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61 results about "Healed myocardial infarct" patented technology
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Devices and methods for interstitial injection of biologic agents into tissue
The current invention discloses a method for treating infracted / ischemic injury to a myocardium by injecting a substance into the myocardium. The injected substance helps to prevent negative adaptive remodeling by providing mechanical reinforcement or mechanical reinforcement combined with biological therapy. A number of substances for injection are disclosed, including multi component substances such as platelet gel, and other substances. The substances disclosed may contain additives to augment / enhance the desired effects of the injection. The invention also discloses devices used to inject the substances. The devices can include means for ensuring needles do not penetrate beyond a desired depth into the myocardium. The devices can also include needles having multiple lumens such that the components of the platelet gel will be combined at the injection site and begin polymerization in the myocardium.
Owner:MEDTRONIC INC
Traditional Chinese medicine composition for treating myocardial infarction and application of traditional Chinese medicine composition
ActiveCN103816280AFully functionalRemissionAnthropod material medical ingredientsCardiovascular disorderHealed myocardial infarctPharmacology
The invention belongs to the technical field of medicines, and relates to a traditional Chinese medicine composition and particularly relates to a traditional Chinese medicine composition for treating myocardial infarction and an application of the traditional Chinese medicine composition in preparation of medicines for preventing or treating myocardial infarction. Aiming at the problem that current chemical therapeutic for myocardial infarction is greater in hepatotoxicity, the invention provides the traditional Chinese medicine composition for treating or preventing myocardial infarction. The composition comprises the following components in parts by weight: 15 parts of gallnuts, 6 parts of honeysuckle, 10 parts of eucommia ulmoides, 10 parts of circium japonicum, 10 parts of ligusticum wallichii, 20 parts of radix rehmanniae, 20 parts of periostracum cicada, 10 parts of poria cocos, 5 parts of radix paeoniae alba, 5 parts of codonopsis pilosula and 10 parts of liquorice. The traditional Chinese medicine composition has a very good curative effect in the aspect of treating myocardial infarction and has a remarkable clinical promotional value.
Owner:吴琼
Medical application of CREG protein in preventing or treating myocardial infarction
ActiveCN105056208AEnhance regulatory moleculesGenetic material ingredientsMicrobiological testing/measurementHeart failure cellCardiac muscle
The invention relates to application of E1A-simulated gene cellular repressor (CREG) protein, in particular to application of CREG protein or active fragment thereof in preparation of drug used for preventing and / or treating acute myocardial infarction, heart failure after acute myocardial infarction and / or ventricular remodeling after the same. The invention further relates to application of recombinant vector or recombinant cell expressing the CREG protein or the active fragment thereof in preparation of the drug used for preventing and / or treating acute myocardial infarction, heart failure after acute myocardial infarction and / or ventricular remodeling after the same.
Owner:GENERAL HOSPITAL OF THE NORTHERN WAR ZONE OF THE CHINESE PEOPLES LIBERATION ARMY
Natural protein/polycaprolactone nanofiber electrospun membrane, and preparation and application thereof
InactiveCN105233345AEasy to operateSimple materialNon-woven fabricsProsthesisCardiac muscle tissueBiological simulation
The invention provides a natural protein / polycaprolactone nanofiber electrospun membrane, and preparation and application thereof. The natural protein / polycaprolactone nanofiber electrospun membrane is obtained by mixing natural protein and polycaprolactone to prepare a spinning solution and performing electrospinning, and the natural protein comprises natural elastin and natural collagen. The natural protein containing cardiac muscle tissue extracellular matrix components is mixed with an artificially synthesized degradable material, and the nanofiber membrane can be prepared quickly and effectively through an electrostatic spinning technically. The natural protein / polycaprolactone nanofiber electrospun membrane has the advantages that preparation is simple, materials are easy to obtain, and preparation cost is low. The natural protein / polycaprolactone nanofiber electrospun membrane not only has a good biomechanical property, but also can fully simulate cardiac muscle tissue extracellular matrix environment. Biological simulation can be carried out in the aspects of the structure and the ingredient, and an effect of treating myocardial infarction by stem cell transplantation is improved. Therefore, the natural protein / polycaprolactone nanofiber electrospun membrane can serve as an extracellular culture medium to provide an extracellular matrix microenvironment for promoting cell adhesion, survival and multiplication.
