35 results about "Chronic gastric ulcer" patented technology

The invention discloses a Chinese and western compound medicine for treating stomach diseases, which comprises seventeen traditional Chinese medicinal materials including pilose asiabell root, white atractylodes rhizome, Poria cocos, chicken's gizzard-skin, astragalus root, licorice root, haw, medicated leaven and malt, and a small number of Western medicinal materials including chloramphenicol, terramicin and furazolidone.

The invention provides an MG53 (mitsugumin53) mutant and a preparation method thereof. The mutant is a serine-site mutant of MG53 protein in a Coiled-coil structural domain, and the mutant results in inactivation of MG53 phosphorylation. Meanwhile, the MG53 protein mutant can be used for preventing or treating diseases related to cellular membrane damage, such as diseases related to myocardial cell injury, diseases related to ulcer, trauma with a wound, particularly a difficult-to-heal wound, intestinal leakage, kidney injury and the like. The diseases related to myocardial cell injury can include one or more diseases related to following symptoms: myocardial ischemia, heart ischemia, heart ischemia / reperfusion injury, myocardial infarction, cardiac failure, arrhythmia and cardiac rupture. The diseases related to ulcer include one or more of following diseases: chronic ulcer, peptic ulcer, diabetic foot ulcer, diabetic foot gangrene and chronic gastric ulcer. Besides, the invention further provides a dry powder preparation, a spray preparation, a gel preparation and an emulsion containing MG53 or MG53 mutant as well as preparation methods of the preparations.

The invention discloses an application of a herba schizonepetae-radix saposhnikoviae preparation in preparation of gastric ulcer treatment medicines and a preparation method of the herba schizonepetae-radix saposhnikoviae preparation, and belongs to the field of medicines. The herba schizonepetae-radix saposhnikoviae preparation is prepared from 11 raw medicinal materials including herba schizonepetae, radix saposhnikoviae, notopterygium root, doubleteeth pubescent angelica root, Chinese thorowax root, common hogfenneI root, szechuan lovage rhizome, fructus aurantii, poria cocos, platycodon grandiflorum and liquoric root and has the effects of inducing sweat, dispelling exogenous evils, dispelling wind and eliminating dampness. The herba schizonepetae-radix saposhnikoviae preparation can effectively treat stress gastric ulcer and acetic acid induced chronic gastric ulcer, inhibit gastric acid secretion and reduce free acid and total acidity in gastric juice, has the effect of reducingpepsase activity, treats both symptoms and root causes, and has an exact treatment effect on gastric ulcer.

The invention provides six cyclic dipeptides used for wound healing. The cyclic dipeptide is one of pro-phe, pro-pro, pro-val, pro-his, pro-tyr and pro-gly. The cyclic dipeptide has remarkable therapeutic effect on wound. Inhibition rate of acute and chronic gastric ulcer is high, wound healing speed of burns and scalds is fast, and scars are shallow.

The invention provides composite health-care fruit wine which belongs to the technical field of food machining and biological fermentation. The composite health-care fruit wine comprises pawpaw, tangerines, oranges, cane sugar, cooled water and saccharomycetes, wherein the saccharomycetes comprise rice and distiller yeast; the brewing steps comprise preparing the saccharomycetes, treating raw materials, fermenting, sterilizing and bottling. The composite health-care fruit wine provided by the invention is simple in process, high in security and good in taste, has the effects of maintaining beauty, keeping young and moistening the skin, furthermore has the effect of cleaning heat and diminishing inflammation, has a good curative effect on chronic gastric ulcer and recurrent oral ulceration, and has the functions of spasmolysis and relaxing tendon and relieving pain.

The invention provides a novel herbal synergistic formulation for treatment of acute and chronic ulcers in stomach. Formulation(s) comprises of plant extracts together with the conventional additives to form the oral dosage forms which include tablets, capsules and powders ready for suspension. Utleria solicifolia along with this plants used traditionally like Asparagus racemosus, Foeniculum vulgare, and Ficus glomerata are added which are used in intestinal discomforts and as an galactogogue.

