34 results about "Scarring skin" patented technology

The invention discloses scar repairing gel. The scar repairing gel is prepared from, by weight, 0.03-0.05 part of heparin sodium, 0.04-0.06 part of hyaluronic acid, 0.04-0.06 part of aloe powder, 0.04-0.06 part of grape seed extract, 0.05-0.15 part of vitamin E, 0.05-0.15 part of lavender oil, 0.12-0.25 part of bisabolol, 0.35-0.7 part of nicotinamide, 0.6-0.8 part of Carbomer, 0.8-1.3 parts of allantoin, 0.8-1.3 parts of centella extract, 5-6.8 parts of glycerinum, 1-1.4 parts of solubilizer, 0.2-0.3 part of neutralizer, 0.05-0.15 part of essence, 0.25-0.35 part of preservative and 85-91 parts of water. The preparing process is simple, and the product is stable in quality, safe and non-irritant, moistens the skin and can repair the scar skin after being used for a long time.

The invention discloses a portable mini vacuum pump negative pressure scar treatment device which comprises a scar repair paster, a biological semipermeable membrane, a suction cup and a mini vacuum pump. The scar repair paster covers the scar skin. The suction cup covers the scar repair paster. The biological semipermeable membrane covers the scar repair paster and the suction cup. One end of the suction cup is provided with a drainage pipe and connected with the mini vacuum pump through a connecting pipe. The portable mini vacuum pump negative pressure scar treatment device is provided with a pressure detection device, the mini vacuum pump is adopted for generating negative pressure, the system adjusts and controls the negative pressure, a large-capacity lithium battery is used for continuously supplying power, no large center negative pressure system or electric negative pressure instrument is needed, no socket power is needed, and the portable mini vacuum pump negative pressure scar treatment device is small in size, portable and capable of being used for patients inside or outside hospitals for a long time, produces no complication or side effects, is low in price and convenient to use and avoids the risks of chemical substance leakage and corrosion and environment pollution possibly caused when a battery is used for a long time.

The present invention provides a composition for correcting scar of skin which corrects a scar of skin such as a mark of skin injury, which achieves an excellent effect of correcting a scar of skin with a good covering ability and an ease in applying the composition repeatedly or another thereover and has a good feeling in use as well as an excellent long-lasting effect in makeup. The composition comprises (a) 30 to 50% by mass of titanium oxide and (b) 2 to 20% by mass of coating agents including acrylic-silicone graft copolymer and siliconated polysaccharide compound.

A composition for promoting regeneration of tissue which has degenerated in a subject as a result of a disease or disorder and a method of using the composition is provided. The composition comprises a biodegradable acellular matrix, and passaged autologous fibroblasts substantially free of immunogenic proteins, e.g., culture medium serum-derived proteins, integrated within the matrix. The method of using the composition to promote regeneration of tissue involves placing the composition on a site of degenerated tissue in a subject so that the composition promotes tissue regeneration at the site. The composition and the method of its use have applications promoting regeneration of tissue (i) that has degenerated as a result of numerous diseases or disorders or (ii) that has a defect, including, but not limited to, defects of the oral mucosa, trauma to the oral mucosa (e.g., extraction of a tooth), periodontal disease, diabetes, cutaneous ulcers, venous stasis, scars of the skin, or wrinkles of the skin. Also provided is an injectable composition comprising any type of collagen and passaged autologous fibroblasts substantially free of immunogenic proteins, e.g., culture medium serum-derived proteins, for correcting defects in skin, such as wrinkles or scars, and for augmenting tissue in the subject, particularly facial tissue.

