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102 results about "Intestinal adhesions" patented technology
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Medical anti-adhesion material with controllable degradation and preparation method thereof
InactiveCN102380121AVolatileControllable degradation rateSurgeryAbsorbent padsCross-linkBiocompatibility Testing
The invention discloses a medical anti-adhesion membrane material with controllable degradation and a preparation method thereof, belonging to the field of biomedical materials. According to the invention, the membrane material is prepared by blending sodium hyaluronate and konjac klucomannan, using lactic acid as a property-modifying additive and using a mixed solution of ammonia water and anhydrous ethanol as a cross-linking agent; sodium hyaluronate is a good anti-adhesion material, but individually used sodium hyaluronate has a fast degradation speed and can not fulfill a good anti-adhesion effect; konjac klucomannan can control the degree of cross-linking, thereby realizing the goal of controllable degradation, and blending of sodium hyaluronate and konjac klucomannan enables sodium hyaluronate to be released slowly, thereby allowing the membrane material to meet demands for anti-adhesion action at different parts. The membrane material has the advantages of nontoxic degradation products, good biocompatibility, hygroscopicity and tensile properties, and the like, and can be used for intervertebral adhesion, intestinal adhesion, skin adhesion, intrauterine adhesion, etc.
Owner:KUNMING UNIV OF SCI & TECH
Pain relieving sterilized electronic plaster instrument for trauma
ActiveCN101427961AImprove conductivityGood paste performanceElectrotherapyAdhesive dressingsScar tissueElectric field
Owner:龙丹
Traditional Chinese medicine preparation for treating surgical intestinal adhesions
InactiveCN101716298ASimple preparation processEasy to useDigestive systemSulfur/selenium/tellurium inorganic active ingredientsIntestinal structureSide effect
The invention relates to a traditional Chinese medicine preparation for treating surgical intestinal adhesions. The traditional Chinese medicine preparation is prepared from the following raw materials in parts by weight: 19-23 parts of radish seed, 10-14 parts of mangnolia officinalis, 10-14 parts of fructus aurantii, 10-14 parts of ligusticum wallichii, 10-14 parts of fructus toosendan, 13-17 parts of red-rooted salvia root, 10-14 parts of common peony root, 10-14 parts of peach kernel, 10-14 parts of red flower, 10-14 parts of bighead atractylodes rhizome, 8-10 parts of costustoot, 19-23 parts of rheum officinale, 5-7 parts of coke hawthorn, 5-7 parts of coke malt, 5-7 parts of coke medicated leaven, 8-10 parts of rhizoma corydalis, 19-23 parts of astragalus membranaceus and 8-10 parts of mirabilite. The traditional Chinese medicine preparation has the advantages of simple preparation process, convenient use, no toxic or side effects, obvious curative effect and low price, and good curative effect on stomachaches, abdominal distensions, unsmooth exhaust, dry stools, intestinal obstructions, and the like caused by intestinal adhesions and is suitable for treating symptoms of stomachaches, abdominal distensions, emesia, constipations, and the like caused by abdominal operations and simple adhesive intestinal obstructions.
Owner:李淑花
Intelligent digital multifunctional therapeutic apparatus mainly used for treating intestinal adhesion
InactiveCN103272331ASafe and easy treatmentQuick fixMedical devicesLight therapySilicon-controlled rectifierMicrocontroller
The invention provides an intelligent digital multifunctional therapeutic apparatus mainly used for treating intestinal adhesion, and belongs to the technical of medical apparatuses and instruments. The intelligent digital multifunctional therapeutic apparatus mainly used for treating intestinal adhesion comprises a main machine, a power line, a thermal therapy bag and electrode paster, electrode connection lines, a dynamic cupping device, a heating body and the like, wherein a liquid crystal display screen, buttons and accessory interfaces are mounted outside a case of the main machine, an MCU single chip microcomputer, a dynamic air pump, a pulse transformer and an electronic circuit board are mounted inside the case of the main machine, and an integrated circuit, a silicon controlled rectifier, a diode, a triode and an electrolytic capacitor are mounted on the electronic circuit board. A double-line power source supplies power to the circuit, the buttons are connected with the MCU single chip microcomputer, the MCU single chip microcomputer is connected with the liquid crystal display screen, an air pump control system, an electromagnetic valve, the pulse transformer and the power source respectively, the electromagnetic valve is connected with a dynamic electrotherapy outlet and a throttle air chamber, the throttle air chamber is connected with an air pump, a water outlet and the dynamic electrotherapy outlet, the pulse transformer is connected with a electrotherapy outlet and the dynamic electrotherapy outlet, the MCU single chip microcomputer and a functional chip control the circuit, and the buttons have the functions of setting and adjustment.