The invention provides cyclic dipeptide used for wound healing. The cyclic dipeptide is one of ala-gly and ala-leu. The cyclic dipeptide has remarkable therapeutic effect on wound. Inhibition rate of acute and chronic gastric ulcer is high, wound healing speed of burns and scalds is fast, and scars are shallow.

The invention relates to a traditional Chinese medicine preparation for treating chronic gastric ulcer. The traditional Chinese medicine preparation for treating chronic gastric ulcer is prepared from the following raw materials including dendrobium officinale, combined spicebush roots, peach seeds, fingered citron, semen coicis, white hyacinth beans, Chinese thorowax roots, magnolia bark, pseudo-ginseng, myrrh, cyperus rotundus, liquorice, dandelions, roots of bidentate achyranthes, poria cocos, chicken's gizzardskin, fructus aurantii, ophiopogon japonicus, orange peel, bighead atractylodes rhizomes and boswellia carterii. The prepared traditional Chinese medicine preparation can solve the current problems and eliminate the root causes of the chronic gastric ulcer, has no side effects on a human body, is low in cost, can take effects fast and has wide application prospects.

The invention discloses a Chinese medicinal composition for treating chronic gastric ulcer, which relates to the technical field of traditional Chinese medicines. The Chinese medicinal composition is prepared from the following Chinese medicinal materials in parts by weight: 8-12 parts of common bletilla pseudobulb, 15-20 parts of dahurian angelica root, 3-6 parts of nardostachyos root and rhizome, 10-15 parts of hairyvein agrimonia herb and bud, 8-12 parts of areca nut, 8-12 parts of Chinese angelica, 8-12 parts of rhizoma corydalis, 8-12 parts of paniculate swallowwort root, 4-8 parts of amomum fruit, 20-30 parts of Chinese yam, 4-8 parts of coptis root and 8-12 parts of malaytea scurfpea fruit. The Chinese medicinal composition related to the invention has a remarkable curative effect on chronic gastric ulcer, can be used for tonifying spleen, regulating qi, dissipating swelling and relieving pain, and has high safety.

The invention discloses a medicine for treating chronic gastric ulcer. The medicine is prepared from the following raw materials in parts by weight: 15-25 parts of root of Chinese pulsatilla, 8-12 parts of goldthread, 8-12 parts of golden cypress, 8-15 parts of indigo naturalis, 8-12 parts of corydalis tuber, 4-8 parts of pseudo-ginseng, 8-12 parts of codonopsis pilosula, 8-12 parts of bletilla striata, 8-12 parts of radix paeoniae alba, 7-13 parts of processed nutgrass galingale rhizome and 4-8 parts of liquorice. By adopting the medicine for treating the chronic gastric ulcer disclosed by the invention, 11 natural traditional Chinese medicines are selected to be combined; each crude medicine plays the roles of clearing heat and cooling blood, detoxicating and curing furuncles, soothing liver and regulating qi, tonifying stomach and promoting fluid, invigorating spleen and replenishing qi and the like by the synergistic effect, has an inhibiting effect on viruses and bacteria, can treat both symptoms and root causes, and is good in treatment effect on the chronic gastric ulcer, and free of toxic and side effects. Furthermore, the medicine is simple in preparation method, short in treatment course, convenient to take, and low in cost; the effective rate can be up to over 90%.

The invention relates to a traditional Chinese medicine formula for treating chronic gastric ulcer. Ulcer is a common chronic systematic disease, is divided into gastric ulcer and duodenal ulcer, and is also called peptic ulcer. The disease brings pain to patients when the disease attacks, and is too stubborn to be cured. The disease is usually caused by the years of bad living habits, engorgement and the like.

The invention provides a novel herbal synergistic formulation for treatment of acute and chronic ulcers in stomach. Formulation(s) comprises of plant extracts together with the conventional additives to form the oral dosage forms which include tablets, capsules and powders ready for suspension. Utleria solicifolia along with this plants used traditionally like Asparagus racemosus, Foeniculum vulgare, and Ficus glomerata are added which are used in intestinal discomforts and as an galactogogue.

