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67 results about "Cholesterylester transfer protein" patented technology
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Cholesteryl ester transfer protein (CETP), also called plasma lipid transfer protein, is a plasma protein that facilitates the transport of cholesteryl esters and triglycerides between the lipoproteins. It collects triglycerides from very-low-density (VLDL) or low-density lipoproteins (LDL) and exchanges them for cholesteryl esters from high-density lipoproteins (HDL), and vice versa. Most of the time, however, CETP does a heteroexchange, trading a triglyceride for a cholesteryl ester or a cholesteryl ester for a triglyceride.
4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines
Cholesteryl ester transfer protein inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and / or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases in some mammals, including humans.
Owner:PFIZER INC
4-amino substituted-2-substituted-1,2,3,4-tetrahydroquinolines
Cholesteryl ester transfer protein inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and / or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases in some mammals, including humans.
Owner:PFIZER INC
Trisubstituted amine compound
InactiveUS20090023729A1Strong inhibitory activityUseful in treatmentBiocideNervous disorderDyslipidemiaCholesterylester transfer protein
The present invention relates to a compound of the general formula (1):wherein, Y is a methylene group, and the like; A is an optionally substituted heterocyclic group, and the like; B is an optionally substituted heterocyclic group, and the like; R1 is an optionally substituted alkyl group, wherein the alkyl group further may optionally be substituted by an optionally substituted homocyclic group, and the like; and R2 is an optionally substituted amino group, and the like; or a pharmaceutically acceptable derivative thereof, which has an inhibitory activity against cholesteryl ester transfer protein (CETP), thereby being useful for prophylaxis and / or treatment of arteriosclerotic diseases, hyperlipemia or dyslipidemia, and the like.
Owner:MITSUBISHI TANABE PHARMA CORP
Annulated 4-carboxyamino-2-methyl-1,2,3,4,-tetrahydroquinolines
Cholesteryl ester transfer protein inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and / or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases in some mammals, including humans.
Owner:PFIZER INC
4-amino substituted-2-substituted-1,2,3,4-tetrahydroquinolines
Cholesteryl ester transfer protein inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and / or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases in some mammals, including humans.
Owner:PFIZER INC
Annulated 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinolines
Cholesteryl ester transfer protein inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and / or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases in some mammals, including humans.
Owner:PFIZER INC
4-carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines
Owner:PFIZER INC
Oxy substituted 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinolines
Cholesteryl ester transfer protein inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and / or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases in some mammals, including humans.
Owner:PFIZER INC
Pharmaceutical compositions of cholesteryl ester transfer protein inhibitors
InactiveUS20020103225A1Improve aqueous concentrationImprove solubilityAntibacterial agentsPowder deliveryCholesterylester transfer proteinBiochemistry
A pharmaceutical composition comprises a solid amorphous dispersion of a cholesteryl ester transfer protein inhibitor and a concentration-enhancing polymer.
Owner:BEND RES
Novel benzylamine derivatives and their utility as cholesterol ester-transfer protein inhibitors
The present invention provides, among other things, new benzylamine compounds, compositions comprising benzylamine compounds, methods of making benzylamine compounds, and methods of using benzylamine compounds for treating or preventing a variety of conditions or diseases associated with lipoprotein metabolism.
Owner:DR REDDYS LAB LTD
Nanoparticles comprising a cholesteryl ester transfer protein inhibitor and anon-ionizable polymer
InactiveUS8703204B2Organic active ingredientsPowder deliveryCrystallographyCholesterylester transfer protein
Owner:BEND RES
Oxy substituted 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinolines
Cholesteryl ester transfer protein inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and / or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases in some mammals, including humans.
Owner:PFIZER INC
Trisubstituted amine compound
InactiveUS20090029994A1Strong inhibitory activityUseful in treatmentBiocideNervous disorderDyslipidemiaCholesterylester transfer protein
The present invention relates to a compound of the general formula (1):wherein, Y is a methylene group, and the like; A is an optionally substituted heterocyclic group, and the like; B is an optionally substituted phenyl group, and the like; R1 is an optionally substituted alkyl group, and the like; and R2 is an optionally substituted amino group, and the like; or a pharmaceutically acceptable derivative thereof, which has an inhibitory activity against cholesteryl ester transfer protein (CETP), thereby being useful for prophylaxis and / or treatment of arteriosclerotic diseases, hyperlipemia or dyslipidemia, and the like.
Owner:MITSUBISHI TANABE PHARMA CORP
Compounds and methods for regulating triglyceride levels
InactiveUS20060148763A1Treating and preventing hypertriglyceridemiaBiocideOrganic chemistryLipid formationHMG-CoA reductase
The present invention provides a method of administering vitamin B6 related compounds for treatment of hypertriglyceridemia. Vitamin B6 related compounds include pyridoxal, pyridoxal-5′-phosphate, pyridoxamine, a 3-acylated analogue of pyridoxal, a 3-acylated analogue of pyridoxal-4,5-aminal, and mixtures thereof. Embodiments of the present invention also comprise co-administering a lipid lowering agent, such as a nicotinic acid, a fibrate, a HMG CoA reductase inhibitor, a cholesteryl ester transfer protein inhibitor, and combinations thereof.
