94 results about "Stomach ulcers" patented technology

A medicine Leibeilazuona for injection contains Leibeilazuona, excipient, pH regulator and antioxidizing agent. It can be used for treating stomach ulcer, duodenal ulcer, erosive gastroesophageal reverse flor disease, pyloric halicobacterium, and zollinger-ellison syndrome. Its advantages are high biological utilization rate and quickly taking its effect.

The invention provides an MG53 (mitsugumin53) mutant and a preparation method thereof. The mutant is a serine-site mutant of MG53 protein in a Coiled-coil structural domain, and the mutant results in inactivation of MG53 phosphorylation. Meanwhile, the MG53 protein mutant can be used for preventing or treating diseases related to cellular membrane damage, such as diseases related to myocardial cell injury, diseases related to ulcer, trauma with a wound, particularly a difficult-to-heal wound, intestinal leakage, kidney injury and the like. The diseases related to myocardial cell injury can include one or more diseases related to following symptoms: myocardial ischemia, heart ischemia, heart ischemia/reperfusion injury, myocardial infarction, cardiac failure, arrhythmia and cardiac rupture. The diseases related to ulcer include one or more of following diseases: chronic ulcer, peptic ulcer, diabetic foot ulcer, diabetic foot gangrene and chronic gastric ulcer. Besides, the invention further provides a dry powder preparation, a spray preparation, a gel preparation and an emulsion containing MG53 or MG53 mutant as well as preparation methods of the preparations.

The invention relates to a gastrointestinal disease treatment Chinese herbal, which provides significant treatment effects for various stomach pains, stomach ulcer, duodenal ulcer, colonic ulcer, rectum ulcer, various gastritis, antral gastritis, hypertrophic gastritis, superficial gastritis, atrophic gastritis, reflux gastritis, hemorrhagic gastritis, alimentary tract hemorrhage, gastroptosis, colonitis and allergic colitis. Clinical trial and treatment results show that the effective rate of various types of gastrointestinal disease patients is 96%, and the cure rate is 91%. The gastrointestinal disease treatment Chinese herbal is prepared from the following raw materials: sharpleaf galangal fruit, dandelion, reed rhizome, chrysanthemum, cassia bark, ma-yuen jobstears seed, medlar, aloe powder, fennel powder, common yam rhizome, licorice root, hyacinth bean, chicken's gizzard-membrane, malt, hawthorn, angelica archang lica, cape jasmine, heartleaf houttuynia herb, lily, common jujube, and dried ginger. According to the present invention, the drugs in the formula are the food with medicine food homology so as to be easily accepted by patients due to the food therapy idea, the gastrointestinal disease treatment Chinese herbal has no toxic-side effect so as to be easily accepted by patients, and the gastrointestinal disease treatment Chinese herbal has effects of liver soothing, qi regulating, stomach regulating, pain relieving, blood cleaning, heat regulating, yin improving, immune function enhancing, internal secretion regulating, and yin and yang balance promotion so as to achieve a symptom and root cause treatment effect.

The invention relates to a biological adhesive microsphere with a nuclear shell double-layer structure and a preparation method of the microsphere. By taking Zujin pill total alkaloids as a model medicine, taking natural high-molecular polymers such as chitosan, sodium alga acid and gelatin as carrier materials, an intelligent hydrogel medicine release system with biological adhesiveness is constructed. Due to the biological adhesive microsphere with the nuclear shell structure, detention time of the medicine in stomach is prolonged, medicine absorption is increased, and the biological availability of oral medicine for treating gastrohelcosis is improved. The biological adhesive microsphere is a reasonable and effective novel dosage form of gastrohelcosis-resisting medicine developed by using ancient prescription into a modern research method. The invention further illuminates in-vitro medicine release performance of the microsphere and in-vitro biological adhesion effect of the microsphere.

The inventors have discovered that food and pharmaceutical compositions containing (−)-hydroxycitric acid, its salts, amides and esters can be employed for delaying gastric emptying and increasing receptive relaxation for preventing and treating diverse conditions. The invention provides for HCA-containing compound useful to delay gastric emptying and increase receptive relaxation for preventing and treating diverse conditions, e.g., stomach ulcers, portal hypertension, liver dysfunction, diabetes and obesity. The invention provides methods for delaying gastric emptying and increasing receptive relaxation in individuals. The invention also provides methods of preventing or treating disorders or conditions related to aberrant gastric emptying and receptive relaxation.

The invention discloses vonoprazan fumarate dispersible tablets, used for treating gastric and duodenal ulcers. The vonoprazan fumarate dispersible tablets are prepared from vonoprazan fumarate, with the addition of adjuvant materials. The vonoprazan fumarate dispersible tablets are rapid in disintegration and absorption, high in bioavailability, convenient to take, low in content of intestinal residues, light in side effects, sweet in taste and fragrant; and especially, the dispersible tablets are easy to improve the medication compliance of patients.