The invention belongs to a traditional Chinese medicine and specifically discloses a traditional Chinese medicine for treating chronic gastric ulcer. The traditional Chinese medicine for treating chronic gastric ulcer comprises 3-5g of dandelion and 2-4g of pseudo-ginseng. The above traditional Chinese medicines are grinded into fine powder together. 1g of the traditional Chinese medicine is taken with warm boiled water each time, three times every day. In a treatment course, the traditional Chinese medicine is taken for continuous five days. The traditional Chinese medicine is designed according to the traditional Chinese medicine differentiation theory, has a simple formula, utilizes the easily acquired raw materials, has a low cost, high curative effects and no toxic or side effect, and can regulate the human body to a normal state.

The invention relates to an application of Weichangan to preparation of drugs for preventing and treating alcohol-induced acute and chronic gastric ulcers. Animal experiments show that a Weichangan extract has obvious inhibiting effects on gastric ulcer in mice caused by 90% of short-term alcohol and 50% of long-term alcohol, so that Weichangan can serve as a drug for preventing and protecting alcoholic gastric ulcer. Weichangan has the obvious advantages that Weichangan has small treatment side effects on diseases, is small in dosage, has good effects and has not only good prevention effects but also better treatment and protection effects on alcoholic gastric ulcer.

The invention relates to a medicine for treating chronic gastric ulcer. The medicine comprises, by weight, 13 parts of rabdosia rubescens, 5 parts of pogostemon cablin, 8 parts of folium microcotis, 9 parts of pinellia ternata, 7 parts of piper cubeba, 5 parts of discolor cinquefoil herb, 8 parts of entada phaseoloides and 9 parts of greater celandine herb. Effects of clearing heat and removing toxicity can be realized by the rabdosia rubescens; effects of promoting appetite and preventing vomiting can be realized by the pogostemon cablin; effects of helping digestion and resolving phlegm can be realize by the folium microcotis; effects of calming reverse-rising energy and preventing vomiting can be realized by the pinellia ternate; effects of promoting qi circulation to relieve pain can be realized by the piper cubeba; effects of clearing heat and removing toxicity can be realized by the discolor cinquefoil herb; effects of promoting qi circulation to relieve pain can be realized by the entada phaseoloides; effects of clearing heat and removing toxicity can be realized by the greater celandine herb. The medicine has the advantages that various medicines are jointly used, accordingly, effects of nourishing spleens, invigorating stomachs, soothing livers and regulating qi can be jointly realized, and the chronic gastric ulcer can be effectively treated; as proved by clinical experiments, the chronic gastric ulcer can be safely and effectively treated by the medicine.

The invention discloses a traditional Chinese medicine compound treating chronic gastric ulcers and a preparation method thereof and belongs to the technical field of traditional Chinese medicine. The traditional Chinese medicine compound treating the chronic gastric ulcers is prepared from the following raw materials and pharmaceutically acceptable carriers. The raw material include, by weight, 15-25 parts of poria cocos, 15-25 parts of pinellia ternate, 15-25 parts of cassia twigs, 10-20 parts of lindera aggregate, 10-20 parts of peony, 10-20 parts of hawthorn fruits, 10-20 parts of peach kernels, 10-20 parts of red dates, 10-15 parts of endothelium corneum gigeriae galli, 10-15 parts of coptidis rhizome, 10-15 parts of dried ginger and 10-15 parts of liquorice. The invention further discloses the preparation method of the compound. According to the pattern of traditional Chinese medicine diagnosis and treatment based on overall analysis and assistant and guide, the traditional Chinese medicines are subjected to scientific compatibility, effective medicine combinations are provided, the medicines are collaboratively and mutually balanced, and the gastric ulcers, gasteremphraxis, emesis and the like which are caused by the gastric ulcers can be well treated.