Owner:RENJI HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
Traditional Chinese medicine composition for treating myocardial infarction and preparation method thereof
InactiveCN105213574ASignificant effectGood treatment effectCardiovascular disorderPlant ingredientsHealed myocardial infarctBiology
The invention belongs to the technical field of traditional Chinese medicine, and relates to a traditional Chinese medicine composition for treating myocardial infarction and a preparation method thereof. The traditional Chinese medicine composition is prepared from, by weight, 12-20 parts of caulis spatholobi, 3-10 parts of radix maclurae, 6-12 parts of burdock, 6-10 parts of immature bitter oranges, 10-15 parts of panax notoginseng, 3-10 parts of fructus toosendan, 8-15 parts of fennel, 10-15 parts of hawthorns, 3-10 parts of cornus officinalis, 3-10 parts of cinnamon, 3-10 parts of prepared common monkshood daughter roots and 3-10 parts of herba leonuri. The traditional Chinese medicine composition mainly promotes blood circulation, removes stasis, invigorates the spleen and replenishes Qi and is supplemented by promoting Qi circulation to relieve pain, an obvious curative effect on the myocardial infarction is achieved, and the traditional Chinese medicine is low in side effect, convenient to take and easy to apply and promote.
Owner:GUANGDONG JUZHICHENG TECH
Traditional Chinese medicine composition for treating myocardial infarction and preparation method thereof
InactiveCN105343761AHigh clinical application valueIncrease contentCardiovascular disorderPlant ingredientsSalvia miltiorrhizaOfficinalis
The invention belongs to the field of traditional Chinese medicine and relates to a traditional Chinese medicine composition for treating myocardial infarction and a preparation method thereof. The traditional Chinese medicine composition is mainly prepared from, by weight, 20-30 parts of Vitex, 18-26 parts of Rhizoma corydalis, 20-28 parts of Flos carthami, 16-24 parts of Curcuma zedoary, 14-20 parts of Salvia miltiorrhiza, 14-22 parts of Caulis polygoni multiflori, 12-16 parts of Folium ginkgo bilobae, 10-18 parts of leaf of Moringa oleifera, 8-12 parts of Allium macrostemon, 6-10 parts of Mangnolia officinalis, 6-12 parts of Radix aconiti carmichaeli, 10-16 parts of Costus root, 8-16 parts of Herba taxilli and 8-18 parts of Radix glycyrrhiza. The traditional Chinese medicine composition has efficacy of activating blood to dredge collaterals, dispersing stasis to stop pain and activating blood to nourishing heart, has remarkable effect on treating myocardial infarction and is high in clinical popularization and application value.
Owner:叶宗耀
Natural medicine composition used for treating cardiovascular diseases
ActiveCN104873527ASignificant synergyEnhanced inhibitory effectKetone active ingredientsCardiovascular disorderHard CapsuleFibrosis
The invention relates to a natural medicine composition used for treating cardiovascular diseases. The natural medicine composition comprises aconitine, liquiritin and 6-gingerol and is prepared into oral preparations, such as hard capsules, soft capsules, tablets, granules, powder, pills, tea bags and medicinal liquor by utilizing synergistic effects of the components. The composition can achieve the effects of treating rats with heart failures caused by myocardial infarction, increasing the ejection fractions and fractional shortening of the rats, obviously improving cardiomyocyte morphologies, reducing the degree of cardiac collagen fibrosis and reducing the contents of aldosterone and atrial natriuretic peptide in serums, and has the function of treating cardiovascular diseases. The composition has definite pharmacodynamic effects, is rigorous in quality control and small in taking dosage and is convenient to take.
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Traditional Chinese medicine composition for treating myocardial infarction and application thereof
The invention belongs to the technical field of traditional Chinese medicine and relates to a traditional Chinese medicine composition for treating myocardial infarction. The traditional Chinese medicine composition is prepared from rhizoma corydalis, safflower, curcuma zedoary, salviae miltiorrhizae, curcuma longa, tuber fleeceflower stems, ginkgo seed leaves, horseradish tree leaves, allium macrostemon, mangnolia officinalis, monkshood, rhizoma zingiberis, elecampane, loranthus parasiticus and liquorice. The traditional Chinese medicine composition has the effects of promoting blood circulation to remove meridian, dispersing blood static to stop pain, invigorating blood circulation to nourish the heart and the like, the effect of treating myocardial infarction is remarkable, and clinical application and popularization value is high.