Owner:周建设
Degradable gasket with anti-bacterial anti-adhesion performance
InactiveCN104606722AAntibacterial and anti-adhesion functionGood biocompatibilitySurgeryCoatingsBiocompatibility TestingKnee Joint
The invention provides a degradable gasket with anti-bacterial anti-adhesion performance. The degradable gasket is prepared via weaving or knitting of a plurality of bundles of magnesium-based metal wire, or via punching of magnesium-based metal sheets. The magnesium-based metal wire can be made of pure magnesium or a magnesium-based alloy of different elements based on disease characteristics and treatment requirements. The degradable gasket possesses excellent biocompatibility; in vivo degradation and absorption can be realized; degradation speed can be controlled; the degradable gasket is capable of preventing postoperative adhesion and infection, and promoting wound healing, can be used for preventing epidural adhesion after orthopedic surgery laminectomy, adhesion after tendon rupture repairing operation, adhesion after knee surgery, dura adhesion after transcranial surgery, eye socket soft tissue adhesion, intestinal adhesion after abdominal surgery, and intrauterine adhesion, is capable of reducing infection risk of the above surgeries, and possesses significant clinical application value.
Owner:SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
Berberine ultrafine-particle intestinal adhesion-type sustained-release pellet and preparation method thereof
ActiveCN103393602ASustained decrease in absorptionReduce absorptionOrganic active ingredientsMetabolism disorderSustained release pelletsCellulose
The invention discloses berberine ultrafine-particle intestinal adhesion-type sustained-release pellets and a preparation method for the same, which are applied to the field of pharmaceutical preparations. The berberine ultrafine-particle intestinal adhesion-type sustained-release pellets are composed of berberine small-particle-size pellets and a coating material, wherein the berberine small-particle-size pellets are prepared by wrapping a medicine suspension on blank pellet cores; the medicine suspension is composed of berberine and a hydrophilic carrier material; the hydrophilic carrier material is selected from any one or more of hydroxy propyl cellulose, hydroxypropyl methyl cellulose, polyvinylpyrrolidone and polyvinyl alcohol; a plasticizer is selected from any one or more of triethyl citrate, polyethylene glycol-6000, castor oil and polyethylene glycol-1500. The ultrafine-particle sustained-release pellets disclosed by the invention can be retained in the upper section of an intestinal canal for a long time and continuously release medicines, and can effectively act on local targets for treating glucolipid metabolic syndrome, of the intestinal canal, so as to achieve a goal of continuously reducing absorption for glycolipid substances, and then achieve goals of reducing blood sugar and regulating blood lipid; the ultrafine-particle intestinal adhesion-type sustained-release pellets are convenient to take and suitable for industrialized production.
Owner:SHENYANG NO 1 PHARMA FACTORY DONGBEI PHARMA GRP
Thermal therapeutical medicated bag for recovering intestines and stomach function after abdomen operation and production method
InactiveCN1422648AInanimate material medical ingredientsPharmaceutical product form changeIntestinal structureTherapeutic effect
The present invention discloses a thermotherapeutic medicated bag for restoring gastrointestinal function after abdominal operation and its production method. It is characterized by that its composition comprises 17 Chinese medicinal materials of radish seed, unripe tangerine peel, fennel fruit, unripe bitter orange, magnolia bark and others. Said invented bag can improve local blood circulation, promote restoration of gastrointestinal function afte abdominal operation, and also can obtain obvious therapeutic effect for curing incomplete intestinal adhesion, ileus, constipation and other abdominal chronic inflammation, etc.
