39 results about "Plasma Albumin" patented technology

This invention describes a point-of-care or home use device for measuring the ratio of glycated albumin to total albumin in saliva and other body fluids. Diabetics and prediabetics may have elevated levels of glucose in their blood that can react with plasma albumin to form glycated albumin. The amount of glycated albumin formed is directly correlated with the level of plasma glucose that the albumin has been exposed to over a period of time. Saliva albumin is derived from plasma albumin and therefore contains glycated and non-glycated albumin fractions that can be measured. The ratio of glycated albumin to total albumin in saliva will provide an indication of the average amount of protein glycation that occurred over the preceding 2-3 week period.The test is performed using a disposable strip or cassette that contains the testing reagents and the results are measured in a measuring instrument that automatically reads, calculates and displays the final result. The results of tests performed over a period of time are stored in the instrument's memory and presented in a numerical or graphical format so that the individual's glycated albumin level can be monitored over time.

This invention describes a rapid immunochromatographic assay for measuring the ratio of glycated albumin to total albumin in saliva. Patients with diabetes have elevated levels of glucose in their blood that can react with plasma albumin to form glycated albumin. The amount of glycated albumin formed is directly correlated with the level of plasma glucose that the albumin has been exposed to over a period of time. Saliva albumin is derived from plasma albumin and therefore contains glycated and non-glycated albumin fractions that can be measured. The ratio of glycated albumin to total albumin in saliva will provide an indication of the average amount of protein glycation that occurred over the preceding 2-3 week period.The test is performed using a disposable strip that contains the testing reagents and the results are measured in a measuring instrument that automatically reads, calculates and displays the final result. The results of tests performed over a period of time are stored in the instrument's memory and presented in a numerical or graphical format so that the individual's glycated albumin level can be monitored over time.

This invention describes a rapid assay for measuring the ratio of glycated albumin to total albumin in blood. Patients with diabetes have elevated levels of glucose in their blood that can react with plasma albumin to form glycated albumin. The amount of glycated albumin formed is directly correlated with the level of plasma glucose that the albumin has been exposed to over a period of time. The ratio of glycated albumin to total albumin in blood will provide an indication of the average amount of protein glycation that occurred over the preceding 2-3 week period.The test is performed using a disposable strip or cassette that contains the testing reagents and the results are measured in a measuring instrument that automatically reads, calculates and displays the final result. The results of tests performed over a period of time are stored in the instrument's memory and presented in a numerical or graphical format so that the individual's glycated albumin level can be monitored over time.

An intestinal nutrition peptide as an additive of feed for piglet is prepared from one or more of oligopeptide, plycyl-L-glutamine, alanyl glutamine and iron glycinate. It can prevent the delactation stress of piglet and can be used to replace to plasma albumin powder. Said oligopeptide is prepared from soybean protein and rapeseed protein through sterilizing, enzymolyzing, deactivating enzyme and ultra-filtration.

The invention discloses an application of naja atra venin to preparation of a medicament for treating diabetes and a diabetic nephropathy complicating disease. As proved by animal experiments, after the total toxicity of naja atra venin which is modified and renatured physically in a range of 10-3,000 mug / kg is applied, the weight of a mouse suffering from diabetic nephropathy can be reduced, the blood sugar level of a mouse suffering from diabetes can be lowered, urokinase proteins are reduced, plasma albumin is raised, blood plasma triglyeride is reduced, plasma creatinine and urea nitrogen are reduced, the expression of inflammatory factors in kidney is reduced, the oxidative stress level is lowered, glomerulosclerosis is reduced, and nephridial tissue and islet injury are relieved.

A tip filter containing nano-material for cigarette is prepared through adding sodium selenite to the solution containing plasma albumin and heme, constant temp, adding hydrazine hydrate, reacting to become nano-material, preparing the solution of glyceride acetate, spraying it onto acetate fibers, and rolling.

The invention provides medicine for treating uremia and urine protein. The medicine is a mixture of glycoprotein or polysaccharide and protein or polypeptide or protein. The medicine achieves a good treatment effect for uremia and urine protein, and after three treatment courses are completed, the total effective rate is 84-94%; the medicine lowers toxin of uremia and urine protein and remarkably lowers the content of SCr, the content of urine protein and the content of blood urea nitrogen, after three treatment courses are completed, the SCr content of a patient is 282.4-290. micromole / L, the urine protein content is 2.42-2.54 g / 24h, and the blood urea nitrogen content is 14.2-15.0 mmol / L. The medicine improves the nutrition condition of the organism, raises the content of plasma albumin (Alb) and the content of hemoglobin (Hb), improves the immunity, has the advantages of being safe, high in efficiency and free of side effect and has an obvious treatment effect for uremia and urine protein.

A method for inactivating and removing dengue virus from a biological sample comprising the dengue virus and at least one biomolecule of interest is characterized by: inactivating dengue virus by using an organic solvent lonely or combined with a nonionic detergent, and separating the dengue virus from the biomolecule of interest actually by using cation exchange chromatography. In another aspect of the present invention, a method is provided for producing human plasma albumin that is substantially free from infective dengue virus. According to the invention, dengue virus can be removed effectively to avoid danger of viral infection or immunological response caused by exogenetic virus or the genetic material thereof transmitted into human body. The invented method is provided with simplicity, economy and high efficiency.