Owner:崔新明
Human adipose mesenchymal stem cell exosome with high expression of IL-10 for treating myocardial infarction and use of exosome
PendingCN111944748ADamage reliefStabilizing exosome effectCell dissociation methodsGenetically modified cellsCardiac functioningHealed myocardial infarct
The invention provides a human adipose mesenchymal stem cell exosome with high expression of IL-10 for treating myocardial infarction and use of the exosome, and relates to the technical field of biology. The invention provides the human adipose mesenchymal stem cell exosome with high IL-10 expression for treating myocardial infarction. The human adipose mesenchymal stem cell exosome is secreted by human adipose mesenchymal stem cells with over-expression of IL-10. According to the present invention, the human adipose mesenchymal stem cell exosome has the advantages that the human adipose mesenchymal stem cell exosome with over-expression of IL-10 is prepared by culturing the human adipose mesenchymal stem cells with over-expression of IL-10, and the human adipose mesenchymal stem cell exosome with over-expression of IL-10 contains a large amount of IL-10 and other various RNAs and cell factors, so that infarcted myocardial cells are effectively repaired, the heart function is enhanced, the compensatory myocardial load is reduced, and the heart failure is relieved; and a treatment medicine or a treatment strategy is provided for myocardial infarction.
Owner:FUJIAN MEDICAL UNIV UNION HOSPITAL
Myocardial infarction treating cell preparation, preparation method and applications thereof
InactiveCN106606511APromote regenerationImprove heart functionUnknown materialsCardiovascular disorderFibrosisIschemic myocardium
The present invention discloses a myocardial infarction treating cell preparation, a preparation method and applications thereof, wherein the main components in the cell preparation are CTs and BMSCs. According to the present invention, with the direct intracardiac injection or the interventional intracardiac injection of the cell preparation, by performing cell preparation transplantation on the ischemic area and ischemic margin area of the heart of acute myocardial infarction, the severely damaged cell network formed from CTs in the ischemic myocardium ischemic area can be effectively repaired and regenerated so as to repair the cell structure microenvironment beneficial for the regeneration of the infarcted myocardium, such that the regeneration of the infarcted myocardium is easily achieved; and after the transplantation treatment on the acute myocardial infarction, the effects in the fields of infarction area reducing, myocardial infarction heart cardiac function improving, ischemic myocardium fibrosis improving, ischemic area angiogenesis and marginal area angiogenesis promotion, infarcted heart pathological reconstruction improving and after-myocardial-infarction heart failure incidence reducing are superior to the effect of the current commonly-used separate BMSCs treatment.
Owner:JINAN UNIVERSITY
Application of multi-type mixed cells in myocardial infarction cell treatment
ActiveCN111184743AKeep aliveReduce distractionsUnknown materialsCardiovascular disorderHealed myocardial infarctBiology
The invention discloses an application of multi-type mixed cells in myocardial infarction cell treatment, wherein the multi-type mixed cells are cells derived from vein bridge vessels after a vein istransplanted to an artery. The invention also provides the application of the multi-type mixed cells as a medicament for preventing or treating myocardial infarction. When the multi-type mixed cell disclosed by the invention is applied to myocardial infarction treatment, the cardiac function after myocardial infarction can be improved, the left ventricular ejection fraction can be increased, the infarct area and the wall thickness can be reduced, and the inner diameter of the ventricle can be reduced, so that symptoms can be improved, and the application has important clinical significance.
Owner:ZHONGSHAN HOSPITAL FUDAN UNIV
Method for preparing myocardial patch and application of myocardial patch
ActiveCN110201233AImprove performanceImprove proliferation efficiencyTissue regenerationProsthesisSocial benefitsEngineering
The invention provides a method for preparing a myocardial patch. The method includes the steps: (1) preparing myocardial patch materials; (2) controlling uniform arrangement of cells in the patch materials by dielectrophoresis. The cells are controlled by the dielectrophoresis and uniformly distributed in the myocardial patch materials, and the proliferation efficiency of the cells in the materials is improved. Besides, cell arrangement on the patch materials can be adjusted according to characters of a myocardial infarction portion, the myocardial infarction portion can be completely coveredby the smaller patch, and myocardial infarction can be more effectively treated. The industrially applicable myocardial patch with excellent performances and capable of more effectively reactivatingthe myocardial infarction portion is provided for the prior art, and the myocardial patch has good market prospects and social benefit values.
