solid materials with one or more low molecular weight solid materials or no low molecular weight solid material to obtain a mixture and dissolving the mixture in water; 2, adding functional cosmetics materials having functions of whitening, moisturizing, resisting wrinkles, removing dark eye circles and the like in the mixed water solution so as to prepare a uniform and stable mixed water solution; 3, preparing a film in a certain processing way, drying and cutting the film to form the shapes of the eye masks. According to a water-soluble base material prepared by adopting the method, the water-soluble base material has certain mechanical performance, additional supporting materials such as non-woven fabrics are not needed, and the functional cosmetics materials are fully dissolved in the base material; in a using process, the eyes are moistened with clean water or moisture gel, then the eye masks are applied to the eyes, the eye masks can be quickly dissolved by using fingers to knead, and functional components are released and are absorbed by the skin of the eyes, and the eye masks have the advantages of good water solubility, simpleness in use and operation and quick absorption.
Owner:上海世领生物科技有限公司

Ketoconazole vaginal suppository as well as preparation method and detection method thereof

The invention relates to a ketoconazole vaginal suppository as well as a preparation method and a detection method thereof. The suppository comprises a drug-containing base formed of ketoconazole and a base, a drug-containing mucous layer formed of ketoconazole and a mucous layer, and a swelling carrier. The oleaginous base and water soluble base are added, thereby ensuring that the whole body absorption and application risk of ketoconazole are reduced and the concentration and bioavailability of ketoconazole are effectively improved, so as to take full play of the efficacy of ketoconazole; an absorption promoting agent and chitosan are added, the absorption of a human body to ketoconazole is promoted; the solid disperse carrier can be used for improving the dissolution of ketoconazole, and further promoting absorption of the human body; the drug-containing mucous layer can be adsorbed on vaginal skin to promote skin absorption and can be used for further improving the bioavailability of ketoconazole. The ketoconazole vaginal suppository provided by the invention adopts six original advanced techniques, and has the beneficial effects of drug liquid outflow prevention, good human body absorption, high bioavailability, lasting curative effect, secondary infection prevention, and the like.
Owner:哈尔滨田美药业股份有限公司

Yuanhuzhitong dropping pills and method for extracting and preparing active ingredients of Yuanhuzhitong dropping pills

The invention relates to a method for extracting active ingredients of Yuanhuzhitong dropping pills and a preparation method of Yuanhuzhitong dropping pills. The method comprises the following steps: taking coarse powder of cleansing rhizoma corydalis and radix angelicae according to a ratio, extracting by using an organic solvent, collecting the extract, filtering, performing vacuum concentration on the filtrate so as to obtain extract without alcohol taste; sequentially adding petroleum ether, chloroform and water-saturated n-butyl alcohol into the extract for fully extracting by utilizing an organic solvent extraction technology, performing reduced pressure solvent recovery on each extracting part, thereby obtaining an active ingredient extract; preparing the Yuanhuzhitong dropping pill preparation by using the active ingredient extract. The invention further discloses a method for preparing the active ingredient extract and water-soluble base dropping pill preparation. The preparation disclosed by the invention is fast in dissolution, fast in absorption, rapid in efficacy and lasting in effects of relieving various kinds of pain, has the effects of regulating the flow of vital energy, invigorating the circulation of blood and relieving pain and can be used for treating the symptoms such as qi stagnation and blood stasis type stomachache, costalgia and dysmenorrhea.
Owner:GANSU LONGSHENRONGFA PHARMACEUTICAL INDUSTRY CO LTD