Owner:川北医学院
Composition of rheinic acid or rheinic acid compounds, its preparing method and its use in preparing medicine for preventing intestinal adhesion
InactiveCN1899276AReduce solubilityNot easy to use medicinallyPowder deliveryOrganic active ingredientsIrritationNitrogen
The present invention discloses application of compositions of rheinic acid or rheinic acid compound in preparation of drugs for treating stomach and intestine function recover or recovering the stomach and intestine function. The left side of the compound shown in the general formal (I) is one of the two: (1) the rheinic acid or rheinic acid compound monomer, wherein R2-R3, R6-R7 have 1-2 substitutions: -COOH and R1-R8, other positions are optional substitutions: -H, -O-glucose, -OH, -OCH3, and -CH3, at least two of R1-R8 are ..CH; (2) effective parts containing the rheinic acid and extracted from plants. M in the general formula (l) represents nitrogenous organic alkali or alkaline amino acid. The rheinic acid or the rheinic acid compound and the nitrogenous organic alkali or alkaline amino acid are joined through intermolecular forces to form the compound. The invention is a weak acid and weak alkalis compound and its solution is near neutral. The compound of the invention has easily acceptable pharmaceutical performance, better human body compliance and steady and less irritation.
Owner:南京中敬医药科技研究所 +1
Traditional Chinese medicine suppository and preparation method thereof
InactiveCN101099784AAvoid destructionEasy to useDigestive systemSuppositories deliveryIntestinal ObstructionsCITRUS MEDICA FRUIT
The invention is concerned with the Chinese traditional medicine suppository and the preparation method for treating and defending intestine paralysis, intestine conglutination and intestinal obstruction, composes of bark of official magnolia, rhubarb and fruit of immature citron that compounds with weight, which is by distill, filtration, concentration, dryness, crush to get dry cream powder, melts and mixes with the suppository base, irrigate module, cooling, gets the suppository. The invention is fast effect and dramatic curative effect.
Owner:JINAN KANGZHONG PHARMA TECH DEV
Medicinal composition for treating intestinal obstruction and method for preparing the same
The present invention discloses a pharmaceutical composition for treating intestinal obstruction and the preparation method, which is composed of the active ingredients of 7 raw materials of rhubarb, officinal magnolia bark, immature bitter orange, matrii sulfas exsiccatus, red paeony root, peach seed and radish seed, the mix ratio by weight of all the raw materials are: 3.81 to 38.0 parts of rhubarb, 3.81 to 38.0 parts of officinal magnolia bark, 3.04 to 30.4 parts of immature bitter orange, 1.0 to 10.0 parts of matrii sulfas exsiccatus, 3.81 to 38.0 parts of red paeony root, 3.04 to 30.4 parts of peach seed and 7.61 to 76.1 parts of radish seed respectively. Compared with the prior art, the present invention is characterized by significant efficacy, easy administration, no side effects and moderate price; the present invention has the functions of dredging intestines, promoting qi and removing blood stasis, which is used for intestinal obstruction, and the prevention and treatment of abdominal postoperative tympanites and intestinal adhesion.
Owner:广西壮族自治区药物研究所有限公司
Chinese medicine preparation for preventing and treating intestinal adhesion after abdominal cavity operation and its preparing process and application
The present invention discloses a kind of Chinese medicine preparation for preventing and treating intestinal adhesion after abdominal cavity operation. The Chinese medicine preparation is prepared with six kinds of Chinese medicinal materials, including rhubarb, peach kernel, mirabilite, sufflower, corydalis tuber and radish seed, and through crushing into meal, mixing, alcohol reflux extracting, filtering the extracted liquid, concentrating, decompression drying, crushing to obtain fine powder and other steps to prepare granule, capsule, tablet, etc. The Chinese medicine preparation has obvious curative effect, no toxic side effect, low cost, convenient treatment and other features.
Owner:NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
Medicine for treatment of cancer intestinal obstruction and preparation method thereof
ActiveCN103191203APromote peristalsisPromote circulationHydroxy compound active ingredientsDigestive systemClinical efficacyMotility
The present invention relates to a medicine for treatment of cancer intestinal obstruction and a preparation method thereof. The medicine comprises the following components by weight: 30-90 parts of clove, 10-30 parts of cinnamon, 10-40 parts of raw rhubarb, 6-12 parts of borneol, and 20-40 parts of mirabilite. The present invention has the advantages that: through external application of the invention, the medicine has the effects of tonifying spleen and warming the middle, moving qi and directing qi downward, promoting digestion and removing food retention, clearing away heat and relaxing the bowel, relieving swelling and pain, resolving hard lump, and removing stagnate and inducing menstruation; can release intestinal adhesion, increase gastrointestinal motility, improve intestinal blood circulation, reduce capillary permeability, protect the intestinal mucosal barrier and reduce bacterial translocation, promote inflammation edema recession, and inhibit the growth of enteric bacilli, and finally achieve the functions of promoting fart and cacation, diminishing inflammation and swelling, relieving abdominal distension and pain, and restoring gastrointestinal function. Proved by clinical application, the medicine has remarkable clinical efficacy, is easy, economical and safe to use, is high in patient compliance and is worthy of promotion.