Owner:嘉兴莱普晟医疗科技有限公司
Method for preparing traditional Chinese medicine composition for treating myocardial infarction
InactiveCN105796685APromote peristalsisReduce backlogBryophyta medical ingredientsCardiovascular disorderRhodobryumCoptis
Owner:YANTAI LANYANGZHICAO PHARMA BIOTECH CO LTD
Nilotinib-loaded heart microneedle patch for targeted myocardial anti-fibrosis treatment, and preparation method of nilotinib-loaded heart microneedle patch
PendingCN112972433AEasy to fixAvoid breakingOrganic active ingredientsMacromolecular non-active ingredientsCardiac fibrosisLeft ventricular size
The invention discloses a nilotinib-loaded heart microneedle patch for targeted myocardial administration and myocardial fibrosis treatment, and a preparation method of the nilotinib-loaded heart microneedle patch. According to the method, GelMA hydrogel with natural biocompatibility and biodegradability is used for loading an anti-fibrosis drug nilotinib; a drug-loaded microneedle patch is prepared through ultraviolet light cross-linking curing; the microneedle patch naturally forms a radian attached to the surface of the heart in the curing process, has good mechanical properties and drug release performance, is attached to the surface of an epicardium, not only can release drugs in a targeted myocardial manner and exert the drug effect at a safe dosage, but also can provide mechanical support for the heart, prevent cardiac rupture, prevent left ventricular remodeling after myocardial infarction, and improve cardiac functions; and the drug-loaded heart microneedle patch has pharmacological and mechanical treatment effects at the same time, has good prospects for treating excessive cardiac fibrosis after myocardial infarction, preventing ventricular remodeling and improving cardiac functions, and has the advantages of high targeting property and high safety.
Owner:NANJING DRUM TOWER HOSPITAL
Manufacturing method of rat myocardial infarction model
PendingCN113855299AEasily damagedIncreased mortalitySurgical veterinaryThrombusHealed myocardial infarct
The invention relates to a manufacturing method and application of a rat myocardial infarction model. The method comprises the steps of anesthesia, intubation, connection with a breathing machine to assist breathing, caudal vein blood drawing, solidification, breaking into tiny thrombus, layer-by-layer thoracotomy of intercostal space, injection of thrombus into a left trunk in the coronary artery direction, and observation of the electrocardiogram condition of a rat. Accurate embolism is caused by using autologous thrombus, target blood vessels can be embolized more accurately, the autologous thrombus can better reflect the pathophysiological state of model I-type myocardial infarction and has no rejection reaction, and a local coronary artery injection technology is far smaller in injury than ligation, more accurate in effect and lower in death rate. The method can be applied to medicines for evaluating and treating myocardial infarction and treatment methods for evaluating and treating myocardial infarction.
Owner:GUIZHOU PROVINCIAL PEOPLES HOSPITAL
5-hydroxytryptamine 1b receptor-stimulating agent for the treatment of myocardial infarction
InactiveUS20180303772A1Small sizeImprove the level ofOrganic active ingredientsCardiovascular disorderScreening methodSurgery
The present invention relates to the field of myocardial infraction (MI). It more specifically relates to an agent stimulating, either directly or indirectly, the 5-hydroxytryptamine 1B receptor, and to a composition comprising said agent, for use in the treatment of a patient having a myocardial infraction (MI). The invention further encompasses therapeutic and screening methods.
Owner:UNIVERSITÉ PARIS CITÉ
Application of agrimonolide in antagonizing myocardial cell injury caused by hypoxia
ActiveCN111603464APromote proliferationAchieve protectionOrganic active ingredientsCardiovascular disorderAgrimonolideMedicine
The invention discloses application of agrimonolide in antagonizing myocardial cell injury caused by hypoxia. The research results show that agrimonolide can protect myocardial cells damaged by hypoxia through promoting myocardial cell proliferation, inhibiting apoptosis caused by anoxia, maintaining the integrity of cell morphology and enhancing the function of mitochondria, and theoretical support is provided for development of new drugs for treating myocardial infarction.
