Degradable gasket with anti-bacterial anti-adhesion performance

Abstract

The invention provides a degradable gasket with anti-bacterial anti-adhesion performance. The degradable gasket is prepared via weaving or knitting of a plurality of bundles of magnesium-based metal wire, or via punching of magnesium-based metal sheets. The magnesium-based metal wire can be made of pure magnesium or a magnesium-based alloy of different elements based on disease characteristics and treatment requirements. The degradable gasket possesses excellent biocompatibility; in vivo degradation and absorption can be realized; degradation speed can be controlled; the degradable gasket is capable of preventing postoperative adhesion and infection, and promoting wound healing, can be used for preventing epidural adhesion after orthopedic surgery laminectomy, adhesion after tendon rupture repairing operation, adhesion after knee surgery, dura adhesion after transcranial surgery, eye socket soft tissue adhesion, intestinal adhesion after abdominal surgery, and intrauterine adhesion, is capable of reducing infection risk of the above surgeries, and possesses significant clinical application value.

Description

technical field [0001] The invention relates to the field of medical biomaterials, in particular to a degradable gasket with antibacterial and anti-adhesion functions. Background technique [0002] Preventing postoperative tissue adhesion in surgical operations is a common problem in various fields of surgery. Severe tissue adhesion will cause corresponding clinical complications. Joint stiffness affects the recovery of postoperative motor function. Tendon injury such as Achilles tendon rupture and tendon adhesion after repair is also a common clinical problem. Posterior lumbar discectomy often requires removal of part or all of the lamina, but fibrous fibers are prone to appear after surgery. Scar hyperplasia, adhesion to dura mater and nerve root causes compression on both, which can cause neurological symptoms and affect the surgical effect; brain tissue adhesion in craniotomy can cause traumatic epilepsy; orbital space is small but prone to postoperative soft tissue Adh...

AI Technical Summary

Problems solved by technology

However, the chitosan film has poor adhesion to the body, it is difficult to wrap and fix during surgery, the suture strength is obviously insufficient, and the degradation rate is not easy to control

Hyaluronic acid film has excellent biocompatibility and good biodegradability, high viscoelasticity, non-toxic, non-antigenic, but the retention time of sodium hyaluronate in the body is short, and it often disappears before the tissue is completely repaired. Degradation, leading to adhesions and poor hemostatic effect

Poly-DL-lactic acid absorbable anti-adhesion film can degrade lactic acid in the body, and then decompose it into carbon dioxide and water through the tricarboxylic acid cycle, which can be absorbed by the body and excreted from the body. It is non-toxic and has no side effects, but it is not flexible enough and the texture It is hard, not tight enough when wrapping the tissue, easy to slip, has no micropores, is not conducive to secretion or blood penetration, relatively poor nutrient supply to the tissue, and it does not have special hemostatic and other auxiliary effects, especially the degradation of polylactic acid The resulting acidic environment is more irritating to the surrounding tissues

The anti-adhesion effect of the oxidized cellulose film will be significantly reduced when it encounters bleeding, so it cannot be applied when there is local bleeding

It can be seen that none of the above materials can have anti-adhesion and anti-infection functions at the same time