Owner:NANTONG CHUNLIANG HOSPITAL OF CHINESE MEDICINE
Gel material for preventing intestinal adhesion
InactiveCN102793952ARelieve inflammationImprove isolationOrganic active ingredientsAerosol deliveryIsolation effectFibrin blood clot
The invention relates to a gel material for preventing intestinal adhesion, which is used for preventing peritoneal adhesion after operation. Hyaluronic acid crosslinking preparations for isolating damaged wounds can cause severe adverse reactions during application, such as abdominal pain, abdominal infection, and intestinal adhesion, and even reoperation is performed due to adverse reactions for some patients; the hyaluronic acid crosslinking preparations also have a dissociation phenomenon in the body, and the isolation effect is reduced. The gel material for preventing intestinal adhesion of the invention is a gel system formed by polyacrylamide, a hydrotalcite colloid material, iron ion crosslinked hyaluronic acid gel liquid, 2-deoxy-D-glucose (2-DG) with anti-inflammation and pain-relieving efficacy, tramadol hydrochloride, and acetaminophen. After operation, the gel material is coated directly on a wound; crosslinking effect is generated with fibrin blood clots on the wound; thus the gel material is firmly adhered to the wound; good isolation effect is reached. The medicinal components with anti-inflammation pain-relieving efficacy are directly applied to the wound; and inflammation caused by singly application of hyaluronic acid isolating substances is alleviated.
Owner:SHANDONG PROVINCIAL HOSPITAL
Rehabilitation equipment for preventing intestinal adhesion after abdominal surgery
InactiveCN103445933APrevent intestinal adhesionChiropractic devicesVibration massageAbdominal cavitySmall intestine
The embodiment of the invention discloses rehabilitation equipment for preventing intestinal adhesion after an abdominal surgery. The rehabilitation equipment comprises a base frame, a support plate connected to the base frame in a sliding fit manner, a leg support block movably arranged on the support plate and used for supporting a leg of a patient, a pedal plate arranged on the support plate and located at one side of the leg support block so as to support against feet of the patient, and a driving device. As the driving device is adopted to drive composite movement of the support plate, the leg support block and the pedal plate in the embodiment of the invention, the feet of the patient can do front-and-back, up-and-down and left-and-right movements, and effects of massaging ankles and shanks are achieved. Therefore, the rehabilitation equipment for preventing the intestinal adhesion after the abdominal surgery can enable a patient who cannot seat and stand to finish movement and massage of the lower limbs in a sickbed and finally enable small intestines in the abdominal cavity of the patient to wriggle normally, and can prevent intestinal adhesion by utilizing the restoring function of the body per se.
Owner:雷兴邦
New medicinal use of paeonidin
The present invention provides the application of paeonidin in preparing medicine for promoting post-operational intestinal function and preventing post-operational intestinal adhesion.