Owner:山东鑫谷健康产业有限公司 +1
Preparation method of human adipose tissue-derived stromal cell exosome with high expression of IL-10 for treating myocardial infarction
PendingCN111925983AImprove repair effectDamage reliefCell dissociation methodsGenetically modified cellsCardiac functioningCytokine
The invention provides a preparation method of human adipose tissue-derived stromal cell exosome with high expression of IL-10 for treating myocardial infarction, and relates to the technical field ofbiology. The preparation method comprises the following steps: culturing human adipose tissue-derived stromal cells over-expressing IL-10, and collecting a cell culture solution; and carrying out differential centrifugation on the cell culture solution, collecting the supernatant, carrying out ultracentrifugation on the supernatant to obtain target microspheres, and filtering, purifying and sterilizing the target microspheres to obtain the exosome. The preparation method has the advantage that by culturing human adipose tissue-derived stromal cells over-expressing IL-10, the human adipose tissue-derived stromal cell exosome capable of over-expressing IL-10 is prepared; the IL-10 overexpression human adipose tissue-derived stromal cell exosome contains a large amount of IL-10 and other various RNAs and cytokines, effectively repairs infarcted myocardial cells, enhances the cardiac function, reduces compensatory myocardial load, relieves heart failure, and provides a therapeutic drug ora therapeutic strategy for myocardial infarction.
Owner:FUJIAN MEDICAL UNIV UNION HOSPITAL
Collagen composite bioactive stent and preparation method thereof
InactiveCN110152061AIncrease elasticityReduce tensionPharmaceutical delivery mechanismTissue regenerationSodium glycerophosphateCulture mediums
The invention discloses a collagen composite bioactive stent and a preparation method thereof. The collagen composite bioactive stent is prepared through the steps that I-type rat tail collagen is dissolved in an acetic acid solution, a DME / F12 culture medium and a NaOH solution are added to prepare an I-type rat tail collagen solution, CSCI and beta-sodium glycerophosphate are dissolved in the DME / F12 culture medium to prepare a temperature-sensitive CSCI solution, and the I-type rat tail collagen solution is mixed with the temperature-sensitive CSCI solution. The collagen composite bioactivestent can be used for treating myocardial infarction ischemic heart diseases by being taken as tissue engineered myocardium to be injected into a myocardial ischemia area.
Owner:SHANXI MEDICAL UNIV
Heart microneedle patch loaded with TGF (Transforming Growth Factor)-beta inhibitor Galunsertib, and preparation method of heart microneedle patch
InactiveCN112972432AEasy to fixAvoid breakingOrganic active ingredientsMacromolecular non-active ingredientsCardiac fibrosisUltraviolet lights
The invention discloses a heart microneedle patch loaded with a TGF-beta inhibitor Galunsertib, and a preparation method of the heart microneedle patch. According to the method, natural polymer hydrogel GelMA and an anti-fibrosis drug TGF-beta inhibitor Galunsertib are premixed according to a certain proportion; a drug-loaded microneedle patch is prepared through ultraviolet light cross-linking curing; the microneedle patch has good mechanical properties and drug release performance and is attached to the surface of an epicardium after myocardial infarction; a microneedle array can absorb interstitial fluid to swell and degrade, target myocardial release drugs and inhibit myocardial fibrosis; furthermore, mechanical support is provided for a heart by forming a membrane structure system with certain strength, so that heart rupture is prevented; and the drug-loaded heart microneedle patch has pharmacological and mechanical treatment effects at the same time, has good prospects for treating excessive cardiac fibrosis after myocardial infarction, preventing ventricular remodeling and improving cardiac functions, and has the advantages of high targeting property and high safety.
Owner:NANJING DRUM TOWER HOSPITAL
Preparation and application of cardiac cell exosome
PendingCN111849877APreparation method is stableGood effectCell dissociation methodsCulture processLimb ischemiaDisease
The invention discloses preparation and application of a cardiac cell exosome, and aims to provide an exosome for treating cardiovascular and limb ischemic diseases. The exosome has the advantages ofsimple preparation method, high efficiency and low toxicity, and can effectively prevent and treat myocardial infarction related diseases and limb ischemic diseases. The invention particularly relatesto a method for purifying c-Kit + cells from human heart tissue, a culture method and an exosome separation method, and the exosome separation method overcomes the defects of a traditional method andis high in yield, short in period and good in effect. Besides, no effective medicine for effectively treating heart failure, myocardial hypertrophy and ventricular wall tumor caused by myocardial infarction exists clinically. The exosome can promote angiogenesis of human umbilical vein endothelial cells in vitro, repair of limb ischemic tissues and blood vessels can be effectively improved through in-vivo local injection, the exosome can be applied to treatment of heart failure, myocardial hypertrophy, ventricular wall tumors, limb ischemia and the like caused by myocardial infarction, and the exosome is clear in pharmacological action, small in dosage and free of toxic and side effects.