The invention discloses a horizontal continuous casting crystallizer of a cast iron and a preparing method of cast iron proximate matter. The crystallizer comprises a crystallizer body; a collector nozzle type isolation ring is arranged at the front end of a high-purity graphite casting mold of the crystallizer body; according to the horizontal continuous casting crystallizer of the cast iron, the collector nozzle type isolation ring is arranged at the front end of the high-purity graphite casting mold, the blocking effect of the collector nozzle type isolation ring is used for forcing molten iron not to enter the high-purity graphite casting mold in a laminar flow manner, the molten iron must enter the high-purity graphite casting mold in a forced laminator flow manner, the high-speed washing effect generated by turbulent fluid flowing of the molten iron is sufficiently utilized, the molten iron is pushed backwards before being solidified, and the molten iron enters a forced cooling area of a water-cooled iron sleeve of the crystallizer and then is crystallized and solidified; and the surface of the cast iron proximate matter produced through the crystallizer is smooth in surface, the phenomenon of scar skin discharging is prevented from appearing, the structure is compact and uniform, hardness distribution is uniform, the mechanical property is improved to a certain degree, the cutting machining performance is good, the machining allowance is small, and the production cost is reduced.

This invention describes methods for treating wound healing pathologies, inhibiting or reversing fibrotic skin disorders, including but not limited to keloids, atrophic and hypertrophic scars, and reversing skin aging via generating new dermal adipocytes (DAs). Methods described herein comprise (a) grafting of human hair follicles or (b) direct delivery of conditioned media from in vitro cultured hair follicles, or (c) delivery of purified individual factors secreted by hair follicles, or (d) delivery of small molecule agonists that mimic hair derived signaling activities, or (e) delivery of small molecule antagonists that inhibit anti-adipogenic programs, or (f) delivery of small molecule agonists of pro-adipogenic programs to convert endogenous wound or scar skin fibroblasts into new DAs.

The invention belongs to the technical field of tissue engineering, and provides a preparation method of a tissue-engineered scar skin model. Scar tissue acellular dermal matrix protein, scar fibroblasts and rat tail collagen are subjected to tissue engineering skin culture so as to obtain tissue-engineered skin. The method comprises the following steps: S1, extracting acellular dermal matrix protein of scar tissue; S2, extracting scar fibroblasts; S3, carrying out mixed culture on the scar tissue acellular dermal matrix protein obtained in the S1, the scar fibroblasts obtained in the S2 and the rat tail collagen; and S4, after one week of culture, adding epidermal stem cells, and performing culturing until the tissue-engineered skin is formed. The technical scheme solves the problem of lack of a proper human scar model in the prior art.

The invention provides an ointment for promoting skin tissue regeneration. The ointment is prepared by mixing 2 ml of platelet rich plasma (the blood platelet concentration is 0.9-1.4*1015 / L), 0.01-0.15 mg of thrombin, 2-5 g of royal jelly, 0.03-0.12 mg of glutathione, 0.001-3 mg of vitamins, 5-25 mg of collagen peptide, 0.01-7.5 mg of nucleotide, 0. 03-0.5 mg of calcium chloride, 0.1-0.3 mg of chitosan, 2-5 mg of gelatin, 3-10 mg of glycerin, 0.1-2 mg of coenzyme, 0.01-0.4 mg of potassium chloride, 0.04-0.6 mg of magnesium sulfate, 0.03-0.5 mg of zinc oxide and 10-50 ml of distilled water. The ointment for promoting skin tissue regeneration can promote regeneration of depression scar skin tissue of the human body, is suitable for adjuvant treatment of depression scars and especially has the remarkable treating effect on depression scar wounds having the depth (5-15mm), meanwhile a treatment period can be shortened, and the treating period can be shortened to 25 days for depression scars having the depth of 5mm or below.