Owner:SHANDONG GREENERY NATURAL MEDICINE RES & DEV
Oral traditional Chinese medicine preparation for treating postoperative intestinal adhesion
ActiveCN102698024ADefinite curative effectGood curative effectDigestive systemPlant ingredientsPatriniaOfficinalis
The invention discloses an oral traditional Chinese medicine preparation for treating postoperative intestinal adhesion. The oral traditional Chinese medicine preparation comprises the following components in parts by weight: 30-60 of patrinia, 30-60 of dandelion, 30-60 of selfheal, 30-60 of seaweeds, 15-25 of raw rheum officinale, 15-25 of rhizoma cyperi, 15-25 of fried pomeron, 15-25 of magnolia obavata, 15-25 of wormwood ash, 10-25 of peach kernels, 10-25 of Chinese angelica, 10-25 of the root of three-nerved spicebush, 10-25 of root of common peony, 10-25 of lithospermum, 10-25 of the root of red-rooted salvia, 10-15 of immature bitter orange, 10-15 of pseudo-ginseng, 10-15 of Mangnolia officinalis, 10-15 of raw Astragalus mongholicus and proper amount of honey. The oral traditional Chinese medicine preparation can be decocted into decoction by using water and taken orally. According to the invention, the oral traditional Chinese medicine preparation disclosed by the invention has the functions of purging internal organs, draining turbidity, promoting the circulation of qi and expelling stagnation; all drugs are compatible; therefore, the oral traditional Chinese medicine preparation is more accurate in curative effect, more steady, free from toxic and side effects, short in treatment course and difficult to recur; aiming at various postoperative intestinal adhesion symptoms, such as stomachache, abdominal distension, non-smooth exhaust, belching, vomit, constipation and the like, the curative effective rate is up to 100%; furthermore, the oral traditional Chinese medicine preparation is low in raw material cost, good in curative effect and free from any toxic and side effect.
Owner:JIANGSU BAIJIAN PHARMA TECH CO LTD
Absorbable haemostatic material prepared based on rat tail collagen and preparation method of same
InactiveCN102526796AIncrease productivityAvoid rising costsPeptide/protein ingredientsAerosol deliveryPolyvinyl alcoholFreeze-drying
The invention relates to an absorbable haemostatic material prepared based on rat tail collagen and a preparation method of the absorbable haemostatic material. The absorbable haemostatic material is prepared from the rat tail collagen, polyvinyl alcohol and chitosan with respective weight percentages of 1%-10%, 0.2%-5% and 0.2%-2%, and the balance of water by a freeze-drying technology. The haemostatic material of the invention is mainly prepared with the rat tail collagen; compared with disadvantages that the conventional haemostatic material is unabsorbable, body allergy is easily caused, the haemostatic effect is poor, and the like, the haemostatic material prepared by the invention is absorbable in a human body, good in biocompatibility, quick in hemostasis and strong in hydrophilia; platelet aggregation can be activated to form a thrombus, thereby promoting the plasma agglomeration and stopping blood flowing; and a specific region on the surface of the collagen can be bound with glycoprotein similar to fibronectin on the surface of a cell, so that the haemostatic material has a function of preventing intestinal adhesion.
Owner:广东省医学实验动物中心
Traditional Chinese medicine extract for treating postoperative intestinal adhesion
InactiveCN102698130ADefinite curative effectGood curative effectAntipyreticAerosol deliveryPatriniaOfficinalis
The invention discloses a traditional Chinese medicine extract for treating postoperative intestinal adhesion The traditional Chinese medicine extract comprises the following components in parts by weight: 30-60 of patrinia, 30-60 of dandelion, 30-60 of selfheal, 30-60 of seaweeds, 15-25 of rhubarb carbon, 15-25 of coix seeds, 15-25 of fried pomeron, 15-25 of magnolia obavata, 15-25 of gleditschia xylocarpa, 10-25 of peach kernels, 10-25 of Chinese angelica, 10-25 of elecampane, 10-25 of root of common peony, 10-25 of lithospermum, 10-25 of the root of red-rooted salvia, 10-15 of immature bitter orange, 10-15 of pseudo-ginseng, 10-15 of Mangnolia officinalis and 10-15 of raw Astragalus mongholicus. The traditional Chinese medicine extract can be decocted into decoction by using water and taken orally. According to the invention, the traditional Chinese medicine extract disclosed by the invention has the functions of purging internal organs, draining turbidity, promoting the circulation of qi and expelling stagnation; all drugs are combined; therefore, the traditional Chinese medicine extract is accurate in curative effect, more steady, free from toxic and side effects, short in treatment course and difficult to recur; aiming at various postoperative intestinal adhesion symptoms, such as stomachache, abdominal distension, non-smooth exhaust, belching, vomit and constipation, the curative effective rate is up to 100%; furthermore, the traditional Chinese medicine extract is low in raw material cost, good in curative effect and free from any toxic and side effect.