The mechanism of action of Ebselen differentiates between bacterial and mammalian thioredoxin reductase (TrxR). It displays fast oxidation of mammalian Trx and via the NADPH-TrxR catalyzed turnover of ebselen selenol with hydrogen peroxide, and therefore are mammalian antioxidants. Ebselen, and its diselenide, are strong competitive inhibitors of E. coli TrxR with K_i of 0.14 μM and 0.46 μM, respectively. E. coli mutants lacking glutathione reductase or glutathione were much more sensitive to inhibition by ebselen. Since either glutaredoxin or thioredoxin systems are electron donors to ribonucleotide reductase, ebselen targets primarily glutathione and glutaredoxin-negative bacteria, a class which includes major pathogens. Ebselen, and similar compounds are therefore useful as antibacterial agents, even for multiresistant strains. Two major pathogenic bacteria, which previously had not been known to be sensitive to ebselen, Mycobacterium tuberculosis (tuberculosis) and Helicobacter pylori (stomach ulcer and cancer), were shown to be excellent targets. Helicobacter pylori was also sensitive to ebsulfur.

The invention discloses a soybean peptide nutrient solution, which is prepared by extracting pale yellow clear liquid of soybeans. An extraction method comprises the following steps of 1) electromagnetic cracking, 2) press extraction, 3) filtering concentration, 4) drying extraction and 5) merging extraction liquid. The soybean peptide nutrient solution is rich in small molecule polypeptide and soybean isoflavone and has good prevention and treatment effects on a variety of diseases including chronic hepatitis b, acne, gastric ulcer or superficial gastritis and the like. A preparation method of the soybean peptide nutrient solution is further provided.

The invention discloses a traditional Chinese medicine for treating the stomach ulcer and the duodenal ulcer. The traditional Chinese medicine is prepared from the following medicinal materials in parts by weight: kadsura coccinea, belladonna herbs, sterculia nobilis smith, fleshfingered citron flowers, white mume flowers, greater celandine, white peony roots, poria cocos, cuttlebone, atractylodes rhizomes, dried orange peels, cortex magnoliae officinalis, medicated leaven, endothelium corneum gigeriae galli, ginger, cassia twigs, rhizoma corydalis, medicinal evodia fruits, radix gentianae, raw malt, oyster, astragalus membranaceus, dandelions, smoked plums, Chinses angelica, rhizoma alismatis, ligusticum wallichii, Chinese date, dried rhizomes of rehmannia, cortex moutan, heterophylly falsestarwort roots, combined spicebush roots, frankincense, myrrh, costus roots, rhizoma coptidis, nutgrass galingale rhizomes, radix salviae miltiorrhizae, pseudo-ginseng, fried hyacinth beans, common bletilla tubers, aspongopus, cinnamon, haws, szechwan chinaberry fruits, Chinese thorowax, ficus cariolosa lindl, ardisia affinis hemsl, roots and leaves of ananas comosus, carum carvi caraway, knotweed rhizomes, Sichuan hazels, aristolochia impressinervis, common canscora herbs, fruits of dahurian roses, bitter citrus immature flowers, zanthoxylum dissitum, Chinese enkianthus, tangut dragonhead and licorice roots. Clinical tests prove that the traditional Chinese medicine disclosed by the invention can safely and effectively treat the stomach ulcer and the duodenal ulcer.

The invention discloses a traditional Chinese medicine composition for treating a stomach ulcer and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 7-14 parts of adenophora elata, 15-20 parts of astragalus membranaceus, 12-18 parts of white peony roots, 5-10 parts of rhizoma coptidis, 12-18 parts of Chinese yams, 8-15 parts of radix cyathulae, 10-16 parts of fingered citron, 5-10 parts of licorice roots, 4-9 parts of dried orange peels, 10-16 parts of rhizoma corydalis, 16-20 parts of cuttlebone, 4-10 parts of bighead atractylodes rhizomes, and 8-15 parts of coke malt, coke hawthorn and coke medicated leaven. The traditional Chinese medicine composition disclosed by the invention has the beneficial effects that selected materials are all natural traditional Chinese medicine materials which have no toxic or side effects, the traditional Chinese medicine composition operates quickly on treating the stomach ulcer, the curative effect is reliable, and the traditional Chinese medicine composition is convenient for being taken.

Disclosed is a medicinal composition for treating gastritis and gastric ulcer, which is prepared from Gypsum Rubrum, Ganqing Qinglan, banksia rose, chebula fruit, belleric terminalia fruit and emblic leafflower fruit as the raw material. The invention also discloses the process for preparing the pharmaceutical composition.