The invention discloses a traditional Chinese medicine formula for treating chronic gastric ulcer. The traditional Chinese medicine formula is characterized by consisting of the following components in parts by weight: 14-18g of codonopsis pilosula, 13-17g of poria, 10-14g of roasted Chinese atractylode rhizome, 10-14g of Sichuan magnolia officinalis, 13-17g of tangerine peel, 10-14g of trogopterus dung, 10-14g of Chinese angelia root, 10-14g of coix seed, 10-14g of costustoot, 10-14g of bitter orange, 10-14g of radix rehmanniae, 10-14g of roasted ark shell, 10-14g of oriental stephania root, 8-10g of orange leaf, 12-16g of propolis, 10-14g of black jujubes, 10-14g of common burreed rhizome and 10-14g of ferrocholinate powder. The traditional Chinese medicine formula disclosed by the invention fully considers the advantages and disadvantages of each traditional Chinese medicine by years of practical experiences, and is reasonable in matching; and by adopting the traditional Chinese medicine formula, excessive gastric acid secretion can be effectively inhibited, the gastric mucosa can be protected, the resistance of the gastric mucosa can be enhanced, and the effect of fundamentally treating gastric ulcer can be achieved.

The invention relates to the field of medicines, and in particular relates to stomach rehabilitation capsules for treating stomach diseases. The stomach rehabilitation capsules are characterized by consisting of the following raw materials in parts by weight: 10-20 parts of liquorice root, 10-20 parts of dahurian angelica root, 10-15 parts of codonopsis pilosula, 8-10 parts of panax notoginseng, 5-7 parts of milkvetch root, 5-7 parts of Saussurea costus, 3-5 parts of root of wilford swallowwort, 3-5 parts of barbed skullcap herb, 1-3 parts of aluminum hydroxide, 1-3 parts of calcium carbonate, 1-3 parts of starch, 0.1-0.3 part of chloromycetin and 0.1-0.3 part of terramycin. The stomach medicine disclosed by the invention has the effects of promoting qi circulation and relieving pain, astringing and promoting granulation, and promoting ulcer healing, and is mainly used for treating various acute or chronic gastric ulcers, reflux gastritis and atrophic gastritis and preventing the occurrence of stomach cancer. The stomach rehabilitation capsules disclosed by the invention can be clinically used for treating diseases such as gastrectasia, stomach stuffiness, stomachache, belching and gastric acid increase, nausea and vomiting, reduced appetite, fatigue and weakness, and constipation and unsmooth defecation, have the functions of dispelling cold and removing fever, activating blood and regulating qi, benefiting the stomach, tonifying the spleen and regulating the spleen and stomach, are short in treatment course, reliable in curative effect and very low in relapse rate, and can be prepared into capsule preparations to be conveniently taken.

The invention discloses a traditional Chinese medicine decoction for treating chronic skin ulcer. The traditional Chinese medicine decoction is prepared from the following traditional Chinese medicinal materials in parts by weight: 15 parts of angelica, 15 parts of ligusticum wallichii, 15 parts of peach kernel, 9 parts of bidentate achyranthes root, 15 parts of salix araeostachya, 30 parts of raw radix astragalis, 15 parts of eel blood, 9 parts of leaves of purpleflower holly, 5 parts of sapium baccatum, 5 parts of incarvillea younghustandii sprague, 12 parts of aizoon stonecrop herb, 6 parts of mutton tallow, 15 parts of herba pyrolae, 6 parts of raw liquorice, 6 parts of radix trichosanthis, 5 parts of sapium baccatum, 6 parts of wild sword beans and 6 parts of aizoon stonecrop herb. Clinical experiments prove that the traditional Chinese medicine decoction, by selecting proper medicinal materials and proportions thereof, can achieve a significant effect of treating chronic skin ulcer, and the traditional Chinese medicine decoction is safe and free from toxic or side effect.

The invention provides an MG53 mutant and a preparation method thereof. The mutant is a serine site mutant of an MG53 protein in a Coiled-coil structural domain, so that the inactivation of phosphorylation of the MG53 is caused. Meanwhile, the MG53 protein mutant can be used for preventing or treating cell membrane injury related diseases, such as myocardial cell injury related diseases, ulcer related diseases, trauma with wounds, especially difficult-to-heal wounds, intestinal leakage, kidney injury and the like. The diseases associated with myocardial cell injury may include one or more diseases selected from the group consisting of diseases associated with the following symptoms: myocardial ischemia, cardiac ischemia / reperfusion injury, myocardial infarction, heart failure, arrhythmia, and cardiac rupture. The ulcer related diseases comprise one or more of chronic ulcer, peptic ulcer, diabetic foot ulcer, diabetic foot gangrene and chronic gastric ulcer. In addition, the invention also provides a dry powder preparation, a spray preparation, a gel preparation and an emulsion containing the MG53 or the mutant thereof, and a preparation method of the dry powder preparation, the spray preparation, the gel preparation and the emulsion.