Owner:MEDICURE INT INC
Substituted pyridines useful for inhibiting cholesteryl ester transfer protein activity
A class of substituted pyridines that are useful for inhibiting the activity of cholesteryl ester transfer protein, and have the structural formula (IA), wherein R2, R3, R4, R5, and R6 are defined in the claims.
Owner:PHARMACIA CORP
Biological markers for longevity and diseases and uses thereof
InactiveUS7491543B2Raise the possibilityLikelihood of longevityMicrobiological testing/measurementPeptide preparation methodsInsulin-like growth factorCholesterylester transfer protein
This invention provides methods of using of the sizes and levels of high-density lipoprotein (HDL) and low-density lipoprotein (LDL) particles, the -641 allele of the promoter of the gene encoding apolipoprotein C-3 (APOC-3), the 405 allele of the gene encoding cholesteryl ester transfer protein (CETP), and plasma levels of insulin-like growth factor-1 (IGF-1), adiponectin, CETP and APOC-3, for determining and increasing an individual's likelihood of longevity and of retaining cognitive function during aging, and for determining and decreasing an individual's likelihood of developing a cardiovascular-, metabolic- or age-related disease.
Owner:ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIV
Tetrahydronaphthyridine derivatives and a process for preparing the same
InactiveUS20070032485A1Reduce usageUseful in treatmentBiocideOrganic chemistryCholesterylester transfer proteinHydrogen
A novel compound of the formula (I): wherein R1 is alkoxycarbonyl or the like, R2 is alkyl or the like; R3 is hydrogen or the like; R4 is alkylene or the like; R5 is optionally substituted heterocyclic group; R6, R7, and R8 are independently hydrogen; alky, alkoxy, or the like; R10 is optionally substituted aromatic ring, or the like; or a pharmaceutically acceptable salt thereof, which has an inhibitory activity against cholesteryl ester transfer protein (CETP).
Owner:MITSUBISHI TANABE PHARMA CORP
Process for controlled crystallization of an active pharmaceutical ingredient from supercooled liquid state by hot melt extrusion
InactiveUS20120213827A1Reduce the overall diameterSmall particle sizePowder deliveryBiocideCholesterylester transfer proteinCholesterol
A process for controlling the crystallization of certain hydrophobic active pharmaceutical ingredients (APIs) from a supercooled liquid state by hot-melt extrusion processing is described. Also described is a pharmaceutical composition comprising a solid crystalline dispersion of a cholesterol ester transfer protein inhibitor in a hydrophilic excipient matrix. In the process of the present invention, the API is fed to an extrusion system in a crystalline state contemporaneously with carrier excipients where it is first converted to a non-crystalline state by the application of heat and then subsequently recrystallized in-situ by the removal of heat and application of shear. Recrystallization of the API is controlled by carrier formulation design and the hot-melt extrusion process parameters; i.e. barrel temperature profile, feed rate, etc.
Owner:F HOFFMANN LA ROCHE & CO AG
Novel pyrimidine compound having dibenzylamine structure and medicament comprising the same
InactiveUS20090082352A1Inhibitory activityImprove actionOrganic active ingredientsBiocideCholesterylester transfer proteinHydrogen atom
A compound represented by the following general formula (I), wherein R1, R2, R3, R4 and R5 represent hydrogen atom, a halo(lower alkyl) group, cyano group and the like, R6 represents an alkyl group, a cycloalkyl group and the like, R7, R8, R9 and R10 represent hydrogen atom, a halogen atom, a lower alkyl group, a halo(lower alkyl) group and the like, R11 and R12 represent hydrogen atom, a lower alkyl group, a (lower cycloalkyl) (lower alkyl) group and the like, and R13 represents hydrogen atom, a halogen atom, a lower alkoxy group and the like, which has potent inhibitory activity on cholesterol ester transfer protein (CETP).
Owner:KOWA CO LTD
Dosage Forms Providing Controlled and Immediate Release of Cholesteryl Ester Transfer Protein Inhibitors and Immediate Release of Hmg-Coa Reductase Inhibitors
A dosage form that includes a cholesteryl ester transfer protein inhibitor in a solubility-improved form and an HMG-CoA reductase inhibitor, wherein the dosage form provides immediate release of the HMG-CoA reductase inhibitor and controlled release and immediate release of the cholesteryl ester transfer protein inhibitor.
Owner:BERCHIELLI ALFRED +3
Tetrahydroquinoline derivatives and a process for preparing the same
ActiveUS7872126B2High activityIncreasing HDL cholesterolAntibacterial agentsOrganic active ingredientsCholesterylester transfer proteinHydrogen
Owner:NEWAMSTERDAM PHARMA BV
Biological markers for longevity and diseases and uses thereof
InactiveUS20060068432A1Raise the possibilityLikelihood of longevityMicrobiological testing/measurementPeptide preparation methodsInsulin-like growth factorCholesterylester transfer protein
This invention provides methods of using of the sizes and levels of high-density lipoprotein (HDL) and low-density lipoprotein (LDL) particles, the−641 allele of the promoter of the gene encoding apolipoprotein C-3 (APOC-3), the 405 allele of the gene encoding cholesteryl ester transfer protein (CETP), and plasma levels of insulin-like growth factor-1 (IGF-1), adiponectin, CETP and APOC-3, for determining and increasing an individual's likelihood of longevity and of retaining cognitive function during aging, and for determining and decreasing an individual's likelihood of developing a cardiovascular-, metabolic- or age-related disease.