The invention provides a medicated food for improving the nutrition state of liver cirrhosis, which is prepared from the following raw materials: tuckahoe, coix seed, Chinese yam, finger citron, endothelium corneum gigeriae galli, jujubes and ordinary rice; and the raw materials have the effects of strengthening the spleen and eliminating dampness as well as soothing the liver and regulating the flow of qi. By virtue of the characteristics of foods according to the homology of medicines and foods, the medicated food can supply partial energy and nutritional ingredients required by patient bodies; and moreover, by virtue of the effects of the traditional Chinese medicine components for strengthening the spleen and eliminating dampness as well as promoting qi circulation for diuresis, the functions of tri-jiao for promoting qi circulation, dredging collaterals and promoting diuresis are optimal, so that pathological factors are eliminated, the physiological functions of the liver are improved, physiologic conditions favorable for repairing liver tissues are formed, and a benign auxiliary treatment effect on the condition of a patient suffering liver cirrhosis is achieved. The medicated food has the effects of increasing plasma albumin, promoting liver regeneration and promoting recovery of liver functions. The invention provides a new simple, feasible, economical, practical, safe and effective method for auxiliary treatment of the patient suffering liver cirrhosis in the decompensated period. Through clinical practice for many years, the effective rate of the medicated food is 92.7%.

A forage for piglet is prepared through dissolving 8 soluble materials (plasma albumin powder, whey powder, emulsified fat, glucose, etc) in water, mixing 5 insoluble materials (puffed soybean powder, fish powder, calcium hydrogen phosphate, etc), mixing both together, stirring, granulating, baking and cooling.

An intestinal nutrition peptide as an additive of feed for piglet is prepared from one or more of oligopeptide, plycyl-L-glutamine, alanyl glutamine and iron glycinate. It can prevent the delactation stress of piglet and can be used to replace to plasma albumin powder. Said oligopeptide is prepared from soybean protein and rapeseed protein through sterilizing, enzymolyzing, deactivating enzyme and ultra-filtration.

The present application relates to a series of redox-sensitive albumin-bound prodrugs specifically responsive to tumor tissue, and in particular, to three small-molecule docetaxel-maleimide prodrugs. A maleimide ring in the prodrug structure is used as a target for binding a free thiol group at position 34 of a plasma albumin in the body, such that the drug rapidly and specifically binds to the albumin after intravenous injection into the body and forms an albumin-drug complex, thereby enhancing drug stability and significantly prolonging the circulation time of the drug in the body. Furthermore, the EPR effect is leveraged to achieve drug accumulation in tumor tissue.

The medicine for increasing leukocyte comprises 10 Chinese medicinal materials of turtle shell, millettia root and stem, ginseng, prepared flowery knotweed root, jujube and others. Its preparation process includes the following steps: (1). drying and pulverizing turtle shell to obtain fine powder; (2) making millettia root and stem into millettia paste; and (3) making other ingredients into oral liquor, said three portions are formed into the medicine with the functions of raising physiological function and immunity of human body and a certain anticancer action. It has no any adverse reactions.

The invention provides a medicated food for improving the nutrition state of liver cirrhosis, which is prepared from the following raw materials: tuckahoe, coix seed, Chinese yam, finger citron, endothelium corneum gigeriae galli, jujubes and ordinary rice; and the raw materials have the effects of strengthening the spleen and eliminating dampness as well as soothing the liver and regulating the flow of qi. By virtue of the characteristics of foods according to the homology of medicines and foods, the medicated food can supply partial energy and nutritional ingredients required by patient bodies; and moreover, by virtue of the effects of the traditional Chinese medicine components for strengthening the spleen and eliminating dampness as well as promoting qi circulation for diuresis, the functions of tri-jiao for promoting qi circulation, dredging collaterals and promoting diuresis are optimal, so that pathological factors are eliminated, the physiological functions of the liver are improved, physiologic conditions favorable for repairing liver tissues are formed, and a benign auxiliary treatment effect on the condition of a patient suffering liver cirrhosis is achieved. The medicated food has the effects of increasing plasma albumin, promoting liver regeneration and promoting recovery of liver functions. The invention provides a new simple, feasible, economical, practical, safe and effective method for auxiliary treatment of the patient suffering liver cirrhosis in the decompensated period. Through clinical practice for many years, the effective rate of the medicated food is 92.7%.

The invention belongs to the technical field of medicine, and relates to an albumin-binding near-infrared fluorescent dye-maleimide conjugate. The albumin-binding near-infrared fluorescent dye-maleimide conjugate specifically uses a maleimide-containing group to replace the chlorine in the conjugated chain of the cyanine dye, through the intramolecular charge transfer effect Its optical properties have been modified so that it can be used as a blue biological dye. Secondly, the maleimide group in the conjugate can be covalently bonded to the free sulfhydryl group of cysteine ​​34 on plasma albumin through Michael addition reaction, thus having excellent lymph node targeting. This near-infrared fluorescent bioimaging agent overcomes the shortcomings of the imaging method used in clinical sentinel lymph node navigation surgery, and is safe, reliable, accurate in positioning, and high in imaging efficiency. As a whole, it can realize the dual imaging function of lymph node positioning in vivo.