The invention discloses a preparation method of a traditional Chinese medicine and western medicine composition for treating the chronic gastric ulcer. The method comprises the following step that 1,cimetidine is taken and added into a mixed solution of acetonitrile / water, stirring is conducted for dissolution under the conditions that the stirring rotating speed is 6-10 r / min and stirring time is 8-14 min, then a solubilizing agent and a leaching auxiliary agent are added into the mixture sequentially, stirring is continued for 12-16 min, then an extraction solution of herba lysimachiae doped with radix astragali seu hedysari and propolis are added into the mixture, stirring is continued for 4-10 min, and then suction filtration is conducted. The purpose of the invention is to provide the preparation method of the traditional Chinese medicine and western medicine composition for treating the chronic gastric ulcer, the composition can cure the chronic gastric ulcer, has the health care treatment effect at the same time, does not cause secondary damage to the intestines and stomach, and has high use values and good application prospects.

The invention discloses a medicament for treating liver-stomach heat type chronic gastritis, and a preparation method. The medicament comprises the following active pharmaceutical ingredients: common nandina roots, herba lophatheri, rhizoma phragmitis, fresh bamboo sap, herba artemisiae scopariae, common aeschynomene stem-xylem, fructus chaenomelis, faeces bombycis, polyporus umbellatus, cowpea, rhizoma atractylodis, herba pogostemonis, radix stephaniae tetrandrae, herba eupatorii, irkutsk anemone rhizome, semen benincasae, rhizoma cyperi, semen arecae, herba inulae, cortex moutan radicis, lumbricus, cowpea, folium rhododendri daurici, radix paeoniae alba, prepared radix licorice, swallowwortlike knotweed root, rhizoma homalomenae, herba dendrobii, lignum dalbergiae odoriferae and pyrolusite. The medicament has the beneficial effects of clearing away heat and promoting diuresis, integrating functions of resolving dampness by means of aromatics, activating the spleen and promoting appetite, regulating qi activity, promoting blood circulation to remove blood stasis, harmonizing the stomach and relieving pain, nourishing yin and preventing dampness, and mainly treating the liver-stomach heat type chronic gastritis; and by utilizing the theory of the traditional Chinese medicine, the organism immunity is enhanced on the basis of integrity by regulating qi-blood circulation, treatment based on syndrome differentiation is carried out, the medicament is safe and effective, the curative course is short, the cure rate can be obviously improved, the recurrence rate can be reduced, and the life quality of patients can be obviously improved.

The invention relates to a stomach disease treating drug, which is prepared from the following components by weight, 20-30 parts of malt, 10-15 parts of dried ginger,12-18 parts of coptis chinensis, 10-20 parts of egg shell, 5-20 parts of hawthorn, 15-25 parts of fructus aurantii, 5-10 parts of clove, 15-23 parts of salvia miltiorrhiza, 12-20 parts of coptis chinensis, 15-25 parts of the leaf of eupatorium japonicum thunb, 10-15 parts of smilax glabra roxb, and 5-12 parts of cape jasmine. According to the present invention, the stomach disease treating drug has advantages of simple and easy-performing preparation method, short treatment course, no toxic-side effect, significant treatment effect, rapid treatment effect, no requirement of other expensive assisted treatment, low cost, painless and non-invasive use and no recurrence after cure, and can be used for treating various types of acute and chronic gastric ulcers and gastritis.

The invention discloses a Chinese and western compound medicine for treating stomach diseases, which comprises seventeen traditional Chinese medicinal materials including pilose asiabell root, white atractylodes rhizome, Poria cocos, chicken's gizzard-skin, astragalus root, licorice root, haw, medicated leaven and malt, and a small number of Western medicinal materials including chloramphenicol, terramicin and furazolidone.