Owner:李刚
Application of p75ECD in preparation of drugs for treating myocardial infarction
InactiveCN109999178AReduce infarct sizeEasy to refactorPeptide/protein ingredientsCardiovascular disorderMyocardial Reperfusion InjuryMyocardial infarction syndrome
The invention belongs to the field of medicine, discloses an application of p75ECD in preparation of drugs for treating myocardial infarction, and especially relates to a method for prevention and / ortreatment of myocardial infarction / myocardial reperfusion injury. The method includes the step of administering an effective dose of a p75 extracellular structural domain (p75ECD) to a desired objectbefore reperfusion.
Owner:陈良龙 +2
Application of allicin multilayer enteric-coated tablet to prepare medicines treating myocardial infarction disease
ActiveCN104491849ASignificant dose-dependent relationshipEffective controlOrganic active ingredientsPeptide/protein ingredientsDiseasePharmaceutical drug
The invention relates to the technical field of allicin application, and relates to application of an allicin multilayer enteric-coated tablet to prepare medicines treating myocardial infarction disease. The allicin multilayer enteric-coated tablet is intragastrically administrated, histopathologic examination and blood and heart tissue homogenate biochemical index examination are performed on a mouse myocardial infarction animal model, and results show that the allicin multilayer enteric-coated tablet has the drug effect of resisting myocardial infarction, and the substantial dose-dependent relation among dosage groups instructs that the allicin multilayer enteric-coated tablet is capable of effectively controlling myocardial infarction diseases, and further instructs that an allicin preparation can become a new drug preparation for efficiently treating myocardial infarction disease.
Owner:XINJIANG AILEXIN PHARMA
Left ventricle geometric model construction method and device for injectable hydrogel curative effect evaluation
ActiveCN111584093APredict treatment outcomeSave time and costImage enhancementImage analysisLeft ventricular sizeHealed myocardial infarct
The invention discloses a left ventricle geometric model construction method and device for injectable hydrogel curative effect evaluation, and belongs to the field of image processing. The method comprises the following steps: acquiring a magnetic resonance image comprising a left ventricle; segmenting the magnetic resonance image to obtain different organ tissue sets of the left ventricle; for each pixel, constructing a three-variable quadratic polynomial volume function block on a 3*3*3 image block taking the pixel as the center; on each unit cube formed by eight adjacent pixels, weightingand averaging the quadratic polynomial volume function blocks of all the pixels in the cube, and constructing a three-variable cubic polynomial volume function block; and combining all cubic polynomial volume function blocks together to obtain a left ventricle three-dimensional geometric model. The method for constructing the high-precision left ventricular solid model is provided for evaluating the curative effect of the hydrogel on myocardial infarction treatment, an effective technology is provided for high-accuracy evaluation, and an important auxiliary technology is provided for medical staff to improve the curative effect on myocardial infarction treatment.
Owner:LUDONG UNIVERSITY
A kind of mixed cell preparation for treating myocardial infarction and its preparation method and application
ActiveCN106606512BEfficient regenerationPromote myocardial endogenous CSCsOrganic active ingredientsGenetic material ingredientsBULK ACTIVE INGREDIENTMyocardial ischaemia
The invention discloses a mixed cell preparation used for treating myocardial infarction as well as a preparation method thereof and an application thereof. The mixed cell preparation consists of active ingredients and a solvent, wherein the active ingredients are mainly CTs and CSCs. The mixed cell preparation is transplanted for an ischemic region and an ischemic penumbra region of a heart with acute myocardial infarction, so that survival, differentiation and multiplication, on the ischemic penumbra region, of transplanted CSCs or myocardial endogenous CSCs and other derived stem cells can be effectively promoted, and a severely damaged cell network which consists of CTs of a regenerative ischemic myocardium ischemic region is effectively repaired, and therefore, regeneration of infarcted myocardium is facilitated. The mixed cell preparation has curative effect, which is superior to that of independent use of CSCs, BMSCs and CTs, in reducing an infarct size and improving the function of a myocardial infarction heart, and the like after implementing transplantation therapy on acute myocardial infarction. Therefore, the mixed cell preparation can be prepared into a drug for treating myocardial infarction or applied to mechanical apparatuses and instruments.