Owner:史俊英
Air pressure cabin for restraining scorching wounded surface transudation
InactiveCN101156820AReduce exudationReduce edemaBreathing protectionTreatment roomsExhaust valveEngineering
The invention relates to an air pressure compartment used for restraining a burn surface and a wounded surface to be exuded, and belongs to the medical equipment technical field. The invention can ensure that certain constant pressure keeps in the sealed compartment under the function of an air compressor through arranging a sealed compartment connected with the air compressor and an air conditioning unit; the invention can ensure that the air in the sealed compartment flow and the temperature is constant under the function of the air conditioning unit and an exhaust valve, an animal experiment shows that the invention can reduce the fluid exudation of the wounded surface under the condition of boosting the air pressure to 30 cm H2O air pressure, the organization oedema is lightened, the conglutination time of the wounded surface is shortened, obviously, the invention is used in the clinical work to position a patient in the sealed compartment; under the proper air pressure, the invention can completely assist to cure the burn patient, and realize the purpose of reducing the hospitalization cost, shortening the curing time and reducing the patient pain; the invention is also suitable for skin hurt, the prevention and the remedy of intestinal adhesion, and the prevention and the remedy of a scar, and has strong practicability and obvious social significance.
Owner:施正
Lactobacillus paracasei for reducing cholesterol and application of lactobacillus paracasei
ActiveCN113699063AHigh cholesterolHigh cholesterol-lowering abilityAntibacterial agentsBacteriaBiotechnologyIntestinal microorganisms
The invention discloses lactobacillus paracasei for reducing cholesterol and an application of the lactobacillus paracasei. The lactobacillus paracasei is named as lactobacillus paracasei BY2, the preservation number is CGMCC NO.22571, and the lactobacillus paracasei is preserved in the China General Microbiological Culture Collection Center of Institute of Microbiology, Chinese Academy of Sciences, No.3, No.1 Yard, West Beichen Road, Chaoyang District, Beijing on May 20, 2021. The lactobacillus paracasei BY2 disclosed by the invention has relatively good endurance capacity to a gastrointestinal environment, still has relatively good cholesterol-reducing capacity after passing through the gastrointestinal tract, has relatively high intestinal adhesion and antibacterial activity, and is beneficial to maintaining normal microbial flora balance of the intestinal tract, so that the lactobacillus paracasei BY2can be used for reducing serum cholesterol, improving the intestinal microbial flora structure and inhibiting the growth and reproduction of pathogenic bacteria.
Owner:SOUTH CHINA UNIV OF TECH
Traditional Chinese medicine composition for treating adenomyosis uteri
A Chinese medicine for treating endometriosis, abdominal pain with straining before mensis, menoxenia, intestinal adhesion after operation, chronic appendicitis, etc and its preparing process are disclosed.
Owner:BEIJING RUNDEKANG MEDICAL TECH CO LTD
Application of centipede pseudo-ginseng extract product in preparation of medicine against intestinal adhesion and medicine thereof
InactiveCN103381205APrevent intestinal adhesionHigh efficiency and low toxicityAntipyreticAnalgesicsCentipedePANAX NOTOGINSENG ROOT
Owner:WUHAN DAO YI TANG PHARMA RES INST
Application of liver cell growth factor in preventing and treating tissue accretion
ActiveCN1698885AAchieve the purpose of stickingClear curative effectPeptide/protein ingredientsAerosol deliveryGrowth Factor GeneFhit gene
The invention relates to biology and medicine fields, concretely, relates to application of liver cell growth factor in preventing and treating tissue accretion. The invention inserts human hepatocyte growth factor full-length coding region cDNA into plasmid carrier (pc DNA 3 or p UDK or others), or into adenovirus carrier (such as Ad5 or gutless adenovirus) to obtain recombinant plasmid or recombinant adenovirus of the human hepatocyte growth factor gene. The recombinant plasmid or recombinant adenovirus can prevent and cure postoperative intestinal adhesion or pelvic cavity adhesion or other tissue adhesion by being locally painted on abdominal cavity or pelvic cavity. Thus, the recombinant plasmid or recombinant adenovirus carrying the human hepatocyte growth factor gene has excellent application prospect on prevent-curing or treatment for postoperative tissue adhesion.