Double temperature control mattress

The invention belongs to the field of household articles, and discloses a double temperature control mattress, which comprises a mattress cover, a mattress body, and water-soluble base bodies and far-infrared heating layers embedded into the mattress body, and temperature control adjusters for controlling the temperature of the far-infrared heating layers. Each water-soluble base body is formed by a waterproof sheath and water sealed in the waterproof sheath; each far-infrared heating layer is located on the lower surface of the corresponding water-soluble base body; a heating material of each far-infrared heating layer is a carbon fiber material; each temperature control adjuster is connected with the corresponding far-infrared heating layer through a circuit; two bilaterally symmetrical groups of water-soluble base bodies, far-infrared heating layers and temperature control adjusters are arranged; a plurality of temperature detector switches are serially connected onto carbon fiber heating wires in the far-infrared heating layers, and limits the temperature of the heating layers to not exceed 80 DEG C. According to the double temperature control mattress provided by the invention, the water is heated by the far-infrared heating layers through the temperature control adjusters, and the maximum temperature is limited through the temperature detector switches, so that the temperature control on the mattress is realized, the sleep temperature required for a human body is ensured, and the sendible temperature and the comfort level are improved.
Owner:李力

Ketoconazole and clobetasol propionate cream and preparation method thereof

The invention discloses ketoconazole and clobetasol propionate cream which comprises the following components in percentage by weight: 1-6 percent of ketoconazole, 0.1-2 percent of chlorhexidine acetate, 0.01-0.15 percent of clobetasol propionate, 0.1-5 percent of methyl salicylate, 20-28 percent of a greasing base, 5-8 percent of a water-soluble base, 3-8 percent of an emulsifier, 3-6 percent of a cosolvent, 0.01-0.4 percent of an antioxidant, 0.1-1 percent of an essence and purified water in balancing amount. The ketoconazole and clobetasol propionate cream provided by the invention has the effects of fungus resistance, bacterium resistance and inflammation resistance and achieves a good transdermal effect.
Owner:GUANGDONG SHUNFENG PHARMA

Solid dispersion dropping pill adopting persimmon leaf total flavonoids and preparation method of solid dispersion dropping pill

The invention discloses a solid dispersion dropping pill adopting persimmon leaf total flavonoids and a preparation method of the solid dispersion dropping pill, and belongs to the field of preparation of the solid dispersion dropping pill. The invention discloses the solid dispersion dropping pill adopting the persimmon leaf total flavonoids firstly. The solid dispersion dropping pill comprises the following components: a persimmon leaf total flavonoid and phospholipid complex, a water-soluble base and a surfactant. The phospholipid complex is prepared from the persimmon leaf total flavonoids with the phospholipid complex technology, the lipophilicity of the persimmon leaf total flavonoids is improved effectively, and the membrane permeation performance is improved; the solid dispersion dropping pill adopting the persimmon leaf total flavonoids is prepared by taking the persimmon leaf total flavonoid and phospholipid complex as the intermediate, and the water solubility of the persimmon leaf total flavonoid and phospholipid complex is improved effectively, so that the dissolution quantity and dissolution rate of the persimmon leaf total flavonoids are increased. Pharmacokinetic test results show that the oral bioavailability of the persimmon leaf total flavonoids of the prepared solid dispersion dropping pill is improved effectively.
Owner:SHENYANG DONGXIN PHARMA CO LTD

Fleabane extraction method and preparation of its extract dispersion tablet and drop pills

A extracting method for fleabane and method for preparing dispersion flake and drop bill of extract. The process is that fleabane is pulverized, added with 80 % alcohol extracted two times, filtered until alcohol become thick paste, added with 0.1 % sodium hydroxide, filtered, filtered solution is extracted by water saturated normal butyl alcohol, recovering normal butyl alcohol until it becomes thick paste. The drop bill disintegrating agent is made from low substituted hydroxypropyl cellulose, sodium carboxymethyl starch, crosslinked sodium cellulose glycolate, crosslinked polyvinyl pyrolidon. The weight of disintegrating agent is 5-25 % of total weight. The water soluble base of drop bill is made from carbowax 4000, carbowax 6000, carbowax 1500, carbowax 400, carbowax 600, carbowax 1000, sodium stearate, glycerogelatin, one or several kinds of poloxamer. The proportion of extract dry powder and water soluble base is 1 : 2-10.
Owner:BEIJING BOERDA BIO TECH DEV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products