Owner:JINAN UNIVERSITY
An ionic reagent capable of treating myocardial infarction and its preparation method and application
ActiveCN108310010BNo secondary damageSimple manufacturing processHeavy metal active ingredientsPharmaceutical delivery mechanismBiocompatibilityHealed myocardial infarct
The present invention provides an ion reagent capable of treating myocardial infarction, and a preparation method therefor and an application thereof. The ion reagent comprises: a liquid having biocompatibility and a bioactive ion dispersed in the liquid, the bioactive ion being selected from at least one of Si, Sr, Mg, Zn, Cu, Co, Mn and Ca ions.
Owner:SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
A method and device for constructing a geometric model of the left ventricle for evaluating the efficacy of injectable hydrogels
ActiveCN111584093BPredict treatment outcomeSave time and costImage enhancementImage analysisLeft ventricular sizeHealed myocardial infarct
Owner:LUDONG UNIVERSITY
Application of Neogenin to preparation of medicine for preventing, relieving and/or treating myocardial infarction and related diseases thereof
InactiveCN113209277AImprove protectionPeptide/protein ingredientsCardiovascular disorderDiseaseAntiendomysial antibodies
The invention discloses an application of Neogenin to preparation of a medicine for preventing, relieving and / or treating myocardial infarction and related diseases thereof, and belongs to the field of functions and application of genes. According to the invention, the research results show that a Neogenin (Neo1) neutralizing antibody can aggravate myocardial remodeling after myocardial infarction, and can deteriorate cardiac functions. Research results show that Neo1 shows a protective effect in myocardial infarction, the Neo1 is taken as a target or the Neo1 can be used for preparing the medicine for preventing, relieving and / or treating myocardial infarction and related diseases thereof, and myocardial infarction and related diseases thereof comprise acute ST segment elevation type myocardial infarction, acute non-ST segment elevation type myocardial infarction, ischemic cardiomyopathy, heart failure and the like. According to the pharmaceutical application, the Neo1 is used as a medicine, a Neo1 activator is used as a medicine, and a substance for promoting Neo1 expression is used as a medicine. The invention provides a new medicine for preventing, relieving and / or treating myocardial infarction.
Owner:WUHAN UNIV
Traditional Chinese medicine composition for treating myocardial infarction, pharmaceutical preparation and preparation method of pharmaceutical preparation
PendingCN111467422AGood treatment effectShort course of treatmentAnthropod material medical ingredientsPteridophyta/filicophyta medical ingredientsTherapeutic effectPharmaceutical Aids
The invention provides a traditional Chinese medicine composition for treating myocardial infarction, a pharmaceutical preparation and a preparation method of the pharmaceutical preparation. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 32-60 parts of radix cudramiae, 13-36 parts of bulbus allii macrostemi, 7-23 parts of cantharides, 17-42 parts of semen vaccariae, 6-21 parts of mulberry barks, 10-33 parts of rhizoma anemarrhenae, 7-18 parts of diverse wormwood herb, 3-11 parts of radix angelicae pubescentis, 5-12 parts of fructus corni,3-8 parts of impatiens leptocaulon rhizome, 10-20 parts of herba rabdosiae, 6-13 parts of herba patriniae and 2-9 parts of herba selaginellae. The raw materials are subjected to water extraction andalcohol extraction, an extracting solution is concentrated, dried into powder and mixed to prepare the traditional Chinese medicine composition, and pharmaceutically acceptable auxiliary materials aresupplemented to prepare the pharmaceutical preparation. The traditional Chinese medicine composition and the pharmaceutical preparation thereof have a good treatment effect on myocardial infarction patients, the required treatment course is short, the medicine property is mild, and the preparation method is simple and convenient.
Owner:FOSHAN UNIVERSITY
Biomarker for diagnosing and treating myocardial infarction
PendingCN113025704AMicrobiological testing/measurementDisease diagnosisPharmaceutical drugBiologic marker
The invention discloses a biomarker for diagnosing and treating myocardial infarction. The biomarker comprises LINC00997 and / or HAUS3. The invention discloses application of a reagent for detecting the expression level of LINC00997 and / or HAUS3 genes in the preparation of a product for diagnosing myocardial infarction. The invention also discloses a method for screening candidate drugs for preventing or treating myocardial infarction.
Owner:THE SECOND AFFILIATED HOSPITAL OF SHANDONG FIRST MEDICAL UNIV +1
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