Owner:RADIOLOGY INST ACAD OF MILITARY MEDICINE SCI PLA
Composition for preventing adhesion, containing surface-modified chondrocyte-derived extracellular matrix membrane as active ingredient
ActiveCN106163531AExcellent adhesion prevention effectOrganic active ingredientsMammal material medical ingredientsCell-Extracellular MatrixECM Protein
The present invention relates to a composition for preventing adhesion, containing a surface-modified chondrocyte-derived extracellular matrix membrane as an active ingredient, and it was observed that the efficiency of adhesion of fibrocytes to a chondrocyte-derived extracellular matrix material in vitro is low and an excellent adhesion prevention effect is exhibited in a subcutaneous adhesion animal model using a mouse and in an intestinal adhesion model using a rat. In addition, it was ascertained that the adhesion prevention effect remarkably increases when the surface charge of the present material is modified to be neutral by using poly-L-lysine (PLL), and thus the chondrocyte-derived extracellular matrix material can be applied as an adhesion barrier with excellent in vivo stability and an adhesion prevention effect.
Owner:AJOU UNIV IND ACADEMIC COOP FOUND
Medicine preparation for treating adhesive intestinal obstruction
InactiveCN104547686AReduce adhesionHigh cure rateDigestive systemPlant ingredientsAdemetioninePromotion effect
The invention discloses a medicine preparation for treating adhesive intestinal obstruction. The medicine preparation is prepared from raw materials and supplementary materials, wherein the raw materials comprises components in parts by weight asfollows: 15-22 parts of seeds of gleditsia sinensis, 15-22 parts of potentilla fulgens, 15-22 parts of fruits of a cypress, 4-8 parts of rosa rugosa, 4-8 parts of sophora flavescens, 21-36 parts of sorghum, 4-8 parts of allium tuberosum rottler, 9-15 parts of pycnonotus sinensis, 9-15 parts of szechwan chinaberry fruits and 10-20 parts of leaves and roots of Chinese desmos. The medicine preparation has a remarkable promotion effect on intestine peristalsis, and can obviously reduce intestinal adhesion simultaneously.
Owner:江志鑫
Traditional Chinese medicine composition for promoting intestine peristalsis to expel flatus to prevent intestinal adhesion and preparation method thereof
ActiveCN107875370ATrigger regulationMaintain continuityOrganic active ingredientsDigestive systemIntestinal structurePeristalsis
The invention relates to a traditional Chinese medicine composition for promoting intestine peristalsis to expel flatus to prevent intestinal adhesion and a preparation method thereof. The traditionalChinese medicine composition contains the following components in parts by weight: 6-10 parts of pericarpium zanthoxyli, 10-15 parts of rhizoma zingiberis, 6-10 parts of ginseng and 20-30 parts of maltose. The preparation method comprises the following steps: mixing all components, then uniformly mixing with a matrix paste to obtain a paste; uniformly coating a non-woven fabric of a backing layerwith the paste, and then laminating, thus obtaining emplastrum. The traditional Chinese medicine composition provided by the invention is prepared by adopting pure traditional Chinese medicine, is free from injection, free from pain, good in absorption, convenient to use, extract in curative effect, rapid to take effect and economical and practical, can recover the intestinal function of a patient as soon as possible, promote intestine peristalsis and intestinal flatus expelling and prevent the occurrence of intestinal adhesion, and can overcome shortages of existing clinical treatment technology, and further can enable patients to recover the physical power as soon as possible, promote healing of the wound, reduce length of stay, relieve the family financial burden, bring convenience andgreatly facilitate the doctor and the patient.
Owner:SHENZHEN JIAN AN PHARMA CO LTD
Salmon calcitonin-phospholipid complex and its lipid nanoparticle and preparation method
ActiveCN105919974AImprove long-term stabilityFor long-term storageNervous disorderPeptide/protein ingredientsRecombinant salmon calcitoninMembrane permeability
The invention belongs to the technical field of medicines and relates to a salmon calcitonin-phospholipid complex and its lipid nanoparticle and preparation method. The salmon calcitonin-phospholipid complex and its lipid nanoparticle can improve drug lipid solubility, have a certain intestinal adhesion, can be easily absorbed through intestinal mucosa and can prevent drug degradation caused by gastrointestinal tract protease. The lipid nanoparticle of the salmon calcitonin-phospholipid complex comprises the salmon calcitonin-phospholipid complex, a lipid material, a surfactant and water and is prepared through a film dispersion method. The water-soluble drug nanoparticle obtained through the preparation method has a high drug oil-liquid distribution coefficient and good membrane permeability and improves oral bioavailability. The preparation method has simple processes.