The invention discloses a Chinese and western medicine combined treatment method for scar hyperplasia. The Chinese and western medicine combined treatment method for scar hyperplasia comprises the steps that 1, local triamcinolone acetonide injection is carried out, wherein triamcinolone acetonide injection and 2% of lidocaine injection are mixed evenly according to a ratio of 1: 1, mixed liquid is extracted through a 1ml injector, the scar skin lesion surface and the surrounding skin are disinfected, the medicine liquid is injected into the skin lesion from the different portions of the edge of a scar in a surrounding, multi-point and layered mode until the skin lesion becomes white, the medicine dosage of each time is smaller than or equal to 40 mg, injection is carried out once every week, and six times of injection is a course of treatment; 2, self-made scar removing cream is smeared, wherein on the basis of the local triamcinolone acetonide injection, the self-made scar removing cream of a proper amount is taken and smeared on the scar skin lesion surface, the scar skin lesion surface is massaged spirally with the finger pulp, the massage lasts for 30 minutes twice every day, and 15 days is one course of treatment. The treatment method adopts the local triamcinolone acetonide injection and self-made traditional Chinese medicine cream for exterior application, the time for taking effect is brought forward, the defect that scar hyperplasia easily recurs only through hormone is also overcome, and the dosage of hormone is also reduced.

The invention discloses traditional Chinese medicine soap for removing scar. The traditional Chinese medicine soap is prepared from 10 to 20 parts by weight of folium artemisiae argyi, 20 to 30 parts by weight of pine bark, 7 to 15 parts by weight of radix clematidis, 10 to 15 parts by weight of safflower, 6 to 11 parts by weight of trogopterus dung, 6 to 11 parts by weight of Chinese gall, 5 to 10 parts by weight of red sage root, 10 to 15 parts by weight of radix lithospermi, 10 to 15 parts by weight of dark plum, 3 to 5 parts by weight of radix sophorae flavescentis, 5 to 10 parts by weight of rhizoma curcumae, 7 to 20 parts by weight of licorice root, 7 to 10 parts by weight of coconut oil, 7 to 10 parts by weight of palm oil, 7 to 10 parts by weight of ethanol and 10 to 15 parts by weight of sodium hydroxide. The traditional Chinese medicine soap is prepared from traditional Chinese medicines, can slowly care and remove scar in the daily life, does not stimulate patient scar skin and has high safety.

The invention relates to beauty soap. The beauty soap is formed by mixing and pressing traditional Chinese medicine composition and a soap base according to the mass ratio of 1 to 1-5. The traditional Chinese medicine composition is composed of, by weight, 1-10 parts of ginseng, 1-10 parts of jasmine flower, 5-12 parts of saposhnicovia divaricata, 10-15 parts of fructus lycii, 1-15 parts of red peony root, 1-12 parts of fritillary bulb, 1-15 parts of chamomile, 1-20 parts of rose and 1-11 parts of giant typhonium rhizome. The beauty soap can effectively remove dirt on skin, is moderate and free of harm to skin, has the functions of whitening, moisturizing, wrinkle removing and scar removing, and is suitable for patients with scarred skin and is free of toxic and side effects after long-term use.

A method for the prevention and / or treatment of skin damage using chaperonin proteins in a dermatologically acceptable carrier is provided. The compositions are applied topically to treat conditions such as sunburn, aged skin, and scarred skin. The compositions may additionally include additional proteins such as rice hemoglobin, superoxide dismutase and / or catalase, as well as antioxidant molecules such as vitamin E, and vitamin C.

The invention provides a composition for treating striae gravidarum and blemish. The composition comprises the following active components of arabinogalactan, zinc gluconate, copper gluconate, sodiumascorbate and a stem cell culturing supernatant. According to the prepared composition for repairing striae gravidarum and blemish, the taking-effect time that single mesenchymal stem cells are used for culturing the supernatant is shortened, and quick repair of skin blemish is promoted. In addition, several active components are added, so that repair of the striae gravidarum is facilitated. Afterthe composition is continuously used for 5 weeks, striae gravidarum of 60-68% or more of an examinee can be obviously improved, and after the composition is continuously used for 8 weeks, striae gravidarum of 92-98% or more of the examinee can be obviously improved, length and width of the striae gravidarum are obviously shortened, and the moisturizing capacity of round skin is improved. Only composition containing the supernatant cultured with the mesenchymal stem cells is used for experiment, and after continuous use lasts for 8 weeks, striae gravidarum of only 54-60% of the examinee is obviously improved.

