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Application of allicin multilayer enteric-coated tablet to prepare medicines treating myocardial infarction disease

A technology of allicin and myocardial infarction, which is applied in cardiovascular system diseases, drug combination, drug delivery, etc., and can solve the problem of unsatisfactory drug effect in myocardial infarction

Active Publication Date: 2015-04-08
XINJIANG AILEXIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0028] The present invention provides a kind of allicin multi-layer enteric-coated tablet as the application of the medicine for the treatment of myocardial infarction, which overcomes the deficiencies of the above-mentioned prior art, and can Effectively solve the problem that there is no "high-efficiency new preparation of garlic" at home and abroad and the current effect of drugs for the treatment of myocardial infarction is not ideal

Method used

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  • Application of allicin multilayer enteric-coated tablet to prepare medicines treating myocardial infarction disease
  • Application of allicin multilayer enteric-coated tablet to prepare medicines treating myocardial infarction disease
  • Application of allicin multilayer enteric-coated tablet to prepare medicines treating myocardial infarction disease

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Embodiment 1

[0057] Example 1, the application of the allicin multilayer enteric-coated tablet as a medicine for the treatment of myocardial infarction.

Embodiment 2

[0058] Embodiment 2, as a preference of the above embodiment, the medicine for treating myocardial infarction is allicin multilayer enteric-coated tablet.

Embodiment 3

[0059] Example 3, as the preference of the above examples, the allicin multi-layer enteric-coated tablet is obtained according to the following preparation method: the first step, the preparation of the alliin layer: weigh the filler I 55.8 in parts by weight Parts to 68.2 parts, binder I 3 parts to 5 parts, internal disintegrant I 1.8 parts to 3.3 parts, external disintegrant I 1.8 parts to 3.3 parts, glidant I 1.8 parts to 2.2 parts, 0.9 to 1.1 parts of lubricant Ⅰ and 112.5 to 137.5 parts of alliin are crushed separately, and the mixture Ⅰ is obtained after uniformly mixing alliin, filler Ⅰ, binder Ⅰ and internal disintegrating agent Ⅰ, According to the ratio of adding 10% to 99% ethanol water solution in the ratio of 10% to 99% ethanol water solution to the mixture I in the ratio of adding 10% to 99% ethanol water solution per kilogram of the mixture I, stirring while adding the ethanol water solution to obtain a soft Material I, pass soft material I through a sieve of 1...

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Abstract

The invention relates to the technical field of allicin application, and relates to application of an allicin multilayer enteric-coated tablet to prepare medicines treating myocardial infarction disease. The allicin multilayer enteric-coated tablet is intragastrically administrated, histopathologic examination and blood and heart tissue homogenate biochemical index examination are performed on a mouse myocardial infarction animal model, and results show that the allicin multilayer enteric-coated tablet has the drug effect of resisting myocardial infarction, and the substantial dose-dependent relation among dosage groups instructs that the allicin multilayer enteric-coated tablet is capable of effectively controlling myocardial infarction diseases, and further instructs that an allicin preparation can become a new drug preparation for efficiently treating myocardial infarction disease.

Description

technical field [0001] The invention relates to the application technical field of allicin, and relates to the application of an allicin multilayer enteric-coated tablet as a medicine for treating myocardial infarction. Background technique [0002] Since ancient times, garlic (Allium sativum L) has been recognized as a medicinal and edible plant in different regions and nations of the world. Before BC, there were many medicinal records of garlic in the archaeological information and medical literature of ancient Egypt, ancient India, and ancient Rome. In ancient my country, garlic was a commonly used medicine. "Compendium of Materia Medica" records: Garlic "passes the five internal organs, reaches all the orifices, removes cold and dampness, wards off evil, and eliminates carbuncles", "stops cholera, eliminates evil spirits, relieves plague, removes poison, evil sores, snakes, and stream poisons." ", "If you take it with you on the journey, the wind, miasma and rain will ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/51A61K9/36A61P9/10A61K31/105
Inventor 李连达李贻奎张金艳李新霞陈坚
Owner XINJIANG AILEXIN PHARMA
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