Owner:ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIV
Pyrimidine compound having dibenzylamine structure and medicament comprising the same
InactiveUS7659271B2Inhibitory activityImprove actionBiocideOrganic active ingredientsCholesterylester transfer proteinCholesterol
Owner:KOWA CO LTD
Compounds and methods for regulating triglyceride levels
The present invention provides a method of administering vitamin B6 related compounds for treatment of hypertriglyceridemia. Vitamin B6 related compounds include pyridoxal, pyridoxal-5′-phosphate, pyridoxamine, a 3-acylated analogue of pyridoxal, a 3-acylated analogue of pyridoxal-4,5-aminal, and mixtures thereof. Embodiments of the present invention also comprise co-administering a lipid lowering agent, such as a nicotinic acid, a fibrate, a HMG CoA reductase inhibitor, a cholesteryl ester transfer protein inhibitor, and combinations thereof.
Owner:MEDICURE INT INC
Pharmaceutical composition and therapeutic combination comprising a cholesteryl ester transfer protein inhibitor and HMG CoA reductase inhibitors
ActiveUS10300059B2Good effectImprove abilitiesMetabolism disorderEster active ingredientsHMG-CoA reductaseCholesterylester transfer protein
Owner:NEWAMSTERDAM PHARMA BV
2,4,5-trisubstituted selenazole compounds and preparation method, compositions and application thereof
ActiveCN102190632AInhibitory activityReduce secretionOrganic chemistryMetabolism disorderDiseaseCholesterylester transfer protein
The invention relates to 2,4,5-trisubstituted selenazole compounds and a preparation method, a composition and application thereof, in particular to compounds in a formula (I), or all possible isomers, predrugs, pharmaceutically acceptable salts, solvates or hydrates thereof, wherein each substituent is shown as the description. The invention also relates to a method for preparing the compounds in the formula (I), medicinal compositions comprising the compounds in the formula (I), and application of the compounds in the formula (I) or the medicinal compositions in preparation of medicines for treating and / or preventing phospholipid transfer protein (PLTP) activity increase and / or diseases or syndromes related with the phospholipid transfer protein activity increase. The compounds in the formula (I) have good effect of inhibiting the PLTP activity and / or cholesteryl ester transfer protein (CETP) activity of blood plasma, and can be used for treating diseases on the basis.
Owner:INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
Trisubstituted amine compound
InactiveUS7906517B2Useful in prophylaxis and treatmentImprove the level ofBiocideNervous disorderCholesterylester transfer proteinDyslipidemia
The present invention relates to a compound of the general formula (1):wherein, Y is a methylene group, and the like; A is an optionally substituted heterocyclic group, and the like; B is an optionally substituted phenyl group, and the like; R1 is an optionally substituted alkyl group, and the like; and R2 is an optionally substituted amino group, and the like; or a pharmaceutically acceptable derivative thereof, which has an inhibitory activity against cholesteryl ester transfer protein (CETP), thereby being useful for prophylaxis and / or treatment of arteriosclerotic diseases, hyperlipemia or dyslipidemia, and the like.
Owner:MITSUBISHI TANABE PHARMA CORP
Inhibitors of cholesteryl ester transfer protein
Owner:ARRAY BIOPHARMA
Immuno enzymatic quantification method for cholesterol ester transferring protein (CETP)
InactiveUS7749721B2Easy to detectEasy diagnosisEgg immunoglobulinsBacteriaCholesterylester transfer proteinSerum ige
The invention relates to an immunoenzymatic method for the quantification of protein CETP in plasma, which requires the utilization of fusion protein GST / CETP, the synthetic peptide CETP 11486-S496 and polyclonal antibody anti-CEPT 11486-S496. The method is used in the study of pathologies involving alterations in the CETP levels in plasma or in seric lipids and makes it possible to detect, evaluate and follow-up patients suffering from dyslipidemia and / or risk of altergenesis.
Owner:UNIV NAT AUTONOMA DE MEXICO
Tetrahydronaphthyridine derivatives and a process for preparing the same
InactiveUS7781443B2High activityBlock compoundBiocideOrganic chemistryCholesterylester transfer proteinHydrogen
A novel compound of the formula (I):wherein R1 is alkoxycarbonyl or the like, R2 is alkyl or the like; R3 is hydrogen or the like; R4 is alkylene or the like; R5 is optionally substituted heterocyclic group; R6, R7, and R8 are independently hydrogen; alkyl, alkoxy, or the like; R10 is optionally substituted aromatic ring, or the like; or a pharmaceutically acceptable salt thereof, which has an inhibitory activity against cholesteryl ester transfer protein (CETP).
Owner:MITSUBISHI TANABE PHARMA CORP
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