The invention discloses an inhibitor for apple tree viruses and making and using methods and belongs to the field of forestry pest control. The inhibitor comprises magnetized industrial water, honeysuckle, radix saposhnikoviae, fructus forsythiae, herba andrographitis, radix isatidis, dandelion, herba patriniae, rhizoma belamcandae, semen sinapis, melanterite, turtle shell, radix paeoniae rubra, pseudo-ginseng, rhizoma cimicifugae, radix sophorae flavescentis, radix zanthoxyli, radix scrophulariae, herba cayratica jeponicae, nightshade, boric acid, acetic acid, copper sulfate and potassium sorbate. Little three wastes are generated in the process of production, the production process is free of environment pollution, land pollution and apple pollution, and high-quality apples with quite low pesticide residue content can be produced. The inhibitor is low in production cost, good in using effect and capable of resisting fungi and various apple tree viruses, does not cause pesticide resistance of apple trees and has remarkable treatment effect on apple tree scar skin virus especially.

The invention relates to the field of skin care products, in particular to a bioactive substance freeze-dried solid facial mask and a preparation method thereof. The bioactive substance freeze-dried solid facial mask is prepared from a facial mask cloth soaked with a facial mask liquid through low-temperature drying, the mask liquid comprises a phase A, a phase B and a phase C, the phase A is prepared from water, glycerol, propylene glycol, plant extract, sodium hyaluronate, tranexamic acid, raspberry ketone glucoside, sclerotium gum, erythritol, allantoin, a thickening agent and p-hydroxyacetophenone, the phase B is prepared from olive fruit oil, grape seed extract, jojoba seed extract, sweet orange essential oil, vitamin E, dioctyl carbonate and hydrogenated lecithin, and the phase C isan adipose tissue-derived stromal cell lysate. The bioactive substance solid mask disclosed by the invention has the effects of whitening and moisturizing the skin, improving the glossiness of the skin and repairing acne marks and scar skin.

The invention discloses a debridement therapeutic method which belongs to the technical field of medical treatment and comprises the steps of wound debridemnet, wound blow therapy and allergy test, wherein the wound debridemnet is carried out by uniformly spraying ozone water, formed by mixing high-concentration ozone gas and clear water, to a wound dermic layer; the wound blow therapy is carried out by treating the wound surface directly with the ozone gas; and the allergy test is carried out by directly blowing the wound surface with the ozone gas to detect allergy. The invention uses the ozone water in the wound debridement treatment so as to ensure the comfortable feeling of patients and achieve the effects of infection resistance, blood circulation promotion, and increase of immunity of wound surface skin, moreover, no pollution exists during cleaning, the healing speed is high, scar skin color is light, and local oxygen therapeutic, analgesic and anti-inflammatory effects can be exerted on the wound surface.

The invention discloses a thymosin beta-4 ethosome, and a preparation method thereof. The thymosin beta-4 ethosome comprises 0.022 to 0.043% of thymosin beta-4, 0.054 to 0.084% of phosphatide, 0.018 to 0.028% of cholesterol, 0.02 to 0.04% of an anionic surfactant, 10.10 to 30.30% of ethanol, and the balance distilled water. The thymosin beta-4 ethosome is capable of improving medicine transdermalabsorption effect, and improving the restoration technical effect of thymosin beta-4 on scar skin. According to the preparation method, the anionic surfactant and cholesterol are added to solve a stability problem of thymosin beta-4 ethosome. The thymosin beta-4 ethosome prepared through the preparation method is high in encapsulation efficiency, and stability; the technology is simple; excellenteconomical benefit is achieved, and the invention also discloses applications of the thymosin beta-4 ethosome in the technical field of scar restoration.