The invention discloses capsules for treating stomach diseases and a preparation method thereof. The capsules for treating the stomach diseases comprise the following components in parts by weight: 10-60 parts of common bletilla pseudobulb, 2-30 parts of bulb of thunberg fritillary, 1-10 parts of Chinese eaglewood, 1-10 parts of panax notoginseng and 2-30 parts of coptis chinensis. The capsules for treating the stomach diseases, disclosed by the invention, have significant effects on promoting blood circulation and relieving pain, astringing and stopping bleeding, and resisting stomach ulcers and gastritis, and have the characteristics of quick curative effect, high cure rate, no side effects and the like in treating chronic gastritis, stomach heat and phlegmatic mass, blood stasis and qi stagnancy, gastric cavity swelling pain, stomach ulcer and duodenal ulcer.

The invention belongs to the technical field of traditional Chinese medicine preparations and health food, and particularly relates to a pharmaceutical composition with effects of gastric mucosa protection, chronic gastritis prevention and treatment, and stomach ulcer prevention and treatment, and a preparation method thereof, and applications of the pharmaceutical composition in drugs and health food. According to the present invention, the drug or health food adopts grifola frondosa as the main active component, citrus medica l. var. sarcodactylis swingle, atractylodes macrocephala and cynanchum otophyllum are combined, and the further matching is performed; the drug or health food can promote gastric mucosa epithelial cell proliferation, promote gastric mucosa epithelial cell to migrate to the wound surface, and accelerate damaged area epithelial cell growth so as to promote gastric mucosa injury repair; and the pharmaceutical composition can be used for preparation of drugs and health food with effects of gastric mucosa protection, chronic gastritis prevention and treatment, and stomach ulcer prevention and treatment, and has good application prospects and good economical benefits.

The invention belongs to the technical field of medicines, and concretely relates to health-care tea used for gastric ulcer. The health-care tea used for gastric ulcer is composed of the following bulk drugs in parts by weight: 1-5 parts of radix glycyrrhizae, 1-5 parts of semen coicis, 1-5 parts of bitter apricot seed, 1-5 parts of rhizoma phragmitis, 1-5 parts of flos rosae rugosae, 1-5 parts of flos chrysanthemi, 1-5 parts of jasminum sambac, 1-5 parts of flos lonicerae, 1-5 parts of medicated leaven, 1-5 parts of fructus hordei germinatus, and 1-5 parts of fructus crataegi. The health-care tea used for gastric ulcer has the cure rate of 56.25% and the total effective rate of 96.3% when being used to treat 192 examples of gastric ulcer patients for 20 days as two treatment courses.

The invention discloses a balanced health-care pill. The balanced health-care pill is prepared from the following raw materials in parts by weight: 20-30 parts of codonopsis pilosula, 20-30 parts of astragalus membranaceus, 8-10 parts of white atractylodes rhizome, 8-10 parts of white hyacinth bean, 8-10 parts of ligusticum wallichii, 1.5-2 parts of bezoar, 0.1-0.8 part of musk, 15-20 parts of rhodiola rosea, 10-15 parts of platycodon grandiflorum, 10-15 parts of white mulberry root bark, 6-8 parts of liquorice, 10-12 parts of poria cocos, 10-20 parts of elecampane, 6-9 parts of pericarpium zanthoxyli, 3-6 parts of agilawood, 10-15 parts of rhizoma polygonati, 10-20 parts of purple lucid ganoderma, 20-30 parts of oldenlandia diffusa, 10-20 parts of dendrobium huoshanense, 10-20 parts of pollen and 260-300 parts of honey. The balanced health-care pill not only can treat cervical spondylosis, scapulohumeral periarthritis, lumbar disc herniation, waist and leg pain, hyperostosis, hand andfoot numbness, bodily sores and itching, gastritis, stomach ulcer, anal fistula, dizziness, headache, insomnia, high blood pressure, high blood lipid, diabetes, hemiplegia, dysmenorrhea and other diseases, but also has a relatively health-care effect on people suffering from physical weakness, postoperative conditioning and subhealth. The invention further discloses a preparation method and application of the balanced health-care pill.

The invention discloses an ursolic acid derivative capable of protecting gastric mucosa and a preparation method thereof, and the preparation method comprises the following steps: dissolving ursolic acid in an organic solvent, and carrying out substitution and esterification with a halogenating agent to obtain the ursolic acid derivative; an animal gastric ulcer model test proves that the ursolic acid derivative has a relatively good treatment effect on gastric ulcer and can play a certain protection effect on gastric mucosa; the preparation method has the advantages of simple process steps, cheap and easily available raw materials and reusable solvent, and is suitable for industrial development.

The invention relates to a method for extracting small molecule polypeptides for medicament preparation, which comprises carrying out alkali hydrolysis to the duck's egg membrane, removing residue after the completion of hydrolysis, diluting the solution for use as medicament directly, which has the function for treating stomach ulcer. The hydrolysate can also be neutralized for alkali expelling, so as to prepare concentrated liquid or dried product after concentration.