Owner:CHENGDU UNIV
Preparation method of anti-intestinal-adhesion double-layer biogel and double-layer biogel
ActiveCN111437444AAvoid painPlay the role of fixing intestinal woundsSurgeryPharmaceutical delivery mechanismMethacrylateIntestino-intestinal
The invention provides a preparation method of anti-intestinal-adhesion double-layer biogel. The preparation method comprises the following steps: S1, preparing a chitosan solution in advance; S2, preparing a methacrylic acid esterification chitosan pure product; S3, preparing a methacrylic acid esterification chitosan solution; S4, preparing an HA-DA-AEMA pure product; S5, preparing an HA-DA-AEMAsolution; and S6, separately curing the HA-DA-AEMA solution and the methacrylic acid esterification chitosan solution into inner-layer biogel adhering to the tissue and anti-adhesion outer-layer biogel. The inner-layer biogel adhered to the tissue can be tightly combined with the surface of the intestinal tract, the effect of fixing the wound of the intestinal tract can be achieved, and inflammatory exudation and bleeding are prevented; and the anti-adhesion outer-layer biogel can prevent the adhesion of the adhesive surface of the inner-layer biogel adhered to the tissue and the abdominal cavity or other intestinal tracts, and the pain of a patient caused by intestinal adhesion is avoided.
Owner:SOUTHERN MEDICAL UNIVERSITY
Preparation method of nano-silver/polydopamine/polypropylene composite patch material
InactiveCN110801539AReduce the risk of complications such as intestinal adhesionsReduce Biosecurity RisksSurgeryCoatingsWhite blood cellBiocompatibility
The present invention relates to the field of medical materials and particularly to a preparation method of a nano-silver / polydopamine / polypropylene composite patch material. By utilizing characteristics of good adhesiveness, hydrophilicity and biocompatibility of polydopamine, dopamine is oxidized and polymerized into the polydopamine to coat a surface of a polypropylene mesh, so that risks of complications of intestinal adhesion, etc. caused by contact of polypropylene with abdominal organs are reduced. The polydopamine has chelation and reduction characteristics on metal ions and silver ions are reduced into nano-silver to be deposited on a surface of a polydopamine film, so that a microorganism-inhibiting property is obtained. A used technical scheme is as follows: the preparation method comprises the following steps: S1, placing the polypropylene mesh into a dopamine solution for reaction to form a polydopamine film to coat the surface of the polypropylene mesh to obtain a polydopamine / polypropylene composite mesh; and S2, putting the polydopamine / polypropylene composite mesh material into a silver nitrate solution for reaction, and depositing the nano-silver on the surface ofthe polydopamine film to obtain a nano-silver / polydopamine / polypropylene composite patch material which still maintains an original mesh structure and is beneficial to tissue ingrowth and free accesses of macrophages and leukocytes. The manufacturing method is simple and low in cost.
Owner:NATONG HORCO N MEDICAL TECH CO LTD
Medicine for treating abdominopelvic cavity disease postoperative intestinal adhesion
The invention discloses a pharmaceutical composition for preventing belly postoperative adhesion and preparation method thereof. The pharmaceutical composition consists of astragalus or Radix Codonopsis, red sage root, banksia rose, bitter orange, rheum officinale or senna leaf, saltcake, magnolia cortex, Chinese angelica and licorice. The composition is prepared by: decocting by water, collecting the volatile oil; removing the residues; concentrating the extract, adding 95% ethanol to raise the alcohol content to 40-60%; leaving statically for 24 hours; centrifuging, removing deposition, recovering ethanol from supernatant and adding volatile oil. And the medicine can be made into oral liquid, tablet, soluble granules, capsule and injection by adding pharmaceutics acceptable auxiliary materials according to common technology. The composition achieves the effects of supplementing qi, removing blood stasis, promoting qi circulation and clearing hollow viscera, can be used for treating belly postoperative adhesion which belongs to qi-deficiency blood stasis qi stagnation hollow viscera filled disease.
Owner:NAN FANG HOSPITAL
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