The invention relates to a hydrogel scar patch for softening and fading scars. The invention is characterized in that: besides serving as a drug delivery platform, a gel plaster also can treat scars; it has good therapeutic effects on scars, can soften and fade scar tissues, and can flatten scars. The principle of the hydrogel scar patch is based on a gel plaster's hydrophilic matrix, which has the characteristics that: 1. the hydrophilic gel matrix has a high moisture content up to over 70%, can actively hydrate scar skin, and the hydration degree is high, thus being more conducive to softening and flattening of scars; and 2. the hydrophilic gel matrix generates mechanical compression on skin surfaces, thus exerting a mechanical pressure on scar bodies.

The invention discloses a nutritional repair composition for strengthening the effect after medical beautifying treatment. The invention belongs to the technical field of biological medicine, the composition is prepared from the following substances in parts by weight: 40 to 50 parts of elastin extract, 5 to 8 parts of fish maw, 2 to 5 parts of chitosan, 0.5 to 1 part of green tea extract, 6 to 9parts of fruit seed extract, 0.2 to 0.4 part of composite vitamin, 0.1 to 0.3 part of zinc gluconate, 0.2 to 0.5 part of citric acid, 0.1 to 0.2 part of L-malic acid and 50 to 55 parts of auxiliary materials. The nutritional repair composition can enhance the recovery speed and recovery capability of the scar skin of a patient, strengthens the effect recovery after medical and art treatment, has agood comprehensive use effect, and is green and safe.

The invention provides application of stem cell-derived microvesicles in preparation of a preparation for repairing scars, and relates to the technical field of scar skin repair. In the invention, theextracellular vesicles derived from the mesenchymal stem cells obviously inhibit the expression of collagen III, the collagen III in the treatment group of the high-concentration microvesicles and the low-concentration microvesicles is obviously lower than that in the PBS group, and the expression of collagen I also presents a decreasing trend; both the high-concentration microvesicles and the low-concentration microvesicles can promote reasonable distribution of a skin structure, specifically, the structure of collagen is more reasonable, and accessory structures are remarkably increased; therefore, the stem cell-derived microvesicles have a scar repairing effect, the low-concentration microvesicles and the high-concentration microvesicles can promote the repairing effect of scar skin, the scar area of the repaired high-concentration microvesicles is smaller than the treatment of the low-concentration microvesicles, the treatment effect is remarkable, and the stem cell-derived microvesicles can be used for preparing preparations for repairing scars.

The invention relates to the technical field of cosmetics, in particular to a composition for promoting scar skin repair and a preparation method thereof. The composition for promoting the scar skin repair includes, in percentage by mass, a 0.5 to 5% birch extract and a biological active polypeptide compound which serve as active ingredients. The birch extract is selected from one or more of betulin, betulinic acid, betulin derivatives, and betulinic acid derivatives. The invention provides the composition for promoting the scar skin repair, and the composition includes the birch extract and the biological active polypeptide compound which serve as active ingredients. Together with the remaining components, the composition solves the conditions that active polypeptides are easily aggregated, a turbid composition system is caused, and the active polypeptides are difficult to absorb and easy to layer, thereby improving the overall stability, extending the shelf life of the product and further improving the product utilization rate. At the same time, through the synergistic effect of the active ingredients and a vitamin A compound, the composition can effectively repair skin scars.

The invention relates to a cream for burns and scalds and a preparing method and application thereof. The scream for burns and scalds is prepared from, by weight, 1-100 parts of herba artemisiae anomalae, 1-100 parts of coptidis rhizoma, 1-100 parts of gypsum rubrum, 1-100 parts of herba schizonepetae, 1-100 parts of radix sanguisorbae, 1-100 parts of rheum officinale, 1-100 parts of semen plantaginis and 1-100 parts of radix sileris. The cream has an extremely good treatment effect on physical and chemical burns and scalds and electrical injuries caused by various reasons. Compared with similar products on the market, the cream for burns and scalds has the advantages of being rapid in pain stopping, good in pain stopping effect, high in wound restoring speed, free of scars in I-degree andII-degree burns and scalds and not prone to scars in III-degree burns and scalds (except for patients with improper nursing and congenital scar skin) and has quite good commercial prospects.