The invention discloses a preparation for treating chronic gastric ulcer. The preparation is prepared from, by weight, 11-16 parts of Herba Ajugae, 13-17 parts of Radix Curcumae, 13-16 parts of Folium seu Radix Uvariae, 9-15 parts of Herba Psiloti, 13-18 parts of Bulbus Allii Macrostemonis, 13-17 parts of Flos Lilii, 11-15 parts of Radix Calystegiae Sepium, 9-14 parts of Herba Belladonnae, 13-16 parts of Radix Pruni Dimonii, 7-12 parts of Caulis Cucurbitae, 9-14 parts of Radix Helicteris Isorae, 11-15 parts of beta vulgaris, 9-15 parts of Fructus Juniperi Rigidae, 11-16 parts of Radix Fici Beecheyanae and 8-12 parts of Semen Oroxyli. The preparation is obtained by refining of the common Chinese herbal medicines which have synergistic effects to jointly function in heat clearing, blood cooling, spleen nourishing, stomach notifying, liver Qi discharging and regulating, stomach tonifying and body fluid secretion promoting, and the preparation is effective in inhibition of hyperacidity to protect gastric mucosa and capable of enhancing resistance of the gastric mucosa to realize radical cure of gastric ulcer.

The invention relates to a traditional Chinese medicine preparation for treating chronic gastric ulcer. The traditional Chinese medicine preparation for treating chronic gastric ulcer is prepared from the following raw materials including dendrobium officinale, combined spicebush roots, peach seeds, fingered citron, semen coicis, white hyacinth beans, Chinese thorowax roots, magnolia bark, pseudo-ginseng, myrrh, cyperus rotundus, liquorice, dandelions, roots of bidentate achyranthes, poria cocos, chicken's gizzardskin, fructus aurantii, ophiopogon japonicus, orange peel, bighead atractylodes rhizomes and boswellia carterii. The prepared traditional Chinese medicine preparation can solve the current problems and eliminate the root causes of the chronic gastric ulcer, has no side effects on a human body, is low in cost, can take effects fast and has wide application prospects.

The invention discloses a traditional Chinese medicine leaven for treating Hp (helicobacter pylori) infection and a preparation method of the leaven. The leaven is prepared from components of raw materials in parts by weight as follows: 10-25 parts of rhizoma pinelliae praparata, 10-25 parts of rhizoma atractylodis, 10-25 parts of panax ginseng, 10-25 parts of tangerine peel, 6-15 parts of fructus amomi, 6-15 parts of cortex magnoliae officinalis, 6-15 parts of fructus amomi rotundus, 10-25 parts of rhizoma zingiberis, 10-15 parts of processed endothelium corneum gigeriae galli, 6-15 parts of glycyrrhiza uralensis, 20-60 parts of hedyotis diffusa, 20-60 parts of houttuynia cordata, 20-60 parts of bidens pilosa, 20-60 parts of taraxacum, 15-80 parts of wheat flour, 15-80 parts of rice flour and 10-50 parts of white koji. The traditional Chinese medicine leaven can effectively control and treat the Hp infection, has effects of tonifying the spleen, invigorating the stomach and helping digestion, treats abdominal distention, stomachache and other symptoms caused by chronic gastritis, chronic gastric ulcer and dyspepsia, is convenient to take and reduces the medicine dosage and side effects.

The invention relates to method for separating and extracting 20(S)-protopanaxatriol from cortex juglandis mandshuricae and use of 20(S)-protopanaxatriol and discloses a method for separating and extracting 20(S)-protopanaxatriol from cortex juglandis mandshuricae and use of 20(S)-protopanaxatriol. The method comprises the following steps of carrying out ultrasound extraction on cortex juglandis mandshuricae medicinal material which is harvested in current year with dichloromethane, adsorbing with activated carbon and a Girard reagent to remove impurity and separating by the silica gel column chromatography and the like to obtain the target product 20(S)-protopanaxatriol. The whole process is simple and feasible. In addition, the invention also relates to application of 20(S)-protopanaxatriol in preparing drugs for treating mucosal injury caused by chronic gastric ulcer and the comprehensive utilization value of cortex juglandis mandshuricae can be increased.