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Biomarker for diagnosing and treating myocardial infarction

A biomarker, myocardial infarction technology, applied in the field of biomedicine, can solve problems such as no biological function

Pending Publication Date: 2021-06-25
THE SECOND AFFILIATED HOSPITAL OF SHANDONG FIRST MEDICAL UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Lnc RNAs were previously considered as "noise of gene translation" and considered to be by-products of RNA polymerase II transcription without specific biological functions

Method used

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  • Biomarker for diagnosing and treating myocardial infarction
  • Biomarker for diagnosing and treating myocardial infarction
  • Biomarker for diagnosing and treating myocardial infarction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Example 1 Screening for Differentially Expressed Genes in Acute Myocardial Infarction

[0052] 1. Data source

[0053] Download the acute myocardial infarction (AIM) dataset GSE66360 from the GEO database, and the sample size is control: AIM=50:49.

[0054] 2. Differential expression analysis

[0055] The "limma" package in R software was used for differential expression analysis, and the screening standard for differential genes was adj.Pvalue<0.05.

[0056] 3. Experimental results

[0057] The analysis results show that the biomarkers LINC00997 and HAUS3 involved in the present invention are up-regulated in acute myocardial infarction samples, as shown in Table 1 and figure 1 shown.

[0058] Table 1. Differential expression of LINC00997 and HAUS3

[0059] Gene AveExpr t P.Value LINC00997 5.23 3.64 0.00 HAUS3 8.87 4.67 0.00

[0060] Example 2 Diagnostic efficacy verification

[0061] 1. Experimental method

[0062] The R packa...

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Abstract

The invention discloses a biomarker for diagnosing and treating myocardial infarction. The biomarker comprises LINC00997 and / or HAUS3. The invention discloses application of a reagent for detecting the expression level of LINC00997 and / or HAUS3 genes in the preparation of a product for diagnosing myocardial infarction. The invention also discloses a method for screening candidate drugs for preventing or treating myocardial infarction.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a biomarker for diagnosis and treatment of myocardial infarction. Background technique [0002] Myocardial infarction is a cardiovascular emergency with the highest morbidity and mortality rate in the world, and it is the necrosis of myocardial tissue caused by continuous severe ischemia. Timely and accurate diagnosis can improve the survival rate of patients with myocardial infarction and can improve long-term prognosis. Troponin I (cTnI) is currently a widely used biomarker for the diagnosis of myocardial infarction in clinical practice, but plasma cTnI concentration may play a role in some cardiac and noncardiac diseases such as severe heart failure, atrial fibrillation, chronic renal Therefore, it is necessary to find new biomarkers that can diagnose myocardial infarction with high sensitivity and specificity. [0003] Non-coding RNA (non-coding RNA, ncRNAs) is a kind of RNA in t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6883G01N33/68
CPCC12Q1/6883C12Q2600/136C12Q2600/158C12Q2600/178G01N33/6893G01N2333/47G01N2800/324G01N2800/52
Inventor 赵强李正美康玲江科赵洋李元民姜广运
Owner THE SECOND AFFILIATED HOSPITAL OF SHANDONG FIRST MEDICAL UNIV
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