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Pharmaceutical composition having gastric mucosa protection effect, preparation method and applications thereof

A composition and technology of gastric mucosa, applied in the field of traditional Chinese medicine preparation technology and health food field, can solve problems such as gastritis reversal and gastric mucosa trauma, and achieve the effects of promoting repair, low side effects, and good application prospects

Inactive Publication Date: 2016-02-10
ZHANGZHOU PIEN TZE HUANG PHARM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] 3. Drug treatment of Hp-related gastritis requires eradication of Hp, while other chronic gastritis has no specific treatment, and most of them cannot reverse gastritis, so symptomatic treatment is mainly
These are theoretically unexplainable, but empirically
[0008] It can be seen that the current treatment of chronic gastritis is still dominated by highly irritating western medicine, which may also cause secondary trauma to the damaged gastric mucosa itself.

Method used

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  • Pharmaceutical composition having gastric mucosa protection effect, preparation method and applications thereof
  • Pharmaceutical composition having gastric mucosa protection effect, preparation method and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Example 1 Granules

[0055] [Prescription] Grifola frondosa extract 5kg, Baizhu 5kg, Radix Paeoniae Alba 3kg, Bergamot 3kg.

[0056] [Preparation method] Take the prescription amount of Atractylodes Rhizome, Radix Paeoniae Rubra and Bergamot, mix it, add 8 weight times purified water and extract twice for 1 hour each time, extract the combined solution, and concentrate in vacuo to a relative density of 1.20g / mL (measured at 90℃) ) To obtain a concentrated cream; take the prescription amount of Grifola frondosa extract and the concentrated cream and conventional auxiliary materials and fully mix, and carry out belt vacuum drying (feed rate 3000mL / h, each stage temperature 95℃, 95℃, 90℃, 75℃ , Temperature 20℃, belt speed 100mm / min), after the dried material is granulated, add 40% ethanol for wet granulation, dry at 60℃, sizing and packaging, ready to get.

Embodiment 2

[0057] Example 2 Capsules

[0058] [Prescription] 3 parts by weight of Grifola frondosa extract, 8 parts by weight of Baizhu, 2 parts by weight of white peony, and 4 parts by weight of bergamot.

[0059] [Preparation method] Take the prescription amount of Atractylodes macrocephala, Radix Paeoniae Rubra and Bergamot, mix it, add 6 weight times purified water and extract twice, 0.5 hours each time, extract and extract the solution, vacuum concentrate to a relative density of 1.15g / mL (measured at 90℃ ) To obtain a concentrated paste; fully mix the concentrated paste with the prescribed amount of Grifola frondosa extract and conventional auxiliary materials, and carry out belt vacuum drying (feed rate 3500mL / h, temperature of each stage 98℃, 95℃, 85℃, 70 ℃, temperature 25℃, belt speed 100mm / min), after the dry material is granulated, add 60% ethanol to wet granulation, dry at 70℃, granulate, fill capsule, aluminum-plastic packaging or bottling, ready to get.

Embodiment 3

[0060] Example 3 Tablets

[0061] [Prescription] 7 parts by weight of Grifola frondosa extract, 4 parts by weight of Baizhu, 6 parts by weight of white peony, and 2 parts by weight of bergamot.

[0062] [Preparation method] Take the prescription amount of Atractylodes Rhizome, Radix Paeoniae Rubra and Bergamot and mix it, add 10 weight times of purified water and extract twice for 2 hours each time, extract the combined solution, and concentrate in vacuo to a relative density of 1.10g / mL (measured at 90℃) ) To obtain a concentrated paste; fully mix the concentrated paste with Grifola frondosa extract and conventional auxiliary materials, and carry out belt vacuum drying (feed rate 3000mL / h, temperature of each stage is 99℃, 90℃, 85℃, 70℃, temperature 30°C, belt speed 150mm / min), after the dry material is granulated, add 50% ethanol to wet granulation, dry at 80°C, granulate, press, aluminum-plastic packaging or bottling, ready to get.

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Abstract

The invention belongs to the technical field of traditional Chinese medicine preparations and health food, and particularly relates to a pharmaceutical composition with effects of gastric mucosa protection, chronic gastritis prevention and treatment, and stomach ulcer prevention and treatment, and a preparation method thereof, and applications of the pharmaceutical composition in drugs and health food. According to the present invention, the drug or health food adopts grifola frondosa as the main active component, citrus medica l. var. sarcodactylis swingle, atractylodes macrocephala and cynanchum otophyllum are combined, and the further matching is performed; the drug or health food can promote gastric mucosa epithelial cell proliferation, promote gastric mucosa epithelial cell to migrate to the wound surface, and accelerate damaged area epithelial cell growth so as to promote gastric mucosa injury repair; and the pharmaceutical composition can be used for preparation of drugs and health food with effects of gastric mucosa protection, chronic gastritis prevention and treatment, and stomach ulcer prevention and treatment, and has good application prospects and good economical benefits.

Description

Technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations and the technical field of health foods, and specifically relates to a pharmaceutical composition capable of protecting gastric mucosa, preventing chronic gastritis and gastric ulcer, a preparation method and its application in medicines and health foods. Background technique [0002] Chronic gastritis (chronic gastritis) is a common disease and frequently-occurring disease. Its onset area spreads all over the world, involving all kinds of people. And with the advancement of modern society, the pace of life is accelerating, and various pressures are everywhere. Various internal and external factors continue to stimulate and destroy the human gastric mucosa, causing many diseases such as stomach pain and inflammation, making chronic Gastritis has become a major disease affecting human health. Chronic gastritis is divided into two types: primary and secondary, and prima...

Claims

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Application Information

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IPC IPC(8): A61K36/752A61P1/04A23L1/30
Inventor 刘建顺王丽菊黄进明黄婧张泽修
Owner ZHANGZHOU PIEN TZE HUANG PHARM
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