The invention relates to a method for solvent refining during isoprene rubber production. According to the method, the solvent recovered from a self-condensation process is conveyed into a distillation tower from the top of the tower; light components on the top of the tower are subjected to a total reflux operation through a tower top condenser and a reflux tank, or are subjected to small amount continuous recovery under the operation with a large reflux ratio more than 20, and the free water is separated from the reflux tank, and a small amount of uncondensed gases on the top of the tower are discharged to a tail gas condenser; the tower kettle liquid containing weight components is subjected to intermittent or continuous small flow rate recovery; the treated solvent is recovered from the side stream through the middle part of the tower in a vapor phase form, and is condensed by a side stream condenser, and the resulting solvent is conveyed to a polymerization process to directly use, wherein the treated solvent is the qualified solvent through the refining. According to the present invention, only a distillation tower is adopted in the method, the removal works of the water and other light components, and the heavy components are achieved in the single tower, the process is simple, the equipment investment is low, and the energy consumption is small, such that the production and operation cost can be effectively reduced.