The invention discloses a horizontal continuous casting crystallizer of a cast iron and a preparing method of cast iron proximate matter. The crystallizer comprises a crystallizer body; a collector nozzle type isolation ring is arranged at the front end of a high-purity graphite casting mold of the crystallizer body; according to the horizontal continuous casting crystallizer of the cast iron, the collector nozzle type isolation ring is arranged at the front end of the high-purity graphite casting mold, the blocking effect of the collector nozzle type isolation ring is used for forcing molten iron not to enter the high-purity graphite casting mold in a laminar flow manner, the molten iron must enter the high-purity graphite casting mold in a forced laminator flow manner, the high-speed washing effect generated by turbulent fluid flowing of the molten iron is sufficiently utilized, the molten iron is pushed backwards before being solidified, and the molten iron enters a forced cooling area of a water-cooled iron sleeve of the crystallizer and then is crystallized and solidified; and the surface of the cast iron proximate matter produced through the crystallizer is smooth in surface, the phenomenon of scar skin discharging is prevented from appearing, the structure is compact and uniform, hardness distribution is uniform, the mechanical property is improved to a certain degree, the cutting machining performance is good, the machining allowance is small, and the production cost is reduced.

The invention discloses an in-vitro culture method and injection of autologous breast milk stem cells and application of the autologous breast milk stem cells in skin injury repair. The in-vitro culture method comprises the following steps: separating breast milk stem cells; the method comprises the following steps: performing induced differentiation on breast milk stem cells to differentiate the breast milk stem cells into fibroblasts, and culturing the breast milk stem cells in a tension culture medium under the condition of mechanical tension in induced differentiation; loading and culturing fibroblasts to obtain a complex which is a complex of the polylactic acid hydrogel and the fibroblasts. The fibroblast efficiently expresses cell waveform protein and fibronectin and highly expresses I / III type collagen. The complex can promote efficient expression of scar skin I / III type collagen and normalization of I / III type collagen egg fiber arrangement through a PI3K / Akt signal channel mechanism, has the function of promoting scar repair, and has the application prospects of being widely applied to wound repair, skin wrinkle and scar removal, aging resistance and the like.

The invention relates to a preparation for removing acne and freckles, promoting tissue regeneration and repairing skin and a preparation method, and belongs to the field of pharmacy. The preparationand the preparation method take the advantages of traditional Chinese medicine and western medicine, and biological agents such as periplaneta extracts which promote cell regeneration is solved; on the basis of acne removing, skin protection, beauty maintaining and young keeping, defective skin repairing and fistula functions are added, so that the product has the function of regenerating the skinwithout scarring. Hard, dead, dull, stagnant, defective and scar skin caused by chemical drug poisoning can be tender and fade, and agile vitality is shown.

The invention provides a preparation for treating acne and a preparation method of the preparation. The preparation comprises, by weight, 0.1-2 parts of metronidazole, 0.3-10 parts of aloe extracts, 5-20 parts of white vinegar, 0.2-5 parts of peppermint extracts, 0.1-3 parts of vitamin C and the rest double distilled water. According to the preparation, antisepsis and anti-inflammation functions are enhanced by the aid of the metronidazole and the white vinegar in the treating process of the acne, inflammation symptoms are effectively relieved, facial sympathetic nerves are stimulated by the aid of the vitamin C, so that the infected acne easily heals, and scar skins are effectively repaired to rehabilitate. In addition, the preparation is effective for other skin diseases such as rosacea, acne and tinea versicolor, has nursing and cleaning functions on the skins, has fewer components and is simple to prepare.